Non-Langerhans Cell Histiocytosis

About the Disease
Non-Langerhans-Cell Histiocytosis, also known as histiocytosis, non-langerhans-cell, is related to multicentric reticulohistiocytosis and histiocytosis-lymphadenopathy plus syndrome. An important gene associated with Non-Langerhans-Cell Histiocytosis is SERPINA3 (Serpin Family A Member 3), and among its related pathways/superpathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. The drugs TEMPO and Aluminum hydroxide, magnesium hydroxide, simethicone drug combination have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and bone marrow, and related phenotype is neoplasm.

Common Targets
G673 | NF1 | RUNX1

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