Type 2 Charcot-Marie-Tooth Disease

About the Disease
Charcot-Marie-Tooth Disease, Axonal, Type 2e, also known as charcot-marie-tooth disease type 2, is related to charcot-marie-tooth disease, axonal, type 2j and charcot-marie-tooth disease, axonal, type 2t. An important gene associated with Charcot-Marie-Tooth Disease, Axonal, Type 2e is IGHMBP2 (Immunoglobulin Mu DNA Binding Protein 2), and among its related pathways/superpathways are Cytoskeletal Signaling and tRNA Aminoacylation. Affiliated tissues include skeletal muscle, heart and cortex, and related phenotypes are upper limb muscle weakness and peripheral axonal neuropathy

Common Targets
SH3TC2 | YARS1 | GARS1 | AARS1 | SPG11 | TRPV4 | ATP1A1 | MORC2 | MPZ | HADHA | PLCL1 | CPA6 | EGR2 | ARHGAP39 | DNM2 | MTRFR | HARS1 | LRSAM1 | KIF5A | BSCL2 | IGHMBP2 | HSPB8 | CYP7B1 | HINT1 | NOXRED1 | JAG1 | MME | AASS | MFN2 | ZNF264 | MTMR2 | SCN9A | PLEKHG5 | PRKCB | HSPB1 | TTN | LMNA | EFCAB8 | KARS1 | ZNF551 | MARS1 | ATP6 | VCP | NEFH | STRN | REEP1 | NAPRT | SORD | FAM86B1 | DHTKD1 | JPH1 | GDAP1 | DCST2 | NEFL | KIF1B | HDAC6 | GJB1 | MICAL1 | DCAF8

Note: If you'd like to get a target analysis report for Type 2 Charcot-Marie-Tooth Disease, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Type 2 Charcot-Marie-Tooth Disease at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Retinopathy Of Prematurity | Congenital Hypofibrinogenemia | Nephrosclerosis | Transient Bullous Dermolysis Of The Newborn | Aromatic L-amino Acid Decarboxylase Deficiency | Hyperammonemia | Patent Foramen Ovale | Open-angle Glaucoma | Thyroiditis, Autoimmune | Dyggve-Melchior-Clausen Disease | Benign Familial Neonatal Convulsions | Cherubism | Osteopathia Striata With Cranial Sclerosis | Hemochromatosis Type 2 | Acrodysostosis | Parkinson Disease 6, Autosomal Recessive Early-onset | Pain | Benign Hereditary Chorea | LMNA-related Congenital Muscular Dystrophy | Hamartoma | Goldenhar Syndrome | Meniere's Disease | Distal Spinal Muscular Atrophy | Mitochondrial DNA Depletion Syndrome, Hepatocerebral Form | Aceruloplasminemia | Proctitis | H Syndrome | Hypobetalipoproteinemias | Cluster Headache | Preaxial Polydactyly | Kindler Syndrome | Pitt-Hopkins Syndrome | Tetraplegia | Heavy Chain Disease | Epilepsy Of Infancy With Migrating Focal Seizures | Joubert Syndrome | Interstitial Lung Diseases | Infertility, Male | Veno-occlusive Disease | Panuveitis | Hemochromatosis | Auriculocondylar Syndrome | Endometriosis | Rhabdomyosarcoma, Embryonal | Wolfram Syndrome 2 | Muscle Wasting | Cutaneous Angiosarcoma | Pulmonary Tuberculosis | Hyperparathyroidism, Primary | Spinal Muscular Atrophy With Progressive Myoclonic Epilepsy | Arteriovenous Malformations | Cryptosporidiosis | Trachoma | Nicotine Dependence | Glycogen Storage Disease Type 4 | Nance-Horan Syndrome | Cholestasis | Rhinitis | Plasma Cell Dyscrasia | Pycnodysostosis | Diabetes Type 1 | Renal Dysplasia | VACTERL/VATER Association | Autoimmune Hemolytic Anemia | Tracheal Disorders | Ectodermal Dysplasia | Prostatitis | Fibrillation, Atrial | Congenital Nystagmus | Pernicious Anemia | Twin-to-twin Transfusion Syndrome | Steel Syndrome | Epidermolysis Bullosa Simplex, Localized | Irritable Bowel Syndrome | Conn Syndrome | Acne Vulgaris | Corneal Dystrophy And Perceptive Deafness | Pontocerebellar Hypoplasia Type 7 | Hemimegalencephaly | Sotos Syndrome | Familial Hypertrophic Cardiomyopathy | Leukocyte Adhesion Deficiency Type 1 | Polycystic Ovary Syndrome | Dysfibrinogenemia | Nevus | Clouston Hidrotic Ectodermal Dysplasia | Hemangioblastoma | Neuropathy | Primary Pigmented Nodular Adrenocortical Disease | Branchiootorenal Syndrome | Leukemia-lymphoma, Adult T-cell | Spinocerebellar Ataxia Type 23 | Keratosis, Seborrheic | Graves Disease | Achromatopsia | Blepharo-cheilo-odontic Syndrome | Sporadic