Tatton-Brown-Rahman Syndrome

About the Disease
Tatton-Brown-Rahman Syndrome, also known as dnmt3a overgrowth syndrome, is related to overgrowth syndrome and adult syndrome. An important gene associated with Tatton-Brown-Rahman Syndrome is DNMT3A (DNA Methyltransferase 3 Alpha), and among its related pathways/superpathways are One-carbon metabolism and related pathways and Chromatin Regulation / Acetylation. The drugs Dasatinib and Teicoplanin have been mentioned in the context of this disorder. Affiliated tissues include myeloid, bone marrow and prostate, and related phenotypes are macrocephaly and proportionate tall stature

Common Targets
DNMT3A | H1-4

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