Disease

Netherton Syndrome

About the Disease
Netherton Syndrome, also known as comel-netherton syndrome, is related to dermatitis, atopic and ichthyosis, and has symptoms including trichorrhexis invaginata An important gene associated with Netherton Syndrome is SPINK5 (Serine Peptidase Inhibitor Kazal Type 5), and among its related pathways/superpathways are Nervous system development and Collagen chain trimerization. The drugs Serine Proteinase Inhibitors and protease inhibitors have been mentioned in the context of this disorder. Affiliated tissues include skin, kidney and heart, and related phenotypes are malabsorption and sparse scalp hair

Common Targets
IL17RA | SPINK5 | G7124 | KLK5 | IL10 | Chymotrypsin (nonspecified subtype) | Trypsin (nonspecified subtype) | Serine protease (nonspecified subtype) | KLK1 | Kallikrein (nonspecified subtype) | ELANE | KLK14 | KLK7

疾病靶点研报
Netherton Syndrome

Note: If you'd like to get a target analysis report for Netherton Syndrome, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Netherton Syndrome at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Pycnodysostosis | Vitamin A Deficiency | Desmosterolosis | Spinal Muscular Atrophy | Hypokalemic Periodic Paralysis | Acquired Partial Lipodystrophy | Von Willebrand Disease | Paraganglioma | Vertebrobasilar Insufficiency | Graves Disease | Osteopathia Striata With Cranial Sclerosis | Basal Cell Nevus Syndrome | Glomerulonephritis, Membranoproliferative | Herpes Genitalis | Spinocerebellar Ataxia Type 8 | Hyperkeratosis | Cancer, Bladder | Hereditary Pyropoikilocytosis | Mixed Connective Tissue Disease | Atrial Septal Defect | Bronchitis, Chronic | Fetal Akinesia Deformation Sequence | Hemimegalencephaly | Axenfeld-Rieger Syndrome | Chromosome 5q Deletion Syndrome | Fibrosarcoma | Congenital Poikiloderma | Tyrosinemia | Reticular Dysgenesis | Presbycusis | Congenital Primary Aphakia | Chediak-Higashi Syndrome | Mast Cell Leukemia | Ehlers-Danlos Syndrome With Progressive Kyphoscoliosis, Myopathy, And Hearing Loss | Teratozoospermia | Carney-Stratakis Syndrome | Tuberculosis | 3-methylglutaconic Aciduria Type IV | Pompe Disease | Liebenberg Syndrome | Charcot-Marie-Tooth Disease Type 2D | Pseudohypoparathyroidism Type 1C | HUPRA Syndrome | Eclampsia | Amelanotic Melanoma | Usher Syndrome Type III | Hepatorenal Syndrome | Nephrosclerosis | Long-chain 3-hydroxyacyl-coenzyme A Dehydrogenase Deficiency | Perry Syndrome | Ornithine Transcarbamylase Deficiency | Pseudohypoparathyroidism Type 1A | Carpal Tunnel Syndrome | Metabolic Diseases | Conjunctivitis | Multicystic Renal Dysplasia | Hyperoxaluria | Discoid Lupus Erythematosus | Allergic Contact Dermatitis | Dyggve-Melchior-Clausen Disease | Cardiac Sarcoidosis | Guanidinoacetate Methyltransferase Deficiency | Galactosemia | Trichorhinophalangeal Syndrome | Pendred Syndrome | X-linked Sideroblastic Anemia | Pyruvate Dehydrogenase Deficiency | Waardenburg Syndrome | Bronchiolitis | Multiple Sclerosis | Atherosclerosis | Progressive Osseous Heteroplasia | Dowling-Degos Disease | Stroke, Hemorrhagic | Charcot-Marie-Tooth Disease Type 4 | Joubert Syndrome | Congenital Sodium Diarrhea | Leukoplakia | Exostoses | Hypervalinemia | Low Tension Glaucoma | Renal Failure | Periventricular Nodular Heterotopia | Bleeding Disorder Due To CalDAG-GEFI Deficiency | Tylosis With Esophageal Cancer | Cystinuria | Sleep Apnea, Obstructive | Acromicric Dysplasia | Rhabdomyosarcoma | Carney Triad | Ureteropelvic Junction Obstruction | Hypogonadism | Methemoglobinemia | DICER1 Syndrome | Hypercalciuria | Cancer, Lung | Osteoglophonic Dysplasia | Lung Diseases | Stroke, Ischemic | Hypoalbuminemia | Early Infantile Epileptic Encephalopathy 4 | Chondrodysplasia Punctata | Chromosome 9q34.3 Deletion Syndrome | Lipid Storage Myopathy | Niemann-Pick Disease, Type C | Peripheral T-cell Lymphoma | Walker-Warburg Syndrome | Motion Sickness | Distal Myopathy 2 | Aneurysm, Abdominal Aortic | Gardner Syndrome | Adenoma, Pituitary | Mitochondrial DNA Depletion Syndrome, Encephalomyopathic Form | Optic Neuropathy | Megacystis-microcolon-intestinal Hypoperistalsis Syndrome | Lipid Storage Diseases | Cervical Dystonia | B-cell Prolymphocytic Leukemia | Acute Tubular Necrosis | Short-chain Acyl-CoA Dehydrogenase Deficiency | Glanzmann Thrombasthenia | Systemic Mastocytosis | Hereditary Xerocytosis | Glycogen Storage Disease Type 3 | Hereditary Coproporphyria | Gaucher Disease | Exocrine Pancreatic Insufficiency | Retinopathy, Diabetic | Major Depression | Heavy Chain Disease | Intermittent Claudication | Postpartum Depression | Pseudohermaphroditism | Hyperparathyroidism, Secondary | Primary Sclerosing Cholangitis | Osteopetrosis | Proopiomelanocortin Deficiency | Spondylo-ocular Syndrome | Congenital Adrenal Hyperplasia 1 | Pontocerebellar Hypoplasia Type 7 | Fontaine Progeroid Syndrome | Acute Motor Axonal Neuropathy | Salla Disease | Thanatophoric Dysplasia | Smith-Lemli-Opitz Syndrome | Hyperprolactinemia | Epidermolysis Bullosa Simplex With Mottled Pigmentation | Peyronie's Disease | GNE Myopathy | Multiple Congenital Anomalies-hypotonia-seizures Syndrome 2 | Myositis, Focal | Muckle-Wells Syndrome | Charcot-Marie-Tooth Disease, Type 1A | Osteoporosis, Postmenopausal | Neurofibromatosis | Sjogren Syndrome | Diabetic Encephalopathy | Keratoconjunctivitis | Chronic Kidney Disease | Spinal Cord Diseases | Cenani-Lenz Syndactyly Syndrome | Niemann-Pick Disease, Type A | Non-small Cell Lung Cancer | Myasthenia | Oculocutaneous Albinism Type 1 | Primary Aldosteronism | Amish Infantile Epilepsy Syndrome | Colitis, Lymphocytic | Neural Tube Defect | Alveolar Capillary Dysplasia | Menetrier Disease | Blepharoconjunctivitis | Charcot-Marie-Tooth Disease, Type 6 | 3-methylcrotonyl-CoA Carboxylase Deficiency | Herpes Simplex Dermatitis | Ocular Surface Squamous Neoplasia | Paroxysmal Kinesigenic Dyskinesia | Thrombotic Microangiopathy | Carbamoyl Phosphate Synthetase I Deficiency | Malaria | Mucolipidosis | Atelosteogenesis Type 1 | Imerslund-Grasbeck Syndrome | Congenital Fiber-type Disproportion Myopathy | Ellis-Van Creveld Syndrome | Aceruloplasminemia | Lattice Corneal Dystrophy | Polymyalgia Rheumatica | Carcinoma In Situ | Kidney Stones | Hypersomnia | Speech Disorders | Cryoglobulinemia | Macular Corneal Dystrophy | Epidermolysis Bullosa Simplex | Episodic Ataxia Type 2 | Infantile Spasm | GM2-gangliosidosis AB Variant | Benign Familial Neonatal Convulsions | Withdrawal Syndrome | MIRAGE Syndrome | Epidermolysis Bullosa Simplex, Dowling-Meara Type | Anxiety Disorders | Hereditary Hemorrhagic Telangiectasia | HELLP Syndrome | Hepatitis A | McLeod Syndrome | Heterotopic Ossification | Anterior Segment Dysgenesis | Trichuriasis | Iron Deficiency Anemia | Bursitis | Communication Disorders | Frontotemporal Dementia | Cholesteryl Ester Storage Disease | Ligneous Conjunctivitis | Dengue Hemorrhagic Fever | Autoimmune Polyendocrinopathy Syndrome Type I | Familial Thoracic Aortic Aneurysm | Congenital Tufting Enteropathy | Antisynthetase Syndrome | Myopia | Schizencephaly | Metachondromatosis | Klippel-Feil Syndrome | Torticollis | Richter's Syndrome | Congenital Bile Acid Synthesis Defect | Osteogenesis Imperfecta Type IV | Sialidosis | Glycogen Storage Disease Type 0, Muscle | Dengue Shock Syndrome | Bronchitis | Hyperparathyroidism, Primary | Angiosarcoma Of The Breast | Osteogenesis Imperfecta Type III | Tracheal Disorders | Lupus Erythematosus | Multiple Mitochondrial Dysfunctions Syndrome Type 1 | Rubinstein-Taybi Syndrome | Amyotrophic Lateral Sclerosis-parkinsonism-dementia Complex | Pseudohypoaldosteronism | Progressive Myoclonic Epilepsy | Haim-Munk Syndrome | Paraplegia | Postaxial Polydactyly | Paget's Disease Of The Breast | Corneal Ulcer | Kaposi Sarcoma | L-2-Hydroxyglutaric