Muscle Wasting

About the Disease
Muscular Atrophy, also known as muscle wasting, is related to spinal muscular atrophy and spinal and bulbar muscular atrophy, x-linked 1, and has symptoms including muscular fasciculation, muscle cramp and spasm. An important gene associated with Muscular Atrophy is SMCHD1 (Structural Maintenance Of Chromosomes Flexible Hinge Domain Containing 1), and among its related pathways/superpathways is SARS-CoV-2 modulates host translation machinery. The drugs Acetaminophen and Goserelin have been mentioned in the context of this disorder. Affiliated tissues include skeletal muscle, spinal cord and bone marrow, and related phenotypes are nervous system and homeostasis/metabolism

Common Targets
DYM | FOXO1 | ALDH1A2 | PGR | UBR5 | G367 | CCN2 | UBR3 | USP19 | TGFA | ACVR2A | DLEU1 | INHBA | UBR2 | Transforming growth factor beta (nonspecified subtype) | ACVR2B | INHBB | NAMPT | FTO | MC4R | MSTN | BRSK1 | UBR1 | SLC39A8 | ZNF678 | ZBTB38

Note: If you'd like to get a target analysis report for Muscle Wasting, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Muscle Wasting at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Pleurisy | Thrombasthenia | Autoimmune Polyendocrine Syndrome | Blue Rubber Bleb Nevus Syndrome | Spondylolisthesis | Arteriosclerosis | Ornithine Transcarbamylase Deficiency | Benign Familial Pemphigus | Cancer, Prostate | Epidermolytic Ichthyosis, Annular | Craniosynostosis | Intestinal Obstruction | Rhabdoid Tumor | IgA Deficiency | Barrett Esophagus | Waardenburg Syndrome Type 4 | Corneal Dystrophy And Perceptive Deafness | Olmsted Syndrome | Biotinidase Deficiency | Measles | Carcinoma, Small Cell | Osteonecrosis | Scapuloperoneal Myopathy, X-linked Dominant | Perry Syndrome | Leiomyosarcoma | Nevus | Pterygium | Pontocerebellar Hypoplasia Type 7 | Spinocerebellar Ataxia Type 21 | Lymphoma, Follicular | Keratosis, Seborrheic | Frank-ter Haar Syndrome | Hypophosphatemic Rickets, Autosomal Recessive, 1 | Chromosome 9q34.3 Deletion Syndrome | Dental Caries | Retinal Telangiectasia | MELAS Syndrome | Cole-Carpenter Syndrome | Hypophosphatemic Rickets With Hypercalciuria, Hereditary | Thyroiditis | Polycystic Liver | Sarcoma, Alveolar Soft Part | Hypercalcemia | Larsen Syndrome | Meningioma, Benign | Cantu Syndrome | Isovaleric Acidemia | Argininosuccinic Aciduria | Hypophosphatasia | Blepharo-cheilo-odontic Syndrome | Microcephaly, Seizures, And Developmental Delay | Goldenhar Syndrome | Spinal Cord Diseases | Influenza | Moyamoya Disease | Hemorrhoids | Osteochondrosis | Chronic Thromboembolic Pulmonary Hypertension | Mosaic Variegated Aneuploidy Syndrome 2 | Basal Cell Nevus Syndrome | Lesch-Nyhan Syndrome | Asperger Syndrome | Heart Septal Defects | Iron Overload | Autoimmune Disease | Plasma Cell Dyscrasia | Gaze Palsy, Familial Horizontal, With Progressive Scoliosis, 2 | Enlarged Vestibular Aqueduct | Mitochondrial DNA Depletion Syndrome, Myopathic Form | Adrenal Insufficiency | Carcinoid Syndrome | Aromatic L-amino Acid Decarboxylase Deficiency | H Syndrome | Erythromelalgia | Vaginitis | Cerebral Amyloid Angiopathy | Atrioventricular Septal Defect | Optic Neuropathy, Anterior Ischemic | Diabetic Encephalopathy | Sensory Ataxic Neuropathy, Dysarthria, And Ophthalmoparesis | Vitiligo | Congenital Nephrotic Syndrome | Portal Vein Thrombosis | Oculopharyngeal Muscular Dystrophy | Bietti Crystalline Dystrophy | Gerstmann-Straussler-Scheinker Syndrome | Microcephalic Osteodysplastic Primordial Dwarfism, Type II | Pompe Disease | Bronchiolitis | Megalencephaly | Renal Oncocytoma | 3-hydroxy-3-methylglutaryl-CoA Synthase Deficiency | Primary Pigmented Nodular Adrenocortical Disease | Fibrillation, Atrial | Hepatitis C, Chronic | Microcephalic Primordial Dwarfism | Schizoaffective Disorder | Corneal Dystrophy | Angioedema, Acquired | Focal Cortical Dysplasia Type 2 | Chromosome 8q21.11 Deletion