Disease

Type 2 Charcot-Marie-Tooth Disease

About the Disease
Charcot-Marie-Tooth Disease, Axonal, Type 2e, also known as charcot-marie-tooth disease type 2, is related to charcot-marie-tooth disease, axonal, type 2j and charcot-marie-tooth disease, axonal, type 2t. An important gene associated with Charcot-Marie-Tooth Disease, Axonal, Type 2e is IGHMBP2 (Immunoglobulin Mu DNA Binding Protein 2), and among its related pathways/superpathways are Cytoskeletal Signaling and tRNA Aminoacylation. Affiliated tissues include skeletal muscle, heart and cortex, and related phenotypes are upper limb muscle weakness and peripheral axonal neuropathy

Common Targets
SH3TC2 | YARS1 | GARS1 | AARS1 | SPG11 | TRPV4 | ATP1A1 | MORC2 | MPZ | HADHA | PLCL1 | CPA6 | EGR2 | ARHGAP39 | DNM2 | MTRFR | HARS1 | LRSAM1 | KIF5A | BSCL2 | IGHMBP2 | HSPB8 | CYP7B1 | HINT1 | NOXRED1 | JAG1 | MME | AASS | MFN2 | ZNF264 | MTMR2 | SCN9A | PLEKHG5 | PRKCB | HSPB1 | TTN | LMNA | EFCAB8 | KARS1 | ZNF551 | MARS1 | ATP6 | VCP | NEFH | STRN | REEP1 | NAPRT | SORD | FAM86B1 | DHTKD1 | JPH1 | GDAP1 | DCST2 | NEFL | KIF1B | HDAC6 | GJB1 | MICAL1 | DCAF8

