Spina Bifida

About the Disease
Meningocele, also known as isolated spina bifida, is related to lateral meningocele syndrome and cervical spina bifida aperta. An important gene associated with Meningocele is NOTCH3 (Notch Receptor 3), and among its related pathways/superpathways are Wnt / Hedgehog / Notch and Gene regulatory network modelling somitogenesis. The drugs Acetylcholine and Oxybutynin have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, bone marrow and brain, and related phenotypes are nervous system and limbs/digits/tail

Common Targets
CIC | SUFU | BMP7 | LMX1A | BRINP2 | IRX5 | VANGL1 | GRHL3 | FEZF1 | SV2C | SCRIB | VAX1 | PLXNA4 | TRIM26 | LBX1 | SOX9 | GNAS | LHX1 | TULP3 | RIMS1 | KCNMA1 | NMUR1 | PTK7 | PELP1 | SIM2 | GRIN3A | BDNF | LRP6 | GDNF | PTPRR

Note: If you'd like to get a target analysis report for Spina Bifida, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Spina Bifida at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

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