Netherton Syndrome

About the Disease
Netherton Syndrome, also known as comel-netherton syndrome, is related to dermatitis, atopic and ichthyosis, and has symptoms including trichorrhexis invaginata An important gene associated with Netherton Syndrome is SPINK5 (Serine Peptidase Inhibitor Kazal Type 5), and among its related pathways/superpathways are Nervous system development and Collagen chain trimerization. The drugs Serine Proteinase Inhibitors and protease inhibitors have been mentioned in the context of this disorder. Affiliated tissues include skin, kidney and heart, and related phenotypes are malabsorption and sparse scalp hair

Common Targets
IL17RA | SPINK5 | G7124 | KLK5 | IL10 | Chymotrypsin (nonspecified subtype) | Trypsin (nonspecified subtype) | Serine protease (nonspecified subtype) | KLK1 | Kallikrein (nonspecified subtype) | ELANE | KLK14 | KLK7

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