Tatton-Brown-Rahman Syndrome

About the Disease
Tatton-Brown-Rahman Syndrome, also known as dnmt3a overgrowth syndrome, is related to overgrowth syndrome and adult syndrome. An important gene associated with Tatton-Brown-Rahman Syndrome is DNMT3A (DNA Methyltransferase 3 Alpha), and among its related pathways/superpathways are One-carbon metabolism and related pathways and Chromatin Regulation / Acetylation. The drugs Dasatinib and Teicoplanin have been mentioned in the context of this disorder. Affiliated tissues include myeloid, bone marrow and prostate, and related phenotypes are macrocephaly and proportionate tall stature

Common Targets
DNMT3A | H1-4

Note: If you'd like to get a target analysis report for Tatton-Brown-Rahman Syndrome, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Tatton-Brown-Rahman Syndrome at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Beckwith-Wiedemann Syndrome | Campomelic Dysplasia | Ectodermal Dysplasia | Recurrent Respiratory Papillomatosis | Joubert Syndrome 2 | Carcinoma, Merkel Cell | Chronic Kidney Disease | Amyotrophic Lateral Sclerosis | Tricho-hepato-enteric Syndrome | Meniere's Disease | Hemolytic Uremic Syndrome | Cervical Dystonia | Adams-Oliver Syndrome | Priapism | Carney-Stratakis Syndrome | Epidermolysis Bullosa Simplex, Generalized | Pseudoexfoliation Syndrome | Schizencephaly | Milk Allergy | Follicular Dendritic Cell Sarcoma | Anorchia | Pituitary Stalk Interruption Syndrome | Blastoma, Pleuropulmonary | Kaposi Sarcoma | Krabbe Disease | Encephalopathy | Dupuytren Disease | Tracheal Disorders | Cranial Nerve Disease | Myocardial Infarction | Corneal Dystrophy And Perceptive Deafness | Agnathia-Otocephaly Complex | Angiodysplasia | CREST Syndrome | Tenosynovial Giant Cell Tumor | Gastroenteritis, Eosinophilic | Poikiloderma With Neutropenia | Coffin-Siris Syndrome | Meningitis | Cramp Fasciculation Syndrome | Infertility | Synpolydactyly | Chondrodysplasia Punctata 1, X-linked Recessive | Oligospermia | Pernicious Anemia | Gangliosidosis, GM1 | Centronuclear Myopathy | Meckel-Gruber Syndrome | Waardenburg Syndrome Type 2A | Sorsby Fundus Dystrophy | Conn Syndrome | Pityriasis Rubra Pilaris | Neurofibroma | Sweet Syndrome | Corneal Dystrophies, Hereditary | Nemaline Myopathy 8 | Albinism | High Molecular Weight Kininogen Deficiency | Blood Protein Disorders | Creutzfeldt-Jakob Disease | N-acetylglutamate Synthase Deficiency | Brenner Tumor | Progressive Encephalopathy-optic Atrophy Syndrome | Thanatophoric Dysplasia Type 1 | Spondyloepiphyseal Dysplasia Tarda, X-linked | X-linked Creatine Transporter Deficiency | GM2-gangliosidosis AB Variant | Bethlem Myopathy | Chronic Lymphocytic Leukemia | Optic Nerve Hypoplasia, Bilateral | Cryopyrin-associated Periodic Syndromes | Craniosynostosis | Vitamin K Deficiency | Keratoconus | Bone Marrow Necrosis | Nephritis, Interstitial | Charcot-Marie-Tooth Disease, Type 2 | Light Chain Amyloidosis | Pseudo-pseudohypoparathyroidism | Malaria | Branchiootorenal Syndrome | LRBA Deficiency | Glycogen Storage Disease Type 5 | Gnathodiaphyseal Dysplasia | Steel Syndrome | Hidradenitis | Treacher Collins Syndrome | Wolff-Parkinson-White Syndrome | Acrodermatitis Enteropathica | Intermittent Explosive Disorder | Mumps | Hyperinsulinemic Hypoglycemia | Inflammatory Joint Disease | Adrenal Insufficiency | Menkes Disease | Macrodactyly | Focal Cortical Dysplasia Type 2 | Encephalitis, Tick-borne | Mabry Syndrome | Epidermolysis Bullosa Acquisita | Spinocerebellar Ataxia Type 15 | Osteosclerosis | Persistent Fetal Circulation | Neurofibromatosis Type 1 | Hemangioblastoma | Partington Syndrome | Pouchitis | Aphasia | Kearns-Sayre