Disease

Primary Lateral Sclerosis

About the Disease
Lateral Sclerosis, also known as primary lateral sclerosis, is related to frontotemporal dementia and/or amyotrophic lateral sclerosis 2 and frontotemporal dementia and/or amyotrophic lateral sclerosis 3, and has symptoms including ataxia, muscular fasciculation and hemiplegia. An important gene associated with Lateral Sclerosis is SPG7 (SPG7 Matrix AAA Peptidase Subunit, Paraplegin), and among its related pathways/superpathways is Amyotrophic lateral sclerosis (ALS). The drugs Mexiletine and Dronabinol have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, bone marrow and brain, and related phenotypes are babinski sign and abnormal upper motor neuron morphology

Common Targets
CCNF | C9orf72 | ALS2 | CSF1R

疾病靶点研报
Primary Lateral Sclerosis

Note: If you'd like to get a target analysis report for Primary Lateral Sclerosis, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Primary Lateral Sclerosis at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Fetal Akinesia Deformation Sequence | Best Macular Dystrophy | Short-chain Acyl-CoA Dehydrogenase Deficiency | Neurodermatitis | Hyperglycemia | Malnutrition | Tremor | Microcephaly, Seizures, And Developmental Delay | Congenital Tufting Enteropathy | Ocular Surface Squamous Neoplasia | GNE Myopathy | Pityriasis Rubra Pilaris | CHOPS Syndrome | Birk-Barel Syndrome | Binge Eating Disorder | Spinocerebellar Ataxia Type 42 | Atopy | Pseudohypoaldosteronism | Thin Basement Membrane Disease | Holt-Oram Syndrome | Non-Hodgkin Lymphoma | Colitis, Collagenous | Meier-Gorlin Syndrome | Tendinopathy | Klinefelter Syndrome | Transcobalamin Deficiency | Epidermolysis Bullosa | Vestibular Disease | Juvenile Polyposis | Prediabetes | Intracranial Hypertension | Cholestasis, Intrahepatic | Metachondromatosis | Reticular Dysgenesis | Hepatorenal Syndrome | Menkes Disease | Aphasia | Vaginitis | Bietti Crystalline Dystrophy | Neurodevelopmental Disorder With Central Hypotonia And Dysmorphic Facies | Gastritis | Metabolic Syndrome | Spinocerebellar Ataxia Type 14 | Branchiootorenal Syndrome | Pain | Constipation | Osteogenesis Imperfecta Type I | Psoriasis | Generalized Epilepsy With Febrile Seizures Plus | Gilbert Syndrome | Neuroblastoma | Cardiac Sarcoidosis | Hemosiderosis | Nicotine Addiction | Retinal Coloboma | Astrocytoma | Phosphoglycerate Dehydrogenase Deficiency | Usher Syndrome | Myositis, Focal | Pulmonary Tuberculosis | Infantile Neuroaxonal Dystrophy | Gingivitis | Antithrombin III Deficiency | Lymphomatoid Granulomatosis | Rothmund-Thomson Syndrome | Spinocerebellar Ataxia Type 2 | Carpenter Syndrome | Basal Ganglia Disease, Biotin-responsive | Sjogren Syndrome | Greenberg Dysplasia | Long QT Syndrome Type 1 | Congenital Poikiloderma | Swine Influenza | Carbohydrate Metabolism Disorders | Whipple's Disease | Oculocutaneous Albinism | Cone Dystrophy | Infantile Spasm | Takayasu's Arteritis | Thyroiditis, Autoimmune | Urethritis | Craniometaphyseal Dysplasia | Graft-versus-host Disease | Polymyositis | Dupuytren Disease | Pernicious Anemia | Donnai-Barrow Syndrome | Infantile Liver Failure Syndrome 1 | Hydronephrosis | Hyperprolactinemia | Atrioventricular Septal Defect | Neurodegeneration With Brain Iron Accumulation | Wolff-Parkinson-White Syndrome | Palmoplantar Keratoderma | Gastric Atrophy | Hyperparathyroidism, Primary | Barrett Esophagus | Richter's Syndrome | Learning Disability | Oculocutaneous Albinism Type 1 | Hemorrhoids | Hypertension, Renovascular | Methemoglobinemia | Creatine Deficiency Syndrome | Tangier Disease | Adrenal Insufficiency | Charcot-Marie-Tooth Disease Type 4D | Sleep Disorder | Pseudohypoparathyroidism Type 1C | Early Infantile Epileptic Encephalopathy 4 | Becker Muscular Dystrophy | Osteosclerosis | Premenstrual Syndrome | Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia | Spinal Muscular Atrophy Type 2 | Spondylo-megaepiphyseal-metaphyseal Dysplasia | DiGeorge Syndrome | Herpes Simplex Dermatitis | Congenital Nephrotic Syndrome | Limb Girdle Muscular Dystrophy | Optic Neuropathy, Anterior Ischemic | Veno-occlusive Disease | Waardenburg Syndrome Type 2E | Diarrhea | Cryoglobulinemia | Adult Polyglucosan Body Disease | Epidermolysis Bullosa Simplex, Dowling-Meara Type | Alpers Syndrome | Spinocerebellar Ataxia Type 28 | Woodhouse-Sakati Syndrome | Glaucoma | Paroxysmal Kinesigenic Dyskinesia | Microcephalic Primordial Dwarfism | Arthropathy | Hepatitis A | Krabbe Disease | Congestive Heart Failure | Coffin-Lowry Syndrome | Acute Leukemia | B-cell Prolymphocytic Leukemia | Corneal Dystrophy | Cardiomyopathy, Dilated, 1L | Choreoathetosis, Hypothyroidism, And Neonatal Respiratory Distress | Cardiomyopathy, Restrictive | Familial Partial Lipodystrophy | Alopecia Areata | Osteoporosis | Hemimegalencephaly | Systemic Lupus Erythematosus | Rash | Hairy Cell Leukemia | Thrombophlebitis | Hyperacusis | Hyperparathyroidism | Potocki-Shaffer Syndrome | Jaundice, Obstructive | Adenylosuccinate Lyase Deficiency | Epidermolysis Bullosa Simplex, Generalized | Neuromyelitis Optica | Hypobetalipoproteinemias | Fatty Aldehyde Dehydrogenase Deficiency | Retinal Telangiectasia | Hypophosphatemic Rickets, Autosomal Recessive, 1 | Conduct Disorder | Optic Neuropathy | Epidermolytic Hyperkeratosis | Primary Erythromelalgia | Neurofibroma | Distal Myopathy | Angioedema, Acquired | Hyperphenylalaninemia | Schnitzler Syndrome | Acute Lymphocytic Leukemia | Charcot-Marie-Tooth Disease, Type 2C | Epidermolysis Bullosa Simplex With Mottled Pigmentation | Erythromelalgia | Desbuquois Syndrome | Renpenning Syndrome | Ganglioneuroma | Congenital Heart Defects | Mucolipidosis | Batten Disease | Fibromuscular Dysplasia | Chronic Thromboembolic Pulmonary Hypertension | Choroiditis | Pyloric Stenosis, Infantile Hypertrophic | Disseminated Intravascular Coagulation | Alstrom Syndrome | Major Depression | Methylmalonic Acidemia | Sporadic Hemiplegic Migraine | Angiosarcoma Of The Breast | Hypertension, Renal | Myoclonic Epilepsy With Ragged Red Fibers | Maple Syrup Urine Disease | Postpartum Depression | Spinocerebellar Ataxia Type 21 | Hypervalinemia | Cryptosporidiosis | Addison Disease | Persistent Fetal Circulation | Polycystic Liver | Deafness, Dystonia, And Cerebral Hypomyelination | Spinal Muscular Atrophy With Progressive Myoclonic Epilepsy | Non-bullous Congenital Ichthyosiform Erythroderma | Chronic Neutrophilic Leukemia | Pulmonary Sclerosing Hemangioma | Acute Myeloid Leukemia | Netherton Syndrome | Malaria, Cerebral | Thrombosis | Sickle Cell Anemia | Zygomycosis | Cerebral Cavernous Malformations | Asthma | Familial Pheochromocytoma-paraganglioma | Lymphedema-distichiasis Syndrome | Fuchs Dystrophy | Camurati-Engelmann Disease | Pachyonychia Congenita | Hypocalcemia | Granuloma Annulare | Multiple Epiphyseal Dysplasia | Pleomorphic Xanthoastrocytoma | Uremia | Stevens-Johnson Syndrome | Malaria | Apparent Mineralocorticoid Excess Syndrome | Bardet-Biedl Syndrome | Primary Carnitine Deficiency | Raynaud Phenomenon | Keratosis, Actinic | Diabetes Insipidus, Nephrogenic | Spinocerebellar Ataxia Type 1 | Cleidocranial Dysplasia | Analgesia | Bleeding Disorder Due To CalDAG-GEFI Deficiency | Amyotrophic Lateral Sclerosis-parkinsonism-dementia Complex | VEXAS Syndrome | Waardenburg Syndrome Type 2A | Thrombophilia | Parkinsonism | Adenoma, Villous | Hepatitis | Nance-Horan Syndrome | Spinocerebellar Ataxia Type 13 | Acute Tubular Necrosis | Stuve-Wiedemann Syndrome | Familial Cerebral Amyloid Angiopathy | Hepatitis C, Chronic | Bladder Exstrophy | Thrombocytopenia | Language Disorders | Poirier-Bienvenu Neurodevelopmental