Homocystinuria

About the Disease
Homocystinuria, also known as cystathionine beta synthase deficiency, is related to homocystinuria due to deficiency of n -methylenetetrahydrofolate reductase activity and methylmalonic aciduria and homocystinuria, cblf type, and has symptoms including seizures An important gene associated with Homocystinuria is CBS (Cystathionine Beta-Synthase), and among its related pathways/superpathways are Disease and Metabolism. The drugs Mecobalamin and Hydroxocobalamin have been mentioned in the context of this disorder. Affiliated tissues include eye, liver and kidney, and related phenotypes are Increased shRNA abundance and homeostasis/metabolism

Common Targets
CBS | MTHFR

Note: If you'd like to get a target analysis report for Homocystinuria, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Homocystinuria at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Tibial Muscular Dystrophy | Lewy Body Dementia | Heimler Syndrome | Adenomyosis | Oligoasthenoteratozoospermia | C3 Glomerulopathy | Malignant Fibrous Histiocytoma | Pulmonary Veno-occlusive Disease | Systemic Mastocytosis | Hemolytic Uremic Syndrome, Atypical | Kaposiform Hemangioendothelioma | Portal Vein Thrombosis | Spinocerebellar Ataxia Type 40 | DNA Ligase IV Deficiency | Retinoschisis | Hyperlipidemia | Adams-Oliver Syndrome | Keratitis | Congenital Absence Of Vas Deferens | Osteogenesis Imperfecta Type I | Auriculocondylar Syndrome | Spinal Muscular Atrophy Type 2 | Eosinophilic Asthma | Osteogenesis Imperfecta | Glycogen Storage Disease Type 3 | Colorectal Adenoma | Hemoglobinopathies | Cervical Dystonia | Osteitis | Cardiac Arrest | Panniculitis | DRESS Syndrome | Pregnancy, Ectopic | Neurodevelopmental Disorder With Central Hypotonia And Dysmorphic Facies | Retinal Dystrophy | Olmsted Syndrome | Autoimmune Interstitial Lung, Joint, And Kidney Disease | Spondylo-megaepiphyseal-metaphyseal Dysplasia | Hypokalemia | Steel Syndrome | Seizures-scoliosis-macrocephaly Syndrome | Aplasia Cutis Congenita | Extramammary Paget's Disease | Myopathy | Chiari Malformation Type I | Analgesia | Hypertension | 3-methylglutaconic Aciduria Type IV | Schwannomatosis | Vitreoretinopathy, Proliferative | Diabetes Gestational | Charcot-Marie-Tooth Disease, Type 1A | GLUT1 Deficiency Syndrome | Neurodermatitis | Delirium | Encephalitis, Tick-borne | Cystinuria | CHOPS Syndrome | Growth Hormone Excess | Glaucoma | Idiopathic Multicentric Castleman Disease | Fibrosis | Venous Insufficiency | Polyomavirus Nephropathy | Carbohydrate Metabolism Disorders | Astrocytoma | Alazami Syndrome | Postaxial Polydactyly | Papillorenal Syndrome | Jacobsen Syndrome | Amenorrhea | Infantile Nephropathic Cystinosis | Sleep Apnea | Pierson Syndrome | Kawasaki Disease | Pseudohypoparathyroidism Type 1B | Hyperthermia, Malignant | Thrombocythemia, Essential | Dyskeratosis Congenita | VEXAS Syndrome | Glycogen Storage Disease Type 9 | Corticobasal Syndrome | Hypereosinophilic Syndrome | Cataplexy | MELAS Syndrome | Noonan Syndrome | Porphyria | Esophageal Carcinoma | Craniometaphyseal Dysplasia | Chronic Inflammatory Demyelinating Polyneuropathy | Aromatic L-amino Acid Decarboxylase Deficiency | Hemorrhoids | Hydrops Fetalis | Keratoconus | Norrie Disease | Poirier-Bienvenu Neurodevelopmental Syndrome | Parvovirus B19 Infection | Episodic Ataxia Type 1 | Pancreatitis, Chronic | Spitz Nevus | Iron Deficiency Anemia | Chronic Myeloid Leukemia | Spinocerebellar Ataxia Type 31 | Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia | Mevalonate Kinase Deficiency | Plasmacytoma | Macrodactyly | Loeys-Dietz Syndrome Type 4 | Myofibrillar Myopathy | Tinea Versicolor | Basal Ganglia Disease | Acromicric Dysplasia | Benign Familial Infantile Seizures | Acute