Arteriosclerosis

About the Disease
Arteriosclerosis, also known as arteriosclerotic vascular disease, is related to arteriosclerosis obliterans and aortic atherosclerosis, and has symptoms including angina pectoris An important gene associated with Arteriosclerosis is HS3ST1 (Heparan Sulfate-Glucosamine 3-Sulfotransferase 1), and among its related pathways/superpathways are Metabolism and Extracellular matrix organization. The drugs Estradiol and Polyestradiol phosphate have been mentioned in the context of this disorder. Affiliated tissues include heart, endothelial and smooth muscle, and related phenotypes are Increased free cholesterol and homeostasis/metabolism

Common Targets
Diacylglycerol Acyltransferase (DGAT) (nonspecified subtype) | EPHX2 | MTHFR | GPR119 | NR1H2 | PIK3CA | IL37 | ALOX5AP | DGAT1 | MOGAT2 | Phosphodiesterase 1 (PDE1) (nonspecified subtype) | CA5A | AURKB | PGR | mTOR complex 1 | Phospholipase A2 (nonspecified subtype) | NR1H3 | SCD | MGAT2 | GCK | HSD11B1 | KDR | TGFBR1 | SGK1 | SLC22A12 | ABCA1 | NOS3 | CA6 | AKR1B1 | XDH | PPARD | TLR2 | PCSK9 | S1PR2 | G3480 | G3569 | Guanylate cyclase (nonspecified subtype) | HPGD | Peroxisome Proliferator-Activated Receptors (PPAR) (nonspecified subtype) | Oxysterols receptor LXR (nonspecified subtype) | NR1H4 | MRC1 | G5595 | DACH1 | HTR2A | CA7 | GIPR | ALKBH3 | MTHFD2 | PTGER4 | CA13 | RORA | TEK | G7124 | AGTR1 | Trypsin (nonspecified subtype) | NOS2 | CCND3 | JAK2 | NF-kappaB (NFkB) | mTOR complex 2 | ADIPOR1 | Transforming growth factor beta (nonspecified subtype) | Proteasome Complex | CCR5 | NLRP3 Inflammasome | SOAT1 | G114548 | Sterol O-acyltransferase (ACAT) (nonspecified subtype) | RORB | LPAR4 | SLC10A2 | AGER | SGMS2 | ADH5 | MEP1A | G7099 | G3146 | GLP1R | MEP1B | PIK3CG | Focal Adhesion Kinases (FAK) (nonspecified subtype) | CDK6/Cyclin D3 | Arginase (nonspecified subtype) | CYP11B2 | PLA2G7 | Angiotensin receptor (AT) (nonspecified subtype) | ESRRG | CD19 | HMOX1 | MTR | Soluble guanylyl cyclase | Rho kinase (ROCK) (nonspecified subtype) | S1PR1 | SOAT2 | AMP-activated protein kinase (AMPK) | RETN | ACE | CMA1 | AURKA | LIPG | RORC | CSF1R | ENPP2 | PDGFRB | GCGR | LDLR | SPP1 | GPBAR1 | G2475 | Transforming growth factor (TGF)-beta receptor (nonspecified subtype) | CDK4/Cyclin D3 | CETP | ND6 | LCAT | SCN10A | CDK4 | GPR35 | PPARA | E2F1 | PPARG | Fibrinogen | Integrin alphavbeta3 (vitronectin) receptor | Phosphatidylinositol 3-kinase (PI3K) (nonspecified subtype) | VWF | G2335 | LPL | PTGES | CNR1 | RNR1

Note: If you'd like to get a target analysis report for Arteriosclerosis, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Arteriosclerosis at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.tech.

