Disease

Episodic Ataxia Type 2

About the Disease
Episodic Ataxia, Type 2, also known as episodic ataxia type 2, is related to familial hemiplegic migraine and hereditary ataxia, and has symptoms including ataxia, tinnitus and vertigo. An important gene associated with Episodic Ataxia, Type 2 is CACNA1A (Calcium Voltage-Gated Channel Subunit Alpha1 A), and among its related pathways/superpathways are ERK Signaling and MIF Mediated Glucocorticoid Regulation. The drugs Estradiol and Polyestradiol phosphate have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and cerebellum, and related phenotypes are nystagmus and ataxia

Common Targets
CACNA1A

疾病靶点研报
Episodic ataxia type 2

Note: If you'd like to get a target analysis report for Episodic Ataxia Type 2, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Episodic Ataxia Type 2 at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.tech.

Other Diseases

Hypertensive Retinopathy | Lymphoproliferative Disorders | SAPHO Syndrome | Cancer, Lung | Personality Disorders | Hemochromatosis Type 1 | Niemann-Pick Disease, Type A | Xeroderma Pigmentosum | Renal Medullary Carcinoma | Homocystinuria | Epilepsy, Generalized | Cirrhosis | Blepharophimosis Syndrome | Epidermodysplasia Verruciformis | Diffuse Mesangial Sclerosis | Congenital Absence Of Vas Deferens | Tic Disorder | Dubin-Johnson Syndrome | Maple Syrup Urine Disease | Arts Syndrome | Purpura, Thrombotic Thrombocytopenic | Senior-Loken Syndrome | 3-M Syndrome | Epidermal Nevus Syndrome | Sarcoma, Ewing | Basan Syndrome | Neurodermatitis | Dysferlinopathy | Juvenile Hyaline Fibromatosis | Neuroma | Polycystic Liver | Diabetes Gestational | Graves Disease | Sporadic Inclusion Body Myositis | Glutaric Aciduria Type 2 | Tibial Muscular Dystrophy | Dementia | Spinocerebellar Ataxia Type 21 | Optic Neuropathy | Vertigo | Pulmonary Stenosis | Early Infantile Epileptic Encephalopathy 13 | Marinesco-Sjogren Syndrome | Dysfibrinogenemia | Pouchitis | Chylomicron Retention Disease | Neutrophilia | Pulmonary Sclerosing Hemangioma | Shwachman-Bodian-Diamond Syndrome | Tay-Sachs Disease | Absence Epilepsy | Restrictive Dermopathy | Argininosuccinic Aciduria | Citrullinemia | Syphilis | Stroke, Hemorrhagic | Pycnodysostosis | Autoimmune Autonomic Ganglionopathy | Lipid Storage Diseases | Achondrogenesis | Nance-Horan Syndrome | Muir-Torre Syndrome | Mucolipidosis Type IV | Spinocerebellar Ataxia Type 15 | Dermatitis Herpetiformis | Carcinoma In Situ | Cerebral Amyloid Angiopathy | DRESS Syndrome | Cystitis, Interstitial | Glycogen Storage Disease Type 1b | Amyotrophic Lateral Sclerosis | Aspartylglycosaminuria | Intestinal Obstruction | Atelosteogenesis Type 1 | Peutz-Jeghers Syndrome | Acromicric Dysplasia | Feingold Syndrome | Coronary Restenosis | Pyelonephritis | Immunoproliferative Disorders | Lymphoma Lymphoblastic | Conjunctivitis, Allergic | Raynaud Phenomenon | Nemaline Myopathy | Robinow Syndrome | Holoprosencephaly | Meningioma | Exocrine Pancreatic Insufficiency | Keratosis | HUPRA Syndrome | Haim-Munk Syndrome | Alcoholism | Neurocutaneous Melanocytosis | Angina Pectoris | Nanophthalmos | Acrodermatitis | High Molecular Weight Kininogen Deficiency | Sick Sinus Syndrome 1 | Corneal Dystrophy | CREST Syndrome | Myofibromatosis | Early Infantile Epileptic Encephalopathy 1 | Hepatoblastoma | Peeling Skin Syndrome, Acral Type | Craniofrontonasal Syndrome | Porokeratosis | Papulopustular Rosacea | Autoimmune Polyendocrinopathy Syndrome Type I | Double Outlet Right Ventricle | Periodontitis | Johanson-Blizzard Syndrome | Dermatomyositis | Hemochromatosis Type 2 | Schamberg Disease | Dementia, Vascular | Uremia | Tylosis With Esophageal Cancer | Ehlers-Danlos Syndrome | Harlequin Ichthyosis | Ebstein Anomaly | Duodenal Atresia | Very Long-chain Acyl-CoA Dehydrogenase Deficiency | Keloid | Multiple Sulfatase Deficiency | Neurodevelopmental Disorder With Central Hypotonia And Dysmorphic Facies | Amelanotic Melanoma | Adrenal Insufficiency | Kidney Stones | Connective Tissue Disorders | Ataxia-hypogonadism-choroidal Dystrophy Syndrome | Alzheimer Disease, Late Onset | Focal Cortical Dysplasia Type 2 | Ichthyosis | Cystinuria | Shock, Cardiogenic | Schistosomiasis | Frontotemporal Dementia | Delirium | Chronic Thromboembolic Pulmonary Hypertension | Impetigo | Nemaline Myopathy 10 | Hypopituitarism | Periodic Limb Movement Disorder | Spondylocostal Dysostosis | Cardiac Arrest | Clouston Hidrotic Ectodermal Dysplasia | Adenoma, Pleomorphic | Inborn Errors Of Metabolism | Exotropia | AIDS | Dystonia Musculorum Deformans | Peroxisomal Disorder | Oculodentodigital Dysplasia | Camurati-Engelmann Disease | Pulmonary Alveolar Microlithiasis | Charcot-Marie-Tooth Disease, Type 2 | Encephalopathy, Glycine | GAPO Syndrome | Fucosidosis | Pneumococcal Meningitis | Sarcoidosis | Prurigo Nodularis | Gnathodiaphyseal Dysplasia | Coenzyme Q10 Deficiency | Non-epidermolytic Palmoplantar Keratoderma | Cholangiocarcinoma | Cryptorchidism | Glucagonoma | Dental Caries | Peripheral T-cell Lymphoma | Melnick-Needles Syndrome | Spinocerebellar Ataxia Type 5 | Gyrate Atrophy Of The Choroid And Retina | Dengue Shock Syndrome | Oligoastrocytoma | Iron Overload | Alveolar Capillary Dysplasia | Strabismus | Pseudohypoparathyroidism Type 1B | Congenital Nephrotic Syndrome | Acromegaly | Papillon-Lefevre Syndrome | Sleep Apnea | Lymphoma, AIDS-related | Isobutyryl-CoA Dehydrogenase Deficiency | Micropenis | Chondrosarcoma | Infantile Nephropathic Cystinosis | Bronchitis | Cystinosis | Myotonia | Kashin-Beck Disease | Charcot-Marie-Tooth Disease, Type 2A | Multiple Sclerosis, Primary Progressive | DiGeorge Syndrome | Pseudohypoparathyroidism Type 2 | Papillorenal Syndrome | Anti-NMDA Receptor Encephalitis | Macular Corneal Dystrophy | Fetal Akinesia Deformation Sequence | Malonyl-CoA Decarboxylase Deficiency | Charcot-Marie-Tooth Disease, Type 1A | Lichen Sclerosus | Osteogenesis Imperfecta Type IV | Pseudoachondroplasia | Metaphyseal Chondrodysplasia, Schmid Type | Retinitis Pigmentosa 3 | Cramp Fasciculation Syndrome | Rubinstein-Taybi Syndrome | Spondylosis | Cole-Carpenter Syndrome | Acute Lymphocytic Leukemia | Hyperthyroidism | Neovascular Glaucoma | Ovarian Hyperstimulation Syndrome | Hemochromatosis | Hypoparathyroidism | Hereditary Hemorrhagic Telangiectasia Type 2 | Primary Torsion Dystonia | Muscle Wasting | Episodic Ataxia Type 2 | Parvovirus B19 Infection | Leprosy | Oculocutaneous Albinism Type 1 | Oguchi Disease-2 | Vulvovaginitis | Erythrokeratodermia Variabilis | Cholera | Thymoma, Malignant | Fukuyama Congenital Muscular Dystrophy | Neurotoxicity | Nephronophthisis | Ornithine Transcarbamylase Deficiency | Osteitis | Long QT Syndrome Type 3 | Leishmaniasis, Visceral | Epithelial-myoepithelial Carcinoma | Spinocerebellar Ataxia Type 2 | Creatine Deficiency Syndrome Due To AGAT Deficiency | Myelofibrosis | Camptocormia | Polyomavirus Nephropathy | Myositis, Focal | Guttate Psoriasis | Lateral Meningocele Syndrome | Polydactyly | Gestational Trophoblastic Disease | Juvenile Xanthogranuloma | Microcephalic Osteodysplastic Primordial Dwarfism, Type II | Babesiosis | Exostoses | Arthritis, Psoriatic | 17-beta-hydroxysteroid Dehydrogenase X Deficiency | Atrial Septal Defect | Neurofibromatosis Type 1 | Limb Girdle Muscular Dystrophy | Periventricular Nodular Heterotopia | Spinocerebellar Ataxia Type 16 | Dysmorphophobia | Neutropenia | Keratoconjunctivitis | Trismus-pseudocamptodactyly Syndrome | Cranioectodermal Dysplasia | Ependymoma | Van Der Knaap Disease | Brooke-Spiegler Syndrome | Retinal Telangiectasia | Zellweger Syndrome | Schuurs-Hoeijmakers Syndrome | Retinoblastoma | Giant Cell Glioblastoma | Diabetic Encephalopathy | Acral Lentiginous Melanoma | Congenital Myopathy | Tracheal Disorders | Plasma Cell Leukemia | Toxoplasmosis | Infertility | Basal Ganglia Disease | Otopalatodigital Syndrome Type 2 | Non-proliferative Diabetic Retinopathy | Kabuki Syndrome 2 | Vici Syndrome | Primary Hyperoxaluria | Gastritis | Gardner Syndrome | Waardenburg Syndrome | Carcinoma, Signet Ring Cell | Mitochondrial DNA Depletion Syndrome | Progressive Myoclonic Epilepsy | Botulism | Angioimmunoblastic T-cell Lymphoma | Beta-Propeller Protein-associated Neurodegeneration | Retinal Detachment | Heart Block | Unverricht-Lundborg Syndrome | ACTH-independent Macronodular Adrenal Hyperplasia | Trichomegaly | Alkaptonuria | Dupuytren Disease | Congenital Lipoid Adrenal Hyperplasia | Angiosarcoma Of The Breast | Osteoporosis, Postmenopausal | Seizures-scoliosis-macrocephaly Syndrome | Carbohydrate Metabolism Disorders | Proteus Syndrome | Hypoplastic Left Heart Syndrome | Diabetes Type 1 | Bernard-Soulier Syndrome | Systemic Lupus Erythematosus | Angioedema | Greig Cephalopolysyndactyly Syndrome | Steel Syndrome | Shprintzen-Goldberg Syndrome | Familial Exudative Vitreoretinopathy | Periventricular Leukomalacia | KBG Syndrome | X-linked Myotubular Myopathy | Anorectal Fistula | Turner's Syndrome | Mucolipidosis Type II | MELAS Syndrome | Mitochondrial Disease | Pontocerebellar Hypoplasia | Anxiety Disorders | Gastric Atrophy | Axenfeld-Rieger Syndrome | Fanconi Anemia | Reflex Epilepsy | Kabuki Syndrome | Lattice Corneal Dystrophy | Campomelic Dysplasia | Congenital Dyserythropoietic Anemia Type 1 | Larsen Syndrome | Hypertensive Nephropathy | Dyslexia | Benign Familial Infantile Seizures | Seminoma | Leber Congenital Amaurosis | Liver Failure | Meckel-Gruber Syndrome | Retinopathy Of Prematurity | Genee-Wiedemann Syndrome | Weill-Marchesani Syndrome | Congenital Aniridia | Riboflavin Transporter Deficiency Neuronopathy | Relapsing Polychondritis | Pemphigus Vulgaris | T-cell Prolymphocytic Leukemia | Carcinoid Syndrome | Focal Facial Dermal Dysplasia | Autonomic Nervous System Disorders | DNA Ligase IV Deficiency | Hypertelorism | Retinal Degeneration | Tonsillitis | Erythromelalgia | Cone Dystrophy | Asthma | Tenosynovial Giant Cell Tumor | Epilepsy | Cat Eye Syndrome | Myoclonic Atonic Epilepsy | Crimean-Congo Hemorrhagic Fever | Necrobiosis Lipoidica | Peripheral Neuropathy | McCune-Albright Syndrome | Roberts Syndrome | Cartilage Disorders | Corneal Ulcer | Prolymphocytic Leukemia | Atopic Dermatitis | Anorexia Nervosa | Adrenomyeloneuropathy | Sarcoma, Alveolar Soft Part | Chromosome 8q21.11 Deletion Syndrome | Kaposiform Hemangioendothelioma | Waardenburg Syndrome Type 2 | Blepharospasm | Warsaw Breakage Syndrome | Disseminated Intravascular Coagulation | Encephalopathy, Ethylmalonic | Cenani-Lenz Syndactyly Syndrome | Waardenburg Syndrome Type 4A | Cancer, Bladder | Thyroid Dyshormonogenesis | Interstitial Lung Diseases | Pulmonary Tuberculosis | Osteoporosis-pseudoglioma Syndrome | Cataplexy | Glaucoma, Congenital | Usher Syndrome Type II | Tyrosine Hydroxylase Deficiency | Primary Lateral Sclerosis | Multiple System Atrophy | Fontaine Progeroid Syndrome | Nijmegen Breakage Syndrome | Common Cold | Castleman Disease | Hemangioblastoma