Inclusion Body Myositis | Pneumonia, Bacterial | Granular Corneal Dystrophy | Isovaleric Acidemia | Congenital Heart Defects | Liver Failure | X-linked Acrogigantism | Nephroblastoma | Parapsoriasis | Hepatopulmonary Syndrome | Glycogen Storage Disease | Protein C Deficiency | Hyperthyroidism | Tietze Syndrome | Sarcoidosis, Pulmonary | Coffin-Lowry Syndrome | Acute Generalized Exanthematous Pustulosis | Stargardt Disease | Lafora Disease | Rhizomelic Chondrodysplasia Punctata | Pyoderma Gangrenosum | Alkaptonuria | Cri-du-chat Syndrome | Histiocytic Sarcoma | Down Syndrome | Hypogammaglobulinemia | Bainbridge-Ropers Syndrome | Methemoglobinemia Type IV | Barakat Syndrome | Keratitis | Diabetes Mellitus, Transient Neonatal | Acromesomelic Dysplasia | Lipid Storage Myopathy | Charcot-Marie-Tooth Disease, Type 2C | Stromal Corneal Dystrophy | Arts Syndrome | Neutrophilia | Autoimmune Disease | Nephrotic Syndrome Type 1 | Gastric Atrophy | Scleroderma, Diffuse | Trichothiodystrophy | Antenatal Bartter Syndrome Type 1 | Cold-induced Sweating Syndrome | Kabuki Syndrome | Alpha-mannosidosis | Arteriosclerosis | Von Hippel-Lindau Disease | Wolfram Syndrome | Congenital Nephrotic Syndrome | Anorexia Nervosa | Spinocerebellar Ataxia Type 17 | Muckle-Wells Syndrome | Zimmermann-Laband Syndrome | Ophthalmia, Sympathetic | Thrombosis | Salla Disease | Gallstones | Subcortical Band Heterotopia | Epicondylitis | Brachial Plexus Neuropathy | Inflammatory Bowel Disease | Huntington's Disease | Spinocerebellar Ataxia Type 10 | Bleeding Disorder Due To CalDAG-GEFI Deficiency | Retinal Dystrophy | Compartment Syndrome | Odonto-onycho-dermal Dysplasia | Gastrointestinal Disorders | Spondylosis | Benign Recurrent Intrahepatic Cholestasis 1 | Situs Inversus | Occipital Neuralgia | Chondrosarcoma | Ligneous Conjunctivitis | Huntington's Disease-like 2 | Adenoma, Pleomorphic | Dengue Hemorrhagic Fever | Aneurysm, Abdominal Aortic | Waardenburg Syndrome Type 1 | Skin Papilloma | Lymphomatoid Granulomatosis | Bronchitis | Bruck Syndrome | Agoraphobia | Language Disorders | Infantile Neuroaxonal Dystrophy | Pulmonary Alveolar Microlithiasis | Esophageal Adenocarcinoma | Cholecystitis | Cat Eye Syndrome | Cancer, Brain | Currarino Syndrome | Atherosclerosis | Cystinosis | Microcephalic Primordial Dwarfism | Nutrition Disorders | Okihiro Syndrome | Evans Syndrome | Kashin-Beck Disease | Smoldering Myeloma | Retinitis Pigmentosa 3 | Tinea Versicolor | Pemphigus Foliaceus | Hereditary Xerocytosis | Charcot-Marie-Tooth Disease, Type 1A | Hyperparathyroidism-jaw Tumor Syndrome | Leprosy | Anti-glomerular Basement Membrane Disease | Leber Congenital Amaurosis | Schizoaffective Disorder | Creatine Deficiency Syndrome Due To AGAT Deficiency | Chorea | Persistent Hyperplastic Primary Vitreous | Polymicrogyria | Cavitary Optic Disc Anomalies | Colitis, Lymphocytic | Eczema | Fukuyama Congenital Muscular Dystrophy | Behcet's Disease | Cutaneous Lupus Erythematosus | Low Phospholipid Associated Cholelithiasis | Trichorhinophalangeal Syndrome | Lymphoma, AIDS-related | Raine Syndrome | Weill-Marchesani Syndrome | Conduct Disorder | Tenosynovial Giant Cell Tumor | Panniculitis | Pantothenate Kinase-associated Neurodegeneration | Johanson-Blizzard Syndrome | Angiomyolipoma | Pseudoexfoliation Syndrome | Enhanced S-cone Syndrome | Nephrocalcinosis | Coenzyme Q10 Deficiency | Bulimia Nervosa | Carotid Artery Disease | Eclampsia | Frank-ter Haar Syndrome | Glycogen Storage Disease Type 1b | Hereditary Hemorrhagic Telangiectasia Type 2 | Scleritis | Small Lymphocytic Lymphoma | Otosclerosis | Netherton Syndrome | Premature Ejaculation | Ehlers-Danlos Syndrome With Progressive Kyphoscoliosis, Myopathy, And Hearing Loss | Mandibuloacral Dysplasia With Type A Lipodystrophy | Urea Cycle Disorder | Peeling Skin Syndrome Type