Syndrome | Hepatitis D | Poirier-Bienvenu Neurodevelopmental Syndrome | Angiosarcoma Of The Breast | Multisystemic Smooth Muscle Dysfunction Syndrome | Autism Spectrum Disorders | Rett Syndrome | Oculocutaneous Albinism Type 2 | Multiple Myeloma | Ichthyosis | Whipple's Disease | Heimler Syndrome | Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia | Colorectal Adenoma | Nestor-Guillermo Progeria Syndrome | Optic Neuropathy | Eiken Syndrome | Meningioma, Benign | Trichotillomania | Fibronectin Glomerulopathy | Colon Adenoma | Neuromyelitis Optica | Tonsillitis | Usher Syndrome Type I | Apert Syndrome | Sarcoma | Rickets | Granuloma Annulare | Congenital Bilateral Absence Of Vas Deferens | Pseudohypoaldosteronism | Hypobetalipoproteinemias | Hypohidrotic Ectodermal Dysplasia | Benign Familial Neonatal Convulsions | Epidermolytic Palmoplantar Keratoderma | Hereditary Folate Malabsorption | Cholestasis | Focal Segmental Glomerulosclerosis | Giant Cell Glioblastoma | Arthritis, Reactive | Vascular Calcification | Spermatocele | Systemic Lupus Erythematosus | Donnai-Barrow Syndrome | Osteogenesis Imperfecta Type II | Perivascular Epithelioid Cell Tumor | Hepatic Adenomatosis | Cellulitis | Mesothelioma, Malignant | Dysthymia | Dwarfism | Carcinoid Tumor | Rheumatic Heart Disease | Ocular Hypertension | Osteomyelitis | Neurocysticercosis | Hemochromatosis Type 2 | Encephalocele | Thrombophlebitis | Inflammatory Myopathy | Spinocerebellar Ataxia Type 13 | Kabuki Syndrome | Isobutyryl-CoA Dehydrogenase Deficiency | Thromboembolism | Hernia, Inguinal | Vitiligo | HUPRA Syndrome | Eccrine Porocarcinoma | Wiedemann-Steiner Syndrome | Speech Disorders | Kernicterus | Progressive Familial Intrahepatic Cholestasis | Orthostatic Intolerance | Hypogonadism | Silicosis | AIDS | Multifocal Motor Neuropathy | Neural Tube Defect | Craniofacial Dysostosis | Lymphangioma | Bleeding Disorder Due To CalDAG-GEFI Deficiency | Uveitis | Schaaf-Yang Syndrome | Cold-induced Sweating Syndrome | Glycogen Storage Disease | Cystitis, Interstitial | Acute Lymphocytic Leukemia | Congenital Adrenal Hyperplasia 1 | Metaphyseal Chondrodysplasia, Schmid Type | GLUT1 Deficiency Syndrome | Vitamin D Deficiency | Thalassemia | Lymphomatoid Granulomatosis | Leigh Syndrome | Miyoshi Myopathy | Autosomal Recessive Bestrophinopathy | Early Infantile Epileptic Encephalopathy 28 | Adenoma, Pleomorphic | Melnick-Needles Syndrome | Ghosal Syndrome | Motion Sickness | Pyelonephritis | Paternal Uniparental Disomy Of Chromosome 14 | Cirrhosis | Hepatitis, Chronic | Alcoholism | Mitochondrial DNA Depletion Syndrome, Encephalomyopathic Form | Retinoschisis | Retinitis | Feingold Syndrome | Vitelliform Macular Dystrophy | Lymphangiomatosis | Leukemia | Exfoliative Dermatitis | Hyperlipidemia Type V | Primary Cutaneous Amyloidosis | Chondromyxoid Fibroma | Ataxia-hypogonadism-choroidal Dystrophy Syndrome | Onchocerciasis | Lennox-Gastaut Syndrome | Hypothalamic Obesity | 3-methylcrotonyl-CoA Carboxylase Deficiency | Charcot-Marie-Tooth Disease, Type 2C | Vestibular Disease | Proteasome-associated Autoinflammatory Syndrome 2 | Granular Corneal Dystrophy Type 1 | Reflex Epilepsy | Transient Bullous Dermolysis Of The Newborn | Cystitis | Thyrotoxic Periodic Paralysis | Angioedema, Acquired | Hereditary Spherocytosis | ADNP Syndrome | Hypertension, Renal | Cri-du-chat Syndrome | Spinocerebellar Ataxia Type 2 | Methemoglobinemia | Stroke, Ischemic | Dengue Hemorrhagic Fever | Anorectal Fistula | Hereditary Coproporphyria | Anorexia Nervosa | Meningococcal Infections | Peeling Skin Syndrome, Acral Type | Congenital Dyserythropoietic Anemia Type 4 | Charcot-Marie-Tooth