Tardive Dyskinesia

About the Disease
Tardive Dyskinesia, also known as neuroleptic-induced tardive dyskinesia, is related to movement disease and parkinsonism, and has symptoms including spasmodic torticollis and myoclonus. An important gene associated with Tardive Dyskinesia is NQO1 (NAD(P)H Quinone Dehydrogenase 1), and among its related pathways/superpathways are Estrogen metabolism and Biogenic amine synthesis. The drugs Aripiprazole and Varenicline have been mentioned in the context of this disorder. Affiliated tissues include tongue, brain and globus pallidus, and related phenotypes are akathisia and tardive dyskinesia

Common Targets
SIGMAR1 | IL1B | Metabotropic glutamate (mGluR) receptor (nonspecified subtype) | CHRM4 | G23411 | CHRM1 | IL10 | XDH | PDE10A | PTPN1 | SOD2 | AKR1B1 | GSK3B | DBH | SLC6A4 | HTR2A | DISC1 | GRIN2A | NMDA receptor | GSTP1 | GABRG3 | DRD1 | beta-Adrenoceptor (nonspecified subtype) | ABCC8 | HSPG2 | GAA | STS | BDNF-AS | sigma Receptor (nonspecified subtype) | Dopamine receptor (nonspecified subtype) | P2X Receptor (nonspecified subtype) | Nitric oxide synthase (NOS) (nonspecified subtype) | SCN5A | DRD3 | CCKAR | Inosine 5'-monophosphate dehydrogenase (IMPDH) (nonspecified subtype) | NQO1 | OPRM1 | CHRM2 | G1956 | PIP4K2A | DRD2 | BDNF | Glutamate Receptor Ionotropic AMPA Receptor | KCNB2 | G207 | SLC1A2 | ADRA2C | CAT | COMT | MAOA | G7124 | ADRA1A | CCK receptor (nonspecified subtype) | CYP2D6 | SLC18A2 | FMR1 | Kainate Receptor (GluR) (nonspecified subtype)

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