Disease

Burn-McKeown Syndrome

About the Disease
Burn-Mckeown Syndrome, also known as choanal atresia-hearing loss-cardiac defects-craniofacial dysmorphism syndrome, is related to choanal atresia, posterior and postaxial acrofacial dysostosis. An important gene associated with Burn-Mckeown Syndrome is TXNL4A (Thioredoxin Like 4A), and among its related pathways/superpathways are Processing of Capped Intron-Containing Pre-mRNA and mRNA Splicing - Minor Pathway. Affiliated tissues include heart, kidney and eye, and related phenotypes are hypertelorism and short palpebral fissure

Common Targets
PLCB4 | TXNL4A

疾病靶点研报
Burn-McKeown Syndrome

Note: If you'd like to get a target analysis report for Burn-McKeown Syndrome, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Burn-McKeown Syndrome at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Brooke-Spiegler Syndrome | Fuchs Heterochromic Iridocyclitis | Encephalopathy | Schamberg Disease | Congenital Dyserythropoietic Anemia | Multiple Epiphyseal Dysplasia | Spastic Paraplegia Type 7 | Cholangiocarcinoma | Alopecia Totalis | Hyperparathyroidism-jaw Tumor Syndrome | Crisponi Syndrome | Uterine Leiomyoma | Axenfeld-Rieger Syndrome | Oculopharyngeal Muscular Dystrophy | Hepatic Veno-occlusive Disease | Diabetes | Arterial Tortuosity Syndrome | Parkinsonism | Liver Failure | Camurati-Engelmann Disease | Hypoalbuminemia | Ocular Albinism Type 1 | Amebiasis | Parvovirus B19 Infection | Twin-to-twin Transfusion Syndrome | Peyronie's Disease | Alpers Syndrome | Vestibular Disease | Peutz-Jeghers Syndrome | Cystitis, Interstitial | Leprosy | Urolithiasis | Lathosterolosis | Echinococcosis | Trichothiodystrophy | Multisystemic Smooth Muscle Dysfunction Syndrome | Protein C Deficiency | Cholecystitis | Anosmia, Congenital | Macular Corneal Dystrophy Type 1 | Takotsubo Cardiomyopathy | Inborn Errors Of Metabolism | Muscular Dystrophy | Hypercholesterolemia, Familial | Pilomatrix Carcinoma | Pseudohypoparathyroidism Type 1C | Cabezas Syndrome | Congenital Nystagmus | Haim-Munk Syndrome | Chronic Neutrophilic Leukemia | Kindler Syndrome | Liddle Syndrome | Urethritis | Cystitis | Waardenburg Syndrome Type 2A | Potocki-Shaffer Syndrome | Bipolar Disorder | Lyme Disease | Pendred Syndrome | Aromatic L-amino Acid Decarboxylase Deficiency | Pneumoconiosis | Double Outlet Right Ventricle | Parkinson's Disease | Hemolytic Uremic Syndrome, Atypical | Waardenburg Syndrome | Wagner Disease | Spinocerebellar Ataxia Type 7 | Plasmacytoma | Palsy, Cerebral | Growth Hormone Excess | Achromatopsia | Genitopatellar Syndrome | Knobloch Syndrome | Ophthalmoplegia | Pure Autonomic Failure | C3 Glomerulonephritis | VACTERL Association | Familial Pheochromocytoma-paraganglioma | Hyper IgE Syndrome | Becker Muscular Dystrophy | Panniculitis | Muir-Torre Syndrome | Lymphoma, Primary Cutaneous Anaplastic Large Cell | Muscle Wasting | Bladder Exstrophy | Glaucoma | Basal Ganglia Cerebrovascular Disease | Hypotrichosis Simplex | Optic Atrophy 2 | Brenner Tumor | Erythropoietic Protoporphyria | Neuronal Ceroid Lipofuscinosis | Arts Syndrome | Hereditary Folate Malabsorption | X-linked Charcot-Marie-Tooth Disease | Triple A Syndrome | Waldenstrom Macroglobulinemia | Galactosialidosis | Optic Neuritis | Schaaf-Yang Syndrome | Fibronectin Glomerulopathy | Paroxysmal Nocturnal Hemoglobinuria | Diabetes Mellitus, Transient Neonatal | Larsen Syndrome | Precocious Puberty | Urofacial Syndrome | Renal Hypomagnesemia 3 | Glutathione Synthetase Deficiency | Porencephaly | Osteonecrosis | Measles | Keratoconjunctivitis | Mitochondrial