疾病靶点研报
Type 2 Charcot-Marie-Tooth Disease

Note: If you'd like to get a target analysis report for Type 2 Charcot-Marie-Tooth Disease, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Type 2 Charcot-Marie-Tooth Disease at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Gestational Trophoblastic Disease | Primary Aldosteronism | Spondylocostal Dysostosis | Progressive Familial Intrahepatic Cholestasis Type 3 | Creutzfeldt-Jakob Disease | Asperger Syndrome | Agammaglobulinemia | Encephalitis | Myofibromatosis | Desbuquois Syndrome | Myelitis | T-cell Lymphoma, Subcutaneous Panniculitis-like | Goiter, Nodular | Hemolytic Anemia | Meier-Gorlin Syndrome | Pernicious Anemia | Occipital Neuralgia | Presbyopia | Rhizomelic Chondrodysplasia Punctata | Inflammatory Joint Disease | Jaundice, Obstructive | Cellulitis | Protein S Deficiency | Left Ventricular Noncompaction | Avellino Corneal Dystrophy | Absence Epilepsy | Congenital Adrenal Hyperplasia 1 | Osteogenesis Imperfecta Type I | Benign Recurrent Intrahepatic Cholestasis 1 | Pituitary Disorders | Hypertension | Colitis, Lymphocytic | Aarskog-Scott Syndrome | Fetal Akinesia Deformation Sequence | Obsessive-compulsive Disorder | Ocular Surface Squamous Neoplasia | Hemophilia | Pyelonephritis | Optic Atrophy 2 | Progressive Encephalopathy-optic Atrophy Syndrome | Neurodevelopmental Disorder With Central Hypotonia And Dysmorphic Facies | IgA Deficiency | Fowler's Syndrome | Hypertrophy | Polyarteritis Nodosa | Heimler Syndrome | Hypospadias | Phosphoenolpyruvate Carboxykinase Deficiency, Cytosolic | Geleophysic Dysplasia | Megaloblastic Anemia | Carcinoma, Merkel Cell | Osteopetrosis | Keratoconus | Tetraplegia | Smith-Magenis Syndrome | Meningococcal Meningitis | Alzheimer Disease, Late Onset | Neutropenia | Spondylolisthesis | Ovarian Sex Cord-stromal Tumor | Retinoblastoma | Hypoproteinemia, Hypercatabolic | Nevus | Arthrogryposis | Peritonitis | Brooke-Spiegler Syndrome | Neovascular Glaucoma | Cleidocranial Dysplasia | Spinocerebellar Ataxia Type 23 | Hyperostosis | Osteomalacia | Tay-Sachs Disease | Antiphospholipid Syndrome | Cerebrovascular Disorders | Chronic Enteropathy Associated With SLCO2A1 Gene | Familial Episodic Pain Syndrome | Myosin Storage Myopathy | Familial Advanced Sleep Phase Syndrome | Hermansky-Pudlak Syndrome | Gout | D-2-Hydroxyglutaric Aciduria | Usher Syndrome Type IIC | Sialidosis Type I | MELAS Syndrome | Spinocerebellar Ataxia Type 42 | Cutis Laxa | Rothmund-Thomson Syndrome | Isobutyryl-CoA Dehydrogenase Deficiency | Neurofibroma | Thrombasthenia | Prurigo Nodularis | Myoclonic Atonic Epilepsy | Glycogen Storage Disease Type 4 | Benign Familial Neonatal Convulsions | Thrombotic Microangiopathy | Light Chain Amyloidosis | Kabuki Syndrome 2 | Ehlers-Danlos Syndrome With Progressive Kyphoscoliosis, Myopathy, And Hearing Loss | SAPHO Syndrome | Uveitis | Dementia, Vascular | C3 Glomerulonephritis | Microcephaly, Seizures, And Developmental Delay | Asplenia | Aldosterone Deficiency | Waardenburg Syndrome Type 4 | Autism | Cancer, Kidney | Pelizaeus-Merzbacher Disease | Carcinoid Syndrome | Nephrocalcinosis | Tinea | Sialoadenitis | Wolman Disease | Keratitis | Genitopatellar Syndrome | Choreoathetosis, Hypothyroidism, And Neonatal Respiratory Distress | Cholestasis, Intrahepatic | Myasthenia Gravis | Nail-Patella Syndrome | Cirrhosis | Familial Thoracic Aortic Aneurysm | Dysmorphophobia | Cystitis | Gnathodiaphyseal Dysplasia | Liddle Syndrome | Cardiospondylocarpofacial Syndrome | Leukemia-lymphoma, Adult T-cell | Meningitis | Facioscapulohumeral Muscular Dystrophy Type 2 | Hyperuricemic Nephropathy, Familial Juvenile | Mood Disorder | Kabuki Syndrome | Wiedemann-Steiner Syndrome | Nephritis, Interstitial | Lymphoma, Mantle Cell | Graft-versus-host Disease | Klippel-Feil Syndrome | Sarcoma | Pineoblastoma | Gastritis, Atrophic | Creatine Deficiency Syndrome | Neuroendocrine Cancer | Heroin Dependence | Panniculitis | Yellow Fever | Poirier-Bienvenu Neurodevelopmental Syndrome | Myelodysplasia | Multiple Myeloma | Pemphigus | Brachydactyly | Epidermolytic Hyperkeratosis | Restrictive Dermopathy | Anterior Segment Dysgenesis | Lentigo | Rosacea | Maternally Inherited Diabetes And Deafness | Kaposi Sarcoma | Sensorineural Hearing Loss | Angioedema, Acquired | Kernicterus | Neutrophilia | Hereditary Sensory And Autonomic Neuropathy | Leukocyte Adhesion Deficiency Type 1 | Parkinsonism | Hidradenitis | MIRAGE Syndrome | Silicosis | Urolithiasis | Schamberg Disease | Diffuse Intrinsic Pontine Glioma | Hyperlipidemia | Glioma | Mucormycosis | Achondrogenesis | Hypercalciuria | Oguchi Disease-2 | Pontocerebellar Hypoplasia Type 2 | Spinocerebellar Ataxia Type 20 | Endophthalmitis | Lymphopenia | Borjeson-Forssman-Lehmann Syndrome | Exfoliative Dermatitis | Arrhythmogenic Right Ventricular Cardiomyopathy | Oculopharyngeal Muscular Dystrophy | Spinocerebellar Ataxia Type 3 | Anorexia Nervosa | Diabetes Type 1 | Basal Ganglia Cerebrovascular Disease | NDH Syndrome | Subcortical Band Heterotopia | Optic Neuropathy | Tyrosinemia Type 1 | Ligneous Conjunctivitis | Pycnodysostosis | Uveitis, Anterior | Otitis Media | Thyroid Hormone Resistance | Primary Carnitine