Smith-Magenis Syndrome

About the Disease
Smith-Magenis Syndrome, also known as sms, is related to potocki-lupski syndrome and chromosome 16p12.2-p11.2 deletion syndrome, 7.1- to 8.7-mb, and has symptoms including hoarseness and sleep disturbances. An important gene associated with Smith-Magenis Syndrome is RAI1 (Retinoic Acid Induced 1). The drugs Dexamethasone acetate and Dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include kidney, heart and eye, and related phenotypes are intellectual disability and frontal bossing

Common Targets
MC1R | RAI1 | MTNR1A | CES2 | EPS8L1 | RASD1 | MTNR1B | TOM1L2 | MC3R | SMCR2 | PEMT | beta-Adrenoceptor (nonspecified subtype) | TH | MDGA2 | NOS2 | MC4R | MED9 | MBD5 | SREBF1

Note: If you'd like to get a target analysis report for Smith-Magenis Syndrome, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Smith-Magenis Syndrome at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

COACH Syndrome | Plasma Cell Leukemia | Hypercholesterolemia | Keloid | Lathosterolosis | Neurofibroma | Myeloid Leukemia | Lattice Corneal Dystrophy | Synpolydactyly | Meningococcal Infections | Scleroderma, Diffuse | Panuveitis | Cardiomyopathy, Restrictive | Pregnancy, Ectopic | Ganglioneuroma | Seminoma | Oral Lichen Planus | Sorsby Fundus Dystrophy | Carpal Tunnel Syndrome | Omenn Syndrome | Hemophagocytic Lymphohistiocytosis | Hypersensitivity | Acanthosis Nigricans | Specific Granule Deficiency | Facioscapulohumeral Muscular Dystrophy | Werner's Syndrome | GATA2 Deficiency | Hyperthyroidism | Neurotoxicity | Congenital Afibrinogenemia | Charcot-Marie-Tooth Disease | Episodic Ataxia | Contact Dermatitis | Congenital Stromal Corneal Dystrophy | Portal Vein Thrombosis | Glioblastoma | Motion Sickness | Lymphoma, Mantle Cell | Retinal Telangiectasia | 3C Syndrome | Hypothalamic Obesity | Angiosarcoma Of The Breast | Paronychia | Carcinoma, Merkel Cell | Potocki-Shaffer Syndrome | Albinism | Small Lymphocytic Lymphoma | Tetanus | Tylosis With Esophageal Cancer | Lipodystrophy | Myotonic Disorders | Premenstrual Syndrome | Traboulsi Syndrome | Optic Neuropathy, Anterior Ischemic | Porphyria, Acute Intermittent | Mitochondrial Encephalomyopathy | Mixed Connective Tissue Disease | Acute Lung Injury | Renal Hypouricemia | Hypoparathyroidism | Japanese Encephalitis | Gestational Trophoblastic Disease | Hereditary Sensory And Autonomic Neuropathy | Lyme Disease | Astigmatism | Vogt-Koyanagi-Harada Syndrome | Odonto-onycho-dermal Dysplasia | Endophthalmitis | ICF Syndrome | Cerebrovascular Disorders | Diabetes Mellitus, Transient Neonatal | Bronchiectasis | Hyperkeratosis | Gastroschisis | Autoimmune Polyendocrine Syndrome | Bartter Syndrome | Kohlschutter-Tonz Syndrome | Sleep Disorder | Hypogonadism | Pseudohypoparathyroidism Type 1B | Esotropia | Williams Syndrome | Graft-versus-host Disease | Melanoma, Malignant | Cerebellar Ataxia, Cayman Type | Chylothorax, Congenital | Non-Hodgkin Lymphoma | Charcot-Marie-Tooth Disease, Type 6 | Retinopathy, Diabetic | IgA Deficiency | Malignant Fibrous Histiocytoma | Pontocerebellar Hypoplasia Type 2 | Dysplastic Nevus | Diabetes | Tay-Sachs Disease | Chronic Granulomatous Disease, X-linked | Skin Carcinoma | Congenital Dyserythropoietic Anemia | Dent Disease | Tyrosinemia Type 1 | Eosinophilic Asthma | Adult Polyglucosan Body Disease | Megacystis-microcolon-intestinal Hypoperistalsis Syndrome | Prediabetes | Peripheral T-cell Lymphoma | Osteochondrosis | Klinefelter Syndrome | Spinocerebellar Ataxia Type 27 | Currarino Syndrome | Hereditary Hemorrhagic Telangiectasia | Tic Disorder | Postpartum Depression | Globozoospermia | Myelodysplasia | Cerebrotendinous Xanthomatosis | Sarcoidosis | Episodic Ataxia Type 2 | Anti-glomerular Basement Membrane Disease | Raine Syndrome | Van Der Knaap Disease | Pyloric Stenosis, Infantile Hypertrophic | Cavitary Optic Disc Anomalies | Cancer, Breast | Dengue Hemorrhagic Fever | Schizophrenia, Paranoid | Situs Inversus | Liver Failure | Congenital Heart Defects | Shprintzen-Goldberg Syndrome | Mucolipidosis Type III | Atherosclerosis | Bone Marrow Necrosis | Achromatopsia | Danon Disease | Ichthyosis, X-linked | Hepatitis A | Primary Cutaneous Amyloidosis | Anencephaly | Obesity, Morbid | Aspartylglycosaminuria | Miyoshi Myopathy | Leri Pleonosteosis | Chorea | Lymphoma | Epithelioid Hemangioma | Wolff-Parkinson-White Syndrome | Sickle Cell Anemia | Nutrition Disorders | Basal Ganglia Cerebrovascular Disease | Malonyl-CoA Decarboxylase Deficiency | Lattice Corneal Dystrophy Type 1 | Epidermolysis Bullosa Simplex, Localized | Hypercalcemia | Cataract | Non-epidermolytic Palmoplantar Keratoderma | Tangier Disease | Cryopyrin-associated Periodic Syndromes | Carpenter Syndrome | Lipoma | HELLP Syndrome | Keratosis, Seborrheic | Pemphigus Vulgaris | Prostatitis | Chediak-Higashi Syndrome | Giant Cell Glioblastoma | Thalassemia | Antithrombin III Deficiency | Uremic Pruritus | Optic Neuritis | Meniere's Disease | Tibial Muscular Dystrophy | Fibrosarcoma | Hereditary Multiple Exostoses | Pineoblastoma | Hyperhomocysteinemia | Alveolar Capillary Dysplasia | Spinal Muscular Atrophy | Pyelonephritis | Angioedema, Acquired | Kaposi Sarcoma | Peritonitis | Cholangitis | Low Phospholipid Associated Cholelithiasis | Acne Vulgaris | IMAGe Syndrome | N-acetylglutamate Synthase Deficiency | Crisponi Syndrome | Neurodevelopmental Disorder With Central Hypotonia And Dysmorphic Facies | Spondylocostal Dysostosis | Pancytopenia | Sleep Apnea | Osteosarcoma | Parkinsonism | Vulvovaginitis | Krabbe Disease | Leigh Syndrome | Language Disorders | Familial Cerebral Amyloid Angiopathy | Epiphyseal Chondrodysplasia, Miura Type | McCune-Albright Syndrome | Familial Digital Arthropathy-brachydactyly | Multisystemic Smooth Muscle Dysfunction Syndrome | Corticobasal Syndrome | Hypercholesterolemia, Familial | Pelizaeus-Merzbacher Disease | Spasticity | Becker Muscular Dystrophy | Glutaric Aciduria Type 1 | DEND Syndrome | Dysfibrinogenemia | Atrioventricular Septal Defect | Chorea-acanthocytosis | Retinoschisis | