Scleroderma

About the Disease
Systemic Scleroderma, also known as scleroderma, is related to scleroderma, familial progressive and diffuse cutaneous systemic sclerosis, and has symptoms including exanthema, pruritus and hidebound skin. An important gene associated with Systemic Scleroderma is TSIX (TSIX Transcript, XIST Antisense RNA), and among its related pathways/superpathways are Akt Signaling and PAK Pathway. The drugs Metronidazole and Tadalafil have been mentioned in the context of this disorder. Affiliated tissues include skin, lung and heart, and related phenotypes are arthralgia and myalgia

Common Targets
TGFBR2 | HMOX1 | Complement component 1q | ASGR1 | CD19 | HLA-C | Asialoglycoprotein Receptor (ASGPR) (nonspecified subtype) | ENPP2 | PIK3CG | JAK3 | JAK1 | HLA-DQB1 | EDNRA | G596 | G5599 | CRBN | CD247 | RORC | MC1R | MALT1 | F2RL1 | TNPO3 | IFNA13 | FAP | JAK2 | Rho GTPase (nonspecified subtype) | Cyclophilins (nonspecified subtype) | CCR6 | SRF | FFAR1 | ALOX5AP | OPRK1 | ADRA2B | MGLL | ITGB1 | LPAR1 | Integrin alphavbeta3 (vitronectin) receptor | SSH2 | Inhibitor of Apoptosis Proteins (IAPs) (nonspecified subtype) | Relaxin receptor (nonspecified subtype) | OPRM1 | BTK | CNR2 | SGK1 | LOX | HLA-DQA1 | NOX4 | G1950 | NF-kappaB (NFkB) | TYK2 | ADORA1 | HTR2B | CD86 | HLA-B | KIT | CNR1 | CLEC4C | HLA-DRB1 | CCN2 | BRD4 | Integrin alpha5beta1 (VLA-5) receptor | PIK3CD | SLC16A1 | DYRK1A | EDNRB | CCR2 | MIR21 | IL12RB2 | HLA-DPA1 | Integrin alphavbeta5 receptor | HLA-DRA | SYK | ADORA2A | TGFBR1 | G3605 | PRF1 | PTGS1 | OPRD1 | PPARG | CXCR3 | GSK3B | GPR84 | DCX (DDB1-CUL4-X-box) E3 protein ligase complex | ACVR1B | LOXL2 | STAT4 | CD80 | PDE2A | TPH1 | LRRC15 | TNFRSF13C | IFNAR1 | IL1RL2 | Integrin alphavbeta6 receptor | SLC16A3 | HLA-DRB4 | PTPN22 | PSMB8 | IL2 | C5AR1 | LOXL3 | HLA-DPB1 | Integrin alphavbeta1 | PDE5A | EPRS1 | G1786 | G3082 | TNIP1 | NAMPT | MIR146A | G5743 | POLR3A | Integrin alphavbeta8 Receptor | Collagen (nonspecified subtype) | MRTFA | PIK3CA | LGALS1 | TLR4/MD-2 complex | HRH4 | S1PR1 | LY96 | G7124 | Soluble guanylyl cyclase | CMA1 | FGF2 | IFNAR2 | BANK1 | CARMN | Proteasome Complex | GNPTG

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