Syndrome | Epidermolysis Bullosa Simplex, Generalized | Sickle Cell Anemia | Postpartum Depression | Tyrosine Hydroxylase Deficiency | Juvenile Hyaline Fibromatosis | Very Long-chain Acyl-CoA Dehydrogenase Deficiency | Immunoproliferative Disorders | Ocular Hypertension | Glycogen Storage Disease Type 4 | Corneal Edema | Chronic Leukemia | Restrictive Dermopathy | Spondyloarthritis | Hemolytic Uremic Syndrome | AIDS | Cerebellar Ataxia, Cayman Type | Nemaline Myopathy 10 | Crouzon Syndrome With Acanthosis Nigricans | Hypoproteinemia, Hypercatabolic | Limb Girdle Muscular Dystrophy | Riboflavin Transporter Deficiency Neuronopathy | Hypermethioninemia | Hyperinsulinemic Hypoglycemia | Klippel-Feil Syndrome | Down Syndrome | Homocystinuria | Hypolipoproteinemia | Mastitis | Hereditary Mixed Polyposis Syndrome | Gaucher Disease | Esophagitis | Spinocerebellar Ataxia Type 23 | Benign Familial Neonatal Convulsions | Meningococcal Meningitis | Waardenburg Syndrome Type 4A | Trichomegaly | Pfeiffer Syndrome | Juvenile Polyposis | Diffuse Palmoplantar Keratoderma | Pregnancy, Ectopic | Charcot-Marie-Tooth Disease Type 2D | Chromosome 17q21.31 Deletion Syndrome | IgA Nephropathy | Potocki-Shaffer Syndrome | Azoospermia | Glycogen Storage Disease Type 3 | Spinal Muscular Atrophy Type 2 | Papulopustular Rosacea | Mesial Temporal Lobe Epilepsy With Hippocampal Sclerosis | Diabetes Insipidus | Arthritis, Reactive | Nicotine Dependence | Sialidosis Type I | Gray Platelet Syndrome | Cenani-Lenz Syndactyly Syndrome | Creutzfeldt-Jakob Disease | Panuveitis | Dowling-Degos Disease | Woodhouse-Sakati Syndrome | Neurodermatitis | Familial Dysautonomia | Gigantism | Hereditary Multiple Exostoses | D-2-Hydroxyglutaric Aciduria | Primary Lateral Sclerosis | Tularemia | Cutaneous Lupus Erythematosus | Hemangioma | Psoriasis | Lafora Disease | Rhabdomyosarcoma, Embryonal | Congenital Generalized Lipodystrophy | Ectopia Lentis, Isolated, Autosomal Recessive | Otitis Media | Spina Bifida | Li-Fraumeni Syndrome | Posterior Polar Cataract | Aneurysm, Thoracic Aortic | Takotsubo Cardiomyopathy | Congenital Dyserythropoietic Anemia Type 1 | Transthyretin-related Amyloidosis | Conjunctivitis | Meningococcal Infections | Acne Vulgaris | Congenital Diaphragmatic Hernia | Heterotopic Ossification | Major Depression | Postpoliomyelitis Syndrome | Onchocerciasis | Carpal Tunnel Syndrome | Primary Sclerosing Cholangitis | Marinesco-Sjogren Syndrome | Nicotine Addiction | NDH Syndrome | Scoliosis | Sarcoma, Ewing | Sensorineural Hearing Loss | Birk-Barel Syndrome | Inflammatory Myofibroblastic Tumor | Photosensitivity | Panic Disorder | Diabetes Insipidus, Neurogenic | Diabetic Macular Edema | Thalassemia, Beta | Lymphedema-distichiasis Syndrome | Neurodegeneration Due To Cerebral Folate Transport Deficiency | Coronary Artery Disease | Angina Pectoris | Stuttering | Anterior Segment Dysgenesis | Muscular Dystrophy | Cannabis Abuse | Borderline Personality Disorder | Neurodegeneration With Brain Iron Accumulation | Neuromyelitis Optica | Malnutrition | Sturge-Weber Syndrome | Fragile X Syndrome | Chromosome 16p11.2 Deletion Syndrome | Multiple Sclerosis | Learning Disability | Parvovirus B19 Infection | Motion Sickness | Hypercalciuria | B-cell Prolymphocytic Leukemia | Methylmalonic Acidemia | Early Infantile Epileptic Encephalopathy 28 | Porphyria | Oculocutaneous Albinism | Generalized Epilepsy And Paroxysmal Dyskinesia | DOCK8 Immunodeficiency Syndrome | Cholestasis, Intrahepatic | Hyperthyroidism | Jawad Syndrome | Graves Disease | Urofacial Syndrome | Congestive Heart Failure | Turner's Syndrome | Keratitis | Esophageal Motility Disorders | Gangliosidosis, GM1 | Sandhoff Disease | Blepharoconjunctivitis | Distal Spinal Muscular Atrophy | Polycythemia | Schnitzler Syndrome | Chorea | Cleidocranial Dysplasia | Sarcoma, Endometrial Stromal | Connective Tissue Disorders | Amebiasis | Primary Hyperoxaluria | Hypermetropia | Agranulocytosis | Neurofibromatosis Type 1 | Bronchiectasis | Chronic Enteropathy Associated With SLCO2A1 Gene | Fetal Akinesia Deformation Sequence | Adams-Oliver Syndrome | Ehlers-Danlos Syndrome With Progressive Kyphoscoliosis, Myopathy, And Hearing Loss | Lung Diseases | Herpes Simplex Dermatitis | T-cell Chronic Lymphocytic Leukemia | Sponastrime Dysplasia | Choreoathetosis, Hypothyroidism, And Neonatal Respiratory Distress | ACTH-independent Macronodular Adrenal Hyperplasia | Currarino Syndrome | Traboulsi Syndrome | Autosomal Recessive Spastic Paraplegia Type 35 | Cholangiocarcinoma | Jaundice, Obstructive | Fibronectin Glomerulopathy | Parapsoriasis | Early Infantile Epileptic Encephalopathy 4 | Granular Corneal Dystrophy | Inflammatory Myopathy | Renal Failure | Autosomal Recessive Bestrophinopathy | Hyper IgE Syndrome | Myoclonus-dystonia Syndrome | Tremor | Walker-Warburg Syndrome | Galloway-Mowat Syndrome | McLeod Syndrome | Campomelic Dysplasia | Hartsfield Syndrome | Keratoacanthoma | Ocular Surface Squamous Neoplasia | Colitis | Thyroid Dyshormonogenesis | Rickets | Charcot-Marie-Tooth Disease Type 4E | Metachondromatosis | Wolfram Syndrome 2 | Ichthyosis Hystrix, Curth-Macklin Type | Seminoma | Ebstein Anomaly | Pseudo-pseudohypoparathyroidism | Hereditary Folate Malabsorption | Pitt-Hopkins Syndrome | Bronchitis | Wiedemann-Steiner Syndrome | Synovitis | Glycogen Storage Disease Type 5 | Vestibular Disease | Gallstones | Insulinoma | Acute Motor Axonal Neuropathy | Raine Syndrome | 3-methylglutaconic Aciduria | Cholestasis | Hyperandrogenemia | Paget's Disease Of The Breast | Toxoplasmosis | Facioscapulohumeral Muscular Dystrophy Type 2 | Paraganglioma | Mitochondrial Myopathy | Cranial Nerve Disease | Exostoses | Sialidosis | Disseminated Superficial Actinic Porokeratosis | Neurofibroma | Craniofacial Dysostosis | 3C Syndrome | Iron Metabolism Disorders | Intermittent Claudication | Myositis | Seizures-scoliosis-macrocephaly Syndrome | Histoplasmosis | Cardiomyopathy, Restrictive | Wieacker-Wolff Syndrome | Polyarteritis Nodosa | Trichuriasis | Burn-McKeown Syndrome | Frontometaphyseal Dysplasia | Glioblastoma | GLUT1 Deficiency Syndrome | Asthma, Nocturnal | Polycythemia Vera | Giant Cell Arteritis | Fabry's Disease | Hyperglycemia | Interstitial Lung Diseases | Marshall-Smith Syndrome | Rheumatic Heart Disease | Pulmonary Stenosis | Diverticulitis | Preaxial Polydactyly | Neurotoxicity | Spinocerebellar Ataxia | Macrophagic Myofasciitis | Cancer, Breast | Leukocyte Adhesion Deficiency Type 1 | Pathological Gambling | Glioma | Macular Corneal Dystrophy Type 1 | Nail Disorder, Nonsyndromic Congenital | Ichthyosis, X-linked | Treacher Collins Syndrome | Werner's Syndrome | Cri-du-chat Syndrome | Wilson's Disease | Hemoglobinopathies | Peripheral Neuropathy | Charcot-Marie-Tooth Disease Type 2T | Kearns-Sayre Syndrome | Smoldering Myeloma | Nance-Horan Syndrome | Hypertensive Retinopathy | Macular Corneal Dystrophy | Congenital Central Hypoventilation Syndrome | Hyperphosphatasia With Intellectual Disability Syndrome 4 | Dystonia Musculorum Deformans | Pulmonary Capillary Hemangiomatosis | Incontinentia Pigmenti | Hypotrichosis | Maternally Inherited Diabetes And Deafness | Dysthymia | Hyperoxaluria | Spinal Muscular Atrophy Type 3 | Retinal Dystrophy, Early-onset Severe | Otitis Externa | Rhizomelic Chondrodysplasia Punctata | Urolithiasis | Erythematotelangiectatic Rosacea | Gastroenteritis | Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive 1 | Pseudohypoaldosteronism | Ligneous Conjunctivitis | Peeling Skin Syndrome, Acral Type | Pancreatitis | Myoclonic Epilepsy With Ragged Red Fibers | Hepatic Veno-occlusive Disease | Shprintzen-Goldberg Syndrome | Angelman Syndrome | Congenital Stationary Night Blindness | Asplenia | DNA Ligase IV Deficiency | Premature Ejaculation