B | Sezary Syndrome | Melanoma, Malignant | Primary Lateral Sclerosis | Endocarditis | Ectrodactyly | Primrose Syndrome | Bipolar Disorder | McLeod Syndrome | Intestinal Hypomagnesemia 1 | Pterygium | Multiple Epiphyseal Dysplasia | Light Chain Amyloidosis | Lymphoma, B-cell | Japanese Encephalitis | Toxoplasmosis | Acute Tubular Necrosis | Niemann-Pick Disease, Type A | Nicotine Addiction | Keratocystic Odontogenic Tumor | Greenberg Dysplasia | Molybdenum Cofactor Deficiency | Beare-Stevenson Syndrome | Corneal Neovascularization | Fowler's Syndrome | Asphyxia Neonatorum | Polycythemia | Neuroleptic Malignant Syndrome | Metachromatic Leukodystrophy | Nail Disorder, Nonsyndromic Congenital | Thanatophoric Dysplasia | COACH Syndrome | Polymyalgia Rheumatica | Ameloblastic Carcinoma | Glycogen Storage Disease Type 0 | Hyperphosphatasia With Intellectual Disability Syndrome 4 | Waardenburg Syndrome Type 2A | Triphalangeal Thumb-polysyndactyly Syndrome | Cramp Fasciculation Syndrome | Ameloblastoma | Endophthalmitis | Best Macular Dystrophy | Eiken Syndrome | Pyelonephritis | Ichthyosis, X-linked | Pilomatrix Carcinoma | Schizotypal Personality Disorder | Congenital Ichthyosiform Erythroderma | Apraxia | Systemic Lupus Erythematosus | Tularemia | Chronic Inflammatory Demyelinating Polyneuropathy | Neuroma | Creutzfeldt-Jakob Disease | Alopecia Areata | Congenital Adrenal Hyperplasia 1 | Charcot-Marie-Tooth Disease Type 2E | Mitochondrial DNA Depletion Syndrome | Hypercalcemia | Common Variable Immunodeficiency | Carbamoyl Phosphate Synthetase I Deficiency | Harlequin Ichthyosis | Polymyositis | Sandhoff Disease | Thyroid Dysgenesis | Early Infantile Epileptic Encephalopathy 13 | Chylothorax, Congenital | Charcot-Marie-Tooth Disease, Type 2A | Mitochondrial DNA Depletion Syndrome, Myopathic Form | Hypohidrotic Ectodermal Dysplasia | Dysthymia | Familial Pheochromocytoma-paraganglioma | Lathosterolosis | Lactose Intolerance | Pneumoconiosis | Lung Diseases | Familial Partial Lipodystrophy | Angioedema, Hereditary | Encephalopathy | Malaria | Lymphoma, Mantle Cell | Richter's Syndrome | Myositis | Hashimoto Thyroiditis | Avian Influenza | Gigantism | Lesch-Nyhan Syndrome | Hypersensitivity Pneumonitis | Blue Rubber Bleb Nevus Syndrome | Multiple Mitochondrial Dysfunctions Syndrome Type 1 | Spinocerebellar Ataxia Type 20 | Giant Cell Arteritis | Cranial Nerve Disease | Nanophthalmos | Schamberg Disease | Hemophilia | Ependymoma | Primary Familial Brain Calcification | Charcot-Marie-Tooth Disease Type 4B1 | Rash | CEDNIK Syndrome | Meningioma | Senior-Loken Syndrome | Hepatoblastoma | Autism | IMAGe Syndrome | Iron Deficiency Anemia | Polyomavirus Nephropathy | Proteus Syndrome | Familial Episodic Pain Syndrome | Epidermolysis Bullosa Simplex, Dowling-Meara Type | Pulverulent Zonular Cataract | Chylomicron Retention Disease | Mucormycosis | Angioedema, Acquired | Esophagitis, Eosinophilic | Combined Deficiency Of Factor V And Factor VIII | Porokeratosis | Usher Syndrome Type I | Intracranial Hypertension | Chitayat Syndrome | Hemangioendothelioma | Takayasu's Arteritis | Schnyder Crystalline Corneal Dystrophy | Hepatitis A | Papillorenal Syndrome | Menetrier Disease | Atelosteogenesis Type 2 | Lattice Corneal Dystrophy Type 1 | Retinal Degeneration | Bicuspid Aortic Valve | GAPO Syndrome | Cardiomyopathy, Hypertrophic | Fuchs Dystrophy | Dermatofibrosarcoma | Pseudohypoparathyroidism Type 1A | Neuroblastoma | Photosensitivity | Tylosis With Esophageal Cancer | Neuronal Ceroid Lipofuscinosis | Atelosteogenesis Type 1 | Prolactinoma | Obesity | Prune Belly Syndrome | Sengers Syndrome | Porphyria, Variegate | Congenital Tufting Enteropathy | Dental Caries | Vitamin B12 Deficiency | Osteomyelitis | Familial Dysautonomia | GNE Myopathy | Lattice Corneal Dystrophy | Personality Disorders