Cytopathy | Leukemia | Fibrodysplasia Ossificans Progressiva | Blue Rubber Bleb Nevus Syndrome | Infantile Nephropathic Cystinosis | Pyruvate Kinase Deficiency | Fraser Syndrome | Ileitis | Juvenile Myelomonocytic Leukemia | Danon Disease | Adenosine Deaminase Deficiency | Hypogonadism | Mosaic Variegated Aneuploidy Syndrome 2 | Familial Retinal Arterial Macroaneurysm | Hermansky-Pudlak Syndrome | Otopalatodigital Syndrome Type 2 | Encephalitis, Tick-borne | GATA2 Deficiency | Waardenburg Syndrome Type 1 | Seborrheic Dermatitis | Cartilage Disorders | Chorioretinitis | Retinopathy Of Prematurity | Pancreatitis | Sialidosis Type I | Hypersensitivity | Alpha-mannosidosis | Familial Digital Arthropathy-brachydactyly | Megalencephaly | Ollier Disease | Congenital Dyserythropoietic Anemia Type 1 | Absence Epilepsy | Erythema Nodosum | Early Infantile Epileptic Encephalopathy 28 | Peeling Skin Syndrome Type B | Congenital Mirror Movements | Aplastic Anemia | Facioscapulohumeral Muscular Dystrophy Type 1 | Scapuloperoneal Spinal Muscular Atrophy | Menetrier Disease | Dermatitis | Sarcosinemia | Actinomycetoma | Posterior Polar Cataract | Amelogenesis Imperfecta | Cataract | Cancer, Skin | ICF Syndrome | Zygomycosis | Pierson Syndrome | Keratopathy | Lymphangioma | Enlarged Vestibular Aqueduct | Cholelithiasis | Antisynthetase Syndrome | Chorea | Pseudohypoaldosteronism | Gingivitis | CHOPS Syndrome | Zollinger-Ellison Syndrome | Spinocerebellar Ataxia Type 23 | Thanatophoric Dysplasia | Hyperkalemic Periodic Paralysis | Lymphoma, Mantle Cell | Retinal Coloboma | Apparent Mineralocorticoid Excess Syndrome | Lactose Intolerance | Pneumothorax | Seasonal Mood Disorder | Diabetes Gestational | Adult Polyglucosan Body Disease | Strabismus | Rothmund-Thomson Syndrome | Arthritis, Gouty | Keratocystic Odontogenic Tumor | Cold-induced Sweating Syndrome | Spinocerebellar Ataxia Type 1 | Neovascular Glaucoma | Ataxia-ocular Apraxia 2 | Anuria | Heterotopic Ossification | Long QT Syndrome Type 2 | Benign Recurrent Intrahepatic Cholestasis 1 | Wolfram Syndrome | Sick Sinus Syndrome 1 | Kleine-Levin Syndrome | Gerstmann-Straussler-Scheinker Syndrome | Niemann-Pick Disease | Hereditary Neuropathy With Liability To Pressure Palsies | Nicolaides-Baraitser Syndrome | Neurodegeneration With Brain Iron Accumulation | Hypereosinophilic Syndrome | Episodic Ataxia Type 1 | Holt-Oram Syndrome | Keratosis | Muckle-Wells Syndrome | Combined Deficiency Of Factor V And Factor VIII | Chronic Granulomatous Disease, X-linked | Reye Syndrome | Heart Failure | Ehlers-Danlos Syndrome With Progressive Kyphoscoliosis, Myopathy, And Hearing Loss | Hydrocephalus, Normal Pressure | Sclerosteosis 2 | Takenouchi-Kosaki Syndrome | Amenorrhea | Fascioliasis | Hidradenitis | Castleman Disease | Diverticulitis | DRESS Syndrome | Dominant Optic Atrophy | Hyperinsulinemia | Emery-Dreifuss Muscular Dystrophy | Dysmorphophobia | Multiple Myeloma | Microphthalmia | Familial Male-limited Precocious Puberty | Amyotrophic Lateral Sclerosis-parkinsonism-dementia Complex | Cirrhosis | Brachydactyly | Arteriovenous Malformations | Schuurs-Hoeijmakers Syndrome | Familial Hemiplegic Migraine | Platelet Disorders | Oral Lichen Planus | 3C Syndrome | Headache | Bare Lymphocyte Syndrome | Retinitis Pigmentosa | Hyperlipidemia Type V | 3-methylglutaconic Aciduria Type IV | Desbuquois Syndrome | Gastroenteritis, Eosinophilic | Encephalopathy, Ethylmalonic | Acanthosis Nigricans | Epilepsy | Antley-Bixler Syndrome | Malnutrition | Postpartum Depression | Prostatitis | Familial Isolated Hyperparathyroidism | Krabbe Disease | Corneal Dystrophy | Myopia | Carbohydrate Metabolism Disorders | Focal Segmental Glomerulosclerosis | Hartnup Disease | Down Syndrome | Nicotine Addiction | Dementia | Burn-McKeown Syndrome | Esophagitis | Placenta Previa | Stuttering | Esophageal Motility Disorders | Erythrokeratodermia Variabilis | Oculocutaneous Albinism Type 4 | Lipoma | Necrobiosis Lipoidica | Hemorrhage | Pantothenate Kinase-associated Neurodegeneration | Charcot-Marie-Tooth Disease Type 4E | Ischemia | Uveitis, Anterior | Blepharo-cheilo-odontic Syndrome | Ellis-Van Creveld Syndrome | Neuroblastoma | Microtia | Hypertelorism | Pyoderma Gangrenosum | Hypomyelination With Atrophy Of Basal Ganglia And Cerebellum | Schwannoma | Carcinoma, Transitional Cell | Skin Fragility-woolly Hair Syndrome | Chondrodysplasia Punctata 2, X-linked Dominant | Diabetes Type 2 | Charcot-Marie-Tooth Disease, Type 2C | Epithelioid Hemangioma | Myelodysplasia | Williams Syndrome | Panic Disorder | Van Der Knaap Disease | Alstrom Syndrome | Alkaptonuria | Prolidase Deficiency | Hyperkeratosis | Spasticity | Lichen Sclerosus | Dementia, Vascular | Sarcoma | Lamellar Ichthyosis | Hypermetropia | Chylomicron Retention Disease | Epidermolysis Bullosa Simplex, Dowling-Meara Type | Pompe Disease | Urea Cycle Disorder | Addison Disease | Thalassemia | Epidermolysis Bullosa Simplex, Generalized | Marshall-Smith Syndrome | Crohn's Disease | Botulism | Thanatophoric Dysplasia Type 1 | Azoospermia | Klinefelter Syndrome | Moyamoya Disease | Acrodysostosis | Phenylketonuria II | Transient Bullous Dermolysis Of The Newborn | Pontocerebellar Hypoplasia Type 2 | Reticular Dysgenesis | IgA Nephropathy | Acute Kidney Injury | Spinocerebellar Ataxia Type 6 | Myocardial Infarction | Odonto-onycho-dermal Dysplasia | Charcot-Marie-Tooth Disease Type 2D | Otitis Media | Hydronephrosis | Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive 1 | Blastoma, Pleuropulmonary | Chondroma | Carcinoma, Merkel Cell | Lassa Fever | Bartsocas-Papas Syndrome | VEXAS Syndrome | Globozoospermia | Focal Cortical Dysplasia Type 2 | Erythema Multiforme | Oguchi Disease-2 | Lymphedema-distichiasis Syndrome | Hypotrichosis, Congenital, With Juvenile Macular Dystrophy | Sengers Syndrome | Hereditary Spherocytosis | Obesity, Morbid | Cutaneous Mastocytosis | Gerodermia Osteodysplastica | Prolactinoma | Lymphomatoid Granulomatosis | Short-chain Acyl-CoA Dehydrogenase Deficiency | TARP Syndrome | Angelman Syndrome | Exfoliative Dermatitis | KBG Syndrome | Sjogren Syndrome | Duane Retraction Syndrome | Nephrotic Syndrome | Discoid Lupus Erythematosus | Mitochondrial DNA Depletion Syndrome, Encephalomyopathic Form | Encephalitis | Optic Nerve Diseases | Heart Block | Anorectal Fistula | Acute Generalized Exanthematous Pustulosis | Microcephalic Osteodysplastic Primordial Dwarfism, Type II | Pierpont Syndrome | Partington Syndrome | Chitayat Syndrome | Polymyositis | Metatropic Dysplasia | Filariasis | Hepatitis D | Sarcoidosis, Pulmonary | Amyotrophic Lateral Sclerosis | Metachondromatosis | Congenital Torticollis | Nicotine Dependence | Cancer, Prostate | Gangliosidosis | Leigh Syndrome | Vitamin K Deficiency | Agammaglobulinemia | Coronary Heart Disease | Stomatitis | Japanese Encephalitis | Retinoblastoma | Chondrodysplasia Punctata 1, X-linked Recessive | Erythromelalgia | Niemann-Pick Disease, Type A | Protein S Deficiency | Herpes Genitalis | Primary Hyperoxaluria | Photosensitivity | Bloom Syndrome | Vertebrobasilar Insufficiency | Polyneuropathy | Leber Hereditary Optic Neuropathy | Palmoplantar Keratoderma