Atherosclerosis

About the Disease
Atherosclerosis Susceptibility, also known as atherosclerosis, is related to cerebral atherosclerosis and generalized atherosclerosis, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Atherosclerosis Susceptibility is ATHS (Atherosclerosis Susceptibility (Lipoprotein Associated)), and among its related pathways/superpathways are "Plasma lipoprotein assembly, remodeling, and clearance" and Interleukin-4 and Interleukin-13 signaling. The drugs Enalaprilat and Enalapril have been mentioned in the context of this disorder. Affiliated tissues include Heart, and related phenotypes are hypertriglyceridemia and myocardial infarction

Common Targets
CNR1 | RNR1 | G1026 | KCNA3 | C5 | cAMP Phosphodiesterase (nonspecified subtype) | Diacylglycerol Acyltransferase (DGAT) (nonspecified subtype) | G142 | EPHX2 | ESR2 | Integrin alphaMbeta2 (MAC-1) Receptor | P2RY1 | IKBKB | MTHFR | AXL | MAOA | RBFOX1 | RAC1 | Prolyl 4-hydroxylase | GPR119 | G2099 | TRAF1 | TRPV1 | P2RX1 | PIK3CD | C-C chemokine receptor (nonspecified subtype) | NR1H2 | NR3C1 | CARM1 | COLEC10 | HOXD4 | MIR31 | G1950 | PIK3CA | ADAMTS7 | AGT | CCR6 | G5243 | ID1 | Interleukin-1 (nonspecified subtype) | LTA | G1956 | THRB | DDR2 | IL37 | MCPH1-AS1 | Uncharacterized LOC101928822, transcript variant X1 | APOA2 | ROCK1 | G1432 | BRD4 | IKZF1 | HDAC1 | TYR | FOLR2 | ALOX5AP | LINC01394 | METTL4 | MMP3 | F13A1 | ADAM8 | FFAR1 | MAP2K1 | Serine/Threonine Kinase (nonspecified subtype) | G7852 | DGAT1 | IL17RA | SLC35D2 | PTGS1 | MRGPRD | BMP4 | LPAR1 | ADIPOQ | HMGCR | PTGER3 | Lipoxygenase (nonspecified subtype) | MIR200B | MOGAT2 | DAO | PLA2G4A | PTGIR | KEAP1 | INSIG1 | GJA4 | G5743 | SHC4 | MAP3K5 | PTGR2 | Estrogen receptor (nonspecified subtype) | GABA(A) receptor | CFD | ACHE | TRIB1 | AURKB | LCK | PIK3CB | BSG | G9429 | SPHK2 | Rho GTPase (nonspecified subtype) | APLNR | Endothelin-Converting Enzymes (ECE) (nonspecified subtype) | G598 | DNAAF2 | APOA4 | ITGA2 | G23411 | CCNH | HTR2B | FLT4 | ICAM1 | APOA5 | COL4A1 | G6352 | CASP5 | Glycogen phosphorylase (nonspecified subtype) | BRD2 | CA1 | F11R | CTSS | CTSF | FLT1 | ALOX12 | Matrix Metalloproteinase (MMP) (nonspecified subtype) | MIR34A | G4609 | P4HA3 | CDK5 | G3630 | Geranylgeranyl transferase type-1 | Thyroid hormone receptor (nonspecified subtype) | NPC1L1 | Voltage-Gated Sodium Channel Complex | Interleukin 21 receptor complex | Calcium release-activated channel (CRAC) | Phospholipase A2 (nonspecified subtype) | G4318 | VDR | NR1H3 | HMOX2 | SCD | ADORA2B | C-X-C Chemokine Receptor CXCR1/CXCR2 (IL-8 Receptor) (nonspecified subtype) | ACP1 | FDFT1 | GP1BA | ABHD2 | CES2 | TAF1 | MGAT2 | MMP12 | P2RX3 | CDKN2B-AS1 | HSD11B1 | Chymotrypsin (nonspecified subtype) | MIR10B | G4233 | F2 | DGAT2 | Integrin alpha4beta7 (LPAM-1) receptor | THBS2 | TGFBR1 | CASP8 | MAPK11 | KDR | UGCG | FPR1 | CAMK2G | TNC | DPP4 | CCR2 | Protein Tyrosine Phosphatase (PTP) (nonspecified subtype) | Integrin Receptor (nonspecified subtype) | Sodium channel (nonspecified