Disease

Arteriosclerosis

About the Disease
Arteriosclerosis, also known as arteriosclerotic vascular disease, is related to arteriosclerosis obliterans and aortic atherosclerosis, and has symptoms including angina pectoris An important gene associated with Arteriosclerosis is HS3ST1 (Heparan Sulfate-Glucosamine 3-Sulfotransferase 1), and among its related pathways/superpathways are Metabolism and Extracellular matrix organization. The drugs Estradiol and Polyestradiol phosphate have been mentioned in the context of this disorder. Affiliated tissues include heart, endothelial and smooth muscle, and related phenotypes are Increased free cholesterol and homeostasis/metabolism

Common Targets
Diacylglycerol Acyltransferase (DGAT) (nonspecified subtype) | EPHX2 | MTHFR | GPR119 | NR1H2 | PIK3CA | IL37 | ALOX5AP | DGAT1 | MOGAT2 | Phosphodiesterase 1 (PDE1) (nonspecified subtype) | CA5A | AURKB | PGR | mTOR complex 1 | Phospholipase A2 (nonspecified subtype) | NR1H3 | SCD | MGAT2 | GCK | HSD11B1 | KDR | TGFBR1 | SGK1 | SLC22A12 | ABCA1 | NOS3 | CA6 | AKR1B1 | XDH | PPARD | TLR2 | PCSK9 | S1PR2 | G3480 | G3569 | Guanylate cyclase (nonspecified subtype) | HPGD | Peroxisome Proliferator-Activated Receptors (PPAR) (nonspecified subtype) | Oxysterols receptor LXR (nonspecified subtype) | NR1H4 | MRC1 | G5595 | DACH1 | HTR2A | CA7 | GIPR | ALKBH3 | MTHFD2 | PTGER4 | CA13 | RORA | TEK | G7124 | AGTR1 | Trypsin (nonspecified subtype) | NOS2 | CCND3 | JAK2 | NF-kappaB (NFkB) | mTOR complex 2 | ADIPOR1 | Transforming growth factor beta (nonspecified subtype) | Proteasome Complex | CCR5 | NLRP3 Inflammasome | SOAT1 | G114548 | Sterol O-acyltransferase (ACAT) (nonspecified subtype) | RORB | LPAR4 | SLC10A2 | AGER | SGMS2 | ADH5 | MEP1A | G7099 | G3146 | GLP1R | MEP1B | PIK3CG | Focal Adhesion Kinases (FAK) (nonspecified subtype) | CDK6/Cyclin D3 | Arginase (nonspecified subtype) | CYP11B2 | PLA2G7 | Angiotensin receptor (AT) (nonspecified subtype) | ESRRG | CD19 | HMOX1 | MTR | Soluble guanylyl cyclase | Rho kinase (ROCK) (nonspecified subtype) | S1PR1 | SOAT2 | AMP-activated protein kinase (AMPK) | RETN | ACE | CMA1 | AURKA | LIPG | RORC | CSF1R | ENPP2 | PDGFRB | GCGR | LDLR | SPP1 | GPBAR1 | G2475 | Transforming growth factor (TGF)-beta receptor (nonspecified subtype) | CDK4/Cyclin D3 | CETP | ND6 | LCAT | SCN10A | CDK4 | GPR35 | PPARA | E2F1 | PPARG | Fibrinogen | Integrin alphavbeta3 (vitronectin) receptor | Phosphatidylinositol 3-kinase (PI3K) (nonspecified subtype) | VWF | G2335 | LPL | PTGES | CNR1 | RNR1

疾病靶点研报
Arteriosclerosis

Note: If you'd like to get a target analysis report for Arteriosclerosis, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Arteriosclerosis at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Pulmonary Tuberculosis | Cirrhosis | Neurodegeneration With Brain Iron Accumulation | Hypertrophy | Colon Adenoma | Thrombocytopenia | Emery-Dreifuss Muscular Dystrophy | Spinal Muscular Atrophy | Alazami Syndrome | Benign Familial Infantile Seizures | Stickler Syndrome | Spinocerebellar Ataxia Type 12 | Vascular Calcification | Benign Recurrent Intrahepatic Cholestasis 1 | Nemaline Myopathy 8 | AIDS Dementia Complex | Leiomyoma | Atopic Dermatitis | Inflammatory Joint Disease | Joubert Syndrome | Esophageal