Disease

Morbid Obesity

About the Disease
Leptin Receptor Deficiency, also known as obesity due to leptin receptor gene deficiency, is related to morbid obesity and spermatogenic failure and non-alcoholic fatty liver disease. An important gene associated with Leptin Receptor Deficiency is LEPR (Leptin Receptor). The drugs Heparin, bovine and Nadroparin have been mentioned in the context of this disorder. Affiliated tissues include liver, t cells and ovary, and related phenotypes are obesity and decreased serum leptin

Common Targets
TIPIN | SLC39A8 | OR8U3 | FRMD7 | TRIM66 | SULT1A1 | MRPL2 | FUBP1 | TLR5 | PCDHA8 | CLCNKA | OR5M11 | CACNA1B | MALT1 | TNFRSF1B | IL6ST | PF4 | SOCS1 | PCDHA7 | MYD88 | SETD4 | TOMM40 | PAX1 | DISP2 | ACAA1 | FADD | IL13RA1 | TNKS1BP1 | PPARA | ADAM8 | FAIM2 | C1orf112 | DTX2P1-UPK3BP1-PMS2P11 | CD6 | POTED | PCDHA5 | CCDC154 | TRAF2 | SEPTIN4 | PCDHA4 | PKMYT1 | SMG6 | ZBTB4 | TYK2 | GPR26 | IL7 | EVA1A | PGPEP1 | KNG1 | ETV5 | PLXNB2 | IL17RA | KLC4 | ETS2-AS1 | FOXJ1 | CADM2 | G1432 | MMP3 | DMPK | G7852 | IL4R | FAM13A | RASA2 | LAG3 | LCK | PCDHA2 | ART1 | NOD1 | RGS17 | RABEP1 | CCDC171 | NPHP4 | PTH2R | SCD | IL10RA | ATP2C2 | PCDHA1 | SNRPC | ADCY3 | NRDE2 | EGR1 | THY1 | NLRC3 | ACOT2 | TNFRSF18 | PABPC4L | KAT8 | LOC101927947 | ASB16 | PDE10A | SEMA4G | ANKK1 | MMP12 | G3725 | TOLLIP | KLK11 | HHIP | TRAF6 | EEPD1 | LEP | PDGFD | NAV1 | ANXA5 | CXCL14 | FPGT-TNNI3K | OR10AG1 | AKAP13 | ECT2L | LAMB3 | SSH1 | OR5F1 | CD40 | IL17C | IGFN1 | NXPH1 | FHIT | TCP11L2 | TIRAP | DPP4 | ATP2A1 | WRN | IL10RB | SECTM1 | PGPEP1L | GBE1 | LOC105371116 | G6772 | INHA | IL15 | NAV2 | ZFHX3 | EHBP1 | CLIP1 | ADA | HIP1 | SEMA5B | ATF2 | XDH | IQCB1 | G5743 | S1PR3 | PKHD1 | TLR2 | POU6F2 | EPG5 | BCL10 | DNAH1 | ACSM5 | OR5I1 | NFATC3 | CSMD1 | GPC1 | CASC17 | APBA2 | NCK1 | LTB | MMP7 | G2309 | CXCL12 | LRRC31 | RANBP17 | BLM | QPCTL | INHBA | CSF1 | JUP | LOC105374287 | UNC13C | CEBPB | BCL3 | LARGE1 | OR51A2 | ASB4 | IL15RA | CCL15 | MTHFR | MTCH2 | GRID1 | CD7 | LMX1B | ASB16-AS1 | RARB | ENDOV | LEPR | KCNK3 | LINC00682 | HDAC4 | LOC102724934 | LOC107984221 | OR2T34 | MEGF8 | PDPR | IL1A | ELAVL4 | CXCL1 | POC5 | INHBB | ARHGAP10 | TMPRSS9 | ICOSLG | ANKS1B | ZNF260 | F5 | TMC5 | INO80E | INHBC | TGM4 | HSD17B12 | SCARB2 | TRPM2 | PIK3R6 | PPP6R2 | USH2A | G5970 | LOC105371956 | SYPL2 | FIGN | TAL1 | LOC100507221 | SMPD3 | GAA | MIR99AHG | CXCL2 | DAB2IP | TKFC | CDHR2 | ABCF1 | CXCL3 | PIH1D2 | SLC6A18 | SCD5 | RUNX1 | CD47 | GM2A | RMC1 | DMXL2 | IGF2BP3 | MC4R | TBL2 | SMAD3 | PKD1L2 | HSPA12A | NKX2-6 | MRPL43 | NPTXR | GPC6 | LOC107984928 | GATA3 | AMH | AGO4 | FTO | LINC00907 | LOC105378797 | G6776 | IL6R | ILRUN | BTBD8 | ENGASE | BCL6 | SIPA1L3 | RIPK3 | APLN | IGF2BP2 | ZC3H4 | CALCR | LINC01541 | MTIF3 | IL13 | LOC107985440 | MAPK7 | PCNT | MIR3064 | WDFY4 | RIPK1 | RNH1 | TGFB3 | ABCC3 | USP37 | EIF1B-AS1 | PRKN | HMOX1 | CCL25 | TFR2 | MMP1 | LOC107985979 | CXCL6 | LOC105372666 | TCF7L2 | FOS | FOXP3 | INF2 | OR5D14 | OR14I1 | LOC105372667 | LTB4R | G6647 | OR8H3 | DDX5 | NFKB1 | OR5T3 | SLC7A14 | CXCL5 | OR5D18 | COPG1 | AGBL4 | GNAT2 | OR8K1 | TMIE | SEPTIN4-AS1 | IL12B | OR8K5 | MYRIP | G29126 | MAP2K5 | OR8H1 | NRXN3 | LINGO2 | SOS1 | RPTOR | SBK1 | BDNF | PTPRR | NT5C2 | PARP10 | LOC107986544 | OR8J1

疾病靶点研报
Morbid Obesity

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