Restrictive Dermopathy

About the Disease
Restrictive Dermopathy 1, also known as lethal tight skin contracture syndrome, is related to lethal restrictive dermopathy and mandibuloacral dysplasia with type a lipodystrophy. An important gene associated with Restrictive Dermopathy 1 is ZMPSTE24 (Zinc Metallopeptidase STE24), and among its related pathways/superpathways are Adipogenesis and Overlap between signal transduction pathways contributing to LMNA laminopathies. Affiliated tissues include skin, placenta and lung, and related phenotypes are stiff skin and osteopenia

Common Targets
ZMPSTE24 | LMNA

Note: If you'd like to get a target analysis report for Restrictive Dermopathy, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Restrictive Dermopathy at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Hepatorenal Syndrome | Aneurysm, Thoracic Aortic | Trachoma | Charcot-Marie-Tooth Disease | Eiken Syndrome | Sarcoidosis, Pulmonary | Dental Caries | Carcinoma, Signet Ring Cell | Hyperparathyroidism | Mucolipidosis | Spinal Cord Diseases | Chronic Periodontitis | Histoplasmosis | Jaundice, Obstructive | Ameloblastic Carcinoma | Sick Sinus Syndrome | Lymphomatoid Granulomatosis | Macular Corneal Dystrophy | Thalassemia | Carcinoma, Small Cell | Neurocutaneous Syndromes | Diamond-Blackfan Anemia | Charcot-Marie-Tooth Disease Type 3 | Schizophrenia, Paranoid | Vitreoretinopathy, Proliferative | Albinism | Niemann-Pick Disease, Type A | Congestive Heart Failure | Sclerosing Cholangitis | Encephalitis, Tick-borne | Esthesioneuroblastoma | Exocrine Pancreatic Insufficiency | Encephalitis | Angioedema, Acquired | Smith-Lemli-Opitz Syndrome | Glomerulonephritis, Membranous | Macrophage Activation Syndrome | Costello Syndrome | Weill-Marchesani Syndrome | Vertebrobasilar Insufficiency | Clouston Hidrotic Ectodermal Dysplasia | Primary Ovarian Insufficiency | Frontometaphyseal Dysplasia | Diabetes Insipidus, Nephrogenic | Porokeratosis | Short-chain Acyl-CoA Dehydrogenase Deficiency | DICER1 Syndrome | Basal Ganglia Disease, Biotin-responsive | Acute Kidney Injury | Obsessive-compulsive Disorder | Esophageal Adenocarcinoma | Cholera | Sezary Syndrome | Intracerebral Hemorrhage | Spondylo-megaepiphyseal-metaphyseal Dysplasia | Gangliosidosis, GM1 | Benign Familial Pemphigus | Muir-Torre Syndrome | Congenital Dysfibrinogenemia | Diabetes Insipidus, Neurogenic | Benign Familial Infantile Seizures | Fundus Albipunctatus | Hepatitis D | Kashin-Beck Disease | Rhinitis | Oligoasthenoteratozoospermia | Cardiomyopathy, Restrictive | Blue Rubber Bleb Nevus Syndrome | Thanatophoric Dysplasia | Guanidinoacetate Methyltransferase Deficiency | Spinocerebellar Ataxia Type 10 | Astrocytoma | Branchiootorenal Syndrome | Intermittent Claudication | Fetal Akinesia Deformation Sequence | Williams Syndrome | Klinefelter Syndrome | Sengers Syndrome | Mabry Syndrome | Pseudoachondroplasia | Cutaneous Angiosarcoma | Meningitis | Acute Lymphocytic Leukemia | Anorectal Fistula | Optic Neuropathy, Anterior Ischemic | Spondylocarpotarsal Synostosis Syndrome | Dwarfism | Carcinoid Tumor | Bulimia Nervosa | Colitis | Neurodegeneration With Brain Iron Accumulation | Cervical Dystonia | Autism Spectrum Disorders | Sponastrime Dysplasia | Hyperkalemic Periodic Paralysis | Inflammatory Myofibroblastic Tumor | Apraxia | Kleine-Levin Syndrome | Marshall-Smith Syndrome | Rothmund-Thomson Syndrome | Apert Syndrome | Angiosarcoma Of The Breast | Dysequilibrium Syndrome | 5-oxoprolinase Deficiency | Autoimmune Disease | Hyperinsulinism-hyperammonemia Syndrome | Learning Disability | Hypereosinophilic Syndrome | Gnathodiaphyseal Dysplasia | Nemaline Myopathy 