DNA Ligase IV Deficiency

About the Disease
Lig4 Syndrome, also known as dna ligase iv deficiency, is related to nijmegen breakage syndrome and telangiectasis. An important gene associated with Lig4 Syndrome is LIG4 (DNA Ligase 4), and among its related pathways/superpathways are Homology Directed Repair and DNA Damage. Affiliated tissues include skin, bone marrow and bone, and related phenotypes are global developmental delay and microcephaly

Common Targets
LIG4

Note: If you'd like to get a target analysis report for DNA Ligase IV Deficiency, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of DNA Ligase IV Deficiency at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Carpenter Syndrome | Schistosomiasis | Acromesomelic Dysplasia | Urethritis | Knobloch Syndrome | Gerodermia Osteodysplastica | Dengue Hemorrhagic Fever | Craniolenticulosutural Dysplasia | Basal Cell Nevus Syndrome | Gastritis | Idiopathic Pulmonary Fibrosis | Pityriasis Rubra Pilaris | Myoclonus | Porphyria, Acute Intermittent | Nutrition Disorders | Neurofibromatosis Type 1 | Familial Hypobetalipoproteinemia | Neuroendocrine Cancer | Nephrocalcinosis | Prolidase Deficiency | Becker Muscular Dystrophy | Diastrophic Dysplasia | Inflammatory Bowel Disease | Auriculocondylar Syndrome | Cancer, Prostate | Cardiofaciocutaneous Syndrome | Glycogen Storage Disease Type 0, Muscle | Congenital Hereditary Endothelial Dystrophy Type II | Evans Syndrome | Neurofibroma | Esophageal Carcinoma | Familial Partial Lipodystrophy | Ghosal Syndrome | Desbuquois Syndrome | Arterial Tortuosity Syndrome | Pineoblastoma | Hemorrhoids | Gingivitis | Gangliosidosis, GM1 | Progressive Myoclonic Epilepsy | Spinocerebellar Ataxia Type 20 | Spondyloarthritis | Non-epidermolytic Palmoplantar Keratoderma | Macular Degeneration | Pierre Robin Syndrome | Lattice Corneal Dystrophy | Colitis | Frontometaphyseal Dysplasia | Persistent Truncus Arteriosus | Heart Septal Defects | Angioimmunoblastic T-cell Lymphoma | Diabetic Encephalopathy | Majeed Syndrome | Trachoma | Stiff-man Syndrome | Ectrodactyly | GM2-gangliosidosis AB Variant | Peters-plus Syndrome | Retinal Detachment | Ataxia-ocular Apraxia 2 | Canavan Disease | Infantile Nephropathic Cystinosis | Hypokalemic Periodic Paralysis | Babesiosis | Pleural Tuberculosis | Conn Syndrome | Brugada Syndrome 1 | Familial Glucocorticoid Deficiency | Craniometaphyseal Dysplasia | Galloway-Mowat Syndrome | Heart Failure | Rhizomelic Chondrodysplasia Punctata | Galactosialidosis | Lupus Erythematosus | Kashin-Beck Disease | Sick Sinus Syndrome 1 | Diabetes Insipidus, Nephrogenic | Lymphomatoid Granulomatosis | Hemolytic Uremic Syndrome, Atypical | Alpers Syndrome | Analgesia | Thyroid Hormone Resistance | Mohr-Tranebjaerg Syndrome | Epidermolysis Bullosa | Pycnodysostosis | Leprosy | Tetanus | ACTH-independent Macronodular Adrenal Hyperplasia | Omenn Syndrome | Bursitis | Sclerosing Cholangitis | Epithelial-myoepithelial Carcinoma | Retinal Coloboma | Spinocerebellar Ataxia Type 17 | Juvenile Polyposis | Giant Axonal Neuropathy | Encephalitis | Cardiac Sarcoidosis | Congenital Poikiloderma | Acanthosis Nigricans | Sulfite Oxidase Deficiency | Hypospadias | Vascular Calcification | Tetraplegia | Van Der Knaap Disease | POEMS Syndrome | Spastic Paraplegia Type 7 | Gynecomastia | Klinefelter Syndrome | Systemic Mastocytosis | Porphyria Cutanea Tarda | Hyperammonemia | Netherton Syndrome | Vestibular Disease | Atherosclerosis | Retinitis | Sarcoma, Endometrial Stromal | Bainbridge-Ropers Syndrome | Spinocerebellar Ataxia Type 7 | Globozoospermia | Impetigo | Pearson Syndrome | Cardiomyopathy, Dilated, 1L | Molybdenum Cofactor Deficiency | Hennekam Lymphangiectasia-lymphedema Syndrome | Avellino Corneal Dystrophy | Hepatitis C, Chronic | Familial Digital Arthropathy-brachydactyly | Palsy, Cerebral | Metabolic Diseases | Niemann-Pick Disease, Type A | Tylosis With Esophageal Cancer | Zygomycosis | Fibrosarcoma | Vici Syndrome | Autonomic Neuropathy | Schizophrenia | Myasthenia | Goiter | Fukuyama Congenital Muscular Dystrophy | Distal Myopathy 2 | Keratocystic Odontogenic Tumor | Keratoconjunctivitis | Oculocutaneous Albinism Type 4 | Aarskog-Scott Syndrome | Impulse Control Disorder | Hemolytic Uremic Syndrome | Bietti Crystalline Dystrophy | Trichotillomania | Cerebrotendinous Xanthomatosis | Imerslund-Grasbeck Syndrome | Usher Syndrome Type IIC | Congenital Bilateral Absence Of Vas Deferens | Chorea-acanthocytosis | Narcolepsy | Cryoglobulinemia | Iron Deficiency Anemia | AIDS Dementia Complex | Cat Eye Syndrome | Infantile Spasm | Kallmann Syndrome | Acute Leukemia | Fibrodysplasia Ossificans Progressiva | Lymphoma, Follicular | Cholestasis | Megacystis-microcolon-intestinal Hypoperistalsis Syndrome | Congenital Aniridia | Arteriosclerosis | Congenital Adrenal Hyperplasia 1 | Supravalvular Aortic Stenosis | Shprintzen-Goldberg Syndrome | Chronic Inflammatory Demyelinating Polyneuropathy | Dementia, Vascular | Centronuclear Myopathy | Irritable Bowel Syndrome | Heterotopic Ossification | Neuroma | Calcium Pyrophosphate Deposition Disease | Hyperferritinemia-cataract Syndrome | Measles | Ulcerative Colitis | Waardenburg Syndrome Type 2A | Episodic Ataxia Type 1 | McKusick Type Metaphyseal Chondrodysplasia | Peritonitis | Aceruloplasminemia | Central Pain Syndrome | Mycosis Fungoides | Headache | Autism | Hepatopulmonary Syndrome | Agranulocytosis | Glutaric Aciduria Type 1 | Meckel-Gruber Syndrome | Optic Atrophy 2 | Charcot-Marie-Tooth Disease, Type 2C | Peripheral T-cell Lymphoma | Genee-Wiedemann Syndrome | Hemolytic Anemia | X-linked Charcot-Marie-Tooth Disease | Aplasia Cutis Congenita | Hypoglycemia | Polyarteritis Nodosa | Microcephalic Osteodysplastic Primordial Dwarfism, Type II | Anthrax | Astigmatism | Keratosis | Huntington's Disease | Vitiligo | Persistent Mullerian Duct Syndrome | Long-chain 3-hydroxyacyl-coenzyme A Dehydrogenase Deficiency | Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia | Skin Papilloma | Alstrom Syndrome | Alveolar Capillary Dysplasia | Rheumatic Heart Disease | Dominant Optic Atrophy | Arthritis | Oligospermia | Pulmonary Stenosis | Premature Ejaculation | Oligodendroglioma | Kohlschutter-Tonz Syndrome | Schwartz-Jampel-Aberfeld Syndrome | Diabetic Neuropathy | Succinic Semialdehyde Dehydrogenase Deficiency | Obsessive-compulsive Disorder | Goiter, Nodular | Acromegaly | Ichthyosis Bullosa Of Siemens | Cholangiocarcinoma | Optic Neuropathy | SAPHO Syndrome | Exfoliative Dermatitis | Anencephaly | Purpura, Thrombotic Thrombocytopenic | Palmoplantar Keratoderma | Renal Tubular Acidosis | Pain | Pulverulent Zonular Cataract | Astrocytoma, Anaplastic | Erectile Dysfunction | Aneurysm, Abdominal Aortic | Thrombophlebitis | Abetalipoproteinemia | Stroke | Odonto-onycho-dermal Dysplasia | Lichen Planus | Hepatitis | Macrophage Activation Syndrome | Sleep Apnea | Lissencephaly 2 | Hypertelorism | Hepatoblastoma | Neurofibromatosis Type 2 | Congenital Hypofibrinogenemia | Japanese Encephalitis | Blau Syndrome | Lennox-Gastaut Syndrome | Blomstrand