Deficiency | Chiari Malformation Type I | Chromosome 16p11.2 Deletion Syndrome | Neurofibromatosis-Noonan Syndrome | Central Retinal Artery Occlusion | Milk Allergy | Acute Anterior Uveitis | Colorectal Adenoma | Arthritis | Cancer, Skin | Amyloidosis | Cornelia De Lange Syndrome | Toxoplasmosis | Hodgkin Lymphoma | Cancer, Lung | Cannabis Abuse | Nager Acrofacial Dysostosis | Burn-McKeown Syndrome | Syncope | Personality Disorders | Fontaine Progeroid Syndrome | Congenital Myopathy | Major Depression | Usher Syndrome Type III | Hepatic Steatosis | Endometrial Hyperplasia | Arts Syndrome | Krabbe Disease | Oculocutaneous Albinism Type 2 | Granular Corneal Dystrophy Type 1 | Cri-du-chat Syndrome | Glanzmann Thrombasthenia | Spondylo-ocular Syndrome | Proctitis | Pseudohypoaldosteronism | Benign Familial Pemphigus | Cystitis, Interstitial | Moyamoya Disease | Synpolydactyly | Epidermolysis Bullosa Simplex, Localized | Infantile Nephropathic Cystinosis | Gyrate Atrophy Of The Choroid And Retina | Gitelman Syndrome | Chromosome 5q Deletion Syndrome | Herpes Simplex Dermatitis | Sporadic Hemiplegic Migraine | Congenital Dyserythropoietic Anemia Type 1 | Hypohidrotic Ectodermal Dysplasia | Megalencephaly | Ameloblastoma | Imerslund-Grasbeck Syndrome | Hereditary Multiple Exostoses | Donnai-Barrow Syndrome | Histiocytic Sarcoma | Hyperparathyroidism, Primary | Triphalangeal Thumb-polysyndactyly Syndrome | Epithelioid Hemangioma | Infantile Spasm | Mitochondrial DNA Depletion Syndrome, Myopathic Form | Feingold Syndrome | Hypohidrotic Ectodermal Dysplasia, X-linked | Congenital Muscular Dystrophy | Sleep Apnea | Histiocytosis | Thyroid Dysgenesis | Rheumatic Heart Disease | Malonyl-CoA Decarboxylase Deficiency | Sandhoff Disease | Niemann-Pick Disease, Type A | Hypogonadism | Craniofacial Dysostosis | Succinic Semialdehyde Dehydrogenase Deficiency | Stuttering | Melanocytic Nevus | Coffin-Lowry Syndrome | Diabetes Insipidus, Nephrogenic | Hemosiderosis | Interstitial Lung Diseases | Lymphoproliferative Disease, X-linked | Syphilis | Small Lymphocytic Lymphoma | X-linked Charcot-Marie-Tooth Disease | Epidermolytic Palmoplantar Keratoderma | Avian Influenza | Acute Lung Injury | CDKL5 Deficiency Disorder | Werner's Syndrome | Charcot-Marie-Tooth Disease Type 2T | Klinefelter Syndrome | Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive 1 | Neural Tube Defect | Atelosteogenesis Type 2 | Pleural Tuberculosis | Systemic Mastocytosis | Agranulocytosis | Ornithine Transcarbamylase Deficiency | Sezary Syndrome | Noonan Syndrome-like Disorder With Loose Anagen Hair | Colitis | Lymphoma Lymphoblastic | Hoyeraal-Hreidarsson Syndrome | Giant Axonal Neuropathy | Erdheim-Chester Disease | Nephroblastoma | Keratoacanthoma | Pseudo-pseudohypoparathyroidism | Aneurysm, Abdominal Aortic | Gigantism | Sjogren Syndrome | Keloid | Schaaf-Yang Syndrome | Zygomycosis | Postaxial Polydactyly | Rash | Charcot-Marie-Tooth Disease Type 2E | Leukodystrophies | Keratoconjunctivitis | Melanoma, Uveal | Congenital Aniridia | Atrial Septal Defect | Nutrition Disorders | Ataxia-hypogonadism-choroidal Dystrophy Syndrome | Transient Bullous Dermolysis Of The Newborn | LRBA Deficiency | Binge Eating Disorder | Paracoccidioidomycosis | Aldosteronism | Spondyloepiphyseal Dysplasia Tarda, X-linked | Erythropoietic Protoporphyria | Oral Lichen Planus | Psoriasis | Metatropic Dysplasia | Thanatophoric Dysplasia | Orthostatic Intolerance | Tricho-hepato-enteric Syndrome | Erythema Nodosum | Cocaine-Related Disorders | Adenomatoid Tumor | Atopy | Antithrombin III Deficiency | Ellis-Van Creveld Syndrome | Parkinson Disease 6, Autosomal Recessive Early-onset | Ameloblastic Carcinoma | Pupil Disorders | Temtamy Preaxial Brachydactyly Syndrome | Glucagonoma | Renal Hypomagnesemia 3 | Dysferlinopathy | Retinal Diseases | Adrenoleukodystrophy, X-linked | Diabetes Type 2 | Granular Corneal Dystrophy | Renal Failure | H Syndrome | Charcot-Marie-Tooth Disease | Celiac Disease | Lung Diseases | Chronic Beryllium Disease | Guttate Psoriasis | Hypomyelination With Atrophy Of Basal Ganglia And Cerebellum | Angiodysplasia | Neuronal Ceroid Lipofuscinosis | Epidermolysis Bullosa | Neuromyotonia | Bronchitis, Chronic | Leri Pleonosteosis | Citrullinemia | Myoclonic Epilepsy With Ragged Red Fibers | Dyggve-Melchior-Clausen Disease | Chromosome 17q21.31 Deletion Syndrome | Macular Degeneration | Bone Giant Cell Tumor | Turner's Syndrome | Epilepsy | Lysosomal Acid Lipase Deficiency | Endometriosis | Nephrotic Syndrome | Open-angle Glaucoma | Lipid Metabolism Disorders | Spinocerebellar Ataxia Type 40 | Blastoma, Pleuropulmonary | Primary Hyperoxaluria | Duane Retraction Syndrome | Myocardial Infarction | Treacher Collins Syndrome | Motion Sickness | Diabetic Macular Edema | Osteonecrosis | Castleman Disease | Autoimmune Disease | Oculodentodigital Dysplasia | Familial Retinal Arterial Macroaneurysm | Frontotemporal Dementia With Amyotrophic Lateral Sclerosis | Adenosine Deaminase Deficiency | Agnathia-Otocephaly Complex | Retinitis | Mevalonate Kinase Deficiency | Sclerosteosis | Hyperparathyroidism, Secondary | Photosensitivity | Autosomal Recessive Bestrophinopathy | Chronic Myelomonocytic Leukemia