Carcinoma | Carcinoid Tumor | Tumoral Calcinosis | Hypomyelination With Atrophy Of Basal Ganglia And Cerebellum | Stargardt Disease | Diabetes Insipidus, Nephrogenic | Williams Syndrome | Retinal Vasculitis | Diabetic Nephropathy | Thyroiditis, Autoimmune | Polyomavirus Nephropathy | Headache | Hypercholesterolemia, Familial | Greenberg Dysplasia | Brachial Plexus Neuropathy | Keratitis | Seminoma | Amelanotic Melanoma | Tetraplegia | Subcortical Band Heterotopia | Coma | Hydronephrosis | Avellino Corneal Dystrophy | Usher Syndrome Type I | Vitiligo | Eosinophilic Asthma | Behavioral Variant Of Frontotemporal Dementia | Follicular Dendritic Cell Sarcoma | Primary Lateral Sclerosis | Spondyloepimetaphyseal Dysplasia With Joint Laxity, Type 3 | Proximal Symphalangism | High Molecular Weight Kininogen Deficiency | Smith-Lemli-Opitz Syndrome | Nephroblastoma | Saethre-Chotzen Syndrome | Endocarditis | Retinal Coloboma | Sick Sinus Syndrome 1 | Rubeosis Iridis | Becker Muscular Dystrophy | Waardenburg Syndrome | Congenital Hereditary Endothelial Dystrophy Type II | Arthritis | Coenzyme Q10 Deficiency | Methylmalonic Acidemia | Acanthosis Nigricans | Carbamoyl Phosphate Synthetase I Deficiency | Dermatomyositis | Combined Pituitary Hormone Deficiency | Bruck Syndrome | Waardenburg Syndrome Type 1 | Myelitis | Amyotrophic Lateral Sclerosis | Delayed Sleep Phase Syndrome | Keratocystic Odontogenic Tumor | Angioedema, Hereditary | Pneumoconiosis | Benign Hereditary Chorea | Spinal Cord Diseases | Agoraphobia | VEXAS Syndrome | Hyperuricemic Nephropathy, Familial Juvenile | Parkinsonism | Glioblastoma | Oculopharyngeal Muscular Dystrophy | Impetigo | Hemorrhoids | Ischemia | Phenylketonuria II | Greig Cephalopolysyndactyly Syndrome | Schaaf-Yang Syndrome | Astrocytoma, Anaplastic | Duane Retraction Syndrome | Episodic Ataxia Type 2 | Dystonia | Pyruvate Kinase Deficiency | Methemoglobinemia Type IV | Hemolytic Uremic Syndrome | Glioma | Myopathy | Chanarin-Dorfman Syndrome | Acute Chest Syndrome | Cardiospondylocarpofacial Syndrome | Rhabdomyosarcoma, Alveolar | Adenoma, Pleomorphic | C3 Glomerulonephritis | Relapsing Polychondritis | Chronic Idiopathic Myelofibrosis | Intestinal Tuberculosis | Papilledema | Neurofibrosarcoma | Bladder Exstrophy | Canavan Disease | Congenital Primary Aphakia | Gerodermia Osteodysplastica | Keratitis-ichthyosis-deafness Syndrome | Heart Failure | Melanocytic Nevus | Ophthalmoplegia | Intracranial Hypertension | Hereditary Neuropathy With Liability To Pressure Palsies | Meleda Disease | Multiple Sulfatase Deficiency | Isobutyryl-CoA Dehydrogenase Deficiency | Congenital Stationary Night Blindness | Leukoplakia, Oral | Alopecia | Ovarian Hyperstimulation Syndrome | Peritonitis | Diffuse Mesangial Sclerosis | Melnick-Needles Syndrome | Rhabdoid Tumor | Familial Advanced Sleep Phase Syndrome | Mitochondrial DNA Depletion Syndrome 13 | Proctitis | Ataxia-ocular Apraxia 2 | Vitreoretinal Degeneration, Snowflake Type | Corneal Dystrophy | Polyarteritis Nodosa | Blepharospasm | Pericarditis | Conduct Disorder | Familial Male-limited Precocious Puberty | Gout | Galloway-Mowat Syndrome | Hyperparathyroidism, Secondary | Hepatitis, Alcoholic | Fibrodysplasia Ossificans Progressiva | Choreoathetosis, Hypothyroidism, And