Other Diseases

Erythematotelangiectatic Rosacea | Autoimmune Autonomic Ganglionopathy | Amelogenesis Imperfecta | Keratocystic Odontogenic Tumor | Hydrolethalus Syndrome | Methemoglobinemia | LMNA-related Congenital Muscular Dystrophy | Familial Isolated Hyperparathyroidism | Trimethylaminuria | Pompe Disease | Prediabetes | Arthritis, Reactive | Renal Dysplasia | Klippel-Feil Syndrome | Jaundice, Obstructive | Urolithiasis | Dermatitis | Bursitis | Focal Dermal Hypoplasia | Maple Syrup Urine Disease | Riboflavin Transporter Deficiency Neuronopathy | Amish Infantile Epilepsy Syndrome | Motion Sickness | Neurodegeneration Due To Cerebral Folate Transport Deficiency | Hyperparathyroidism, Secondary | Hepatitis, Alcoholic | Cryoglobulinemia | Cornelia De Lange Syndrome | Dystonia | L-2-Hydroxyglutaric Aciduria | Hypogonadism | Lichen Sclerosus | Hypoglycemia | Familial Hypertrophic Cardiomyopathy | Progressive Familial Intrahepatic Cholestasis Type 3 | Polycystic Ovary Syndrome | Osteonecrosis | Schizotypal Personality Disorder | Persistent Mullerian Duct Syndrome | Congenital Primary Aphakia | Myotonic Disorders | Epidermolysis Bullosa Simplex, Localized | Fibrosarcoma | Autoimmune Disease | Familial Hemiplegic Migraine | Bethlem Myopathy | Angioedema, Hereditary | Arthropathy | Hidradenitis | Hypoplastic Left Heart Syndrome | Patent Ductus Arteriosus | Cat Eye Syndrome | Martsolf Syndrome | Charcot-Marie-Tooth Disease Type 4 | Aldosteronism | Fanconi Anemia | Hypokalemic Periodic Paralysis | Chronic Idiopathic Myelofibrosis | Scleroderma | Peripheral Neuropathy | Spinocerebellar Ataxia Type 3 | Anorchia | Diabetes Insipidus | Pseudohypoaldosteronism | Oral Lichen Planus | Hyperinsulinemia | Cancer, Breast | Hepatoblastoma | Schwannoma | Myocardial Infarction | Colitis, Lymphocytic | Autoimmune Hemolytic Anemia | Endometritis | Esophagitis | Multiple Myeloma | Pure Autonomic Failure | Ichthyosis | Tuberculous Meningitis | Malnutrition | Tetraplegia | Dysgerminoma | Gastroschisis | Kidney Stones | Transient Bullous Dermolysis Of The Newborn | Seasonal Mood Disorder | Ependymoma | Hereditary Spherocytosis | Blue Nevus | Porokeratosis | Noonan Syndrome | Amyotrophic Lateral Sclerosis | Frontotemporal Dementia | Congenital Nystagmus | Distal Myopathy 2 | Endometrial Hyperplasia | Charcot-Marie-Tooth Disease Axonal Type 2N | Farber Disease | Diabetes Type 2 | Brugada Syndrome 1 | Porphyria, Variegate | Lymphedema-distichiasis Syndrome | Glycogen Storage Disease Type 9 | Paraganglioma | Greig Cephalopolysyndactyly Syndrome | Mitochondrial DNA Depletion Syndrome, Encephalomyopathic Form | Rosacea | Bipolar Disorder | Papulopustular Rosacea | Epidermodysplasia Verruciformis | Encephalopathy, Hepatic | Imerslund-Grasbeck Syndrome | Congenital Aniridia | Alpha-thalassemia Myelodysplasia Syndrome | Angiosarcoma Of The Breast | Retinal Dystrophy | Hepatic Steatosis | Seizures-scoliosis-macrocephaly Syndrome | Sarcoidosis, Pulmonary | Liver Diseases | Frank-ter Haar Syndrome | Dermatofibrosarcoma | X-linked Sideroblastic Anemia | Niemann-Pick Disease | Pelizaeus-Merzbacher Disease | Aicardi-Goutieres Syndrome | Dentinogenesis Imperfecta | Multiple Epiphyseal Dysplasia | Van Der Knaap Disease | Eccrine Porocarcinoma | Hypophosphatemic Rickets With Hypercalciuria, Hereditary | Scapuloperoneal Spinal Muscular Atrophy | Ectodermal Dysplasia | Stargardt Disease | Lung