Lymphocytic Leukemia | Juvenile Polyposis | Fetal Akinesia Deformation Sequence | Diffuse Palmoplantar Keratoderma | Neuroleptic Malignant Syndrome | Blepharospasm | Glycogen Storage Disease Type 5 | Adrenoleukodystrophy, X-linked | Ovarian Sex Cord-stromal Tumor | Tendinopathy | VACTERL/VATER Association | Marfan Syndrome | Renal Hypomagnesemia 3 | Neuromuscular Disorders | 6-pyruvoyl-tetrahydropterin Synthase Deficiency | Crisponi Syndrome | Sertoli Cell-only Syndrome | Fetal And Neonatal Alloimmune Thrombocytopenia | Patent Ductus Arteriosus | Gigantism | Angelman Syndrome | Keratitis-ichthyosis-deafness Syndrome | Seborrheic Dermatitis | LRBA Deficiency | Oculocutaneous Albinism Type 1 | Carey-Fineman-Ziter Syndrome | LMNA-related Congenital Muscular Dystrophy | Polycystic Ovary Syndrome | Eczema | Paroxysmal Kinesigenic Dyskinesia | Oculocutaneous Albinism | Hereditary Multiple Exostoses | Campomelic Dysplasia | Relapsing Polychondritis | Schindler Disease | Cutaneous T-cell Lymphoma | Metachromatic Leukodystrophy | Hyperbilirubinemia, Neonatal | Sensorineural Hearing Loss | Paraganglioma | Neurogenic Bladder | Blastomycosis | Pompe Disease | H Syndrome | Multicystic Renal Dysplasia | Best Macular Dystrophy | Inflammatory Myofibroblastic Tumor | Lipid Storage Myopathy | Mixed Connective Tissue Disease | Mitochondrial Cytopathy | Spinocerebellar Ataxia | CHARGE Syndrome | Amish Infantile Epilepsy Syndrome | Sorsby Fundus Dystrophy | Vestibular Disease | Acute Lung Injury | Hernia, Inguinal | Gestational Trophoblastic Disease | Splenomegaly | Proteus Syndrome | B-cell Prolymphocytic Leukemia | Familial Hypobetalipoproteinemia | Exostoses | Lattice Corneal Dystrophy Type 1 | ADNP Syndrome | Sclerosteosis | Usher Syndrome Type II | Osteogenesis Imperfecta Type III | Renal Tubular Dysgenesis | Fanconi Anemia | Hypoglycemia | Nutrition Disorders | Seasonal Mood Disorder | Hypersensitivity Pneumonitis | Tyrosinemia Type 1 | Meconium Ileus | Hereditary Spherocytosis | Multiple Myeloma | Hereditary Pyropoikilocytosis | Diffuse Mesangial Sclerosis | Aplastic Anemia | Cardiac Sarcoidosis | Walker-Warburg Syndrome | Gnathodiaphyseal Dysplasia | Rhabdomyosarcoma | Granuloma Annulare | Cancer, Brain | Spinocerebellar Ataxia Type 20 | Albinism | Muscular Dystrophy | Congenital Diaphragmatic Hernia | Pyloric Stenosis, Infantile Hypertrophic | Ependymoma | Polymyositis | Corneal Neovascularization | Diarrhea | Microphthalmia | Neurofibromatosis-Noonan Syndrome | Barakat Syndrome | Neuroectodermal Tumors, Primitive | Epidermolysis Bullosa Dystrophica | Chronic Neutrophilic Leukemia | Ectrodactyly | DICER1 Syndrome | Porphyria Cutanea Tarda | Hepatitis D | Alzheimer Disease, Late Onset | Cerebral Cavernous Malformations | Leishmaniasis, Visceral | Corneal Dystrophies, Hereditary | Primary Pigmented Nodular Adrenocortical Disease | Speech Disorders | Peripheral Neuropathy | Agnathia-Otocephaly Complex | Tremor | Niemann-Pick Disease, Type A | Cramp Fasciculation Syndrome | Myotonic Disorders | Transient Bullous Dermolysis Of The Newborn | Sporadic Hemiplegic Migraine | Schizophrenia, Paranoid | Alopecia Totalis | AIDS Dementia Complex | Richter's Syndrome | Aspartylglycosaminuria | Neuroendocrine Cancer | Cleidocranial Dysplasia | Chromosome 8q21.11 Deletion Syndrome | AIDS | Congenital Dysfibrinogenemia | Muckle-Wells Syndrome | Acquired Partial Lipodystrophy | Osteogenesis Imperfecta Type IV | McCune-Albright Syndrome | Hepatitis B, Chronic | Smith-Kingsmore Syndrome | Hypohidrotic Ectodermal Dysplasia | Ventricular Septal Defect | Hereditary Mixed Polyposis Syndrome | Bipolar Disorder | Patent Foramen Ovale | Spitzoid Melanoma | Anti-glomerular Basement Membrane Disease | Blepharitis | Nanophthalmos | Frontotemporal Dementia | Carcinoid Tumor | Smoldering Myeloma | Recurrent Respiratory Papillomatosis | Inflammatory Linear Verrucous Epidermal Nevus | Hypoproteinemia, Hypercatabolic | Twin-to-twin Transfusion Syndrome | Acute Anterior Uveitis | IMAGe Syndrome | Anorexia Nervosa | Juvenile Myoclonic Epilepsy | Thanatophoric Dysplasia Type 1 | Ichthyosis Hystrix, Curth-Macklin Type | Tendinitis | Systemic Lupus Erythematosus | Non-epidermolytic Palmoplantar Keratoderma | Low Phospholipid Associated Cholelithiasis | Thrombotic Microangiopathy | Pernicious Anemia | Anxiety Disorders | Leber Congenital Amaurosis | Fetal Alcohol Syndrome | Retinitis Pigmentosa | Kohlschutter-Tonz Syndrome | Tyrosine Hydroxylase Deficiency | Canavan Disease | Uremic Pruritus | Lymphoproliferative Disorders | Fuchs Heterochromic Iridocyclitis | Schnyder Crystalline Corneal Dystrophy | Hepatitis, Chronic | Beckwith-Wiedemann Syndrome | Familial Isolated Hyperparathyroidism | Motor Neuron Diseases | Contact Dermatitis | Orthostatic Intolerance | Progressive Encephalopathy-optic Atrophy Syndrome | Hepatoblastoma | Neurocutaneous Melanocytosis | Spinocerebellar Ataxia Type 42 | Multicentric Carpotarsal Osteolysis Syndrome | T-cell Leukemia | Corneal Dystrophy And Perceptive Deafness | 3-hydroxy-3-methylglutaryl-CoA Synthase Deficiency | GNE Myopathy | Japanese Encephalitis | Hemangioblastoma | Esophagitis, Eosinophilic | Triple A Syndrome | Hyperkalemic Periodic Paralysis | Nijmegen Breakage Syndrome | Aicardi-Goutieres Syndrome | Krabbe Disease | Congenital Aniridia | Benign Familial Neonatal Convulsions | Central Pain Syndrome | Choroideremia | Porokeratosis | Cone Dystrophy | Skin Carcinoma | Sarcomatoid Carcinoma Of The Lung | Osteoarthritis | Distal Spinal Muscular Atrophy | Christianson Syndrome | Schnitzler Syndrome | Specific Granule Deficiency | Craniofrontonasal Syndrome | Hyperammonemia | Dent Disease | Tietze Syndrome | Polydactyly | Dysferlinopathy | Hereditary Xerocytosis | Sleep Apnea, Central | Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive 1 | Polycystic Liver | Erythema Multiforme | Infantile Neuroaxonal Dystrophy | McKusick Type Metaphyseal Chondrodysplasia | Intermittent Explosive Disorder | Pure Red Cell Aplasia | HELLP Syndrome | Cryopyrin-associated Periodic Syndromes | Spastic Paraplegia Type 7 | Kindler Syndrome | Empyema | Peutz-Jeghers Syndrome | Asperger Syndrome | Infantile Spasm | Acrodermatitis Enteropathica | DEND Syndrome | Antisocial Personality Disorder | Hereditary Spastic Paraplegia | Vasculitis | Neurofibromatosis | Coenzyme Q10 Deficiency | Congenital Mirror Movements | Fontaine Progeroid Syndrome | Anuria | Liver Diseases | IgA Deficiency | Desbuquois Syndrome | Azoospermia | Gerodermia Osteodysplastica | Early Infantile Epileptic Encephalopathy 13 | Optic Neuropathy, Anterior Ischemic | Menkes Disease | Subcortical Band Heterotopia | Myositis | Cystitis | Neurodevelopmental Disorders | Silicosis | Thin Basement Membrane Disease | Syndactyly | Progressive Familial Intrahepatic Cholestasis Type 2 | Postpartum Depression | Cholestasis, Intrahepatic | Sturge-Weber Syndrome | Crouzon Syndrome With Acanthosis Nigricans | Hepatic Steatosis | Dwarfism | Triphalangeal Thumb-polysyndactyly Syndrome | Dystonia Musculorum Deformans | Charcot-Marie-Tooth Disease | Methemoglobinemia Type IV | Anorectal Malformations | Angiomyolipoma | Bicuspid Aortic Valve | Huntington's Disease-like 2 | Homocystinuria | Acanthosis Nigricans | Poretti-Boltshauser Syndrome | Holoprosencephaly | Brachial Plexus Neuropathy | Fabry's Disease | Arts Syndrome | Acute Coronary Syndrome | Meesmann Corneal Dystrophy | Hypertension, Pulmonary | Frontotemporal Dementia With Amyotrophic Lateral Sclerosis | Hypervalinemia | Brooke-Spiegler Syndrome