Esophageal Adenocarcinoma

About the Disease
Esophagus Adenocarcinoma, also known as esophageal adenocarcinoma, is related to apocrine adenocarcinoma and peptic esophagitis. An important gene associated with Esophagus Adenocarcinoma is HNF1A-AS1 (HNF1A Antisense RNA 1), and among its related pathways/superpathways are Cell differentiation - expanded index and Head and neck squamous cell carcinoma. The drugs FOLFIRINOX and Ramucirumab have been mentioned in the context of this disorder. Affiliated tissues include lymph node, liver and bone marrow, and related phenotypes are gastroesophageal reflux and feeding difficulties in infancy

Common Targets
HEATR3 | AFG3L1P | ZBTB38 | LINC02257 | CCDC26 | DCLRE1B | CDK4 | OMD | FBN1 | LOC105370500 | APOM | KCNN3 | MGST1 | TOP1 | TSPYL5 | LOC105372985 | DNMT3A | AXL | LINC00824 | FGF3 | TAFA5 | G1950 | EMBP1 | ATRX | TYR | BRD4 | RMI2 | ZNF781 | GRIK1 | EXT2 | CDYL2 | MMP3 | CCDC6 | IKZF1 | FAT1 | UGT1A8 | MTHFR | G4851 | MAP2K1 | DIO3 | G2099 | KDM5C | MLPH | PIK3CA | CIC | PGR | LAG3 | MN1 | H4C9 | POLD3 | LOC107986930 | G5743 | G5243 | ERBB3 | NCAM1 | Hedgehog Protein (nonspecified subtype) | NRG1 | NKX2-1 | G3479 | LEF1 | KLHL14 | STXBP4 | G999 | SFMBT2 | FGF4 | G1956 | G4609 | CRKL | RGS17 | DMRT1 | MMP12 | IRS2 | CASC11 | PIK3R1 | BMP3 | CASC8 | FLT1 | PSCA | TRRAP | AKAP6 | ZEB2 | MICA-AS1 | PADI6 | MYH11 | CTNNA2 | ENG | VDR | CDKN2B-AS1 | LRFN2 | SLC22A3 | OGG1 | CTD-2194D22.4 | SLC18A3 | PRDM2 | BTNL2 | ST8SIA1 | TCEAL7 | SLC14A1 | SYK | NOTCH4 | CASP8 | SCARB1 | ST6GAL1 | AP4B1 | SP140 | G3725 | LIN28B | LOC107987449 | HOXD13 | FLACC1 | KCNN4 | G4233 | NTRK3 | LOC105377732 | GSTT1 | BAK1 | PIGU | GRIN2D | PTCH1 | TSC2 | CACNB2 | POU3F1 | SOX2 | LOC107987459 | KDR | ROS1 | RALY | NFKBIA | TSBP1-AS1 | G3480 | EEFSEC | KITLG | TP63 | FAT3 | ACSL3 | TIPARP | TNFRSF19 | COLCA1 | G2064 | TACC3 | FGF6 | CDH17 | PINX1 | XPO1 | NR5A2 | TET2 | LOC105377871 | STK11 | KAT6A | REL | XXYLT1 | PIGR | LOC105369367 | G4170 | SLC39A12 | PHLDB1 | CYP2E1 | PLCE1 | HAGLROS | EMSY | CYP24A1 | SMAD7 | DICER1 | CCHCR1 | ARID5B | PLEKHM1 | IRF4 | NDRG4 | SMARCA4 | UGT2B4 | G3845 | LOC105373874 | ERCC2 | VPS53 | TPR | ULK4 | MSLN | EHBP1 | HIP1 | HACE1 | HYKK | RNF146 | HUNK | TBX3 | SETBP1 | ADH1B | G4193 | MECOM | FERMT2 | PTPDC1 | MMP7 | FLT3 | HELQ | G2033 | RICTOR | PIK3C2B | RAF1 | TMEM178A | CTLA4 | RET | CASC17 | CASC21 | STAT4 | CAV1 | DNAH11 | CBFA2T3 | ELMO1 | PLA2G6 | INHBA | KLC3 | EBF2 | LOC105369705 | SLC4A7 | BACH1 | SP110 | LSP1 | DIRC3 | ZGPAT | MTMR3 | KMT2A | CCAT2 | LGR6 | AXIN1 | OLIG2 | SETD2 | CDKN2A-DT | RB1 | LOC105374265 | EBF1 | MTAP | CCND3 | RTEL1 | EYS | G7015 | PDGFRA | IDH2 | SKAP1 | APC | RHPN2 | CSNK1A1 | PSORS1C1 | FGF10 | PRKDC | TRIM71 | NF1 | SLC22A18 | CHRNA3 | ANKLE1 | MAML2 | ACKR3 | GHR | CDH11 | EMID1 | NSF | DLX2-DT | CFTR | G672 | G7124 | LMTK2 | CCNE1 | IGFBP-AS1 | LOC107984214 | RXRA | VHL | FGF23 | NUAK1 | GNAS | PRNCR1 | GSTM1 | ERBB4 | JAK3 | ZNF671 | ACOXL | AFAP1 | BPTF | DOCK2 | PSORS1C2 | SRP14-DT | LINC01162 | AJAP1 | FGF19 | GC | MPL | ZNF365 | CCDC170 | LOC105378460 | CREBBP | LOC107984363 | HAGLR | ADH7 | MSMB | UGT1A1 | G472 | ZBTB20 | TPPP | CRTC1 | RPL22 | MX2 | CPXM1 | KMT2D | AFAP1-AS1 | PTPN11 | CLPTM1L | LOC105376400 | GJC2 | G3576 | NAA25 | ZNF331 | MYCL | CHST9 | CLTC | TLL1 | ARHGEF5 | HAVCR2 | CTNNB1 | ZNF217 | FAS | ZNF568 | SYNE1 | RUNX1 | EXOC1 | G3082 | POU2AF3 | PER1 | USP44 | GUCY2C | KIT | TIGIT | LOC105372093 | EPHA5 | IRF8 | NOTCH2 | PCAT19 | G7157 | NT5E | GATA3 | IL13 | PBRM1 | SFRP1 | FTO | ARID1A | PALB2 | TBX15 | CHMP4C | FAM118A | G673 | LTBP4 | G596 | G7099 | LRP1B | LOC105376536 | ZNF703 | XRCC1 | YPEL3 | FARP2 | PCAT2 | LOC105372225 | SPART | ARMC2 | CDK10 | AKT3 | SOX10 | CHEK2 | SNCB | RFX6 | CBX7 | HMOX1 | G5133 | ZNF610 | BCL6 | MMP1 | G6774 | FGF14 | ATR | IL23R | TCF7L2 | TGFBR2 | LOC105370003 | HNF1B | RRAD | PRKD2 | LOC105374875 | PIP4K2A | FBXW7 | MSH6 | EPAS1 | LMO1 | CLDN18 | MICA | PTPRC | PDE4D | CDK12 | GRHL1 | BARD1 | PITX1-AS1 | FGFR2 | LIG3 | GNPTAB | KIF1B | CEP72 | G5728 | AURKA | MLLT10 | HNF4G | MRTFA | MAP3K1 | CTXND2 | LOC105370113 | G6714 | LINC02627 | CCND2-AS1 | TNFRSF9 | ATP2B4 | G29126 | TNFRSF13B | BARX1 | ELL | LINC00506 | RAD51B | KDM5A | VTI1A | G595 | MC1R | G1029 | NBAT1 | FANCC | ZNF132 | THADA | TIMP3 | GPX7 | ITPR1 | EMX2 | RTEL1-TNFRSF6B | ATF7IP | MDM4 | PML | CASC15 | NRAS | TNFRSF10B | VAV3 | FADS1 | OPLAH | RIN2 | XBP1 | LOC105372710 | ADH1C | KDM6A | GPBAR1 | MYNN | RGN | TOGARAM1 | ARFRP1 | KLF4 | G4089 | EPHB1 | TRIM8 | G5562 | ITGA6 | PEX14 | SCN10A | CASC16 | SMO | RAD54L | CD3 Complex (T Cell Receptor Complex) | G2475 | GDNF | NCOR1 | ERCC1 | PDLIM5 | MAP2K4 | SH3GL3 | NOTCH3 | CDK6 | COL23A1 | LOC105372815 | LAMA5 | EWSR1 | BAG6 | AFM | BABAM1 | CEBPE | BRCA2 | PAX9 | LOC105370455 | TAB2

Note: If you'd like to get a target analysis report for Esophageal Adenocarcinoma, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Esophageal Adenocarcinoma at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Trichothiodystrophy | Muckle-Wells Syndrome | Hepatorenal Syndrome | Burn-McKeown Syndrome | Galloway-Mowat Syndrome | Gallstones | Schuurs-Hoeijmakers Syndrome | Coronary Artery Disease | Clouston Hidrotic Ectodermal Dysplasia | Hypopituitarism | Follicular Dendritic Cell Sarcoma | Schamberg Disease | Neonatal Progeroid Syndrome | Neuroma | Kallmann Syndrome | Aceruloplasminemia | Contact Dermatitis | Gangliosidosis | Enterocolitis, Necrotizing | Carey-Fineman-Ziter Syndrome | Ataxia-hypogonadism-choroidal Dystrophy Syndrome | Autoimmune Interstitial Lung, Joint, And Kidney Disease | Choroideremia | Hemorrhoids | Keratitis-ichthyosis-deafness Syndrome | Heart Block | Alopecia Totalis | Batten Disease | Non-bullous Congenital Ichthyosiform Erythroderma | Cardiomyopathy, Restrictive | Microcephalic Osteodysplastic Primordial Dwarfism, Type II | Esophageal Carcinoma | Aplasia Cutis Congenita | HUPRA Syndrome | Meningococcal Infections | Sarcoidosis | Spinocerebellar Ataxia Type 38 | Dent Disease | Cholestasis | Congenital Disorders Of Glycosylation | Proctitis | Prader-Willi Syndrome | Spinocerebellar Ataxia Type 31 | Spinal Muscular Atrophy Type 2 | Alcoholism | Fragile X Syndrome | Neurocysticercosis | Vitamin A Deficiency | Neurotoxicity | Acute Lymphocytic Leukemia | Multiple Sclerosis | Familial Pheochromocytoma-paraganglioma | Dystonia Musculorum Deformans | Polycystic Liver | Martsolf Syndrome | Glycogen Storage Disease Type 0, Muscle | Hypertriglyceridemia | Primrose Syndrome | Fraser Syndrome | Epilepsy, Generalized | Rhizomelic Chondrodysplasia Punctata | Synovitis | Gastroenteritis, Eosinophilic | Anthrax | Dysplastic Nevus | Spinocerebellar Ataxia Type 40 | Von Hippel-Lindau Disease | Thrombotic Microangiopathy | Corneal Dystrophy | Hemangioblastoma | Paroxysmal Kinesigenic Dyskinesia | Primary Carnitine Deficiency | Craniofacial Dysostosis | Palsy, Cerebral | Geleophysic Dysplasia | Calcium Pyrophosphate Deposition Disease | Kawasaki Disease | Platelet Disorders | Hemorrhagic Disorders | Charcot-Marie-Tooth Disease | Kaposi Sarcoma | Schaaf-Yang Syndrome | Leiomyoma | D-2-Hydroxyglutaric Aciduria | Diabetes Insipidus | Cerebrotendinous Xanthomatosis | Waardenburg Syndrome Type 2 | Sialidosis Type I | Metabolic Syndrome | Oligospermia | Chondroma | IgA Deficiency | Plasmacytoma | Perry Syndrome | Combined Malonic And Methylmalonic Acidemia | Sclerocornea | Lymphoma, AIDS-related | Pulverulent Zonular Cataract | Pyruvate Dehydrogenase Deficiency | Diffuse Mesangial Sclerosis | Granuloma Annulare | Atrial Septal Defect | Hypercalciuria | Prolidase Deficiency | 3-methylglutaconic Aciduria Type IV | Stevens-Johnson Syndrome | Osteogenesis Imperfecta Type III | Chronic Idiopathic Myelofibrosis | Osteoarthritis | High Molecular Weight Kininogen Deficiency | Dengue Hemorrhagic Fever | Gastroenteritis | Pancytopenia | Triple A Syndrome | Muscular Dystrophy | Bethlem Myopathy | Ichthyosis | Primary Erythromelalgia | Periodontitis | Light Chain Amyloidosis | Sleep Apnea, Obstructive | Cholesteryl Ester Storage Disease | Bronchitis, Chronic | Erythema Multiforme | Charcot-Marie-Tooth Disease, Type 6 | Pancreatitis, Chronic | Reye Syndrome | Autism | Neurocutaneous Melanocytosis | Klinefelter Syndrome | Thrombophilia | Neuroleptic Malignant Syndrome | Nephrotic Syndrome Type 1 | Gaucher Disease | MELAS Syndrome | Sepiapterin Reductase Deficiency | Meningioma | Congenital Central Hypoventilation Syndrome | Lennox-Gastaut Syndrome | Encephalitis | Heavy Chain Disease | Diabetes Type 1 | Vitamin D Deficiency | Syncope | Fukuyama Congenital Muscular Dystrophy | Birt-Hogg-Dube Syndrome | 3-methylglutaconic Aciduria | Early Infantile Epileptic Encephalopathy 28 | Vaginitis | Atelosteogenesis Type 1 | Pseudohypoparathyroidism Type 1A | Episodic Ataxia Type 2 | Vertigo | Chanarin-Dorfman Syndrome | Chromosome 8q21.11 Deletion Syndrome | Spinocerebellar Ataxia Type 17 | Sclerosing Cholangitis | Superficial Spreading Melanoma | Usher Syndrome | Hepatic Steatosis | Hyperacusis | Long-chain 3-hydroxyacyl-coenzyme A Dehydrogenase Deficiency | Scapuloperoneal Spinal Muscular Atrophy | Anovulation | Gastritis | Potocki-Shaffer Syndrome | Occipital Neuralgia | Ocular Hypertension | Multiple Congenital Anomalies-hypotonia-seizures Syndrome 2 | Situs Inversus | Porokeratosis | Essential Fructosuria | HELLP Syndrome | Giant Cell Arteritis | Osmotic Demyelination Syndrome | Transient Bullous Dermolysis Of The Newborn | Silicosis | Oculocutaneous Albinism Type 4 | Dysgerminoma | Varicocele | Lichen Planus | Central Pain Syndrome | Pseudohypoparathyroidism Type 2 | Infantile Refsum Disease | Hypermethioninemia | Acute Motor Axonal Neuropathy | Neurofibromatosis Type 1 | Neurodegeneration Due To Cerebral Folate Transport Deficiency | Cholecystitis | Melanocytic Nevus | Perivascular Epithelioid Cell Tumor | Cardiomyopathy, Dilated, 1L | Spinocerebellar Ataxia Type 42 | Homocystinuria | Infantile Nephropathic Cystinosis | Behcet's Disease | Pineoblastoma | Cockayne Syndrome | Lichen Sclerosus | Charcot-Marie-Tooth Disease Type 4B1 | Hyperthermia, Malignant | Hypoparathyroidism | Retinitis | Pendred Syndrome | LMNA-related Congenital Muscular Dystrophy | Vitreoretinal Degeneration, Snowflake Type | Exotropia | Sclerosteosis | Thanatophoric Dysplasia Type 1 | Hypercholesterolemia | Asthma, Exercise-induced | Scapuloperoneal Myopathy, X-linked Dominant | Leishmaniasis, Cutaneous | Leukemia-lymphoma, Adult T-cell | Myositis, Focal | Familial Glucocorticoid Deficiency | Keratoconus | Abetalipoproteinemia | Heart Septal Defects | Scleroderma | Spinocerebellar Ataxia Type 21 | Oguchi Disease-2 | Costello Syndrome | Scoliosis | Cardiomyopathy, Peripartum | Systemic Mastocytosis | Hydrops Fetalis | Leber Hereditary Optic Neuropathy | Non-Hodgkin Lymphoma | Molybdenum Cofactor Deficiency | Cancer, Prostate | Hyperuricemic Nephropathy, Familial Juvenile | Pulmonary Tuberculosis | Rolandic Epilepsy | Trismus-pseudocamptodactyly Syndrome | Adenoma, Pituitary | Angiomyolipoma | Distal Spinal Muscular Atrophy | Hereditary Hemorrhagic Telangiectasia Type 2 | Angiodysplasia | Gyrate Atrophy Of The Choroid And Retina | Hypothyroidism | Progressive External Ophthalmoplegia | Congenital Adrenal Hyperplasia 1 | Alkaptonuria | Wolfram Syndrome 2 | Hyperhomocysteinemia | Down Syndrome | Hemolytic Uremic Syndrome | Tumoral Calcinosis | Cystinosis | Glomerulonephritis, Membranous | Kabuki Syndrome 2 | Posterior Polar Cataract | Adenomatoid Tumor | Hyperlipidemia Type V | Adenosine Deaminase Deficiency | Gigantism | Osteogenesis Imperfecta Type IV | Early Infantile Epileptic Encephalopathy 13 | Diabetic Encephalopathy | Frontotemporal Dementia With Amyotrophic Lateral Sclerosis | Multiple Sclerosis, Primary Progressive | Carcinoma, Merkel Cell | ICF Syndrome | Mumps | Lattice Corneal Dystrophy Type 1 | Sponastrime Dysplasia | Schwannomatosis | Lymphoma, Primary Cutaneous Anaplastic Large Cell | Eccrine Porocarcinoma | Left Ventricular Noncompaction | Congenital Dyserythropoietic Anemia Type 4 | Nephritis, Interstitial | Stomatitis | Colitis, Lymphocytic | Crisponi Syndrome | Peyronie's Disease | Antisynthetase Syndrome | Polycystic Kidney, Autosomal Dominant | Papilledema | Persistent Mullerian Duct Syndrome | Bacterial Meningitis | Iron Metabolism Disorders | Osteopathia Striata With Cranial Sclerosis | Ichthyosis Hystrix, Curth-Macklin Type | Chudley-McCullough Syndrome | Histiocytosis | Steel Syndrome | Ameloblastoma | Optic Nerve Hypoplasia, Bilateral | Allergic Contact Dermatitis | Chondromyxoid Fibroma | Anorchia | Tricho-hepato-enteric Syndrome | Impulse Control Disorder | Intestinal Obstruction | Cabezas Syndrome | Shock, Cardiogenic | Acquired Partial Lipodystrophy | Subacute Sclerosing Panencephalitis | Premenstrual Syndrome | Familial Dysautonomia | Uterine Leiomyoma | Language Disorders | Twin-to-twin Transfusion Syndrome | Ichthyosis Bullosa Of Siemens | Heimler Syndrome | Rubeosis Iridis | Arteriosclerosis | Spondylocarpotarsal Synostosis Syndrome | Holoprosencephaly | Otosclerosis | Sjogren Syndrome | Hyperammonemia | Wiedemann-Steiner Syndrome | Thyroid Hormone Resistance | Carcinoma, Squamous Cell | Arthritis, Psoriatic | Infantile Neuroaxonal Dystrophy | Kaposiform Hemangioendothelioma | Nicotine Dependence | Retinopathy Of Prematurity | Cone Dystrophy | Intracerebral Hemorrhage | Myasthenia Gravis | Creatine Deficiency Syndrome | Paraganglioma, Carotid Body | Infantile Spasm | Withdrawal Syndrome | Glycogen Storage Disease Type 1a | Tinea | Cerebellofaciodental Syndrome | Best Macular Dystrophy | Adenocarcinoma | VEXAS Syndrome | Loeys-Dietz Syndrome | Amyloidosis | Postaxial Polydactyly | Mitochondrial DNA Depletion Syndrome, Hepatocerebral Form | Coffin-Siris Syndrome | Pneumococcal Meningitis | 3-methylcrotonyl-CoA Carboxylase Deficiency | Hepatitis E | Graft-versus-host Disease | Jalili Syndrome | Bainbridge-Ropers Syndrome | Angioedema, Acquired | Achromatopsia | Fascioliasis | X-linked Charcot-Marie-Tooth Disease | Anosmia, Congenital | Papillon-Lefevre Syndrome | Acute Anterior Uveitis | Lymphoma, Follicular | Spondylo-ocular Syndrome | McKusick Type Metaphyseal Chondrodysplasia | Hepatitis D | Lipoma | Alzheimer Disease, Late Onset | Pituitary Disorders | VACTERL Association | Dystrophy, Cone-rod | Retinal Telangiectasia | Congenital Diaphragmatic Hernia | Familial Hypobetalipoproteinemia | Bulimia Nervosa | Eclampsia | Blastoma, Pleuropulmonary | Beare-Stevenson Syndrome | Endocarditis | VACTERL/VATER Association | Presbycusis | Aldosterone Deficiency | Diastrophic Dysplasia | Sulfite Oxidase Deficiency | Polydactyly | Spondyloepiphyseal Dysplasia Tarda, X-linked | Carbohydrate Metabolism Disorders | Porphyria, Acute Intermittent | Erythrokeratodermia Variabilis | Ichthyosis, X-linked | Aldosteronism | Trichotillomania | Pitt-Hopkins Syndrome | Macular Corneal Dystrophy Type 1 | Liver Failure | Hennekam Lymphangiectasia-lymphedema Syndrome | GNE Myopathy | Hemolytic Anemia | Mitochondrial DNA Depletion Syndrome, Encephalomyopathic Form | Feingold Syndrome | Vitreoretinopathy, Proliferative | Frank-ter Haar Syndrome | Raine Syndrome | Trichomegaly | Charcot-Marie-Tooth Disease Type 2T | Hypercalcemia | Proximal Symphalangism | Cranial Nerve Disease