Histiocytosis

About the Disease
Histiocytosis, also known as hand schuller christian disease, is related to histiocytosis-lymphadenopathy plus syndrome and langerhans cell sarcoma. An important gene associated with Histiocytosis is SLC29A3 (Solute Carrier Family 29 Member 3), and among its related pathways/superpathways are Innate Immune System and MIF Mediated Glucocorticoid Regulation. The drugs Prednisone and glucocorticoids have been mentioned in the context of this disorder. Affiliated tissues include lung, bone and liver, and related phenotypes are no effect and no effect

Common Targets
MAP2K1 | ALDH2 | G3845 | UNC13D | G7124 | ADH1B | DCX (DDB1-CUL4-X-box) E3 protein ligase complex | SLC29A3 | PRF1 | CBL | G673 | CRBN | PARP2 | Dual Specificity Mitogen-Activated Protein Kinase Kinase (MEK) (nonspecified subtype) | NRAS | PDGFRB | LPIN1 | PARP3 | G142

Note: If you'd like to get a target analysis report for Histiocytosis, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Histiocytosis at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Gastroenteritis, Eosinophilic | Hyperthyroidism | Polycythemia Vera | Endometrial Hyperplasia | Neurodevelopmental Disorder With Central Hypotonia And Dysmorphic Facies | Lymphoma, Mantle Cell | Porphyria Cutanea Tarda | Congenital Muscular Dystrophy | Varicocele | Nephroblastoma | Hemangioma | Congenital Ichthyosiform Erythroderma | Meleda Disease | Retinitis | Parkinsonism | Influenza | Infantile Nephropathic Cystinosis | Myelitis | Arterial Tortuosity Syndrome | Melanocytic Nevus | Generalized Epilepsy And Paroxysmal Dyskinesia | Waardenburg Syndrome Type 2E | Acrodermatitis | Microphthalmia | Congenital Tufting Enteropathy | Lymphoma, B-cell | Angioedema | Cenani-Lenz Syndactyly Syndrome | Cardiomyopathy, Restrictive | Allergic Contact Dermatitis | Peritonitis | High Molecular Weight Kininogen Deficiency | Placenta Previa | Sensorineural Hearing Loss | Still Disease | Cardiofaciocutaneous Syndrome | Dysequilibrium Syndrome | CHOPS Syndrome | Hamartoma | Meningeal Melanocytoma | Atelosteogenesis Type 2 | Persistent Hyperplastic Primary Vitreous | Mitochondrial DNA Depletion Syndrome, Myopathic Form | Hydrolethalus Syndrome | Charcot-Marie-Tooth Disease Type 4B1 | Osteonecrosis Of The Jaw | Congenital Bile Acid Synthesis Defect | Nevus | Optic Nerve Hypoplasia, Bilateral | Glycogen Storage Disease Type 3 | Epidermolysis Bullosa Dystrophica | Motion Sickness | Temporal Lobe Epilepsy | X-linked Myotubular Myopathy | Fowler's Syndrome | Sotos Syndrome | HANAC Syndrome | Systemic Lupus Erythematosus | Ectodermal Dysplasia | Shprintzen-Goldberg Syndrome | Ischemia | Familial Advanced Sleep Phase Syndrome | Fibromyalgia | Vici Syndrome | Congenital Dysfibrinogenemia | Addison Disease | Frank-ter Haar Syndrome | Ameloblastic Carcinoma | Dysferlinopathy | Hypohidrotic Ectodermal Dysplasia, X-linked | Enhanced S-cone Syndrome | Crouzon Syndrome With Acanthosis Nigricans | Chronic Inflammatory Demyelinating Polyneuropathy | Cheilitis | Poirier-Bienvenu Neurodevelopmental Syndrome | Benign Familial Pemphigus | Fibronectin Glomerulopathy | Epidermolysis Bullosa Simplex, Dowling-Meara Type | Congenital Stationary Night Blindness | Localized Scleroderma | Veno-occlusive Disease | Tinea Versicolor | LEOPARD Syndrome | Neuromuscular Disorders | Cavitary Optic Disc Anomalies | Mood Disorder | Familial Retinal Arterial Macroaneurysm | Keratoacanthoma | Hypereosinophilic Syndrome | Tangier Disease | Hemorrhagic Disorders | Varices | Angioedema, Hereditary | Craniopharyngioma | Hepatitis, Autoimmune | Knobloch Syndrome | Cysticercosis | COACH Syndrome | Gangliosidosis, GM1 | Obesity, Morbid | Hepatic Veno-occlusive Disease | Hyperparathyroidism, Primary | Erythropoietic Protoporphyria | Brachydactyly | Cohen Syndrome | Cholangitis | Gyrate Atrophy Of The Choroid And Retina | Chanarin-Dorfman Syndrome | Seborrheic Dermatitis | Neuromyelitis Optica | Hemophagocytic Lymphohistiocytosis | Spinocerebellar Ataxia Type 14 | Jaundice, Obstructive | Plasmacytoma | Subcortical Band Heterotopia | Oral Lichen Planus | Venous Insufficiency | Acute Coronary Syndrome | Acute Tubular Necrosis | Bronchiolitis | Paget's Disease Of The Breast | Pelvic Inflammatory Disease | Acute Kidney Injury | Inflammatory Joint Disease | Glaucoma, Congenital | Vaginitis | Multiple Sclerosis, Chronic Progressive | Osteopathia Striata With Cranial Sclerosis | Micro Syndrome | Tay-Sachs Disease | Trigonocephaly | Hemolytic Uremic Syndrome, Atypical | D-2-Hydroxyglutaric Aciduria | Spinocerebellar Ataxia Type 3 | Polyneuropathy | Malignant Peripheral Nerve Sheath Tumor | Specific Granule Deficiency | Cyst | Pierpont Syndrome | Chromosome 5q Deletion Syndrome | Carney-Stratakis Syndrome | 3C Syndrome | Ichthyosis Hystrix, Curth-Macklin Type | Barrett Esophagus | Chordoid Glioma | Hereditary Mixed Polyposis Syndrome | Stevens-Johnson Syndrome | Blue Rubber Bleb Nevus Syndrome | Pheochromocytoma | Alazami Syndrome | Autoimmune Interstitial Lung, Joint, And Kidney Disease | Primary Aldosteronism | Central Retinal Artery Occlusion | Cholestasis, Intrahepatic | Agnathia-Otocephaly Complex | Hidradenitis | Myelitis, Transverse | Charcot-Marie-Tooth Disease Type 2T | Ectopia Lentis, Isolated, Autosomal Recessive | Galactosialidosis | Juvenile Myoclonic Epilepsy | Ovarian Sex Cord-stromal Tumor | Bare Lymphocyte Syndrome | Sleep Apnea | Temtamy Preaxial Brachydactyly Syndrome | Facioscapulohumeral Muscular Dystrophy Type 2 | Kabuki Syndrome 2 | Diastrophic Dysplasia | Evans Syndrome | Alpha-mannosidosis | Hepatitis, Alcoholic | Glycogen Storage Disease Type 5 | Congenital Mirror Movements | Treacher Collins Syndrome | Sick Sinus Syndrome 1 | Choreoathetosis, Hypothyroidism, And Neonatal Respiratory Distress | Optic Nerve Diseases | Smith-Kingsmore Syndrome | Metabolic Diseases | Hypertension, Renovascular | Premature Ejaculation | Cervicitis | Ataxia-ocular Apraxia 2 | Chronic Myelomonocytic Leukemia | Osteomyelitis | Central Pain Syndrome | Adenocarcinoma | Hereditary Folate Malabsorption | Sialidosis | Anosmia, Congenital | Thyroiditis, Autoimmune | Tetanus | Vitamin D Deficiency | Crisponi Syndrome | Spinocerebellar Ataxia Type 7 | Krabbe Disease | Esophageal Motility Disorders | Dwarfism | Anorchia | Leishmaniasis, Cutaneous | Focal Facial Dermal Dysplasia | Hypertrophy | Heimler Syndrome | DEND Syndrome | Corneal Neovascularization | Dementia | 3-methylcrotonyl-CoA Carboxylase Deficiency | Becker Muscular Dystrophy | Hyperlipidemia | Hyperparathyroidism | Bloom Syndrome | Johanson-Blizzard Syndrome | Dementia, Vascular | Prolidase Deficiency | Nephrosclerosis | Sjogren Syndrome | Aphasia | Wolfram Syndrome | Cardiac Sarcoidosis | Fibrodysplasia Ossificans Progressiva | Pneumonia, Viral | Intermittent Claudication | Hydrops Fetalis | Vertigo | Congenital Diaphragmatic Hernia | Skin Fragility-woolly Hair Syndrome | Encephalitis | Neuroblastoma | Pericarditis | Nephritis, Interstitial | Cancer, Prostate | Autonomic Neuropathy | Ehlers-Danlos Syndrome | Episodic Ataxia Type 2 | Cornelia De Lange Syndrome | Apraxia | Pulmonary Vein Stenosis | Behavioral Variant Of Frontotemporal Dementia | Familial Glucocorticoid Deficiency | Spinocerebellar Ataxia Type 10 | Thrombophlebitis | CDKL5 Deficiency Disorder | Oculodentodigital Dysplasia | Hepatitis E | Pneumonia, Mycoplasma | Acute Chest Syndrome | Adenoid Cystic Carcinoma | Prune Belly Syndrome | Polycystic