Primary Lateral Sclerosis

About the Disease
Lateral Sclerosis, also known as primary lateral sclerosis, is related to frontotemporal dementia and/or amyotrophic lateral sclerosis 2 and frontotemporal dementia and/or amyotrophic lateral sclerosis 3, and has symptoms including ataxia, muscular fasciculation and hemiplegia. An important gene associated with Lateral Sclerosis is SPG7 (SPG7 Matrix AAA Peptidase Subunit, Paraplegin), and among its related pathways/superpathways is Amyotrophic lateral sclerosis (ALS). The drugs Mexiletine and Dronabinol have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, bone marrow and brain, and related phenotypes are babinski sign and abnormal upper motor neuron morphology

Common Targets
CCNF | C9orf72 | ALS2 | CSF1R

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