subtype) | Serine palmitoyltransferase | MTRR | CTSL | SYK | ABCA1 | NOS3 | ANGPTL3 | ARG1 | F3 | PDK2 | PKLR | G367 | CCN2 | F10 | GSTT1 | G3605 | AGL | CYTB | SCARB1 | CD40 | MCOLN1 | CCR7 | ADAM17 | G2064 | CDK9 | CD44 | ABCG1 | Acetylcholine Receptors (Nicotinic) (nAChR) (nonspecified subtype) | AKR1B1 | NR1I2 | XDH | PPARD | PTPN1 | Neurotrophic Factor (nonspecified subtype) | Tyrosine Kinase (nonspecified subtype) | IL10 | TNFSF13B | KCNN4 | CACNA1C | NTRK1 | PCSK9 | CHRNA7 | Cholesterol esterase (nonspecified subtype) | TLR2 | ANGPT2 | GSK3B | CDT1 | S1PR2 | NFATC2 | LTB4R2 | G3480 | G3569 | TRAF6 | ATP5IF1 | Guanylate cyclase (nonspecified subtype) | SERPINE1 | BCHE | PIM3 | OXT | Reverse transcriptase (Telomerase) | PGAM5-KEAP1-NRF2 Complex | Liver Bile Transporters (LBAT) (nonspecified subtype) | Peroxisome Proliferator-Activated Receptors (PPAR) (nonspecified subtype) | IL1B | SMPD1 | VCAM1 | FAM20B | SLC18B1 | Oxysterols receptor LXR (nonspecified subtype) | HDAC11 | EEPD1 | NR5A2 | G836 | NR1H4 | PTK6 | Fibroblast growth factor (FGF) (nonspecified subtype) | Actin related protein 2/3 complex | SELP | EPHB4 | MRC1 | NPY2R | TGM2 | LIPA | MIR122 | PINX1 | MIR495 | ITGB2 | G5595 | APOC3 | GALNT2 | MMP2 | UQCRB | FLNA | P2RY6 | IL15 | MTNR1B | IRAK4 | CES1 | MIR143 | SMAD7 | GPR146 | Histone acetyltransferase (HAT) (nonspecified subtype) | UTS2R | G7422 | ITK | Integrin alpha5beta1 (VLA-5) receptor | Mitogen-Activated Protein Kinase (nonspecified subtype) | CDK8/Cyclin C | ADORA3 | Integrin alphavbeta5 receptor | MOSPD2 | ND2 | PDE5A | Interleukin-12 (IL-12) | GCKR | HTR2A | COL15A1 | Integrin alphaIIbbeta3 (fibrinogen gpIIb/IIIa) receptor | TTK | KLRK1 | GIPR | MAPKAPK2 | RET | NUDT1 | CERS6 | PFKFB3 | Casein kinase II (CKII) | Platelet-Derived Growth Factor Receptor (nonspecified subtype) | PTGER4 | ADRB1 | MCPH1 | PCDH10 | IGFBP3 | IL-20 receptor | FREM1 | cAMP-Dependent protein kinase (PKA) | NPPA | TNKS2 | PYGL | RORA | FGFR4 | MIR124-1 | TEK | DLK1 | STAT5 (nonspecified subtype) | RAF1 | G7124 | FFAR2 | GZMB | CXCL12 | TSPO | MAPK9 | CAV1 | G7015 | FABP3 | MAP1LC3B | P2RY13 | 15-Lipoxygenase (nonspecified subtype) | IL1A | NEU4 | C3AR1 | GBP3 | TLR9 | MERTK | MRE11 | Sphingomyelin phosphodiesterase (nonspecified subtype) | IFNG | P2RX4 | AGTR1 | CTSA | IL2 | SMPD2 | CASP2 | CBFA2T3 | SMYD2 | Pim Kinase (nonspecified subtype) | Vascular endothelial growth factor receptor (VEGFR) (nonspecified subtype) | NRP1 | CXCR3 | IL-6 receptor | MAP4K1 | Trypsin (nonspecified subtype) | Glycogen synthase kinase 3 (GSK-3) (nonspecified subtype) | NOS2 | CASP4 | CCND3 | TRPA1 | JAK2 | P2RY12 | FASN | P4HB | AP4B1-AS1 | Elastase (nonspecified subtype) | SLC10A1 | FGB | G6PC1 | CREG1 | QPCTL | COL4A2 | Prostanoid TP receptor (nonspecified subtype) | HPN | NF-kappaB (NFkB) | EBF1 | ALDH1A1 | Phospholipase A2, Cytosolic (nonspecified subtype) | ACAT1 | FABP5 | PI4KA | CSF1 | LEPR | LIPC | KDM1A | DDR1 | QPCT | FASLG | GPR84 | Estrogen-related receptor (ERR) (nonspecifed subtype) | DHCR24 | STS | CHIA | CBS | ROCK2 | HRH1 | TPH2 | CPB2 | ADRB2 | MMP13 | VHL | MIR210 | AP-1 Transcription Factor Complex | CSNK1A1 | ESRRA | ALOX15B | Triacylglycerol Lipase (TG Lipase) (nonspecified subtype) | MIR185 | ERBB4 | BACE1 | IRF5 | ACP3 | L-Type calcium channel (nonspecified subtype) | TIMP1 | ACKR3 | BCL9 | MTTP | NOX3 | GSTM1 | HNF1A | G196 | FOXF2 | EPX | GRPEL2 | JAK1 | JAK3 | CXCR2 | Proteasome Complex | CCR5 | NLRP3 Inflammasome | ATG4B | Complement Complex | GAA | PIM1 | PTPN22 | HCAR1 | IL18RAP | CD80 | CCR9 | ADRA1D | CTSC | SOAT1 | Histone deacetylase (nonspecified subtype) | TXNRD1 | FPR2 | SLC17A4 | EPHA2 | G114548 | CCR1 | CTNNB1 | TPH1 | CA2 | PON1 | PKM | EEF2K | SFTPD | Janus Kinase (nonspecified subtype) | G1786 | BRD3 | KLRC4-KLRK1 | PNPLA2 | APOE | CDK12/Cyclin K | GPR183 | Platelet-Derived Growth Factor (PDGF) (nonspecified subtype) | alpha1-Adrenoceptor (nonspecified subtype) | Poly [ADP-ribose] polymerase (nonspecified subtype) | LYN | Sterol O-acyltransferase (ACAT) (nonspecified subtype) | IL4 | KIT | CRBN | CHI3L1 | Integrin alphavbeta6 receptor | FCGR2A | S1PR5 | BDKRB1 | G3576 | IL12A | Leukotriene B4 receptor (LTB4-R) (nonspecified subtype) | G673 | MIF | LSS | Vasopressin Receptor (nonspecified subtype) | SLC5A1 | BBOX1 | HTR2C | Cyclooxygenase (COX) (nonspecified subtype) | TOMM6 | SAMHD1 | TDO2 | NEUROG3 | RYR3 | FBP1 | NAMPT | GRK5 | CYP19A1 | TH | Ikzf1 | APOA1 | SLC10A2 | AGER | Adenosine receptor (nonspecified subtype) | SGMS2 | F11 | OLR1 | ACACB | APOC1 | NADPH Oxidase Complex | Cannabinoid receptor (nonspecified subtype) | PLAU | Nitric oxide synthase (NOS) (nonspecified subtype) | PLA2G10 | HLA-C | TNFRSF13C | APP | ADH5 | ERN1 | NT5E | ALOX5 | CD47 | G7099 | ADIPOR2 | IL6R | KLKB1 | NQO2 | CDK8 | DNA topoisomerase (nonspecified subtype) | CCL2 | CTSK | ECE1 | G596 | MMP8 | CYSLTR2 | PLA2G2D | G3146 | MIR92A1 | TIMP2 | ALB | P2RX7 | GLP1R | KL | HPSE | Potassium Channels (nonspecified subtype) | FYN | IL12A-AS1 | Vascular endothelial growth factors (VEGF) (nonspecified subtype) | OSM | TNFSF15 | APOB | FURIN | GP6 | CASP1 | SIRPG | F2R | Phospholipase A2, Secretory (sPLA2) (nonspecified subtype) | MSR1 | G238 | PIK3CG | METAP2 | G5133 | GSN | GPR55 | CDK6/Cyclin D3 | SORD | ZC3HC1 | KRR1 | Arginase (nonspecified subtype) | SERPINA12 | cGMP-inhibited 3',5'-cyclic phosphodiesterase 3 (PDE3) (nonspecified subtype) | DHFR | IKZF2 | 5-Hydroxytryptamine Receptor (nonspecified subtype) | CYP11B2 | PLA2G7 | OXTR | STK25 | Angiotensin receptor (AT) (nonspecified subtype) | CDK2/Cyclin A2 | LIPE | IRAK1 | Endothelin receptor (nonspecified subtype) | MIR92A2 | GSDMD | P2RY14 | Chemokine receptor (nonspecified subtype) | CTSB | SLC22A5 | MTR | EFCAB12 | HMOX1 | Fibroblast Growth Factor Receptor (FGFR) (nonspecified subtype) | MAOB | HSD17B1 | NADPH Oxidase (nonspecified subtype) | G6774 | TLR7 | Soluble guanylyl cyclase | CRP | CYP1B1 | Retinoid RXR receptor (nonspecified subtype) | Rho kinase (ROCK) (nonspecified subtype) | MMP1 | GMNN | NR1D1 | Sterol Regulatory Element-Binding Protein (nonspecified subtype) | S1PR1 | INS-IGF2 | RIPK1 | MEST | ACLY | CDK1 | IL23R | IL18R1 | HCAR3 | Sphingolipid delta(4)-desaturase (nonspecified subtype) | TCF7L2 | C9 | ANXA1 | RIPK3 | Glutathione S-Transferase (GST) (nonspecified subtype) | BMPR1A | SCARF1 | HCAR2 | FGFR2 | IL20 | SOAT2 | LTA4H | MIR126 | MMP14 | CD79B | FGF2 | CERS5 | CDK7/Cyclin H | SAA1 | AMP-activated protein kinase (AMPK) | RETN | REN | ESD | TRNL1 | RAPGEF3 | CX3CR1 | Dual Specificity Mitogen-Activated Protein Kinase Kinase (MEK) (nonspecified subtype) | SGMS1 | ACE | Mitogen-activated protein kinase p38 (MAPK p38) (nonspecified subtype) | ANPEP | ACACA | Serine/Threonine-Protein Kinase PLK (nonspecified subtype) | FABP4 | PI3 | G29126 | MPO | SIRT3 | Mitogen-activated protein kinase (JNK) (nonspecified subtype) | G5347 | HRH4 | KERA | CDC42 | DLL4 | TBK1 | GRK2 | PTAFR | CMA1 | DEGS2 | AURKA | MIR127 | BTK | EDNRA | POLB | CACNA1I | Sphingomyelin synthase (nonspecified subtype) | G6714 | CDK7 | G595 | DEGS1 | DPP9 | Ras GTPase (nonspecified subtype) | TNFRSF9 | AOC3 | Superoxide dismutase (SOD) (nonspecified subtype) | THRA | ODC1 | ARG2 | TREML4 | IKBKE | LIPG | RORC | G3620 | PON2 | CSF1R | ALOX15 | P4HA2 | CNR2 | Phosphodiesterase IV (PDE4) (nonspecified subtype) | ELANE | G4780 | NEK11 | LPAR3 | ENPP2 | SHMT1 | TBXAS1 | MMP10 | NMUR2 | HLA-B | Glutathione peroxidase (nonspecified subtype) | SELE | PDGFRB | GCGR | ECE2 | TLR8 | DNA-Directed DNA Polymerase Complex | TRNL2 | TFAP2D | NEU3 | LTB4R | LDLR | TRPM3 | ADAM33 | FADS1 | SLC5A2 | DNA Methyltransferase (DNMT) (nonspecified subtype) | SPP1 | GLA | TLR3 | SIGLEC6 | ITGAM | KCNB1 | IL21R | KNDC1 | GPBAR1 | YES1 | G2475 | RIPK2 | CCNK | CDK2 | Transforming growth factor (TGF)-beta receptor (nonspecified subtype) | CARD8 | PLA2G2A | HCK | TNFSF4 | FAP | CDK4/Cyclin D3 | ADCK5 | SIRT6 | CDK6 | NR3C2 | CETP | Na+/H+ Exchanger (NHE) (nonspecified subtype) | Acetyl-CoA Carboxylases (ACC) (nonspecified subtype) | LCAT | SCN10A | TYK2 | LRP6 | TNFRSF11B | PPARA | CDK4 | PIM2 | CCR3 | E2F1 | PPARG | ASGR1 | IL33 | LPAR5 | FFAR4 | Heat shock protein 90 (nonspecified subtype) | Integrin alphavbeta3 (vitronectin) receptor | Calcium channel (nonspecified subtype) | TNKS | CFB | Protein farnesyltransferase | Phosphatidylinositol 3-kinase (PI3K) (nonspecified subtype) | SSTR2 | FGR | CD36 | LOC107986300 | CSNK1E | Sphingosine kinase (nonspecified subtype) | FASTKD3 | DLEC1 | Protein kinase C (nonspecified subtype) | FCER2 | MYD88 | TRPM8 | GHSR | MYLIP | CD40LG | SLC2A13 | L-type voltage-dependent calcium channel complex | Asialoglycoprotein Receptor (ASGPR) (nonspecified subtype) | Interleukin-1 receptor-associated kinase (IRAK) (nonspecified subtype) | F2RL1 | ALPL | Cytochrome bc1 complex | Integrin alpha4beta1 (VLA-4) receptor | PHACTR1 | CX3CL1 | MIR130B | TFRC | MGP | MALT1 | Protein Kinase B (PKB/Akt) (nonspecified subtype) | LPL | PTGES | EXD1 | CYSLTR1 | BHMT | Tyrosine-Protein Kinases Src (nonspecified subtype) | PF4 | MRGPRX1

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