Osteochondrodysplasia | Optic Neuropathy, Anterior Ischemic | Paraplegia | Congenital Bile Acid Synthesis Defect | Protein C Deficiency | Pathological Gambling | Bartter Syndrome | Hepatic Steatosis | Congenital Dysfibrinogenemia | Spinocerebellar Ataxia Type 13 | Very Long-chain Acyl-CoA Dehydrogenase Deficiency | Acrodermatitis | Kearns-Sayre Syndrome | Pyruvate Kinase Deficiency | Choriocarcinoma | Arthritis, Reactive | Diffuse Mesangial Sclerosis | Eating Disorder | Bone Marrow Necrosis | Combined Pituitary Hormone Deficiency | Gigantism | Optic Nerve Hypoplasia, Bilateral | Adenoma, Pleomorphic | Papilloma | Charcot-Marie-Tooth Disease Type 2E | Corticobasal Syndrome | Hypohidrotic Ectodermal Dysplasia | Optic Nerve Diseases | Congenital Disorders Of Glycosylation | Splenomegaly | Thalassemia | Toxoplasmosis | Hyperostosis | Encephalitis, Tick-borne | Yellow Fever | Acrocallosal Syndrome | Bicuspid Aortic Valve | Renal Hypomagnesemia 3 | Congenital Hemolytic Anemia | Hyperlipidemia | Milk Allergy | Acute Anterior Uveitis | Vaginitis | Exotropia | Spina Bifida | Seasonal Mood Disorder | Meleda Disease | Choroideremia | Language Disorders | Benign Familial Neonatal Convulsions | Pseudohypoaldosteronism | Pierpont Syndrome | Multicystic Renal Dysplasia | Sarcoma | Familial Hyperaldosteronism | GLUT1 Deficiency Syndrome | Cold-induced Sweating Syndrome | Camurati-Engelmann Disease | Bladder Exstrophy | Spinocerebellar Ataxia Type 23 | Spondylo-ocular Syndrome | Carotid Artery Disease | Smith-Kingsmore Syndrome | Myelitis | T-cell Lymphoma, Subcutaneous Panniculitis-like | Von Hippel-Lindau Disease | Intestinal Tuberculosis | Hypolipoproteinemia | Hemangioma | Graft-versus-host Disease | Spinocerebellar Ataxia Type 12 | Vertebrobasilar Insufficiency | Pseudoachondroplasia | Fundus Albipunctatus | Motion Sickness | Mandibuloacral Dysplasia With Type A Lipodystrophy | Portal Vein Thrombosis | 3-methylglutaconic Aciduria Type I | Chordoid Glioma | Cancer, Colon | Orotic Aciduria | Liver Failure | Tietze Syndrome | Dermatomyositis | Microcephaly | Mucolipidosis Type III | Spinal Muscular Atrophy Type 2 | Neurofibroma, Plexiform | Dermatitis | Renal-hepatic-pancreatic Dysplasia | Methemoglobinemia | Dengue Shock Syndrome | Methylmalonic Aciduria And Homocystinuria, CblC Type | Muscle Wasting | Fibromyalgia | Papilledema | Eccrine Porocarcinoma | Carcinoma, Signet Ring Cell | Mannosidase Deficiency Diseases | Acute Lung Injury | Niemann-Pick Disease | Loeys-Dietz Syndrome | Triple A Syndrome | Ventricular Septal Defect | Cryptococcal Meningitis | Congenital Afibrinogenemia | Carcinoma, Merkel Cell | Mast Cell Leukemia | Multiple Myeloma | Malaria | Crohn's Disease | Neurofibromatosis-Noonan Syndrome | Blepharoconjunctivitis | Multiple Epiphyseal Dysplasia | Spinocerebellar Ataxia Type 15 | Early Infantile Epileptic Encephalopathy 4 | Metanephric Adenoma | Phosphoglycerate Dehydrogenase Deficiency | Congestive Heart Failure | Peeling Skin Syndrome, Acral Type | Dyggve-Melchior-Clausen Disease | Overactive Bladder | Glanzmann Thrombasthenia | Geleophysic Dysplasia | Lewy Body Dementia | Keratosis, Actinic | Alexander Disease | Hydrolethalus Syndrome | Herpes Simplex Dermatitis | Psoriasis | Cholesteryl Ester Storage Disease | Pregnancy, Ectopic | Hypobetalipoproteinemias | Communication Disorders | Diabetes Insipidus, Neurogenic | Infantile Neuroaxonal Dystrophy | Gastrointestinal Disorders | ADNP Syndrome | Marshall-Smith Syndrome | Cardiospondylocarpofacial Syndrome | Malaria, Cerebral