Syndrome | Fetal And Neonatal Alloimmune Thrombocytopenia | Sorsby Fundus Dystrophy | 3-methylglutaconic Aciduria | Plasma Cell Leukemia | Common Variable Immunodeficiency | Lamellar Ichthyosis | Fontaine Progeroid Syndrome | Infantile Nephropathic Cystinosis | Paget's Disease Of The Breast | Cutaneous Angiosarcoma | Isovaleric Acidemia | Still Disease | Niemann-Pick Disease, Type C | Crouzon Syndrome With Acanthosis Nigricans | Medulloblastoma | Diabetes | Endometriosis | Dysfibrinogenemia | Mucormycosis | Hydrocephalus | Retinal Dystrophy | Creutzfeldt-Jakob Disease | Cryptorchidism | Hepatitis B, Chronic | Xeroderma Pigmentosum Variant Type | Trigonocephaly | Hyperbilirubinemia | Hypokalemic Periodic Paralysis | X-linked Creatine Transporter Deficiency | Scleritis | Neuroma | Cri-du-chat Syndrome | Pathological Gambling | Rhizomelic Chondrodysplasia Punctata | Blepharoconjunctivitis | Systemic Mastocytosis | Fascioliasis | Ehlers-Danlos Syndrome With Progressive Kyphoscoliosis, Myopathy, And Hearing Loss | Myofibrillar Myopathy | Early Infantile Epileptic Encephalopathy 1 | Sarcoma, Endometrial Stromal | Malignant Peripheral Nerve Sheath Tumor | Hereditary Elliptocytosis | Macular Corneal Dystrophy | Neuromuscular Disorders | Pyruvate Decarboxylase Deficiency | Dystrophy, Cone-rod | Achondrogenesis | Aspergillosis | Amyloidosis | Lymphoma | Atelosteogenesis Type 1 | Trichomegaly | VACTERL/VATER Association | Twin-to-twin Transfusion Syndrome | Endometritis | Tenosynovial Giant Cell Tumor | Nicotine Dependence | Keratitis-ichthyosis-deafness Syndrome | Hyperostosis | Motor Neuron Diseases | Molybdenum Cofactor Deficiency | Tic Disorder | Miyoshi Myopathy | Epicondylitis | ICF Syndrome | Neurotoxicity | Sarcomatoid Carcinoma Of The Lung | Palsy, Cerebral | Juvenile Xanthogranuloma | Poretti-Boltshauser Syndrome | Polymicrogyria | Actinomycetoma | Neurogenic Bladder | Agnathia-Otocephaly Complex | Papillorenal Syndrome | Sickle Cell Disease | Pituitary Stalk Interruption Syndrome | Leprosy | Incontinentia Pigmenti | Salla Disease | Carey-Fineman-Ziter Syndrome | Brachydactyly | Chronic Kidney Disease | Adenoid Cystic Carcinoma | Sialidosis Type I | Muckle-Wells Syndrome | Imerslund-Grasbeck Syndrome | Purpura, Thrombotic Thrombocytopenic | Scapuloperoneal Spinal Muscular Atrophy | Bronchitis | Prostatitis | Charcot-Marie-Tooth Disease Type 2E | Basal Ganglia Cerebrovascular Disease | Congenital Dyserythropoietic Anemia Type 4 | Heart Failure | Epiphyseal Chondrodysplasia, Miura Type | Retinopathy, Diabetic | Achromatopsia | Blau Syndrome | Hereditary Neuropathy With Liability To Pressure Palsies | Lysosomal Acid Lipase Deficiency | Cocaine-Related Disorders | Mast Cell Leukemia | Amyotrophic Lateral Sclerosis, Juvenile | Epidermodysplasia Verruciformis | Cerebral Amyloid Angiopathy | Peripheral T-cell Lymphoma | Intracerebral Hemorrhage | Long QT Syndrome Type 2 | Fundus Albipunctatus | Neurocutaneous Melanocytosis | Hereditary Multiple Exostoses | Familial Dysautonomia | Cataplexy | Neurofibroma, Plexiform | Plasma Cell Dyscrasia | Benign Recurrent Intrahepatic Cholestasis 1 | Chondrosarcoma | Crimean-Congo Hemorrhagic Fever | Focal Cortical Dysplasia Type 2 | Cousin Syndrome | Non-epidermolytic Palmoplantar Keratoderma | Epithelial-myoepithelial Carcinoma | Carcinoma, Small Cell | Intermittent Claudication | Pulmonary Vein Stenosis | Cabezas Syndrome | Superficial Spreading Melanoma | Hemolytic Uremic Syndrome, Atypical | Histoplasmosis | Sandhoff Disease | Danon Disease | Holoprosencephaly | Diabetic Nephropathy | Anorchia | Eosinophilia | Progressive Encephalopathy-optic Atrophy Syndrome | Withdrawal Syndrome | Smith-Lemli-Opitz Syndrome | Odonto-onycho-dermal Dysplasia | Epidermolysis Bullosa Simplex, Localized | Papilledema | Blue Nevus | Vitiligo | Nevus