Cutaneous Mastocytosis

About the Disease
Mastocytosis, Cutaneous, also known as urticaria pigmentosa, is related to benign mastocytoma and urticaria, and has symptoms including macule and darier's sign. An important gene associated with Mastocytosis, Cutaneous is KIT (KIT Proto-Oncogene, Receptor Tyrosine Kinase), and among its related pathways/superpathways are Akt Signaling and PAK Pathway. The drugs Imatinib Mesylate and Cladribine have been mentioned in the context of this disorder. Affiliated tissues include skin, spleen and bone marrow, and related phenotypes are pruritus and flushing

Common Targets
Tyrosine Kinase (nonspecified subtype) | TLR2 | TLR9 | KIT | LYN | IL31 | G7099 | IL6R | IL13 | BTK | LRRC43 | GPR35 | FGFR3

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