Photosensitivity

About the Disease
Photoparoxysmal Response 1, also known as photosensitivity disease, is related to porphyria, congenital erythropoietic and protoporphyria, erythropoietic, 1, and has symptoms including exanthema, pruritus and photophobia. An important gene associated with Photoparoxysmal Response 1 is PPR1 (Photoparoxysmal Response 1), and among its related pathways/superpathways are superpathway of b heme biosynthesis from glycine and "Platinum Pathway, Pharmacokinetics/Pharmacodynamics". The drugs Fluorouracil and Diclofenac have been mentioned in the context of this disorder. Affiliated tissues include skin, brain and retina, and related phenotypes are eeg with photoparoxysmal response and Increased shRNA abundance (Z-score > 2)

Common Targets
G7099 | PKMYT1 | CHEK1 | LOC102724428 | TIRAP | G3605 | ERCC2 | G836 | CDK1/Cyclin B | G5243 | SIK2 | PRKCB | TLR9 | NOX1 | SIK1 | Serine/Threonine-Protein Kinase PLK (nonspecified subtype) | CDK1 | FCER1A | SIK3 | CR2

Note: If you'd like to get a target analysis report for Photosensitivity, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Photosensitivity at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.tech.

Other Diseases

Mitochondrial DNA Depletion Syndrome | Blepharophimosis Syndrome | Tietze Syndrome | Adult Polyglucosan Body Disease | Rhabdoid Tumor | Knobloch Syndrome | Headache | Homocystinuria | Hemorrhagic Disorders | Skin Fragility-woolly Hair Syndrome | Major Depression | Pancytopenia | Parvovirus B19 Infection | Astrocytoma | Azoospermia | Hydrolethalus Syndrome | Long QT Syndrome Type 2 | Congenital Tufting Enteropathy | Bernard-Soulier Syndrome | Systemic Mastocytosis | Polyradiculopathy | Pulverulent Zonular Cataract | Hypertriglyceridemia | Achromatopsia | Nance-Horan Syndrome | Diabetes Gestational | Syncope | Central Pain Syndrome | Paget's Disease Of The Breast | Steel Syndrome | Acromicric Dysplasia | Dystonia-parkinsonism, X-linked | Acute Motor Axonal Neuropathy | Glucagonoma | Stuttering | Polymicrogyria | Swine Influenza | Hypokalemia | Sporadic Inclusion Body Myositis | Micropenis | Pierre Robin Syndrome | Carcinoma, Signet Ring Cell | Thrombasthenia | Osteochondroma | Brachial Plexus Neuropathy | Thrombocythemia, Essential | GM2-gangliosidosis AB Variant | Lymphoma | Polycythemia Vera | Polycystic Liver | Tularemia | Microvillus Inclusion Disease | Frontotemporal Dementia | Van Der Knaap Disease | Corneal Dystrophies, Hereditary | Skin Papilloma | Spinocerebellar Ataxia Type 31 | Glycogen Storage Disease Type 1b | Galactosemia | Diverticulitis | Periodontitis | Postaxial Polydactyly | Familial Glucocorticoid Deficiency | Mood Disorder | Acromesomelic Dysplasia | Juvenile Myoclonic Epilepsy | Niemann-Pick Disease, Type C | Craniofrontonasal Syndrome | Hypodontia | Seizures | 6-pyruvoyl-tetrahydropterin Synthase Deficiency | Meckel-Gruber Syndrome | Tardive Dyskinesia | T-cell Chronic Lymphocytic Leukemia | Fetal And Neonatal Alloimmune Thrombocytopenia | Vertebrobasilar Insufficiency | McLeod Syndrome | Sponastrime Dysplasia | Primary Progressive Nonfluent Aphasia | Large Granular Lymphocytic Leukemia | Erythromelalgia | X-linked Acrogigantism | Spinocerebellar Ataxia Type 8 | Acrodermatitis Enteropathica | Retinal Detachment | Heart Failure | Renal Hypouricemia | Sclerosteosis | Renpenning Syndrome | Vici Syndrome | Werner's Syndrome | Vitreoretinal Degeneration, Snowflake Type | Goldenhar Syndrome | Von Willebrand Disease | Ileitis | Pneumonia, Mycoplasma | Cushing Syndrome | Hypertension, Pulmonary | Low Phospholipid Associated Cholelithiasis | Blood Protein Disorders | Hypoproteinemia, Hypercatabolic | Auriculocondylar Syndrome | Noonan