Smith-Magenis Syndrome

About the Disease
Smith-Magenis Syndrome, also known as sms, is related to potocki-lupski syndrome and chromosome 16p12.2-p11.2 deletion syndrome, 7.1- to 8.7-mb, and has symptoms including hoarseness and sleep disturbances. An important gene associated with Smith-Magenis Syndrome is RAI1 (Retinoic Acid Induced 1). The drugs Dexamethasone acetate and Dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include kidney, heart and eye, and related phenotypes are intellectual disability and frontal bossing

Common Targets
MC1R | RAI1 | MTNR1A | CES2 | EPS8L1 | RASD1 | MTNR1B | TOM1L2 | MC3R | SMCR2 | PEMT | beta-Adrenoceptor (nonspecified subtype) | TH | MDGA2 | NOS2 | MC4R | MED9 | MBD5 | SREBF1

Note: If you'd like to get a target analysis report for Smith-Magenis Syndrome, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Smith-Magenis Syndrome at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Chylomicron Retention Disease | Chanarin-Dorfman Syndrome | Hypervalinemia | Klinefelter Syndrome | Carcinoma, Merkel Cell | Harlequin Ichthyosis | Retinal Vasculitis | Autosomal Recessive Congenital Ichthyosis | Retinopathy, Diabetic | Charcot-Marie-Tooth Disease Type 4D | Marfan Syndrome | Lactose Intolerance | Rash | Down Syndrome | Hypersensitivity Pneumonitis | Eclampsia | Choriocarcinoma | Renal Oncocytoma | Micro Syndrome | Peritonitis | Early Infantile Epileptic Encephalopathy 4 | Inflammatory Myofibroblastic Tumor | Pierson Syndrome | Anorectal Fistula | Platelet Disorders | Glomerulonephritis, Membranoproliferative | Amelanotic Melanoma | Primary Hyperoxaluria Type 3 | Leukoplakia, Oral | Charcot-Marie-Tooth Disease, Type 1A | Heart Septal Defects | Tetraplegia | Pyruvate Kinase Deficiency | Keratoconus | Contact Dermatitis | Chorioretinitis | Hypogammaglobulinemia | Fukuyama Congenital Muscular Dystrophy | Hydrops Fetalis | McLeod Syndrome | Mesothelioma, Malignant | Carcinoma In Situ | Neuromuscular Disorders | Intestinal Obstruction | Haim-Munk Syndrome | Osteogenesis Imperfecta | Kawasaki Disease | Acute Lung Injury | Hereditary Sensory Neuropathy Type 1 | Hepatoblastoma | Gaucher Disease | Coma | Kearns-Sayre Syndrome | Keratitis | Urea Cycle Disorder | X-linked Creatine Transporter Deficiency | Jacobsen Syndrome | Combined Deficiency Of Factor V And Factor VIII | Spondylolisthesis | Meniere's Disease | Johanson-Blizzard Syndrome | Schistosomiasis | Osteonecrosis | Hyperbilirubinemia | Mucormycosis | Colitis | Non-epidermolytic Palmoplantar Keratoderma | Thrombocytopenia | Myelodysplasia | Hypoproteinemia, Hypercatabolic | Idiopathic Pulmonary Fibrosis | Congenital Generalized Lipodystrophy | Dubin-Johnson Syndrome | Renal Hypouricemia | Hypoparathyroidism | Macular Corneal Dystrophy | Hemophilia | Antithrombin III Deficiency | Colitis, Collagenous | Kaposiform Hemangioendothelioma | Polycystic Liver | Macrophage Activation Syndrome | Glioma | Light Chain Amyloidosis | Chromosome 16p11.2 Deletion Syndrome | Adenomyosis | Binge Eating Disorder | Angiodysplasia | Varicocele | Cholesteryl Ester Storage Disease | Lymphopenia | Branchiootorenal Syndrome | Spinal Cord Diseases | Acral Lentiginous Melanoma | Neuromyelitis Optica | Low Phospholipid Associated Cholelithiasis | Hepatitis B, Chronic | Thrombophlebitis | Zygomycosis | Hypokalemia | Enhanced S-cone Syndrome | Lentigo | Mosaic Variegated Aneuploidy Syndrome 2 | Mountain Sickness | Addison Disease | Mitochondrial DNA Depletion Syndrome | Hypertension | Schindler Disease | Fowler's Syndrome | Microcephaly | Methylmalonic Aciduria And Homocystinuria, CblC Type | Synovitis | Chronic Leukemia | Epilepsy Of Infancy With Migrating