10 | Congenital Fiber-type Disproportion Myopathy | Usher Syndrome Type II | Ichthyosis | Acromegaly | Hypertension, Essential | Neuroblastoma | Diabetes Insipidus | Neuroendocrine Cancer | Fibromyalgia | Sleep Disorder | Lichen Planus | Necrobiosis Lipoidica | Bleeding Disorder Due To CalDAG-GEFI Deficiency | Osteopathia Striata With Cranial Sclerosis | 3-methylglutaconic Aciduria | Greig Cephalopolysyndactyly Syndrome | Non-small Cell Lung Cancer | Cohen Syndrome | MELAS Syndrome | Mucolipidosis Type III | Arts Syndrome | Papulopustular Rosacea | Cold Agglutinin Disease | Hemangioblastoma | Toxic Epidermal Necrolysis | Stromal Corneal Dystrophy | Angiomyolipoma | Stargardt Disease | Cutaneous Lupus Erythematosus | Cabezas Syndrome | Essential Fructosuria | Long QT Syndrome Type 1 | Lipid Metabolism Disorders | Bronchiolitis | Hereditary Hemorrhagic Telangiectasia | Gaze Palsy, Familial Horizontal, With Progressive Scoliosis, 2 | Cardiac Arrest | Erdheim-Chester Disease | Asthma, Exercise-induced | Cholestasis | Van Der Knaap Disease | Common Variable Immunodeficiency | Blue Nevus | Multiple Sclerosis, Primary Progressive | Fetal Alcohol Syndrome | Leprosy | Sandhoff Disease | Spondylo-ocular Syndrome | Multiple Sclerosis, Secondary Progressive | Pheochromocytoma | Ollier Disease | Tumoral Calcinosis | Arthritis | Graves Disease | Congenital Torticollis | Blepharospasm | Spondylolisthesis | Osteogenesis Imperfecta Type V | Polydactyly | Hepatitis C, Chronic | Benign Familial Neonatal Convulsions | Lassa Fever | LMNA-related Congenital Muscular Dystrophy | Polycystic Ovary Syndrome | Gingivitis | Nance-Horan Syndrome | Chanarin-Dorfman Syndrome | Dyggve-Melchior-Clausen Disease | Acral Lentiginous Melanoma | Congenital Nystagmus | Nephrocalcinosis | Familial Cerebral Amyloid Angiopathy | Otitis Externa | Palmoplantar Keratoderma | Familial Mediterranean Fever | Connective Tissue Disorders | Pompe Disease | Leukemia | VACTERL Association | Bullous Pemphigoid | Non-epidermolytic Palmoplantar Keratoderma | Atopy | Multiple Sclerosis, Chronic Progressive | B-cell Prolymphocytic Leukemia | Early Infantile Epileptic Encephalopathy 28 | Pyruvate Dehydrogenase Deficiency | Cellulitis | Lupus Erythematosus | Sporadic Hemiplegic Migraine | Infantile Nephropathic Cystinosis | X-linked Myotubular Myopathy | Multiple System Atrophy | Impulse Control Disorder | Adenomatoid Tumor | Congenital Central Hypoventilation Syndrome | Polyradiculopathy | Kohlschutter-Tonz Syndrome | Diabetic Encephalopathy | Meningococcal Infections | Thrombasthenia | Guttate Psoriasis | Absence Epilepsy | Turner's Syndrome | Nephrotic Syndrome Type 1 | Centronuclear Myopathy | GLUT1 Deficiency Syndrome | Atrioventricular Septal Defect | Otosclerosis | Syndactyly | Urea Cycle Disorder | Lymphoma, Primary Cutaneous Anaplastic Large Cell | Congenital Bile Acid Synthesis Defect | Pain | Precocious Puberty | Chondroma | Premature Ejaculation | Tietze Syndrome | T-cell Leukemia | Hypophosphatemic Rickets, Autosomal Recessive, 1 | Greenberg Dysplasia | Pneumoconiosis | Multiple Epiphyseal Dysplasia | Bartsocas-Papas Syndrome | Evans Syndrome | Methemoglobinemia Type IV | Craniofacial Dysostosis | Hepatitis A | Prader-Willi Syndrome | Thrombocythemia, Essential | Major Depression | Nephroblastoma | Granular Corneal Dystrophy Type 1 | Nephrotic Syndrome | Actinomycetoma | Creatine Deficiency Syndrome | Chitayat Syndrome | Cardiomyopathy, Hypertrophic | Adenomyosis | Plasmacytoma | Usher Syndrome Type IIC | Martsolf Syndrome | Bronchitis | Dyskeratosis Congenita | GATA2 Deficiency | Methylmalonic Aciduria And Homocystinuria, CblC Type | Kindler Syndrome | Idiopathic