Psoriatic Arthritis

About the Disease
Psoriatic Arthritis, also known as psoriatic arthritis, susceptibility to, is related to spondyloarthropathy 1 and juvenile rheumatoid arthritis, and has symptoms including back pain, muscle cramp and sciatica. An important gene associated with Psoriatic Arthritis is LTA (Lymphotoxin Alpha), and among its related pathways/superpathways are Innate Immune System and PAK Pathway. The drugs Methotrexate and Prednisolone phosphate have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and t cells, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Common Targets
IL18 | SERPINF1 | HLA-C | CARD8 | YDJC | LCE1C | RPS6KA4 | G114548 | JAK3 | SUMO4 | C1orf141 | JAK1 | Mitogen-activated protein kinase p38 (MAPK p38) (nonspecified subtype) | HLA-DQB1 | PDE4D | GJB2 | NFKB1 | ICOS | COL6A5 | LCE3B | TRAF3IP2-AS1 | RORC | COL8A1 | POLI | TMPRSS11F | G472 | LCE3C | IL37 | WNT3A | MALT1 | IL23A | MC1R | Interleukin 17 (nonspecified subtype) | TSC1 | SOCS1 | IL12B | JAK2 | LOC105379664 | IL1B | TNFRSF1B | KCNA3 | SERPINB8 | CACFD1 | CTNNA3 | CCR6 | G6774 | MIR1237 | ME1 | IL1RN | ORAI1 | ZNF668 | ZC3H12C | HCP5 | PDE4B | G3569 | Phosphodiesterase IV (PDE4) (nonspecified subtype) | Integrin alphavbeta3 (vitronectin) receptor | BTK | IFNGR1 | IL17RA | Calcium release-activated channel (CRAC) | STAT6 | PLCL2 | Folate Receptor (nonspecified subtype) | HRH2 | TGFB1 | ADAMTS5 | LTA | TBX21 | G1432 | CARD14 | MC2R | CDKAL1 | Phosphatidylinositol 3-kinase (PI3K) (nonspecified subtype) | RUNX3 | IL12RB1 | NF-kappaB (NFkB) | G7099 | TYK2 | ADORA1 | IL4R | CD2 | RNF114 | ADORA2B | ADAM17 | KEAP1 | DHODH | MAP3K14 | CD3 Complex (T Cell Receptor Complex) | G4780 | CD14 | CD86 | G1385 | CCHCR1 | IKZF1 | TIRAP | POU5F1 | HLA-B | LINC01714 | GBP6 | REL-DT | ICAM1 | G7852 | SLC44A2 | NFKBIA | IFNLR1 | DKK1 | HLA-DRB1 | CHRNA7 | IFNGR2 | REV3L | BRD4 | MIR26A1 | LOC105376014 | FBXO27 | ADRA2A | DENND1B | AP4B1-AS1 | CD40 | Interleukin-12 (IL-12) | KLRK1 | MAPKAPK2 | LOC107984144 | ELMO1 | ADORA2A | STAT2 | LOC107984145 | G3605 | DOCK1 | RNF39 | JAM3 | LOC107984146 | CSMD1 | FCGR3A | PPARG | COL10A1 | RYR2 | G920 | CMTM5 | CSNK1A1 | AMPH | SMARCA4 | ARMS2 | LOC285626 | SELPLG | HLA-A | TLR2 | TNFAIP3 | QTRT1 | G3630 | Integrin alphaLbeta2 (LFA-1) receptor | IL25 | FAM149A | IL20RA | NFKBIZ | MMP13 | NRXN2 | COG6 | STAT4 | G2033 | NFIX | CD80 | PTPRN2 | PDE2A | Platelet-Derived Growth Factor Receptor (nonspecified subtype) | ADAMTS4 | IFIH1 | ERAP1 | GCA | Ikzf1 | STX1B | CCL20 | NR3C1 | AP-1 Transcription Factor Complex | Janus Kinase (nonspecified subtype) | IL1A | MBP | IL12A | PTPN22 | PPP1R9A | CCL21 | FCGR2A | PARD3 | PDE4A | IL2 | ZNF816-ZNF321P | KIF3A | PDE5A | LINC02582 | PMAIP1 | TNIP1 | CFH | MIR146A | RCAN1 | TLR9 | EXOC2 | RIPK3 | VDR | LOC105378980 | G5743 | NOS2 | MAPK7 | IFNG | MTUS2 | HTR2A | IRAK1 | KRR1 | CD28 | TRAF3IP2 | LINC02571 | MIF | GSPT1 | KCNH7 | TNFRSF1A | BARD1 | ZPBP2 | RIPK1 | HRH4 | CREBBP | S1PR1 | IL-23 receptor complex | G7124 | LY96 | SLCO1C1 | ATR | DHFR | MICA | PSTPIP1 | IL6R | GLP1R | IL10 | Interleukin 23 complex (IL-23) | PTAFR | IL4 | ELF5 | PLCB3 | MIR499A | cAMP Responsive Element Binding Protein (CREB) (nonspecified subtype) | ZMIZ1 | TLR1 | RIGI | CD226 | ADRA2C | IL13 | IL23R

Note: If you'd like to get a target analysis report for Psoriatic Arthritis, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Psoriatic Arthritis at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

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