Iron Overload

About the Disease
Rare Hereditary Hemochromatosis, also known as iron overload, is related to hemochromatosis, type 5 and iron overload in africa. An important gene associated with Rare Hereditary Hemochromatosis is HFE (Homeostatic Iron Regulator), and among its related pathways/superpathways are Transport of inorganic cations/anions and amino acids/oligopeptides and Insulin receptor recycling. The drugs Orange and Deferasirox have been mentioned in the context of this disorder. Affiliated tissues include liver, heart and bone marrow, and related phenotypes are liver/biliary system and homeostasis/metabolism

Common Targets
HLA-A | WFIKKN2 | ISLR | PNPLA3 | ACAN | CCDC117 | GNPAT | MIOS | IGSF3 | MAN2B2 | ASPM | IRS2 | IL10RA | CCDC85B | AGAP4 | TMPRSS6 | RPUSD2 | PCMTD1 | ZNF354B | LIMS1 | TEK | HGC6.3 | FAM186A | AMOTL2 | RAPGEF2 | DOK7 | SPG21 | PLD4 | ATP8A1 | MERTK | PCDHGB2 | CDC27 | PTPN13 | DNMBP | HRNR | IL5 | HOXA1 | TPTE | ALMS1 | PCSK7 | BLTP1 | INTS2 | LRRC37A3 | COMMD1 | C1RL | SLC40A1 | TARP | MEGF8 | ISX | HLA-C | RABL2A | BMP6 | CLPTM1L | SLC11A2 | GPX4 | DNAAF1 | BCO2 | PRKCQ | NPAS2 | CDHR2 | GPR158 | DMXL2 | PRLR | SAFB2 | DCHS2 | CNR2 | DMBT1 | EPAS1 | PTGES2 | PNLIP | HLA-B | KMT5A | SLC29A1 | TNFRSF10C | FRAS1 | KSR1 | HLA-DRB5 | QRFPR | PABPC1 | THBD | CNKSR2 | TNFRSF13B | SNCA | HJV | NEB | RP1L1 | BMPR1B | NBPF10 | SLC30A1 | TBC1D1 | CHGA | HFE | DDX5 | DNAH9 | FMN2 | TFRC | STRBP | NCR2 | MUC7 | ZNF536 | CSMD3 | NPIPB3 | HAMP | MYO15A

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