Diseases | Absence Epilepsy | Hypohidrotic Ectodermal Dysplasia | Chloridorrhea, Congenital | Myocarditis | Cholera | Spinal And Bulbar Muscular Atrophy | McCune-Albright Syndrome | Raine Syndrome | Crisponi Syndrome | Fabry's Disease | Alstrom Syndrome | Stuve-Wiedemann Syndrome | Hydrocephalus | Tangier Disease | Rolandic Epilepsy | Juvenile Polyposis | Recurrent Respiratory Papillomatosis | Melanocytic Nevus | Idiopathic Multicentric Castleman Disease | Spinocerebellar Ataxia | Sepiapterin Reductase Deficiency | Biotinidase Deficiency | Kaposi Sarcoma | Bartter Syndrome | Pycnodysostosis | Milk Allergy | Early Infantile Epileptic Encephalopathy 1 | Spondyloepiphyseal Dysplasia Tarda, X-linked | Antisocial Personality Disorder | Cervical Dystonia | Adams-Oliver Syndrome | Carey-Fineman-Ziter Syndrome | Macular Corneal Dystrophy Type 1 | Glycogen Storage Disease Type 5 | Generalized Epilepsy And Paroxysmal Dyskinesia | T-cell Prolymphocytic Leukemia | Hypertriglyceridemia | Glomerulonephritis, Membranoproliferative | Vascular Cognitive Impairment | Shock, Cardiogenic | Cyclic Vomiting Syndrome | Melanoma | Basal Ganglia Cerebrovascular Disease | Chondrodysplasia Punctata 1, X-linked Recessive | REM Sleep Behavior Disorder | Uveitis, Anterior | Renpenning Syndrome | Thyroid Dyshormonogenesis | Focal Segmental Glomerulosclerosis | Combined Pituitary Hormone Deficiency | Hepatitis B, Chronic | Torticollis | Muir-Torre Syndrome | Fetal Alcohol Syndrome | Rothmund-Thomson Syndrome | Bulimia Nervosa | Steel Syndrome | Malaria, Cerebral | Inflammatory Linear Verrucous Epidermal Nevus | Alpha-mannosidosis | Mesial Temporal Lobe Epilepsy With Hippocampal Sclerosis | Bloom Syndrome | Pterygium | Long QT Syndrome Type 3 | Takayasu's Arteritis | Optic Neuritis | Loeys-Dietz Syndrome | Conn Syndrome | Dubin-Johnson Syndrome | Twin-to-twin Transfusion Syndrome | Trigonocephaly | Lymphedema | Wieacker-Wolff Syndrome | Long-chain 3-hydroxyacyl-coenzyme A Dehydrogenase Deficiency | Autosomal Recessive Spastic Paraplegia Type 35 | Bare Lymphocyte Syndrome | Hypercholesterolemia, Familial | Coronary Restenosis | Progressive Familial Intrahepatic Cholestasis | Hereditary Multiple Exostoses | Placenta Previa | Desbuquois Syndrome | Hepatitis E | Gingivitis | Molybdenum Cofactor Deficiency | Congenital Disorders Of Glycosylation Type II | Diabetes Mellitus, Transient Neonatal | Anthrax | Hepatic Adenomatosis | Diamond-Blackfan Anemia | Cancer, Brain | Pyelonephritis | Sensory Neuropathy | Chudley-McCullough Syndrome | Thyroiditis, Autoimmune | Snyder-Robinson Syndrome | Common Cold | Osteoarthritis | X-linked Charcot-Marie-Tooth Disease | Contact Dermatitis | Binge Eating Disorder | Primary Erythromelalgia | Lymphangiomatosis | Uremia | Spinocerebellar Ataxia Type 2 | Saethre-Chotzen Syndrome | Tendinitis | Nanophthalmos | Anemia | Myopathy | X-linked Myotubular Myopathy | Thrombosis | Systemic Lupus Erythematosus | Blastomycosis | Leber Hereditary Optic Neuropathy | Coronary Heart Disease | Spondylolisthesis | Limb Girdle Muscular Dystrophy | Granuloma Annulare | Sleep Apnea, Central | Otosclerosis | Colitis, Collagenous | Genee-Wiedemann Syndrome | Nemaline Myopathy 10 | Congenital Adrenal Hyperplasia 1 | Leukoplakia, Oral | Familial Glucocorticoid Deficiency | Ischemia | Sotos Syndrome | Danon Disease | Mixed Connective Tissue Disease | Gastric Atrophy | Epilepsy, Generalized | Cholangiocarcinoma | Spinocerebellar Ataxia Type 21 | Potocki-Shaffer Syndrome | PASLI Disease | Multiple Mitochondrial Dysfunctions Syndrome Type 1 | Mucolipidosis Type IV | Hyperammonemia | Pseudoexfoliation Syndrome | Relapsing Polychondritis | Obesity, Morbid | Goiter | Nephronophthisis | Cholelithiasis | Acral Lentiginous Melanoma | Hereditary Spastic Paraplegia | Cerebellar Ataxia, Cayman Type | Hypospadias | Succinic Semialdehyde Dehydrogenase Deficiency | Heart Failure | Idiopathic Pulmonary Fibrosis | Hypoproteinemia, Hypercatabolic | Peeling Skin Syndrome, Acral Type | Lattice Corneal Dystrophy | Sleep Apnea | Meningococcal Infections | Cutaneous Angiosarcoma | Ebstein Anomaly | Hereditary Mixed Polyposis Syndrome | Cole-Carpenter Syndrome | Poikiloderma With Neutropenia | McLeod Syndrome | Neurogenic Bladder | MIRAGE Syndrome | Glycogen Storage Disease Type 0, Muscle | Poirier-Bienvenu Neurodevelopmental Syndrome | Celiac Disease | Krabbe Disease | Retinal Diseases | C3 Glomerulopathy | HELLP Syndrome | Neurocysticercosis | Hypophosphatasia | Congenital Afibrinogenemia | Hyperphosphatasia With Intellectual Disability Syndrome 4 | Frontometaphyseal Dysplasia | Oculocutaneous Albinism Type 4 | Tularemia | Chromosome 8q21.11 Deletion Syndrome | ADNP Syndrome | Hereditary Inclusion Body Myopathy | Donnai-Barrow Syndrome | Bacterial Meningitis | Extramammary Paget's Disease | Pleurisy | Hyperekplexia | Mitochondrial Myopathy | Priapism | Synpolydactyly | Glomerulonephritis | Hypertrophy | Asperger Syndrome | Tic Disorder | Chorioretinitis | Nail Disorder, Nonsyndromic Congenital | Keloid | Lipid Storage Myopathy | Dent Disease | Lymphomatoid Granulomatosis | Infertility | Vitamin B12 Deficiency | Osteogenesis Imperfecta Type IV | Thanatophoric Dysplasia Type 1 | Usher Syndrome Type II | Erysipelas | GNE Myopathy | Diabetes Gestational | Pseudohypoparathyroidism Type 2 | SAPHO Syndrome | Non-Hodgkin Lymphoma | Meningitis | Thrombasthenia | Pemphigus Vulgaris | Parkinson Disease 6, Autosomal Recessive Early-onset | Adrenoleukodystrophy, X-linked | Cardiofaciocutaneous Syndrome | HANAC Syndrome | Amebiasis | Citrullinemia | Scleritis | Megacystis-microcolon-intestinal Hypoperistalsis Syndrome | Cardiac Arrest | Ovarian Sex Cord-stromal Tumor | Hemolytic Uremic Syndrome, Atypical | Small Lymphocytic Lymphoma | Pyruvate Kinase Deficiency | Silicosis | Cluster Headache | Esophageal Adenocarcinoma | Pulverulent Zonular Cataract | Chondrodysplasia Punctata | Avian Influenza | Ectrodactyly | Peroxisomal Disorder | Speech Disorders | Schaaf-Yang Syndrome | Phosphoenolpyruvate Carboxykinase Deficiency, Cytosolic | Glutaric Aciduria Type 1 | Keratoconjunctivitis | Adenylosuccinate Lyase Deficiency | Diabetes | Dysthymia | Intracerebral Hemorrhage | Spinocerebellar Ataxia Type 1 | Marfan Syndrome | Autoimmune Polyendocrinopathy Syndrome Type I | Papillon-Lefevre Syndrome | Carcinoma, Small Cell | Rett Syndrome | Dystonia Musculorum Deformans | Lymphoproliferative Disease, X-linked | Vitamin K Deficiency | Charcot-Marie-Tooth Disease Type 2D | Carcinoma In Situ | Down Syndrome | Autosomal Recessive Spastic Paraplegia Type 75 | Waldenstrom Macroglobulinemia | Vulvovaginitis | Spinocerebellar Ataxia Type 20 | Hypertelorism | Allergic Contact Dermatitis | Hamartoma | 3-hydroxy-3-methylglutaryl-CoA Synthase Deficiency | Scapuloperoneal Myopathy, X-linked Dominant