Pulmonary Fibrosis | Neuromyelitis Optica | Mountain Sickness | Liver Diseases | Carcinoma, Transitional Cell | 3-hydroxy-3-methylglutaric Aciduria | 6-pyruvoyl-tetrahydropterin Synthase Deficiency | Adenylosuccinate Lyase Deficiency | Thrombocytopenia | Dysgerminoma | Scapuloperoneal Spinal Muscular Atrophy | Spinocerebellar Ataxia Type 7 | Ectrodactyly | Spinocerebellar Ataxia | Spinocerebellar Ataxia Type 5 | Osteonecrosis Of The Jaw | Hypopigmentation | Craniosynostosis | Trichorhinophalangeal Syndrome | Acute Generalized Exanthematous Pustulosis | Gitelman Syndrome | Norrie Disease | Portal Vein Thrombosis | Cone Dystrophy | Anosmia, Congenital | Prolymphocytic Leukemia | Hypothyroidism | Oral Lichen Planus | Occipital Neuralgia | Hypercholesterolemia, Familial | Leiomyosarcoma | Acute Lung Injury | Relapsing Polychondritis | Anencephaly | Congenital Stromal Corneal Dystrophy | Eczema | Leri Pleonosteosis | Tyrosinemia Type 1 | Cole-Carpenter Syndrome | Erythema Multiforme | Globozoospermia | Ichthyosis Hystrix, Curth-Macklin Type | Cryptosporidiosis | Leishmaniasis, Cutaneous | Melanoma | Sorsby Fundus Dystrophy | Lymphoma Lymphoblastic | Jawad Syndrome | HIBCH Deficiency | Mast Cell Leukemia | Anti-glomerular Basement Membrane Disease | Trigonocephaly | Retinal Vasculitis | GM2-gangliosidosis AB Variant | Stroke, Hemorrhagic | Depression | Anorectal Malformations | Brooke-Spiegler Syndrome | Infertility, Male | Lissencephaly 2 | Carbamoyl Phosphate Synthetase I Deficiency | Central Pain Syndrome | Microtia | Thyroiditis | Atelosteogenesis Type 1 | Chronic Thromboembolic Pulmonary Hypertension | Intellectual Disability, Autosomal Dominant 5 | Congenital Absence Of Vas Deferens | Hyperparathyroidism-jaw Tumor Syndrome | Deafness, Dystonia, And Cerebral Hypomyelination | Gout | Heimler Syndrome | Anxiety Disorders | Whipple's Disease | Hypogammaglobulinemia | Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive 1 | Hyperglycemia | Cirrhosis | Transthyretin-related Amyloidosis | Pyelonephritis | Cat Eye Syndrome | Mumps | Infantile Spasm | Facioscapulohumeral Muscular Dystrophy Type 1 | Early Infantile Epileptic Encephalopathy 1 | Constipation | Angioedema, Hereditary | Vaginitis | DRESS Syndrome | Glutathione Synthetase Deficiency | Trichotillomania | Diabetic Neuropathy | GAPO Syndrome | Craniofrontonasal Syndrome | 3C Syndrome | Aarskog-Scott Syndrome | Insulin Resistance | Polycythemia | Cocaine-Related Disorders | Arteriovenous Malformations | Cancer, Skin | Chordoma | Pure Red Cell Aplasia | Limb Girdle Muscular Dystrophy | Schistosomiasis | Smoldering Myeloma | Spinocerebellar Ataxia Type 42 | Donnai-Barrow Syndrome | Pseudohypoparathyroidism Type 2 | Lipoma | Spinocerebellar Ataxia Type 3 | Rickets | Heart Block | Congenital Bilateral Absence Of Vas Deferens | Sleep Apnea | Pityriasis Rubra Pilaris | Persistent Hyperplastic Primary Vitreous | Medulloblastoma | Carcinoma In Situ | Cockayne Syndrome | Pontocerebellar Hypoplasia Type 7 | Epidermolytic Ichthyosis, Annular | Vogt-Koyanagi-Harada Syndrome | Poretti-Boltshauser Syndrome | Sulfite Oxidase Deficiency | Chronic Idiopathic Myelofibrosis | Macrophagic Myofasciitis | Pitt-Hopkins Syndrome | Lymphoma, B-cell | Nicotine Addiction | Keratoconjunctivitis | Pseudohypoaldosteronism | Pleurisy | Glanzmann Thrombasthenia | Corneal Dystrophies, Hereditary | Blepharo-cheilo-odontic Syndrome | Hashimoto Thyroiditis | Riboflavin Transporter Deficiency Neuronopathy | Temporal Lobe Epilepsy | Oculocutaneous Albinism | Epidermolysis Bullosa Simplex With Mottled Pigmentation | Autoimmune Polyendocrine Syndrome | Hemorrhagic Disorders | Schnitzler Syndrome