Photosensitivity

About the Disease
Photoparoxysmal Response 1, also known as photosensitivity disease, is related to porphyria, congenital erythropoietic and protoporphyria, erythropoietic, 1, and has symptoms including exanthema, pruritus and photophobia. An important gene associated with Photoparoxysmal Response 1 is PPR1 (Photoparoxysmal Response 1), and among its related pathways/superpathways are superpathway of b heme biosynthesis from glycine and "Platinum Pathway, Pharmacokinetics/Pharmacodynamics". The drugs Fluorouracil and Diclofenac have been mentioned in the context of this disorder. Affiliated tissues include skin, brain and retina, and related phenotypes are eeg with photoparoxysmal response and Increased shRNA abundance (Z-score > 2)

Common Targets
G7099 | PKMYT1 | CHEK1 | LOC102724428 | TIRAP | G3605 | ERCC2 | G836 | CDK1/Cyclin B | G5243 | SIK2 | PRKCB | TLR9 | NOX1 | SIK1 | Serine/Threonine-Protein Kinase PLK (nonspecified subtype) | CDK1 | FCER1A | SIK3 | CR2

Note: If you'd like to get a target analysis report for Photosensitivity, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Photosensitivity at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Jacobsen Syndrome | Nicotine Dependence | Hyperparathyroidism | Inflammatory Myopathy | Glanzmann Thrombasthenia | Trichuriasis | Hernia, Inguinal | Learning Disability | Genitopatellar Syndrome | Urea Cycle Disorder | Weill-Marchesani Syndrome | Loeys-Dietz Syndrome Type 4 | Jalili Syndrome | Acute Motor Axonal Neuropathy | T-cell Leukemia | Agammaglobulinemia | Krabbe Disease | Idiopathic Multicentric Castleman Disease | Gnathodiaphyseal Dysplasia | Chordoma | Spinocerebellar Ataxia Type 27 | Leiomyosarcoma | Liver Diseases | Primary Progressive Nonfluent Aphasia | Hyperkalemic Periodic Paralysis | Ataxia-ocular Apraxia 2 | Neurofibromatosis Type 1 | Hyperkeratosis | Vertigo | Thrombophlebitis | Azoospermia | Saethre-Chotzen Syndrome | Pilomatrix Carcinoma | Hamartoma | Craniofrontonasal Syndrome | Peritonitis | Cholestasis | Cysticercosis | Pulmonary Stenosis | Ichthyosis Bullosa Of Siemens | Hemangioblastoma | Melanoma, Malignant | Lipoma | Temtamy Preaxial Brachydactyly Syndrome | Heavy Chain Disease | Colitis, Lymphocytic | Hyperprolactinemia | Charcot-Marie-Tooth Disease | Lymphomatoid Granulomatosis | Hyperlipidemia | PHARC Syndrome | Focal Cortical Dysplasia Type 2 | Infantile Neuroaxonal Dystrophy | Coffin-Siris Syndrome | Pseudoexfoliation Syndrome | Hypophosphatasia | Nephroblastoma | Disseminated Intravascular Coagulation | Acromicric Dysplasia | Pantothenate Kinase-associated Neurodegeneration | FG Syndrome | Oculopharyngeal Muscular Dystrophy | Giant Cell Glioblastoma | Congenital Hemolytic Anemia | Pseudohypoparathyroidism Type 1B | Pulmonary Vein Stenosis | Congenital Myasthenic Syndrome | Dystonia | Hereditary Sensory Neuropathy Type 1 | Sengers Syndrome | Brachydactyly | Keratitis-ichthyosis-deafness Syndrome | Migraine | Stroke, Ischemic | Osteogenesis Imperfecta Type I | Fetal Alcohol Syndrome | Angioedema, Acquired | Multiple Epiphyseal Dysplasia | Alstrom Syndrome | Bone Giant Cell Tumor | Sjogren Syndrome | Hereditary Spastic Paraplegia | Leri-Weill Dyschondrosteosis | Membranous Nephropathy | Infectious Diarrhea | Arrhythmogenic Right Ventricular Cardiomyopathy | Frontotemporal Dementia | Meningioma | Charcot-Marie-Tooth Disease, Type 1A | Stuttering | Mitochondrial DNA Depletion Syndrome, Encephalomyopathic Form | Schistosomiasis | Gastrointestinal Disorders | Hypohidrotic Ectodermal Dysplasia | Alveolar Capillary Dysplasia | Neurocysticercosis | Congenital Afibrinogenemia | Placenta Previa | Allan-Herndon-Dudley Syndrome | Retinopathy Of Prematurity | Purpura, Thrombotic Thrombocytopenic | Fahr Disease | Spinal Muscular Atrophy With Progressive Myoclonic Epilepsy | Williams Syndrome | Hyperuricemia | Hyperinsulinemic Hypoglycemia | Reticular Dysgenesis | Mixed Connective Tissue Disease | Erythropoietic Protoporphyria | Chromosome 17q21.31 Deletion Syndrome | Juvenile Polyposis | Poretti-Boltshauser Syndrome | Enterocolitis, Necrotizing | Diabetic Macular Edema | Corneal Edema | Acrodermatitis Enteropathica | Impulse Control Disorder | Angiomyolipoma | Malonyl-CoA Decarboxylase Deficiency | Trichorhinophalangeal Syndrome | Angelman Syndrome | Cardiomyopathy, Hypertrophic | Hodgkin Lymphoma | Best Macular Dystrophy | Hypomyelination With Atrophy Of Basal Ganglia And Cerebellum | Congenital Torticollis | Carcinoma, Merkel Cell | Androgenic Alopecia | Kohlschutter-Tonz Syndrome | Rhizomelic Chondrodysplasia Punctata | H Syndrome | Iron Metabolism Disorders | Carbohydrate Metabolism Disorders | Chanarin-Dorfman Syndrome | Renal Failure | Thalassemia | 6-pyruvoyl-tetrahydropterin Synthase Deficiency | KBG Syndrome | Prurigo Nodularis | Cannabis Abuse | Cohen Syndrome | Toxoplasmosis | Focal Facial Dermal Dysplasia | T-cell Chronic Lymphocytic Leukemia | Wolman Disease | Charcot-Marie-Tooth Disease Type 4D | Hepatopulmonary Syndrome | Smith-Magenis Syndrome | Spondylometaphyseal Dysplasia | Giant Cell Arteritis | Amyotrophic Lateral Sclerosis | GLUT1 Deficiency Syndrome | Episodic Ataxia | Hemolytic Uremic Syndrome, Atypical | Bacterial Meningitis | Cholelithiasis | Hartnup Disease | Fibrosis | Dupuytren Disease | Myopia | Osteoporosis | Diabetes Insipidus | Enlarged Vestibular Aqueduct | Sclerosing Cholangitis | Cryptosporidiosis | Keratosis, Actinic | Borderline Personality Disorder | Mannosidase Deficiency Diseases | Heterotopic Ossification | Otitis Externa | Acanthosis Nigricans | Tuberculous Meningitis | Diarrhea | Hyperacusis | Spondylocarpotarsal Synostosis Syndrome | Peutz-Jeghers Syndrome | Pernicious Anemia | Microphthalmia | Intracranial Hypertension | Macular Degeneration | Meconium Ileus | Macrophage Activation Syndrome | Anorchia | Osteoporosis-pseudoglioma Syndrome | Barakat Syndrome | Oral Lichen Planus | Priapism | Retinoschisis | Myoclonus-dystonia Syndrome | Uterine Leiomyoma | Pterygium | Polyomavirus Nephropathy | Cold Agglutinin Disease | Neurocutaneous Syndromes | Multiple Sulfatase Deficiency | Carcinoma, Small Cell | Strabismus | 3-methylglutaconic Aciduria | Stargardt Disease | Schaaf-Yang Syndrome | Hyperparathyroidism, Primary | Fukuyama Congenital Muscular Dystrophy | Retinopathy, Diabetic | B-cell Chronic Lymphocytic Leukemia | Cryptorchidism | Thrombotic Microangiopathy | Familial Retinal Arterial Macroaneurysm | Wolcott-Rallison Syndrome | Spinocerebellar Ataxia Type 12 | Long QT Syndrome Type 3 | Chronic Enteropathy Associated With SLCO2A1 Gene | Cluster Headache | Osteogenesis Imperfecta Type II | Androgen Insensitivity | Generalized Epilepsy And Paroxysmal Dyskinesia | Apraxia | Echinococcosis | Progressive Familial Intrahepatic Cholestasis Type 1 | Guanidinoacetate Methyltransferase Deficiency | Neurodegeneration Due To Cerebral Folate Transport Deficiency | Pneumonia, Bacterial | Asthma, Nocturnal | Acne | Bethlem Myopathy | Usher Syndrome | Panic Disorder | Ghosal Syndrome | Scleroderma, Diffuse | Ileitis | Mucolipidosis Type III | Osteoporosis, Postmenopausal | Ichthyosis | Spinocerebellar Ataxia Type 16 | DiGeorge Syndrome | Intestinal Hypomagnesemia 1 | Choroiditis | Brugada Syndrome 1 | Malaria | Plasmacytoma | Pulverulent Zonular Cataract | Fetal And Neonatal Alloimmune Thrombocytopenia | Ollier Disease | Vascular Cognitive Impairment | Acute Lung Injury | Alkaptonuria | Axenfeld-Rieger Syndrome | Adrenomyeloneuropathy | Neurofibroma, Plexiform | Waardenburg Syndrome | Urolithiasis | Castleman Disease | Corticobasal Syndrome | Hyperparathyroidism-jaw Tumor Syndrome | Autosomal Recessive Spastic Paraplegia Type 54 | Posterior Polar Cataract | Sleep Disorder | Paget's Disease Of The Breast | Pancytopenia | Liver Failure, Acute Infantile | Congenital Heart Block | Acute Myeloid Leukemia | Mitochondrial Myopathy | Corneal Dystrophy And Perceptive Deafness | Hyperinsulinism-hyperammonemia Syndrome | Metachromatic Leukodystrophy | Splenomegaly | Lymphoma, B-cell | Mitochondrial DNA Depletion Syndrome 13 | Gestational Trophoblastic Disease | Botulism | Conn Syndrome | Hypotension, Orthostatic | Progressive Osseous Heteroplasia | Purpura | Congenital Fiber-type Disproportion Myopathy | Goiter, Nodular | Nijmegen Breakage Syndrome | Fraser Syndrome | Cancer, Kidney | Sensory Neuropathy | Robinow Syndrome | Cellulitis | Cystinuria | Epicondylitis | Situs Inversus | Epidermolytic Palmoplantar Keratoderma | Trichomegaly | Megacystis-microcolon-intestinal Hypoperistalsis Syndrome | Cardiac Arrest | Wagner Disease | Jawad Syndrome | Glutaric Aciduria Type 1 | Histoplasmosis | Odonto-onycho-dermal Dysplasia | Myelitis, Transverse | Hyperbilirubinemia, Neonatal | Rheumatoid Arthritis | Costello Syndrome | Cerebral Amyloid Angiopathy | Molybdenum Cofactor Deficiency | Spondyloepiphyseal Dysplasia Tarda, X-linked | X-linked Creatine Transporter Deficiency | Hypermethioninemia | Gallstones | Multiple Hamartoma Syndrome | Atopy | Sleep Apnea, Central | Retinal Telangiectasia | Spinocerebellar Ataxia Type 28 | Hereditary Spherocytosis | Reye Syndrome | Melanocytic Nevus | Hypotrichosis | Dental Caries | Peeling Skin Syndrome Type B | Alpers Syndrome | Pseudohypoaldosteronism | Common Cold | Carey-Fineman-Ziter Syndrome | Hereditary Multiple Exostoses | Mucolipidosis Type IV | Osteonecrosis | Autoimmune Autonomic Ganglionopathy | Harlequin Ichthyosis | Primary Familial Brain Calcification | Becker Muscular Dystrophy | Cranial Nerve Disease | Methemoglobinemia Type IV | Sarcoidosis, Pulmonary | Anterior Segment Dysgenesis | Hypokalemia | Adenosine Deaminase Deficiency | Thrombophilia | Kallmann Syndrome | Congenital Hypofibrinogenemia | Primary Ovarian Insufficiency | Parkinsonism | Alpha-thalassemia Myelodysplasia Syndrome | HANAC Syndrome | Choreoathetosis, Hypothyroidism, And Neonatal Respiratory Distress | Congenital Sodium Diarrhea | Takayasu's Arteritis | VACTERL Association | Pulmonary Alveolar Microlithiasis | Sleep Apnea | Kleine-Levin Syndrome | Hyperferritinemia-cataract Syndrome | Bloom Syndrome | DOCK8 Immunodeficiency Syndrome | Anencephaly | Immunoproliferative Disorders | Leukoplakia, Oral | Myositis, Focal | Mumps | Milk Allergy | Primary Sclerosing Cholangitis | Mucolipidosis Type II | Anti-glomerular Basement Membrane Disease | Conjunctivitis, Allergic | Waardenburg Syndrome Type 1 | Sensorineural Hearing Loss | Gastritis, Atrophic | Pancreatitis | Osteochondrosis | Protein C Deficiency | Mosaic Variegated Aneuploidy Syndrome 2 | Progressive Familial Intrahepatic Cholestasis Type 3 | Wiedemann-Steiner Syndrome | Exocrine Pancreatic Insufficiency | Lymphoma, Primary Cutaneous Anaplastic Large Cell | Acute Anterior Uveitis | Metabolic Diseases | Desmosterolosis | Alzheimer Disease, Late Onset | Otopalatodigital Syndrome Type 2 | Myotonia | Peeling Skin Syndrome, Acral Type | Zimmermann-Laband Syndrome | Mitochondrial DNA Depletion Syndrome, Myopathic Form | Distal Spinal Muscular Atrophy | Paraganglioma | Niemann-Pick Disease, Type B | Von Willebrand Disease | Long-chain 3-hydroxyacyl-coenzyme A Dehydrogenase Deficiency | Arts Syndrome | Marfan Syndrome | Renal-hepatic-pancreatic Dysplasia | Chronic Granulomatous Disease | Cryoglobulinemia | Autoimmune Interstitial Lung, Joint, And Kidney Disease | Adenomyosis | Tangier Disease | Relapsing Polychondritis | Familial Hypertrophic Cardiomyopathy | Congenital Disorders Of Glycosylation | Proctitis | Epidermolytic Ichthyosis, Annular | McCune-Albright Syndrome | Bartsocas-Papas Syndrome | Olmsted Syndrome