Hypospadias

About the Disease
Hypospadias, also known as hypospadias familial, is related to preaxial deficiency, postaxial polydactyly, and hypospadias and non-syndromic posterior hypospadias. An important gene associated with Hypospadias is SRD5A2 (Steroid 5 Alpha-Reductase 2), and among its related pathways/superpathways are Mesenchymal Stem Cells and Lineage-specific Markers and Metabolism of steroid hormones. The drugs Dexmedetomidine and Dexamethasone acetate have been mentioned in the context of this disorder. Affiliated tissues include skin, prostate and testis, and related phenotypes are growth/size/body region and homeostasis/metabolism

Common Targets
GATA4 | GLI2 | RARA | FGFR1 | CYP17A1 | KDM3A | HHAT | DHH | AKR1C2 | POR | BMP7 | BMP8B | G367 | BMP2 | DGKK | G3480 | WWOX | GLI3 | STAR | SRD5A2 | HOXD13 | ARNT2 | NR5A1 | CHD7 | BBS12 | MAMLD1 | G673 | MID1 | CYP1A2 | GNRHR | AKR1C3 | FGF10 | WT1 | PTPN11 | ANOS1 | PROP1 | ATF3 | BNC2 | SHH | HOXB6 | KLF6 | AMH | WDR11 | MAP3K1 | MKKS | HSD17B3 | HSD3B2 | BBS1 | GLI1 | G2099 | DHX37 | HAAO | WNT5A | ESR2 | PROKR2 | AKR1C4

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