Disease

Autism Spectrum Disorders

About the Disease
Autism Spectrum Disorder, also known as autism spectrum disorders, is related to autism and attention deficit-hyperactivity disorder, and has symptoms including widespread abnormalities of social interactions, severely restricted interests and highly repetitive behavior. An important gene associated with Autism Spectrum Disorder is SHANK2 (SH3 And Multiple Ankyrin Repeat Domains 2), and among its related pathways/superpathways are Thyroid hormones production and peripheral downstream signaling effects and Rett syndrome causing genes. The drugs Acetylcholine and Dexmedetomidine have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and prefrontal cortex, and related phenotypes are nervous system and growth/size/body region

Common Targets
GPR139 | MAP2K6 | HTRA4 | ODF2 | ZRANB3 | HTR1A | PIK3R5 | RBFOX1 | TMEM132C | SLC22A14 | CDC42EP1 | CLEC7A | AKAP9 | CD74 | RALYL | ACHE | COL6A5 | SHANK3 | MKNK2 | C1S | MED13 | CNGA3 | G1432 | RETREG1 | G4233 | RNF135 | AARS1 | KIAA1549L | PRPS2 | EN2 | NOS1 | GTF2F2 | VDR | NEO1 | SPTLC2 | Metabotropic glutamate (mGluR) receptor (nonspecified subtype) | GABA(A) receptor | MTCL1 | TRIM2 | SSBP3 | MEGF11 | PIK3CB | CSNK1G1 | GLRA2 | DRD4 | Voltage-Gated Sodium Channel Complex | TYW1B | TNPO3 | mTOR complex 1 | G3569 | ITPR3 | SCFD2 | EPB41 | ADNP | GNAL | WNT3A | SIGMAR1 | Gamma-Aminobutyric acid type B receptor | SLC12A3 | LIMK1 | GRIN1 | PTPN7 | HSD17B11 | PLA2G4A | THSD4 | UBR5 | TMCO4 | KCNQ4 | CAMK4 | SHC4 | T-Type Calcium Channel | AEBP2 | ZNF148 | MYT1L | PLCZ1 | NLGN3 | KCNQ3 | Sodium channel (nonspecified subtype) | MAP3K9 | LINC02398 | DAB1 | SAMD12 | LRRC24 | ABCA7 | NYNRIN | HTR2B | SCN3A | EPB41L1 | TRPC5 | ASPM | INVS | ABCC12 | ESPNL | ITIH3 | TCF12 | GABRG2 | CDKN2B-AS1 | GNAO1 | PRKCZ | DYNC1H1 | DIP2C | TRPV2 | PAX2 | ATP1B4 | AVPR1B | RNF130 | BANP | TMBIM6 | TRIP12 | MIR137 | G7124 | CARD11 | GFAP | FAM13A | CACNA1G | GPR52 | CAMSAP3 | IVD | IL1B | DYRK1A | KDM4C | CPNE7 | TAF1 | BUB1B | SLC35A3 | CMIP | IRS2 | PIGL | ZPBP | BAZ1A | NWD2 | AQP4 | DPP4 | GABRB2 | RAB11B | CDKL5 | TLN2 | CDKAL1 | LINC02055 | LRP5 | PDE10A | HLA-G | TMEM132B | G3480 | CCKBR | GRIA1 | ZEB2 | TMCC2 | WDR1 | NEDD4L | NIPA2 | CMPK2 | RASGRP1 | FANK1 | DPYSL2 | UBE2D2 | ANKK1 | ABCA9 | HLA-DQB2 | WWP1 | TNC | SCLT1 | CCDC171 | SERPINB13 | TSC2 | CALM1 | ARMC9 | ADCY3 | DDX11 | RASGEF1A | LINC01508 | TP53I3 | PTPN12 | SCN8A | ATP1B1 | CAMTA1 | PTPN1 | CNTNAP5 | SHANK2 | CACNA1C | GTF3C2 | Glutamate Transporter (nonspecified subtype) | LPP | ZHX2 | ASXL3 | ABCA8 | DUSP22 | ADTRP | ROS1 | TCF4 | TM2D1 | MKNK1 | CHRNA7 | CHODL | MGRN1 | MMS22L | AVPR2 | GSK3B | EGFEM1P | GOLM2 | IL12RB1 | PRR21 | DLX6-AS1 | BCHE | SYNE3 | NHS | IMMP2L | PAPPA2 | TCEANC | CACNB2 | NRG2 | PRICKLE2 | BCAS1 | ALLC | NSMCE1 | PPP2R5C | PRKD1 | KCTD16 | PCMTD1 | DNA2 | TCF20 | MECP2 | JMJD1C | OXT | PHF21A | NCKAP1 | CHD2 | RASGRF2 | G protein-Coupled Inwardly-Rectifying Potassium Channel (GIRK) (nonspecified subtype) | TAFA1 | ENPP3 | GRM2 | TRPM1 | ERCC2 | PDGFD | PRTG | CTLA4 | ADRA2A | ZNF496 | NAV1 | SORCS3 | VPS8 | NTM | WDR47 | CUL4B | DYNC1LI2 | SLAIN1 | VPS18 | SEZ6L | Fibroblast growth factor (FGF) (nonspecified subtype) | SEC23A | FOXP1 | GUCY1A2 | LUZP2 | FAM186A | AGMAT | TRIP10 | RYR2 | CYP2E1 | BST1 | FGA | AFG1L | NUDT9 | RCAN2 | MAN1A2 | IL3RA | SLC6A4 | CLASP1 | DDI2 | HTR2A | SORCS1 | PLCE1 | WAC | ASH1L | SS18L1 | FAM47A | TF | ELK4 | TNNI3K | HMGN3 | WWP2 | COL5A1 | ACSL4 | GBE1 | SLC19A1 | POGZ | CPAMD8 | NHSL2 | NSD1 | TAF6 | OPRL1 | PRKAG2 | CNTN6 | CELF5 | ATXN3 | TIAM1 | AGBL1 | NF-kappaB (NFkB) | GRIN2A | CIT | PCDH15 | BBS12 | ADA | NLGN4X | UPF3B | DYTN | PSD3 | MAPKAPK2 | RIT2 | PYGO1 | KIF2A | ZFP1 | EPHA3 | CLN8 | PDGFRA | GLO1 | NAV2 | GPR142 | EXOC7 | MOB3B | NRN1 | DGUOK | KCNK10 | GRIA3 | ATP5MJ | MEF2C | MCPH1 | LINC01484 | LRFN1 | PAX5 | GABRG3 | NEDD4 | FANCL | SLC22A8 | DCX (DDB1-CUL4-X-box) E3 protein ligase complex | GPR153 | IFNLR1 | SLC12A5 | IFNG | RORA | ZNF480 | NMDA receptor | TRPC6 | NDRG1 | OR52L1 | 15-Lipoxygenase (nonspecified subtype) | MGAT5B | FAAH | ATP2B1 | IFT88 | AADACL2-AS1 | TRPA1 | SNRNP35 | MARCKS | NOS2 | RGCC | KMT2A | SPATA13 | NAA10 | FGGY | MAP3K13 | MAP4K4 | POLR3D | DRD1 | TBC1D14 | WDR7 | CHST7 | NF1 | CYP2S1 | POU6F2 | Eukaryotic Translation Initiation Factor 4A (eIF-4A) | CCDC18 | KIT | SMARCC2 | UBE3A | G672 | GALNTL5 | DDR1 | UBE2J1 | GABRA1 | PPP2R5D | GSTM1 | mTOR complex 2 | CAMK2A | Glycogen synthase kinase 3 (GSK-3) (nonspecified subtype) | ERBB4 | GABRB3 | PHF2 | LPCAT1 | MAP4K1 | MKLN1 | CDH9 | BIRC6 | OR10AD1 | WDR72 | SMG7 | CNFN | SRSF11 | CTSH | FREM3 | FOXN3 | SDHC | CCDC77 | PLXDC2 | GPC5 | SLC25A12 | EPC2 | CREB3L1 | MFN2 | LIN7B | ANKRD11 | AGAP2 | RIN3 | PIK3C2G | CYFIP1 | HERC2 | VIPR2 | SNX13 | KMT2D | HCN2 | SLC6A19 | HERC2P10 | KCNMB4 | GRID1 | PRKCB | HIVEP2 | BDNF-AS | TTC34 | AGAP1 | SCN1A | SCTR | CDH11 | KIAA0586 | CC2D2B | AFF2 | HMCN1 | STYK1 | ADGRE2 | PTPN11 | CREBBP | MEGF6 | FCGBP | CCDC157 | NRXN1 | MAP2K2 | EVC2 | FOXF2 | CRBN | RXRA | ADCY8 | IL4 | MLF1 | PDE2A | ATP2A2 | PLEKHG5 | BICD1 | SUV39H2 | LHX6 | MALRD1 | SKP2 | SPATA5L1 | TRIM27 | LMTK2 | TUBA8 | SAMD12-AS1 | HLA-DQB1 | RPS24 | TFB2M | G1786 | PPP5C | FGF19 | HTR6 | CDH18 | OR2L13 | CES1P2 | YJU2 | HSPB1 | DLX1 | HK1 | RFX1 | SEMA4A | ATP2A3 | KDM2B | HUWE1 | GRID2 | 5-Hydroxytryptamine Receptor 2 (5-HT2) (nonspecified subtype) | ARHGAP10 | AUP1 | PLA2G4E | TMPRSS9 | WDR26 | TRIM44 | ANKS1B | SLA | HEPACAM | ZFX | AXIN2 | DLX3 | ZNF594 | DLX4 | CEP89 | SDK2 | TMLHE | CHAT | HTR2C | CACNA1A | PTDSS1 | ITPA | SYNE1 | CDK14 | TPPP | GABRA5 | ITGB3 | FBXW4 | GPR61 | PPP2R2C | CHD8 | ACMSD | RYR3 | MCM2 | TH | ODAD4 | CNTNAP2 | ANAPC1 | SYNGAP1 | FARP1 | PSG1 | KCNMA1 | ALOX5 | NUDT7 | GRM1 | NRXN2 | ZFAND5 | CACNG2 | MOGAT1 | SLC1A1 | XRCC4 | P2RX7 | GNA14 | HSF2BP | SNAP25 | DOCK3 | NT5E | FAM172A | AOPEP | LINC01243 | OPALIN | ERBIN | DRD3 | GPR55 | ZNF568 | SYN1 | PGAM1 | ZMIZ1-AS1 | WDR35 | RAP1A | FANCF | DLX5 | AIRE | LNP1 | SLC6A1 | CDCA7 | HYDIN | DYRK1B | LANCL2 | SLC6A3 | FGF12 | G5728 | CNTN4 | XG | HELZ | NFAT5 | CHL1 | AS3MT | OXTR | BRIP1 | HTT | UBLCP1 | H1-4 | SETD1A | 5-Hydroxytryptamine Receptor (nonspecified subtype) | MAOB | KIFC1 | OR7A10 | POTEG | ATXN1 | SPDYC | PDE7B | SIN3A | ADAMTS18 | GABRA2 | MYO1A | SLC2A9 | HLA-DRB1 | ITPK1 | SNX29 | PTCHD1 | FAM91A1 | VRK2 | DEFB124 | MGAM | PIBF1 | GJD2 | TMIGD3 | OR10A2 | SLC25A48 | GAD1 | ABCB11 | PARPBP | GRIN2B | DDX3X | STAM | USP9X | KLHL7 | ADAMTS2 | NFKB1 | OPRM1 | GRM4 | ANK3 | TFB1M | GK5 | LINC00907 | LY86-AS1 | ANK2 | LRRC4C | ADRA1B | DSCAM | FAM227B | WDFY3 | ATP11B | PLEKHG1 | NID2 | PARK7 | PHF3 | LDB2 | BTBD9 | ANTXR2 | PRKN | PDE4D | ANKRD26P3 | ADCY1 | COL6A3 | LINC01060 | DPYD | ELP4 | WASF3 | OR5A2 | ABCC3 | MYO3A | PRKCE | ENOX2 | PTPRC | WNT1 | G2475 | SORL1 | ITPKB | DMD | IDE | OR52A5 | AP2B1 | LGALS1 | THRA | ACSBG1 | MAML3 | PRKG1 | PITX1-AS1 | PPP1R1A | RAB39B | OR51B6 | MYO5A | PPM1A | BDNF | TAAR1 | CDH23 | MIR29B2 | PLCH1 | PDE1A | ALOX15 | HOTAIR | CADPS2 | CSMD2 | Phosphodiesterase (nonspecified subtype) | C6orf141 | GPHN | HLA-B | RAP1B | ALDH1A3 | ZNF232 | KMT5B | ANKRD13C | RELN | MED12 | TXNDC16 | SV2B | ADCY9 | KCNQ2 | GALNT9 | IL1RAPL2 | DPYSL4 | MTUS2 | PDE3A | KIF26A | INTS6 | DNAJC28 | TAF1C | HTR1D | TAP2 | MIR4443 | HRH3 | Ribosomal Protein S6 Kinase, 70kDa (p70S6K) (nonspecified subtype) | KDM5A | SCN2A | KDM6A | CNOT3 | PITX1 | HTR7 | ZMIZ1 | CTNND2 | KLHDC10 | CAV3 | PPARG | COL14A1 | E2F8 | BBS1 | SH2D1A | PPARA | AMY2B | CD5 | TBC1D23 | BRD9 | DRD2 | MIR4761 | PPIA | AVPR1A | MICAL1 | TSC1 | ATP1A2 | NLGN1 | GABRA3 | CASC15 | G1956 | MTHFR | FOXN1 | ABCA12 | ECM2 | PRPF3 | DOCK10 | WDR46 | IQSEC2 | UBN2 | CYP4B1 | CDH4 | ADAR | CETP | RAP1GDS1 | SLC12A1 | OTX1 | IRF9 | GABRG1 | RAB11FIP5 | JMY | OR5L1 | HECTD4 | CACNA1H | DELEC1 | DNAH9 | EPHB1 | AIPL1 | PDE4B | RPTOR | NEBL | TRPM8 | KAT2B | ANKRD26P1 | CTBP2 | AK5 | PLCG2 | NRXN3 | G5562 | RASAL2 | ARHGAP32 | SOX2-OT | ASMT | CACNA1B | AHI1 | MFN1 | USP43 | PPP5D1P | ASXL1 | PLCB2 | TUBB3 | PACSIN1 | NCOR1 | COMT | ATP2B2 | CDK19 | ANP32A | ARHGEF16 | SGPL1 | NKAIN2 | PDLIM5 | KMT2C | MACROD2 | PHACTR1 | NEK3 | SPEN | PIK3CD | GPATCH1 | MBD5 | DNMT3A | TRPV1 | PER2 | OR51L1 | ZNF713 | PDZD2 | ST8SIA2 | ASAH2 | LLGL2 | TMEM192 | CACNA2D1 | TCF7L1 | OR2F1 | RYR1 | ADRA1A | MAP3K4 | ADCY10 | XIRP2 | MAOA | PTGFRN | G5743 | PTPRR | CNTN5 | PRKG2 | SLC12A2 | LINC01134 | KSR2 | CDH26 | ITPR2 | MED13L | OR51E2 | ANKRD31 | PLCB4 | GRM5 | SORBS1 | PLD5 | MAP2K1 | ARID1B | Serine/threonine-protein kinase (PAK) (nonspecified subtype) | CHST15 | AGT | TOP2B | MAD1L1 | CYP2D6 | AACS | DIAPH2 | FMR1 | GABBR1

疾病靶点研报
Autism Spectrum Disorders

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