Focal Seizures | Spitzoid Melanoma | Walker-Warburg Syndrome | T-cell Leukemia | Large Granular Lymphocytic Leukemia | Colorectal Adenoma | Dental Caries | Alpha-thalassemia Myelodysplasia Syndrome | Cystitis, Interstitial | Bipolar Disorder | Hereditary Spherocytosis | Idiopathic Multicentric Castleman Disease | Localized Scleroderma | Schwannomatosis | Juvenile Xanthogranuloma | Pearson Syndrome | Gaze Palsy, Familial Horizontal, With Progressive Scoliosis, 2 | Retinal Coloboma | Chronic Periodontitis | Pre-eclampsia | Vitamin B12 Deficiency | GNE Myopathy | Neurodegeneration Due To Cerebral Folate Transport Deficiency | Narcolepsy | Thrombocythemia, Essential | Leukoplakia | Kabuki Syndrome 2 | Sensory Neuropathy | Central Retinal Artery Occlusion | AIDS Dementia Complex | Adenylosuccinate Lyase Deficiency | Von Hippel-Lindau Disease | Bulimia Nervosa | Gout | Palmoplantar Keratoderma | Brachydactyly | Periodic Limb Movement Disorder | Babesiosis | Liver Failure, Acute Infantile | Perry Syndrome | Bloom Syndrome | Cystinosis | Thyroid Hormone Resistance | Amenorrhea | Antisynthetase Syndrome | Mabry Syndrome | Lipodystrophy | Alpers Syndrome | Corneal Ulcer | Succinic Semialdehyde Dehydrogenase Deficiency | Ocular Hypertension | Noonan Syndrome-like Disorder With Loose Anagen Hair | Partington Syndrome | Erythema Multiforme | Leishmaniasis, Cutaneous | Charcot-Marie-Tooth Disease, Type 2C | Fuchs Dystrophy | Chronic Thromboembolic Pulmonary Hypertension | Dyskeratosis Congenita | Acanthosis Nigricans | Pericarditis | Pseudohermaphroditism | Multiple Sclerosis, Primary Progressive | Meckel-Gruber Syndrome | Hyperkeratosis | Avellino Corneal Dystrophy | Acute Chest Syndrome | Esophageal Motility Disorders | Limb Girdle Muscular Dystrophy | Spinal Muscular Atrophy With Progressive Myoclonic Epilepsy | Prolymphocytic Leukemia | Hypotrichosis Simplex | Panic Disorder | Osteoporosis-pseudoglioma Syndrome | Aneurysm, Abdominal Aortic | Tinea Versicolor | Seizures | Birt-Hogg-Dube Syndrome | Spinocerebellar Ataxia Type 17 | Congenital Dysfibrinogenemia | Gliosarcoma | Atrial Septal Defect | Cysticercosis | Pulmonary Sclerosing Hemangioma | Eccrine Porocarcinoma | Anemia | Graft-versus-host Disease | Trichomegaly | Carpenter Syndrome | Hypertensive Nephropathy | Mitochondrial DNA Depletion Syndrome, Myopathic Form | Dermatitis Herpetiformis | Glycogen Storage Disease Type 6 | Polymyositis | Asperger Syndrome | Phosphoenolpyruvate Carboxykinase Deficiency, Cytosolic | Meleda Disease | Arthropathy | Peripheral Neuropathy | Keratosis | Chiari Malformation Type I | Cold Agglutinin Disease | Cataract | Diabetic Encephalopathy | Spinocerebellar Ataxia | Orthostatic Intolerance | Dupuytren Disease | Ellis-Van Creveld Syndrome | Nail Disorder, Nonsyndromic Congenital | Wolman Disease | Angiomyolipoma | Amblyopia | Parvovirus B19 Infection | PHARC Syndrome | Pierre Robin Syndrome | Nephrotic Syndrome Type 1 | Hyperlipidemia, Familial Combined | Spina Bifida | Lymphoma, B-cell | Atelosteogenesis Type 1 | Acne Vulgaris | Oculodentodigital Dysplasia | Astrocytoma, Anaplastic | Migraine | Rhabdoid Tumor | Sleep Apnea, Central | Dystonia Musculorum Deformans | Tay-Sachs Disease | Myofibrillar Myopathy | Thromboembolism | Congenital Bile Acid Synthesis Defect | Hypospadias | Oculocutaneous Albinism Type 4 | Chronic Myeloid Leukemia | Mitochondrial DNA Depletion Syndrome, Hepatocerebral Form | Hydrocephalus, Normal Pressure | Chitayat Syndrome | Hypophosphatasia | Carney-Stratakis Syndrome | Hyperthermia, Malignant | Benign Familial Infantile Seizures | CEDNIK Syndrome | Familial Pheochromocytoma-paraganglioma | Panniculitis | Diffuse