Disease

Liver Diseases

About the Disease
Liver Disease, also known as liver diseases, is related to non-alcoholic fatty liver disease and fatty liver disease, and has symptoms including abdominal pain, constipation and diarrhea. An important gene associated with Liver Disease is MEG3 (Maternally Expressed 3), and among its related pathways/superpathways are Metabolism and Nuclear receptors meta-pathway. The drugs Perindopril and Amlodipine have been mentioned in the context of this disorder. Affiliated tissues include liver, bone marrow and kidney, and related phenotypes are Reduced mammosphere formation and liver/biliary system

Common Targets
G5599 | CASP7 | AVPR1A | SLC27A2 | LRP6 | FFAR4 | IL1RN | ITPR2 | FMO4 | EMC10 | SLC22A14 | HFE | Diacylglycerol Acyltransferase (DGAT) (nonspecified subtype) | ALPL | GSR | PROC | Prostaglandin EP Receptor (nonspecified subtype) | CSF1R | Heat shock protein 90 (nonspecified subtype) | PREP | PTGES | CSK | SLC22A1 | HSD17B2 | MLKL | TTR | cAMP Phosphodiesterase (nonspecified subtype) | Prolyl 4-hydroxylase | ELANE | Carnitine O-Palmitoyltransferase 1 (CPT-1) (nonspecified subtype) | GAPDH | GSTM3 | OPRK1 | OPRM1 | Protein Kinase B (PKB/Akt) (nonspecified subtype) | CNR2 | CYP2A6 | Kainate Receptor (GluR) (nonspecified subtype) | SLC38A2 | PPARA | SLC22A7 | L-type voltage-dependent calcium channel complex | Protein kinase C (nonspecified subtype) | NR1H2 | MKNK2 | IKBKB | ITPR3 | ACE | Phosphatidylinositol 3-kinase (PI3K) (nonspecified subtype) | TCAIM | Bone Morphogenetic Protein Receptor Type I (nonspecified subtype) | THRB | TOP1 | LATS1 | DNA-Directed RNA Polymerase (nonspecified subtype) | CYP2C19 | Interleukin-1 (nonspecified subtype) | DAO | G4780 | LGALS3 | DGAT1 | SMARCA2 | SLC25A27 | MTNR1A | SLC28A1 | PRMT5 | CYSLTR1 | TYK2 | NR1I3 | COL1A1 | MARK4 | SLCO5A1 | PNPLA3 | AURKB | Metallothionein (nonspecified subtype) | NAT2 | CDK5/p25 | I-kappa-B-kinase (IKK) complex | VIM | IFNL3 | PTGER3 | ROCK1 | EPHX2 | PDGFRB | IDH1 | C5 | ABCC5 | SLC7A7 | Calcium channel (nonspecified subtype) | CYP17A1 | LPAR1 | ESR2 | SIGMAR1 | MPV17 | TPMT | TYR | FMO1 | G842 | P4HA3 | GSTM5 | IL4R | DDR2 | SLC13A1 | Somatostatin receptor (nonspecified subtype) | LCK | Lipoxygenase (nonspecified subtype) | mTOR complex 1 | IKZF1 | TRMU | FBLN1 | BRD4 | CES2 | MAOA | FZD1 | COMT | Estrogen receptor (nonspecified subtype) | Ephrin Receptor (nonspecified subtype) | Phospholipase A2 (nonspecified subtype) | GABRG2 | PIK3CD | G6352 | MAP3K5 | ALDH3A1 | GH1 | CDK5 | HRH2 | SCD | DNA Topoisomerase II (nonspecified subtype) | NR1H3 | LOC102724428 | AQP3 | Calcium release-activated channel (CRAC) | ABCB4 | BCR | G142 | G2475 | PPARG | DGAT2 | MAPK11 | Chymotrypsin (nonspecified subtype) | HMGCR | APLNR | VKORC1 | KEAP1 | CNR1 | G7124 | IL-1 Receptor (nonspecified subtype) | CPT1A | CYP2A7 | MCOLN1 | CYP1A1 | HLA-G | ICAM1 | GSTA1 | G23411 | ACSL1 | ANKK1 | LOC107987449 | SLC22A3 | CHIT1 | ADORA1 | MMP12 | CCKBR | ABCG1 | MIR208A | ADAM17 | ADORA2B | CD14 | LOC107987459 | HTR2B | KHK | DYRK1A | MAP3K11 | TMPRSS6 | HSD11B1 | ARG1 | GABA(A) receptor | TRPV1 | PTGS1 | Neurotrophic Factor (nonspecified subtype) | Liver Bile Transporters (LBAT) (nonspecified subtype) | HDAC11 | MAP3K8 | MORC4 | TSBP1-AS1 | CCN2 | DNAJC15 | MIR122 | GDF2 | CACNA1C | ALPK1 | HTRA1 | Reverse transcriptase (Telomerase) | SMPD1 | PPARD | IL-4 receptor | SLC9A3 | PCSK9 | CASP8 | GFM1 | GSTA3 | CCR2 | NR5A2 | Acetylcholine Receptors (Nicotinic) (nAChR) (nonspecified subtype) | NR1I2 | Gap junction Connexin ( (nonspecified subtype) | SOD2 | CYP2E1 | PGAM5-KEAP1-NRF2 Complex | VCAM1 | GPX1 | CHRNA9 | SEPTIN9 | APOC3 | ABCC2 | FAH | NR3C1 | ADRB3 | Tubulin | PANX1 | TM6SF2 | BCHE | TGM2 | Histone acetyltransferase (HAT) (nonspecified subtype) | NEK7 | ND2 | PTPN1 | ACHE | PIP4K2B | Guanylate cyclase (nonspecified subtype) | Casein kinase II (CKII) | CYP24A1 | AKR1B1 | SLC13A5 | Voltage-Gated Sodium Channel Complex | IL-20 receptor | GJA8 | IRAK4 | G3630 | XDH | F2 | SCO1 | DBNL | G4318 | CES1 | HLA-DPA1 | SLC19A1 | SMARCA4 | MAP1LC3B | G836 | Inhibitory kappaB Kinase (IKK) (nonspecified subtype) | SLC22A2 | GCKR | GPAM | PIKFYVE | UGT1A6 | Sphingomyelin phosphodiesterase (nonspecified subtype) | RORA | CYP4F11 | Mitogen-Activated Protein Kinase (nonspecified subtype) | LOC100507053 | G5743 | NR1H4 | OPRD1 | SLC22A16 | Platelet-Derived Growth Factor Receptor (nonspecified subtype) | CXCL12 | G367 | NDUFAF6 | CYP4F3 | CTSA | GUSB | G4233 | ADORA3 | P4HB | PTGER4 | LOC157273 | G5243 | K(ATP) Channel (nonspecified subtype) | PTP4A3 | Sodium channel (nonspecified subtype) | TRPC6 | SUMO1 | SLC10A1 | ACVR1 | Vascular endothelial growth factor receptor (VEGFR) (nonspecified subtype) | Heme Oxygenase (HO) (nonspecified subtype) | ADH6 | G6PC1 | DRD1 | FMO2 | BACE1 | CYP39A1 | ESRRA | STS | EPHB6 | MBOAT7 | RNF4 | Trypsin (nonspecified subtype) | UGT1A5 | KDM1A | FLT3 | ATP7B | HSD17B13 | IL2 | KDR | Caspase (nonspecified subtype) | CYP3A5 | FMO6P | Elastase (nonspecified subtype) | SOAT1 | MMP2 | FASN | AOX1 | DDR1 | IL1A | MALAT1 | SST | ABCC8 | PLCG1 | IL10 | CHIA | BLK | GPR183 | AP-1 Transcription Factor Complex | MIR212 | IKZF3 | SIK2 | Heat shock protein 70 (nonspecified subtype) | 17-beta-Hydroxysteroid dehydrogenase (nonspecified subtype) | MMP13 | CHAT | APEX1 | G1956 | FRK | LOXL2 | MPL | PDE5A | Sterol O-acyltransferase (ACAT) (nonspecified subtype) | LDHA | IFNG | SLC22A4 | TLR9 | ACSM2A | L-Type calcium channel (nonspecified subtype) | LYN | Vasopressin Receptor (nonspecified subtype) | NMDA receptor | Poly [ADP-ribose] polymerase (nonspecified subtype) | TPH1 | PDGFRA | G5970 | Cytochrome P450 Enzymes (nonspecified subtype) | G1786 | IL20RA | ROCK2 | G7422 | DCLK1 | Ikzf1 | DNA topoisomerase (nonspecified subtype) | PIN1 | NOX3 | NOS2 | SLC5A1 | Histone deacetylase (nonspecified subtype) | GAA | HTR1B | VHL | NQO2 | SLCO4A1 | SLC10A2 | CYP2C9 | SERPINA1 | GSTP1 | METAP2 | Inositol 1,4,5-Trisphosphate Receptor (InsP3R) (nonspecified subtype) | CTSK | TOP2A | AGTR1 | PBRM1 | GSTM1 | IL1B | SIK1 | AKR1B10 | SLCO1B1 | MMP8 | PLA2G2D | HLA-DPB1 | Proteasome Complex | UGT1A1 | CYP19A1 | CASP1 | SLCO3A1 | G3146 | HSPA1B | FYN | Phospholipase A2, Secretory (sPLA2) (nonspecified subtype) | IL4 | G3569 | Large Conductance BK(Ca) Potassium Channel (Maxi K+ Channel) (nonspecified subtype) | NLRP3 Inflammasome | TXNDC5 | EGLN1 | APOB | Gap Junction Protein (nonspecified subtype) | STING1 | CMKLR1 | Sterol Regulatory Element-Binding Protein (nonspecified subtype) | CTSB | P2RX7 | GJD2 | GBA2 | SLC22A5 | NADPH Oxidase Complex | Nicotinic alpha9alpha10 Receptor | ABCB11 | APOE | NQO1 | Nitric oxide synthase (NOS) (nonspecified subtype) | Arginase (nonspecified subtype) | IL6R | ABCC1 | HTR2C | JAK3 | CRBN | JAK1 | G7015 | KRR1 | ALOX5 | JAK2 | BMPR1A | MMP14 | G114548 | FMO3 | PIP4K2A | EPN1 | TNFRSF1A | FABP4 | MADCAM1 | GLP1R | cGMP-inhibited 3',5'-cyclic phosphodiesterase 3 (PDE3) (nonspecified subtype) | IL13 | CYP11B2 | Potassium Channels (nonspecified subtype) | USP7 | ENOX2 | G3576 | TSBP1 | LPA | S1PR1 | ABCC4 | SIRT3 | ABL1 | MAP1LC3A | RIPK1 | Voltage-Gated Calcium Channel alpha-2/delta (nonspecified subtype) | TLR7 | PIK3CG | CASP6 | LGALS1 | Rho kinase (ROCK) (nonspecified subtype) | Protein phosphatase-1 | G8878 | MRGPRX4 | Collagen (nonspecified subtype) | NADPH Oxidase (nonspecified subtype) | MICOS13 | PPIE | Ribosomal Protein S6 Kinase, 70kDa (p70S6K) (nonspecified subtype) | TAAR1 | THRA | P4HA2 | NF-kappaB (NFkB) | SLCO1B3 | HMOX1 | AOC3 | SCN5A | MMP1 | EGLN2 | NGF | PI3 | COL11A2 | G6774 | G6714 | AURKA | G5133 | CYP4B1 | KIT | GLI1 | UCP2 | DNA-Directed DNA Polymerase Complex | alpha-Mannosidase (nonspecified subtype) | TRPM3 | Ferritin | PDE4D | UGT2A1 | Transforming growth factor (TGF)-beta receptor (nonspecified subtype) | HDAC6 | ADAR | YES1 | LATS2 | Phosphodiesterase (nonspecified subtype) | G3620 | SELE | ENPP2 | HDAC2 | CYP51A1 | CAT | PLA2G2A | UGT1A3 | HCK | Acetyl-CoA Carboxylases (ACC) (nonspecified subtype) | Glutamate Receptor Ionotropic AMPA Receptor | FAP | TLR8 | SCN2A | SNCA | SLC22A11 | ACTB | LDLR | BTK | TGFB1 | ASGR1 | PICK1 | G29126 | EGLN3 | HRH3 | G595 | AMP-activated protein kinase (AMPK) | PON3 | HIF1A | BDKRB2 | Asialoglycoprotein Receptor (ASGPR) (nonspecified subtype) | Protein farnesyltransferase | KCNH2 | G7099 | FGR | MAP2K4 | Phosphatidylinositol 4-Kinase (PI4K) (nonspecified subtype) | GPBAR1 | Carbonic Anhydrase (nonspecified subtype)

疾病靶点研报
Liver Diseases

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