Syndrome | Dyskeratosis Congenita | Rubinstein-Taybi Syndrome | Cerebral Cavernous Malformations | Hemorrhoids | Spasticity | Cutaneous T-cell Lymphoma | Distal Myopathy | Posterior Polar Cataract | Heavy Chain Disease | Temporal Lobe Epilepsy | Alpha-1 Antitrypsin Deficiency | Vestibular Disease | Choroideremia | Pulmonary Alveolar Proteinosis | Leri Pleonosteosis | PASLI Disease | Hypoalbuminemia | IgA Deficiency | Osteosarcoma | Insulin Resistance | Hennekam Lymphangiectasia-lymphedema Syndrome | Ischemia | Vitiligo | Otitis Media | Adenomyosis | Medium-chain Acyl-CoA Dehydrogenase Deficiency | Cancer, Brain | KBG Syndrome | Primrose Syndrome | Diarrhea | Congenital Fiber-type Disproportion Myopathy | Chitayat Syndrome | Adenoma, Pleomorphic | Chiari Malformation Type I | Tay-Sachs Disease | Pneumonia, Viral | Cabezas Syndrome | Spinocerebellar Ataxia Type 5 | Niemann-Pick Disease, Type B | Stroke, Ischemic | Hypotension, Orthostatic | Iron Overload | Charcot-Marie-Tooth Disease Type 4E | Dermatitis | Cutaneous Angiosarcoma | Vertigo | Absence Epilepsy | Esophageal Motility Disorders | Vasculitis | Necrotizing Autoimmune Myopathy | Eosinophilic Asthma | Facioscapulohumeral Muscular Dystrophy Type 1 | Heterotaxy | Waardenburg Syndrome | Infantile Liver Failure Syndrome 1 | Brooke-Spiegler Syndrome | Neurodegeneration With Brain Iron Accumulation | Neurofibromatosis Type 2 | Retinal Dystrophy, Early-onset Severe | Osteosclerosis | Asphyxia Neonatorum | Cancer, Prostate | Juvenile Myelomonocytic Leukemia | Congenital Hypofibrinogenemia | Neurofibromatosis | Rolandic Epilepsy | Cancer, Skin | Retinal Vasculitis | Hemolytic Uremic Syndrome | Dermatomyositis | Gyrate Atrophy Of The Choroid And Retina | Ichthyosis Bullosa Of Siemens | Epidermal Nevus Syndrome | Bacterial Meningitis | Blue Rubber Bleb Nevus Syndrome | Hypolipoproteinemia | Endometriosis | Primary Biliary Cholangitis | Cellulitis | Pompe Disease | Blastomycosis | Glaucoma, Congenital | Phenylketonuria | Extramammary Paget's Disease | Primary Hyperoxaluria Type 3 | DRESS Syndrome | Ameloblastoma | Riboflavin Transporter Deficiency Neuronopathy | Adenoid Cystic Carcinoma | Primary Hyperoxaluria Type 1 | Keloid | Ataxia-hypogonadism-choroidal Dystrophy Syndrome | Treacher Collins Syndrome | Hyperbilirubinemia | Hepatic Veno-occlusive Disease | Wolff-Parkinson-White Syndrome | Lymphoma, Follicular | Oral Lichen Planus | Pleural Tuberculosis | DICER1 Syndrome | Bruck Syndrome | Rubeosis Iridis | Fibronectin Glomerulopathy | Retinal Telangiectasia | Herpes Simplex Dermatitis | Succinic Semialdehyde Dehydrogenase Deficiency | Pulmonary Sclerosing Hemangioma | Bursitis | Idiopathic Pulmonary Fibrosis | Impetigo | Fahr Disease | Methemoglobinemia Type IV | Long-chain 3-hydroxyacyl-coenzyme A Dehydrogenase Deficiency | Renal Tubular Acidosis | Medulloblastoma | Esthesioneuroblastoma | Anodontia | Chylothorax, Congenital | Antisocial Personality Disorder | Osteitis | HUPRA Syndrome | Metachromatic Leukodystrophy | Usher Syndrome Type IIC | Histiocytic Sarcoma | Intestinal Pseudo-obstruction | Hyperthyroidism | Congenital Hereditary Endothelial Dystrophy Type II | Osteoporosis | Episodic Ataxia Type 2 | Focal Facial Dermal Dysplasia | Chorea-acanthocytosis | Alopecia | Cold-induced Sweating Syndrome | Citrullinemia | Cancer, Breast | Chorea | Emery-Dreifuss Muscular Dystrophy | Veno-occlusive Disease | Cockayne Syndrome | Aromatic L-amino Acid Decarboxylase Deficiency | Hyperoxaluria | Keratosis, Seborrheic | Scleroderma | Oligoasthenoteratozoospermia | Cocaine-Related Disorders | Neurodermatitis | Nephrocalcinosis | Cervicitis | Methylmalonic Aciduria And Homocystinuria, CblC Type | DiGeorge Syndrome | Pseudohypoparathyroidism Type 1B | Small Lymphocytic Lymphoma | Myositis, Focal | Lymphangioleiomyomatosis | Tibial Muscular Dystrophy | Primary Hyperoxaluria | Hypophosphatasia | Congenital Aniridia | Schamberg Disease | Monilethrix | Cardiac Arrest | Acne | Macrophagic Myofasciitis | Epidermolytic Ichthyosis, Annular | Donnai-Barrow Syndrome | Malonyl-CoA Decarboxylase Deficiency | Scoliosis | Proopiomelanocortin Deficiency | Basal Cell Nevus Syndrome | Globozoospermia | Hypervalinemia | Delirium | Optic Atrophy 2 | Cardiospondylocarpofacial Syndrome | Myocardial Infarction | Vascular Calcification | Tinea | Multiple Sclerosis, Relapsing-remitting | Epilepsy Of Infancy With Migrating Focal Seizures | Encephalitis, Tick-borne | Situs Inversus | Wilson's Disease | Deafness, Dystonia, And Cerebral Hypomyelination | Waldenstrom Macroglobulinemia | Stroke | Lipid Storage Diseases | Lupus Erythematosus | Eosinophilia | Pemphigus Vulgaris | Thalassemia, Beta | Usher Syndrome Type III | Agnathia-Otocephaly Complex | Anal Fissure | Giant Axonal Neuropathy | Farber Disease | Menkes Disease | Immunoproliferative Disorders | Carney-Stratakis Syndrome | Spondylocarpotarsal Synostosis Syndrome | Marshall-Smith Syndrome | Nicolaides-Baraitser Syndrome | Hyperacusis | Dementia, Vascular | Dupuytren Disease | Stickler Syndrome | Spondyloepiphyseal Dysplasia Tarda, X-linked | Actinomycetoma | Colitis, Collagenous | Sleep Apnea, Central | Carpenter Syndrome | Lafora Disease | Celiac Disease | Maple Syrup Urine Disease | Superficial Spreading Melanoma | Rhinitis | 3C Syndrome | Tatton-Brown-Rahman Syndrome | Aarskog-Scott Syndrome | Sulfite Oxidase Deficiency | CEDNIK Syndrome | Pemphigus | Dysequilibrium Syndrome | Acrodermatitis | Enhanced S-cone Syndrome | Crisponi Syndrome | Cholesteryl Ester Storage Disease | Spinal Muscular Atrophy Type 2 | Precocious Puberty | Gerodermia Osteodysplastica | Bronchitis, Chronic | Raynaud Phenomenon | Gastroschisis | Scabies | Sweet Syndrome | Blastoma, Pleuropulmonary | Spinocerebellar Ataxia | Mesial Temporal Lobe Epilepsy With Hippocampal Sclerosis | Spinocerebellar Ataxia Type 2 | Molybdenum Cofactor Deficiency | Myofibrillar Myopathy | Hepatoblastoma | Spinal Muscular Atrophy Type 3 | Spinocerebellar Ataxia Type 38 | Common Cold | Epidermolysis Bullosa Simplex, Generalized | Dengue Shock Syndrome | Tinea Versicolor | Dysmorphophobia | Lamellar Ichthyosis | Central Retinal Artery Occlusion | Sporadic Hemiplegic Migraine | Spondyloepimetaphyseal Dysplasia With Joint Laxity, Type 3 | Hyperuricemic Nephropathy, Familial Juvenile | Nasodigitoacoustic Syndrome | Placenta Previa | Mandibuloacral Dysplasia With Type A Lipodystrophy | Lipid Metabolism Disorders | Spinocerebellar Ataxia Type 20 | Systemic Lupus Erythematosus | Neuroectodermal Tumors, Primitive | Cone Dystrophy | Frontometaphyseal Dysplasia | Wolfram Syndrome 2 | Aneurysm, Thoracic Aortic | Platyspondylic Lethal Skeletal Dysplasia, Torrance Type | Intestinal Tuberculosis | Chronic Kidney Disease | Heart Septal Defects | Tonsillitis | Bulimia Nervosa | Gardner Syndrome | Angiodysplasia | Spinocerebellar Ataxia Type 6 | Sensory Neuropathy | Reye Syndrome | Ichthyosis | Myositis | Spinal And Bulbar Muscular Atrophy | Hypophosphatemic Rickets, Autosomal Recessive, 1 | Paraganglioma, Carotid Body | Stuve-Wiedemann Syndrome | Orotic Aciduria | Premenstrual Syndrome | Cantu Syndrome | Osteogenesis Imperfecta Type VI | Trichotillomania | Hidradenitis | Nephropathy | Phenylketonuria II | Erysipelas | NGLY1 Deficiency | Exostoses | Lateral Meningocele Syndrome | Pelvic Inflammatory Disease | Progressive Osseous Heteroplasia | Narcolepsy | Pericarditis