Tyrosine Hydroxylase Deficiency

About the Disease
Segawa Syndrome, Autosomal Recessive, also known as tyrosine hydroxylase deficiency, is related to dystonia, dopa-responsive and dystonia, and has symptoms including muscle rigidity, tremor and abnormality of extrapyramidal motor function. An important gene associated with Segawa Syndrome, Autosomal Recessive is TH (Tyrosine Hydroxylase), and among its related pathways/superpathways is Metabolism. Affiliated tissues include eye, brain and thyroid, and related phenotypes are ptosis and constipation

Common Targets
WARS2 | TH

Note: If you'd like to get a target analysis report for Tyrosine Hydroxylase Deficiency, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Tyrosine Hydroxylase Deficiency at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Prolactinoma | Hypoproteinemia, Hypercatabolic | Beare-Stevenson Syndrome | Porphyria, Variegate | Diabetic Macular Edema | Conjunctivitis, Allergic | Hepatic Veno-occlusive Disease | Cataract | Neovascular Glaucoma | Acute Leukemia | Cysticercosis | Infantile Spasm | Wagner Disease | Giant Cell Glioblastoma | Rhabdomyosarcoma | Stuve-Wiedemann Syndrome | Carcinoma, Small Cell | Angioedema, Acquired | Hypocalcemia | Frontometaphyseal Dysplasia | Wieacker-Wolff Syndrome | Saethre-Chotzen Syndrome | Meleda Disease | Megaloblastic Anemia | MELAS Syndrome | Myopathy | Hypophosphatemic Rickets With Hypercalciuria, Hereditary | Borderline Personality Disorder | Arthritis, Reactive | Persistent Hyperplastic Primary Vitreous | Progressive Familial Intrahepatic Cholestasis | Spinocerebellar Ataxia Type 10 | CREST Syndrome | Angiodysplasia | Pneumonia, Viral | Congenital Stromal Corneal Dystrophy | Multiple Hamartoma Syndrome | Meesmann Corneal Dystrophy | Methemoglobinemia Type IV | Autism Spectrum Disorders | Plasma Cell Dyscrasia | Fascioliasis | Tetanus | Phenylketonuria II | Cerebral Cavernous Malformations | Hypolipoproteinemia | Juvenile Polyposis | Blepharo-cheilo-odontic Syndrome | Ophthalmoplegia | Spinocerebellar Ataxia Type 23 | Cartilage Disorders | Methylmalonic Aciduria And Homocystinuria, CblC Type | Glycogen Storage Disease Type 5 | Hepatitis D | Compartment Syndrome | Presbycusis | Proximal Symphalangism | Vulvovaginitis | Hyperferritinemia-cataract Syndrome | Coronary Heart Disease | Canavan Disease | Goiter, Nodular | Keratoconus | Heart Septal Defects | Fetal Alcohol Syndrome | Peripheral Neuropathy | Congenital Mirror Movements | Rosacea | Juvenile Myelomonocytic Leukemia | Diamond-Blackfan Anemia | Smoldering Myeloma | Glaucomatocyclitic Crisis | Benign Familial Neonatal Convulsions | Epilepsy Of Infancy With Migrating Focal Seizures | Insulinoma | Kabuki Syndrome | Mast Cell Leukemia | Polymyositis | Microcephaly, Seizures, And Developmental Delay | Esophagitis | Neutrophilia | Diabetes Mellitus, Transient Neonatal | Fibronectin Glomerulopathy | ACTH-independent Macronodular Adrenal Hyperplasia | Pleural Tuberculosis | Herpes Simplex Dermatitis | Avian Influenza | Eczema | Tuberculosis | Gout | Glomerulonephritis, Membranoproliferative | Cherubism | Niemann-Pick Disease | Myelomeningocele | Primary Hyperoxaluria Type 1 | Necrobiosis Lipoidica | Norrie Disease | Congenital Afibrinogenemia | Hydrocephalus | ADNP Syndrome | Retinitis Pigmentosa 3 | Gastrointestinal Disorders | Basal Ganglia Disease, Biotin-responsive | Calcium Pyrophosphate Deposition Disease | Kabuki Syndrome 2 | Familial Hypobetalipoproteinemia | Primary Progressive Aphasia | Anencephaly | Anorchia | Cardiomyopathy, Peripartum | Intermittent Explosive Disorder | LMNA-related Congenital Muscular Dystrophy | Joubert