Neonatal Respiratory Distress | Tardive Dyskinesia | Schizophrenia | Lattice Corneal Dystrophy | Measles | Hemolytic Uremic Syndrome, Atypical | Angiosarcoma Of The Breast | Aicardi-Goutieres Syndrome | 6-pyruvoyl-tetrahydropterin Synthase Deficiency | Chromosome 8q21.11 Deletion Syndrome | Venous Insufficiency | Dystrophy, Cone-rod | Donnai-Barrow Syndrome | Occipital Neuralgia | Reticular Dysgenesis | Riboflavin Transporter Deficiency Neuronopathy | Echinococcosis | Ectopia Lentis, Isolated, Autosomal Recessive | Sclerosteosis 2 | Ocular Albinism Type 1 | Parapsoriasis | Cyst | Nemaline Myopathy | Toxoplasmosis | Pulmonary Sclerosing Hemangioma | Lichen Sclerosus | Trichothiodystrophy | Hypersomnia | Waardenburg Syndrome Type 2 | Coronary Heart Disease | Macrophagic Myofasciitis | Gnathodiaphyseal Dysplasia | Alpers Syndrome | Biotinidase Deficiency | Goiter | Cherubism | Sensory Ataxic Neuropathy, Dysarthria, And Ophthalmoparesis | Imerslund-Grasbeck Syndrome | Ocular Surface Squamous Neoplasia | Supravalvular Aortic Stenosis | Cholestasis | Preaxial Polydactyly | Cantu Syndrome | Epidermolysis Bullosa Simplex, Localized | Muckle-Wells Syndrome | Microcephaly | Pneumothorax | Lymphoproliferative Disease, X-linked | Myelomeningocele | Thrombotic Microangiopathy | Periventricular Leukomalacia | Pseudoexfoliation Syndrome | Connective Tissue Disorders | 3-hydroxy-3-methylglutaryl-CoA Synthase Deficiency | KBG Syndrome | Marfan Syndrome | Cousin Syndrome | Lassa Fever | Nephropathy | Pulverulent Zonular Cataract | Polycystic Ovary Syndrome | Mesial Temporal Lobe Epilepsy With Hippocampal Sclerosis | Gastric Atrophy | Renal Medullary Carcinoma | Thalassemia, Beta | Cervicitis | Atherosclerosis | Ulcerative Colitis | Pancytopenia | VACTERL/VATER Association | Sarcoma, Endometrial Stromal | Usher Syndrome Type III | Multiple System Atrophy | Mucormycosis | Cone Dystrophy | Chondrodysplasia Punctata 2, X-linked Dominant | Dengue Hemorrhagic Fever | Epiphyseal Chondrodysplasia, Miura Type | Language Disorders | Moyamoya Disease | Cardiomyopathy, Hypertrophic | Epidermolytic Ichthyosis, Annular | Primary Hyperoxaluria | Fahr Disease | Cranioectodermal Dysplasia | Primary Cutaneous Amyloidosis | Nephritis, Interstitial | Blau Syndrome | Parkinson Disease 6, Autosomal Recessive Early-onset | Hepatitis E | Lymphoproliferative Disorders | Creatine Deficiency Syndrome | Pompe Disease | Hemimegalencephaly | Acute Coronary Syndrome | Cleidocranial Dysplasia | Binge Eating Disorder | Familial Glucocorticoid Deficiency | Glaucoma, Congenital | Enterocolitis, Necrotizing | Menkes Disease | Hypertension, Renovascular | Joubert Syndrome 2 | Tuberculosis | Congenital Absence Of Vas Deferens | Cushing Syndrome | Charcot-Marie-Tooth Disease, Type 2C | Hyperphosphatasia With Intellectual Disability Syndrome 4 | Von Willebrand Disease | Guttate Psoriasis | Microcephaly, Seizures, And Developmental Delay | Central Retinal Artery Occlusion | Myhre Syndrome | Dysmorphophobia | Carcinoma, Signet Ring Cell | Polycystic Liver | Borderline Personality Disorder | Gerstmann-Straussler-Scheinker Syndrome | Insulin Resistance | Guanidinoacetate Methyltransferase Deficiency | Urolithiasis | Rotor Syndrome | Skin Carcinoma | Spasticity | Lichen Planus | Chondromyxoid Fibroma | Neuropathy | Traboulsi Syndrome | Autosomal Recessive Bestrophinopathy | Yellow Fever | Congenital Dyserythropoietic Anemia Type 1 | Prediabetes | Epithelioid Hemangioma | Treacher Collins Syndrome | Brooke-Spiegler Syndrome | Lentigo | Liver Failure | Intestinal Hypomagnesemia 1 | Sarcomatoid Carcinoma Of The Lung | Conjunctivitis, Allergic | Encephalopathy | Multifocal Motor Neuropathy | Cholangiocarcinoma | Spinal And Bulbar Muscular Atrophy | Ameloblastoma | Spitzoid Melanoma | Carpal Tunnel Syndrome | Depression | Erythropoietic Protoporphyria | Agranulocytosis | Hypertension | Mitochondrial DNA Depletion Syndrome | PHARC Syndrome | Glomerulonephritis, Membranoproliferative | Localized Scleroderma | Tracheal Disorders | DRESS Syndrome | Mitochondrial Encephalomyopathy | Esophagitis | CEDNIK Syndrome | Charcot-Marie-Tooth Disease, Type 2 | Ehlers-Danlos Syndrome With Progressive Kyphoscoliosis, Myopathy, And Hearing Loss | 3-methylglutaconic Aciduria Type I | Charcot-Marie-Tooth Disease Type 4B1 | Leiomyosarcoma | Hyperkeratosis | Withdrawal Syndrome | Nail-Patella Syndrome | Tietze Syndrome | Sclerocornea | Hypervalinemia | Autosomal Recessive Spastic Paraplegia Type 35 | Congenital Adrenal Hyperplasia | Eczema | Pseudo-pseudohypoparathyroidism | Costello Syndrome | Malonyl-CoA Decarboxylase Deficiency | Chronic Inflammatory Demyelinating Polyneuropathy | Fibrillation, Atrial | Liebenberg Syndrome | Hereditary Multiple Exostoses | Spinocerebellar Ataxia Type 27 | Adenoma, Pituitary | Exfoliative Dermatitis | Anti-NMDA Receptor Encephalitis | Ehlers-Danlos Syndrome | Harlequin Ichthyosis | DICER1 Syndrome | Nephrocalcinosis | Necrobiosis Lipoidica | Congenital Torticollis | Myoclonic Atonic Epilepsy | Papilloma | Retinopathy Of Prematurity | Urea Cycle Disorder | Kaposiform Hemangioendothelioma | Porphyria Cutanea Tarda | Cockayne Syndrome | Adenosine Deaminase Deficiency | Rolandic Epilepsy | Noonan Syndrome-like Disorder With Loose Anagen Hair | Retinal Degeneration | Tendinopathy | Celiac Disease | Hyperparathyroidism | X-linked Sideroblastic Anemia | Idiopathic Multicentric Castleman Disease | Hypertension, Portal | Osteogenesis Imperfecta | Hypotrichosis | Spondylosis | Coronary Restenosis | Fanconi Anemia | Glycogen Storage Disease Type 5 | Hypertriglyceridemia | Antithrombin III Deficiency | Aphasia | Dermatitis | Hyperhomocysteinemia | Alopecia Areata | Oguchi Disease-2 | Epidermolytic Palmoplantar Keratoderma | Thyroid Dyshormonogenesis | Rhabdomyosarcoma, Embryonal | Dentinogenesis Imperfecta | Sclerosing Cholangitis | Cryopyrin-associated Periodic Syndromes | Craniofacial Dysostosis | Benign Familial Pemphigus | Hypoplastic Left Heart Syndrome | Mastitis | Autonomic Nervous System Disorders | Tremor | Tic Disorder | Loeys-Dietz Syndrome Type 4 | Colitis, Microscopic | Disseminated Intravascular Coagulation | Melanoma | Skin Fragility-woolly Hair Syndrome | Duchenne Muscular Dystrophy | GATA2 Deficiency | Spinocerebellar Ataxia Type 17 | Pneumonia, Bacterial | Schnyder Crystalline Corneal Dystrophy | Ependymoma | Birk-Barel Syndrome | Neural Tube Defect | Palmoplantar Keratoderma | Arthritis, Psoriatic | Nicotine Addiction | Neurocysticercosis | Combined Deficiency Of Factor V And Factor VIII