Intrinsic Pontine Glioma | Cerebrovascular Disorders | Juvenile Myelomonocytic Leukemia | Frontotemporal Dementia With Amyotrophic Lateral Sclerosis | Thyroid Dysgenesis | Marshall-Smith Syndrome | Neovascular Glaucoma | Intracerebral Hemorrhage | Myoclonus | Oculocutaneous Albinism Type 1 | Focal Facial Dermal Dysplasia | Angiosarcoma Of The Breast | Androgen Insensitivity | Pemphigus Vulgaris | Angiosarcoma | Trismus-pseudocamptodactyly Syndrome | Presbycusis | Trigonocephaly | Colitis, Lymphocytic | Scapuloperoneal Spinal Muscular Atrophy | Kidney Stones | Ovarian Hyperstimulation Syndrome | Frontotemporal Dementia | Neuroleptic Malignant Syndrome | Ganglioneuroma | Blomstrand Osteochondrodysplasia | Pulmonary Stenosis | Pleurisy | TARP Syndrome | Zellweger Syndrome | Glutaric Aciduria Type 2 | Neurofibromatosis Type 2 | Impetigo | Urticaria | Giant Axonal Neuropathy | Vici Syndrome | Acrocallosal Syndrome | Pneumococcal Meningitis | Pachyonychia Congenita | Infantile Nephropathic Cystinosis | Postpartum Depression | Tonsillitis | Carcinoma, Signet Ring Cell | Herpes Simplex Dermatitis | Gerodermia Osteodysplastica | Galactosemia | Trichotillomania | Pontocerebellar Hypoplasia Type 7 | Spinal Muscular Atrophy Type 2 | LMNA-related Congenital Muscular Dystrophy | Multisystemic Smooth Muscle Dysfunction Syndrome | Bronchiolitis | Myopia | Conn Syndrome | Hyperparathyroidism, Primary | Kindler Syndrome | Creatine Deficiency Syndrome Due To AGAT Deficiency | Guttate Psoriasis | Congestive Heart Failure | Megalencephaly | Dysequilibrium Syndrome | Hyperphosphatasia With Intellectual Disability Syndrome 4 | Salla Disease | Lamellar Ichthyosis | Holt-Oram Syndrome | DiGeorge Syndrome | Corneal Dystrophy | Glycogen Storage Disease Type 4 | Renal Tubular Acidosis | Congenital Hemolytic Anemia | Fontaine Progeroid Syndrome | Myelitis, Transverse | Mumps | Mood Disorder | Acquired Partial Lipodystrophy | Lymphoproliferative Disorders | Chronic Inflammatory Demyelinating Polyneuropathy | Charcot-Marie-Tooth Disease, Type 6 | Familial Exudative Vitreoretinopathy | Hermansky-Pudlak Syndrome | Leri Pleonosteosis | Urofacial Syndrome | Osmotic Demyelination Syndrome | Sjogren Syndrome | Withdrawal Syndrome | Thalassemia, Beta | Epicondylitis | Otosclerosis | Endocarditis | Hyperferritinemia-cataract Syndrome | Polycythemia | Waardenburg Syndrome Type 2 | Hypertension, Portal | Cholestasis | Pitt-Hopkins Syndrome | Agoraphobia | Sengers Syndrome | Neuroblastoma | Epilepsy, Generalized | Acne | Hereditary Neuropathy With Liability To Pressure Palsies | Hypotension, Orthostatic | Oral Lichen Planus | Osteonecrosis Of The Jaw | Acromicric Dysplasia | Pityriasis Rubra Pilaris | Lipoma | Pyruvate Decarboxylase Deficiency | Acute Lymphocytic Leukemia | Fetal And Neonatal Alloimmune Thrombocytopenia | Schistosomiasis Mansoni | Epidermolysis Bullosa Simplex, Dowling-Meara Type | Strabismus | Dermatofibrosarcoma | Atelosteogenesis Type 2 | Epidermolytic Hyperkeratosis | Learning Disability | Very Long-chain Acyl-CoA Dehydrogenase Deficiency | Smith-Kingsmore Syndrome | Amebiasis | Argininosuccinic Aciduria | Influenza | Bare Lymphocyte Syndrome | Epithelial-myoepithelial Carcinoma | Macrophagic Myofasciitis | Desmosterolosis | Erysipelas | Subacute Sclerosing Panencephalitis | Tricho-hepato-enteric Syndrome | Silver-Russell Syndrome | Pineoblastoma | Macrodactyly | Sick Sinus Syndrome 1 | Chromosome 17q21.31 Deletion Syndrome | Menkes Disease | Guanidinoacetate Methyltransferase Deficiency | Crohn's Disease | Speech Disorders | Hyperinsulinism-hyperammonemia Syndrome | Diamond-Blackfan Anemia | Coloboma | Gynecomastia | Trachoma