Aciduria | Proteus Syndrome | Tricho-hepato-enteric Syndrome | Chronic Mucocutaneous Candidiasis | Corneal Dystrophy And Perceptive Deafness | MELAS Syndrome | CEDNIK Syndrome | Endometritis | Esophagitis, Eosinophilic | Cranioectodermal Dysplasia | Cryptococcal Meningitis | Varicocele | Impetigo | Schuurs-Hoeijmakers Syndrome | Porencephaly | Congestive Heart Failure | Heroin Dependence | Polyomavirus Nephropathy | Hypomyelination With Atrophy Of Basal Ganglia And Cerebellum | Fragile X Syndrome | Nager Acrofacial Dysostosis | Poirier-Bienvenu Neurodevelopmental Syndrome | Sweet Syndrome | Epidermal Nevus Syndrome | Coronary Restenosis | Hypertension, Portal | Pancreatitis, Chronic | Thalassemia, Beta | Cavitary Optic Disc Anomalies | Blastomycosis | Duane Retraction Syndrome | Choroideremia | Tangier Disease | Paroxysmal Nocturnal Hemoglobinuria | Alopecia Areata | Dystonia-parkinsonism, X-linked | Aromatic L-amino Acid Decarboxylase Deficiency | Epidermolytic Hyperkeratosis | T-cell Lymphoma, Subcutaneous Panniculitis-like | Pneumococcal Meningitis | Arthrogryposis | Retinitis Pigmentosa 3 | Burn-McKeown Syndrome | Tendinitis | Lentigo | Muscle Wasting | Dysgerminoma | Diffuse Palmoplantar Keratoderma | Nicolaides-Baraitser Syndrome | Lateral Meningocele Syndrome | Angioimmunoblastic T-cell Lymphoma | Aplasia Cutis Congenita | Angiomyolipoma | Vitreoretinal Degeneration, Snowflake Type | Gaze Palsy, Familial Horizontal, With Progressive Scoliosis, 2 | Mitochondrial Cytopathy | Cri-du-chat Syndrome | Fibrillation, Atrial | Lymphoma, B-cell | Silver-Russell Syndrome | Celiac Disease | Congenital Hereditary Endothelial Dystrophy Type I | Cardiomyopathy, Hypertrophic | Inflammatory Joint Disease | Spondyloepimetaphyseal Dysplasia With Joint Laxity, Type 3 | Colitis, Microscopic | Histoplasmosis | Vascular Cognitive Impairment | Early Infantile Epileptic Encephalopathy | Olmsted Syndrome | Sturge-Weber Syndrome | Giant Axonal Neuropathy | Behavioral Variant Of Frontotemporal Dementia | Brugada Syndrome 1 | Left Ventricular Noncompaction | Scabies | Idiopathic Multicentric Castleman Disease | Blastoma, Pleuropulmonary | Primary Hyperoxaluria Type 1 | DEND Syndrome | Pemphigus | Cystitis | Biotinidase Deficiency | Ghosal Syndrome | Nanophthalmos | Vitamin K Deficiency | Kabuki Syndrome 2 | Lymphoma | Alazami Syndrome | Kabuki Syndrome | Lichen Sclerosus | Hemochromatosis | Esthesioneuroblastoma | Otopalatodigital Syndrome Type 2 | Emery-Dreifuss Muscular Dystrophy | Congenital Torticollis | Nemaline Myopathy 8 | Cutaneous T-cell Lymphoma | Platelet Disorders | Parkinson Disease 6, Autosomal Recessive Early-onset | Primary Ovarian Insufficiency | Rash | VACTERL Association | Dysthymia | Pelizaeus-Merzbacher Disease | Bartter Syndrome | Sepiapterin Reductase Deficiency | 3-methylglutaconic Aciduria Type I | Endophthalmitis | Anodontia | Lymphomatoid Granulomatosis | Diffuse Intrinsic Pontine Glioma | Carbonic Anhydrase VA Deficiency | Tuberculous Meningitis | Cancer, Breast | Leukemia-lymphoma, Adult T-cell | Osteosclerosis | Osteoarthritis | Optic Atrophy 2 | Duodenal Atresia | Postpoliomyelitis Syndrome | Oculocutaneous Albinism Type 4 | Alcoholism | Anorchia | Rheumatoid Arthritis | Depression | Carpenter Syndrome | Urea Cycle Disorder | N-acetylglutamate Synthase Deficiency | Leiomyoma | Batten Disease | Danon Disease | Glycogen Storage Disease Type 1 | Arteriovenous Malformations | Myhre Syndrome | Nephrotic Syndrome | Citrullinemia | Enlarged Vestibular Aqueduct | Atrioventricular Septal Defect | Fuchs Dystrophy | Intellectual Disability, Autosomal Dominant 5 | Anorexia Nervosa | Mitochondrial DNA Depletion Syndrome, Hepatocerebral Form | Benign Hereditary Chorea | Tinea Versicolor | Polycystic Kidney, Autosomal Recessive | Alpha-thalassemia Myelodysplasia Syndrome | Multifocal Motor Neuropathy | Exfoliative Dermatitis | Bruck Syndrome | Lymphedema