DNA Ligase IV Deficiency

About the Disease
Lig4 Syndrome, also known as dna ligase iv deficiency, is related to nijmegen breakage syndrome and telangiectasis. An important gene associated with Lig4 Syndrome is LIG4 (DNA Ligase 4), and among its related pathways/superpathways are Homology Directed Repair and DNA Damage. Affiliated tissues include skin, bone marrow and bone, and related phenotypes are global developmental delay and microcephaly

Common Targets
LIG4

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