Disease Type 3 | Primary Carnitine Deficiency | Intestinal Obstruction | Eosinophilic Asthma | Spinocerebellar Ataxia Type 12 | Thymoma, Malignant | Von Hippel-Lindau Disease | Majeed Syndrome | Duodenal Atresia | Senior-Loken Syndrome | Epicondylitis | D-2-Hydroxyglutaric Aciduria | Diamond-Blackfan Anemia | Melanoma, Uveal | Hypopituitarism | Osteogenesis Imperfecta Type V | Teratozoospermia | Wieacker-Wolff Syndrome | Turner's Syndrome | Hypercalcemia | Ligneous Conjunctivitis | Barakat Syndrome | Sturge-Weber Syndrome | Episodic Ataxia Type 1 | Cancer, Lung | Anthrax | Retinal Coloboma | Pneumothorax | Epithelioid Hemangioma | Intestinal Hypomagnesemia 1 | Cornelia De Lange Syndrome | Pemphigus Vulgaris | Astrocytoma | Warsaw Breakage Syndrome | Wagner Disease | Strabismus | Beta-Propeller Protein-associated Neurodegeneration | Overactive Bladder | Dentinogenesis Imperfecta | Molybdenum Cofactor Deficiency | Pierpont Syndrome | Metatropic Dysplasia | Adenocarcinoma | Cryptorchidism | Saul-Wilson Syndrome | DRESS Syndrome | Fuchs Heterochromic Iridocyclitis | Chorea | Epidermolytic Ichthyosis, Annular | Homocystinuria | Spastic Paraplegia Type 7 | Schwartz-Jampel-Aberfeld Syndrome | Hyperthyroidism | Cranioectodermal Dysplasia | Pupil Disorders | Hyperuricemic Nephropathy, Familial Juvenile | Focal Facial Dermal Dysplasia | WAGR Syndrome | Left Ventricular Noncompaction | Delirium | Celiac Disease | Vitamin B12 Deficiency | Brachydactyly | Patent Foramen Ovale | Pulmonary Alveolar Proteinosis | Acute Motor Axonal Neuropathy | Photosensitivity | Schizophrenia, Paranoid | Cousin Syndrome | Anovulation | Aldosterone Synthase Deficiency | Macrophagic Myofasciitis | Uremia | Keloid | Bladder Exstrophy | Goiter, Nodular | Leukocyte Adhesion Deficiency | Progressive Osseous Heteroplasia | Bainbridge-Ropers Syndrome | Subacute Sclerosing Panencephalitis | Low Tension Glaucoma | Erythromelalgia | Crimean-Congo Hemorrhagic Fever | Nance-Horan Syndrome | Behavioral Variant Of Frontotemporal Dementia | Mountain Sickness | Fibrosis | SAPHO Syndrome | Genitopatellar Syndrome | Von Willebrand Disease | Angina Pectoris | Aneurysm, Thoracic Aortic | Pontocerebellar Hypoplasia Type 2 | Schistosomiasis Mansoni | Low Phospholipid Associated Cholelithiasis | Intestinal Pseudo-obstruction | Pneumonia, Viral | Aspergillosis | Aldosteronism | Mandibuloacral Dysplasia With Type A Lipodystrophy | TARP Syndrome | Mitochondrial DNA Depletion Syndrome 13 | Hypotrichosis | Cryptococcal Meningitis | Sleep Apnea, Obstructive | Tyrosine Hydroxylase Deficiency | Coffin-Lowry Syndrome | Coronary Restenosis | Fanconi Anemia | Polycythemia | Autoimmune Disease | Renal Medullary Carcinoma | Holoprosencephaly | Keratitis-ichthyosis-deafness Syndrome | Hyperekplexia | Hypodontia | Charcot-Marie-Tooth Disease | Desmosterolosis | Tardive Dyskinesia | Paroxysmal Kinesigenic Dyskinesia | Blepharoconjunctivitis | Larsen Syndrome | Hemochromatosis Type 1 | Diffuse Intrinsic Pontine Glioma | Gallstones | Diabetes | Yellow Fever | Congenital Stromal Corneal Dystrophy | Woodhouse-Sakati Syndrome | Asperger Syndrome | Schwannomatosis | Mitochondrial Disease | Acrodermatitis | Xeroderma Pigmentosum Variant Type | Neurofibromatosis-Noonan Syndrome | Leri-Weill Dyschondrosteosis | Glycogen Storage Disease Type 1b | Fuchs Dystrophy | Familial Partial Lipodystrophy | Creatine Deficiency Syndrome Due To AGAT Deficiency | Kawasaki Disease | Bone Giant Cell Tumor | Purpura, Thrombotic Thrombocytopenic | Meier-Gorlin Syndrome | Non-bullous Congenital Ichthyosiform Erythroderma | Early Infantile Epileptic Encephalopathy 4 | Neurogenic Bladder | Sarcoma, Ewing