Syndrome | REM Sleep Behavior Disorder | Klippel-Feil Syndrome | Hyperacusis | Familial Advanced Sleep Phase Syndrome | Pulmonary Capillary Hemangiomatosis | Ataxia-hypogonadism-choroidal Dystrophy Syndrome | Spinal Cord Diseases | Cabezas Syndrome | Allergic Contact Dermatitis | Alagille Syndrome | Syphilis | Polyneuropathy | Japanese Encephalitis | Aplasia Cutis Congenita | Osteoglophonic Dysplasia | Hyperinsulinemia | Intracerebral Hemorrhage | Behcet's Disease | Arterial Tortuosity Syndrome | Argininosuccinic Aciduria | Pantothenate Kinase-associated Neurodegeneration | Charcot-Marie-Tooth Disease, Type 2 | Ameloblastoma | Osteogenesis Imperfecta | Episodic Ataxia Type 1 | Vertigo | Thrombophlebitis | Sialidosis | Crisponi Syndrome | Motion Sickness | Early Infantile Epileptic Encephalopathy 13 | Polycythemia | Holoprosencephaly | Metaphyseal Chondrodysplasia, Schmid Type | Kindler Syndrome | Osteogenesis Imperfecta Type II | Meconium Ileus | Dengue Shock Syndrome | Richter's Syndrome | Autoimmune Hemolytic Anemia | Hyperbilirubinemia | Schizotypal Personality Disorder | Adrenal Insufficiency | Ataxia-ocular Apraxia 2 | PHARC Syndrome | Duchenne Muscular Dystrophy | Thanatophoric Dysplasia | Chordoid Glioma | Sleep Apnea, Obstructive | Axenfeld-Rieger Syndrome | Retinal Dystrophy | Specific Granule Deficiency | Tetraplegia | Cholera | Retinal Diseases | Molybdenum Cofactor Deficiency | Thyroid Dyshormonogenesis | Sertoli Cell-only Syndrome | Hyperglycemia | Asthma, Exercise-induced | Platelet Disorders | Porokeratosis | Polymicrogyria | Dystrophy, Cone-rod | Avellino Corneal Dystrophy | Tietze Syndrome | Zellweger Syndrome | Veno-occlusive Disease | Hemosiderosis | Hypercholesterolemia | AIDS | Rift Valley Fever | Porphyria, Acute Intermittent | Muckle-Wells Syndrome | FG Syndrome | Hypermethioninemia | Xeroderma Pigmentosum Variant Type | Proopiomelanocortin Deficiency | Communication Disorders | Atelosteogenesis Type 1 | Dyggve-Melchior-Clausen Disease | Lipoma | Bleeding Disorder Due To CalDAG-GEFI Deficiency | Spondylosis | Thin Basement Membrane Disease | Keratoconjunctivitis | Arthritis, Psoriatic | Paternal Uniparental Disomy Of Chromosome 14 | Hypertrophy | Niemann-Pick Disease, Type B | Desbuquois Syndrome | Batten Disease | Palmoplantar Keratoderma | Macular Degeneration | Malnutrition | Epidermolysis Bullosa Simplex, Dowling-Meara Type | Van Der Knaap Disease | Demyelinating Diseases | Glaucoma, Congenital | Mucormycosis | Overactive Bladder | Cutaneous Lupus Erythematosus | Hypercalciuria | Rhinitis | Hypertension, Essential | Hypopituitarism | Botulism | Dwarfism | Irritable Bowel Syndrome | Spinocerebellar Ataxia Type 7 | Vascular Calcification | Sepiapterin Reductase Deficiency | Ghosal Syndrome | Pituitary Stalk Interruption Syndrome | Pancreatitis, Chronic | Myocarditis | Multiple Sclerosis, Chronic Progressive | Allan-Herndon-Dudley Syndrome | Nephrotic Syndrome | Basal Ganglia Disease | Vitiligo | Phenylketonuria | Small Lymphocytic Lymphoma | Bethlem Myopathy | HUPRA Syndrome | Chloridorrhea, Congenital | Amebiasis | Contact Dermatitis | Aldosterone Deficiency | Porencephaly | Cat Eye Syndrome | Postaxial Polydactyly | Intermittent Claudication | Paronychia | Epidermolysis Bullosa Simplex, Generalized | X-linked Charcot-Marie-Tooth Disease | Polyomavirus Nephropathy | Agammaglobulinemia | Limb Girdle Muscular Dystrophy | Gangliosidosis, GM1 | Spinocerebellar Ataxia Type 16 | Miyoshi Myopathy | Graves Disease | Lipodystrophy | Oculocutaneous Albinism Type 2 | Lymphedema-distichiasis Syndrome | Roberts Syndrome | Zimmermann-Laband Syndrome | Necrotizing Autoimmune Myopathy | Primary Biliary Cholangitis | Congenital Central Hypoventilation Syndrome | Vitamin D Deficiency | Persistent Mullerian Duct Syndrome | Crouzon Syndrome With Acanthosis Nigricans | Mucolipidosis Type IV | Diabetes Insipidus | Subcortical Band Heterotopia | Superficial Spreading Melanoma | Carney-Stratakis Syndrome | Glycogen Storage Disease Type 0, Muscle | Angiosarcoma | Nephroblastoma | Polycystic Ovary Syndrome | Diabetic Encephalopathy | Cocaine-Related Disorders | Majeed Syndrome | Unverricht-Lundborg Syndrome | Shprintzen-Goldberg Syndrome | Keloid | Chediak-Higashi Syndrome | Hernia, Inguinal | Pyruvate Dehydrogenase Deficiency | Spinocerebellar Ataxia Type 2 | Schamberg Disease | Meningococcal Infections | Lipid Storage Diseases | Congenital Hemolytic Anemia | Hemoglobinopathies | Inflammatory Bowel Disease | Chorioretinitis | Acrodermatitis Enteropathica | Nasodigitoacoustic Syndrome | Rheumatoid Arthritis | Heterotaxy | Sick Sinus Syndrome 1 | Neurotoxicity | Maternally Inherited Diabetes And Deafness | Heterotopic Ossification | Myoclonic Atonic Epilepsy | Moyamoya Disease | Melanoma | Incontinentia Pigmenti | Retinal Vasculitis | Spinocerebellar Ataxia Type 3 | Chromosome 9q34.3 Deletion Syndrome | Parapsoriasis | Adenoid Cystic Carcinoma | Focal Dermal Hypoplasia | Hypogonadism | Central Core Disease | Hereditary Mixed Polyposis Syndrome | Relapsing Polychondritis | Raine Syndrome | Retinal Coloboma | Chronic Leukemia | Constipation | Osteoarthritis | Epidermolysis Bullosa Dystrophica | Hyperthermia, Malignant | Bullous Pemphigoid | Blue Rubber Bleb Nevus Syndrome | Episodic Ataxia Type 2 | Familial Hypertrophic Cardiomyopathy | Schindler Disease | Ehlers-Danlos Syndrome | Megalencephaly | Anuria | Congenital Fiber-type Disproportion Myopathy | Glycogen Storage Disease Type 1 | Kaposi Sarcoma | Lewy Body Dementia | Glycogen Storage Disease Type 9 | Benign Familial Pemphigus | Epicondylitis | Spondylocarpotarsal Synostosis Syndrome | Systemic Mastocytosis | Giant Axonal Neuropathy | Pitt-Hopkins Syndrome | Acute Anterior Uveitis | Marinesco-Sjogren Syndrome | Cantu Syndrome | Neurogenic Bladder | Multiple Sclerosis | Panniculitis | Tylosis With Esophageal Cancer | Otopalatodigital Syndrome Type 2 | Deafness, Dystonia, And Cerebral Hypomyelination | Meningioma | Neurodegeneration Due To Cerebral Folate Transport Deficiency | Arrhythmogenic Right Ventricular Cardiomyopathy | Wilson's Disease | Primary Hyperoxaluria | Werner's Syndrome | Angioimmunoblastic T-cell Lymphoma | Endometritis | Gitelman Syndrome | Osteomalacia | Ectodermal Dysplasia | Keratosis, Actinic | Amyotrophic Lateral Sclerosis | Urea Cycle Disorder | Hypodontia | Schnyder Crystalline Corneal Dystrophy | Chronic Enteropathy Associated With SLCO2A1 Gene | Blastomycosis | Choroideremia | Rhabdomyosarcoma, Embryonal | 3-methylglutaconic Aciduria Type IV | B-cell Chronic Lymphocytic Leukemia | Blood Protein Disorders | Spinocerebellar Ataxia Type 20 | Metabolic Diseases | Language Disorders | Chronic Mucocutaneous Candidiasis | Succinic Semialdehyde Dehydrogenase Deficiency | Heart Failure | Dementia | Mitochondrial Encephalomyopathy | Raynaud Phenomenon | Central Pain Syndrome | Acute Chest Syndrome | Diabetes Type 1 | Perivascular Epithelioid Cell Tumor | Cardiomyopathy, Dilated, 1L | Empyema | Fibrosarcoma | Antisocial Personality Disorder | Muscular Dystrophy | Endometrial Hyperplasia | Parkinson Disease 6, Autosomal Recessive Early-onset | Craniometaphyseal Dysplasia | Cystinuria | Sandhoff Disease | Cataplexy | Obsessive-compulsive Disorder | Multisystemic Smooth Muscle Dysfunction Syndrome | SAPHO Syndrome