Brooke-Spiegler Syndrome

About the Disease
Brooke-Spiegler Syndrome, also known as cyld cutaneous syndrome, is related to salivary gland adenoid cystic carcinoma and adenoid cystic carcinoma. An important gene associated with Brooke-Spiegler Syndrome is CYLD (CYLD Lysine 63 Deubiquitinase), and among its related pathways/superpathways are Keratinization and NF-kappaB Signaling. Affiliated tissues include skin, salivary gland and breast, and related phenotypes are subcutaneous nodule and telangiectasia of the skin

Common Targets
CYLD

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