Congenital Heart Defects

About the Disease
Heart Disease, also known as heart failure, is related to lipoprotein quantitative trait locus and heart valve disease, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Heart Disease is NKX2-5 (NK2 Homeobox 5), and among its related pathways/superpathways are Cardiac conduction and Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases. The drugs Salbutamol and Eprosartan have been mentioned in the context of this disorder. Affiliated tissues include heart, bone marrow and kidney, and related phenotypes are muscle and embryo

Common Targets
HRK | PAX1 | DYSF | PTPRD | PLD1 | FGF3 | DNMT3A | POLR1HASP | RBFOX1 | MESP1 | MAOA | SEPTIN5 | TBX1 | THSD4 | GATA4 | CDK13 | BMP4 | OR11A1 | UBA7 | ATIC | SLC9A2 | MSX1 | KIAA1217 | PSMB9 | NFATC1 | SCGB2B2 | CNOT1 | G4851 | MMP21 | GDF1 | HSD17B4 | NRG1 | LZTR1 | COL4A1 | ABCA9 | DNAI1 | TNFSF11 | ASXL3 | MTHFR | G5243 | NRG2 | GATA6 | FGFR1 | MTHFS | TLK2 | MTRR | CRACR2B | RBFOX2 | PRKD1 | NTRK3 | SMAD6 | GART | IQGAP2 | MKRN2 | DNAH5 | MIR143 | RIPPLY3 | SLC24A3-AS1 | SMAD7 | NOS3 | ZFHX3 | PIMREG | CHD7 | SLC19A1 | PLXND1 | DNMT3B | GJA8 | PUM1 | KDR | MEF2C | FGF8 | NKX2-5 | MIR145 | KRT71 | PBX3 | LARS1 | IGFBP3 | CBR1 | PRRC2B | CCAR1 | IARS1 | TCN1 | G3845 | RAF1 | CTSA | MIB1 | RARB | TBX2 | AP4B1-AS1 | JAG1 | MTHFD1 | G7422 | POLG | NRP1 | AXIN1 | NTRK3-AS1 | RPL10A | GATA5 | TCTN3 | DNHD1 | TCN2 | HAND1 | ST20-MTHFS | CBS | LIPC | TGFB2 | TBCK | TNR | GSTP1 | PTPRT | MALAT1 | ZFPM2 | TBX5 | OR5V1 | PIM1 | ZNF423 | PTPN22 | MAP2K2 | SRPK2 | MGMT | LEFTY1 | LTBP2 | ELN | KARS1 | G1786 | NR2F2 | MARS1 | FIGN | PTPN11 | MDN1 | KMT2D | APOE | STX18-AS1 | SMAD3 | MYH6 | AARSD1 | FGFBP2 | GLB1 | USF3 | FUT2 | DPY19L2P1 | CHD4 | FOXH1 | NKX2-6 | FLNB | ZIC3 | MTR | ABL1 | ALPK2 | BCL6 | SLC24A3 | EPRS1 | ACTC1 | TPM1 | MYO1E | Soluble guanylyl cyclase | SCN5A | TSHZ2 | DARS1 | HOXC9 | PLCB1 | IRX4 | PARD6G | G673 | RCAN1 | MYH7 | MAML3 | ST20 | MIR663A | DLL4 | TSC22D1 | MYRF | PRAMEF12 | NPR2 | SOGA1 | SHMT1 | C17orf97 | GZMH | LOC105372669 | NODAL | PGM1 | LEFTY2 | DNAH9 | DES | POLR1H | CARMN | RARS1 | CUBN | CHST11 | YIF1B | BMPR2 | TBX20 | SOX7 | ISL1 | CRELD1 | LINC01951

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