Arteriosclerosis

About the Disease
Arteriosclerosis, also known as arteriosclerotic vascular disease, is related to arteriosclerosis obliterans and aortic atherosclerosis, and has symptoms including angina pectoris An important gene associated with Arteriosclerosis is HS3ST1 (Heparan Sulfate-Glucosamine 3-Sulfotransferase 1), and among its related pathways/superpathways are Metabolism and Extracellular matrix organization. The drugs Estradiol and Polyestradiol phosphate have been mentioned in the context of this disorder. Affiliated tissues include heart, endothelial and smooth muscle, and related phenotypes are Increased free cholesterol and homeostasis/metabolism

Common Targets
Diacylglycerol Acyltransferase (DGAT) (nonspecified subtype) | EPHX2 | MTHFR | GPR119 | NR1H2 | PIK3CA | IL37 | ALOX5AP | DGAT1 | MOGAT2 | Phosphodiesterase 1 (PDE1) (nonspecified subtype) | CA5A | AURKB | PGR | mTOR complex 1 | Phospholipase A2 (nonspecified subtype) | NR1H3 | SCD | MGAT2 | GCK | HSD11B1 | KDR | TGFBR1 | SGK1 | SLC22A12 | ABCA1 | NOS3 | CA6 | AKR1B1 | XDH | PPARD | TLR2 | PCSK9 | S1PR2 | G3480 | G3569 | Guanylate cyclase (nonspecified subtype) | HPGD | Peroxisome Proliferator-Activated Receptors (PPAR) (nonspecified subtype) | Oxysterols receptor LXR (nonspecified subtype) | NR1H4 | MRC1 | G5595 | DACH1 | HTR2A | CA7 | GIPR | ALKBH3 | MTHFD2 | PTGER4 | CA13 | RORA | TEK | G7124 | AGTR1 | Trypsin (nonspecified subtype) | NOS2 | CCND3 | JAK2 | NF-kappaB (NFkB) | mTOR complex 2 | ADIPOR1 | Transforming growth factor beta (nonspecified subtype) | Proteasome Complex | CCR5 | NLRP3 Inflammasome | SOAT1 | G114548 | Sterol O-acyltransferase (ACAT) (nonspecified subtype) | RORB | LPAR4 | SLC10A2 | AGER | SGMS2 | ADH5 | MEP1A | G7099 | G3146 | GLP1R | MEP1B | PIK3CG | Focal Adhesion Kinases (FAK) (nonspecified subtype) | CDK6/Cyclin D3 | Arginase (nonspecified subtype) | CYP11B2 | PLA2G7 | Angiotensin receptor (AT) (nonspecified subtype) | ESRRG | CD19 | HMOX1 | MTR | Soluble guanylyl cyclase | Rho kinase (ROCK) (nonspecified subtype) | S1PR1 | SOAT2 | AMP-activated protein kinase (AMPK) | RETN | ACE | CMA1 | AURKA | LIPG | RORC | CSF1R | ENPP2 | PDGFRB | GCGR | LDLR | SPP1 | GPBAR1 | G2475 | Transforming growth factor (TGF)-beta receptor (nonspecified subtype) | CDK4/Cyclin D3 | CETP | ND6 | LCAT | SCN10A | CDK4 | GPR35 | PPARA | E2F1 | PPARG | Fibrinogen | Integrin alphavbeta3 (vitronectin) receptor | Phosphatidylinositol 3-kinase (PI3K) (nonspecified subtype) | VWF | G2335 | LPL | PTGES | CNR1 | RNR1

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