Kidney, Autosomal Dominant | Gingivitis | Hypohidrotic Ectodermal Dysplasia | Renal Failure | Cerebral Cavernous Malformations | Pleomorphic Xanthoastrocytoma | Bipolar Disorder | Spinal Muscular Atrophy Type 3 | Zimmermann-Laband Syndrome | Alcoholism | Pneumoconiosis | Fetal Akinesia Deformation Sequence | Esophagitis, Eosinophilic | Hermansky-Pudlak Syndrome | Progressive Familial Intrahepatic Cholestasis Type 1 | Intracerebral Hemorrhage | Sclerosteosis 2 | Microcephalic Osteodysplastic Primordial Dwarfism, Type I | Primary Cutaneous Amyloidosis | Zellweger Syndrome | Thromboembolism | Optic Neuropathy, Anterior Ischemic | Scapuloperoneal Myopathy, X-linked Dominant | Cockayne Syndrome | Mitochondrial Myopathy | Adenoma, Pleomorphic | Heavy Chain Disease | SAPHO Syndrome | Erythematotelangiectatic Rosacea | Feingold Syndrome | Bacterial Meningitis | Fetal And Neonatal Alloimmune Thrombocytopenia | Renpenning Syndrome | Familial Episodic Pain Syndrome | Hereditary Spastic Paraplegia | Trimethylaminuria | Hypotonia-cystinuria Syndrome | Sweet Syndrome | Herpes Simplex Dermatitis | Haim-Munk Syndrome | Spasticity | Lysosomal Acid Lipase Deficiency | Multisystemic Smooth Muscle Dysfunction Syndrome | Postpoliomyelitis Syndrome | Osteogenesis Imperfecta Type II | Sandhoff Disease | Neurofibromatosis Type 2 | Thyroid Dysgenesis | Glomerulonephritis | Schizotypal Personality Disorder | Epidermodysplasia Verruciformis | Nasodigitoacoustic Syndrome | Fibrosarcoma | Carpenter Syndrome | Kidney Stones | 3-methylglutaconic Aciduria Type IV | Spinocerebellar Ataxia | Leber Congenital Amaurosis | Inborn Errors Of Metabolism | Colon Adenoma | Analgesia | Eating Disorder | Angiosarcoma Of The Breast | Achondrogenesis | Nephrotic Syndrome | Atherosclerosis | Necrobiosis Lipoidica | Mucolipidosis Type III | Budd-Chiari Syndrome | Cancer, Kidney | Chondromyxoid Fibroma | Pyoderma Gangrenosum | Colitis | Aneurysm, Abdominal Aortic | Tendinopathy | T-cell Prolymphocytic Leukemia | Left Ventricular Noncompaction | Light Chain Amyloidosis | Monilethrix | Bartter Syndrome | Iron Deficiency Anemia | Spondylosis | Otitis Media | Schaaf-Yang Syndrome | Hemophilia | Pre-eclampsia | Epidermolytic Ichthyosis, Annular | Leukoplakia, Oral | Lesch-Nyhan Syndrome | Eccrine Porocarcinoma | Lissencephaly 2 | Progressive External Ophthalmoplegia | Cholecystitis | Farber Disease | Marshall-Smith Syndrome | Fanconi Anemia | Cole-Carpenter Syndrome | Posterior Polar Cataract | Hypotension, Orthostatic | Meckel-Gruber Syndrome | Hypophosphatemic Rickets With Hypercalciuria, Hereditary | Hyperacusis | X-linked Charcot-Marie-Tooth Disease | Psoriasis | Antisynthetase Syndrome | POEMS Syndrome | Nemaline Myopathy | Senior-Loken Syndrome | Spinocerebellar Ataxia Type 1 | Hyperekplexia | Amyloidosis | Acromicric Dysplasia | Epidermal Nevus Syndrome | Transcobalamin Deficiency | Pneumonia, Bacterial | Tumoral Calcinosis | Dermatitis | Pyruvate Dehydrogenase Deficiency | Cabezas Syndrome | Arthrogryposis | Congenital Hereditary Endothelial Dystrophy Type I | Cardiomyopathy, Hypertrophic | Desbuquois Syndrome | Yellow Fever | Combined Malonic And Methylmalonic Acidemia | Panic Disorder | T-cell Leukemia | Fahr Disease | Gaucher Disease | Acrodysostosis | Polyarteritis Nodosa | Idiopathic Pulmonary Fibrosis | Nephrocalcinosis | Hypopigmentation | Aceruloplasminemia | Periventricular Leukomalacia | Dupuytren Disease | Stromal Corneal Dystrophy | Situs Inversus | Neuroectodermal Tumors, Primitive | Wolff-Parkinson-White Syndrome | Intestinal Obstruction | Myocarditis | Lymphangiomatosis | Pituitary Dwarfism | Partington Syndrome | Azoospermia | Duodenal Atresia | ADNP Syndrome | Schnitzler Syndrome | Ependymoma | Barakat Syndrome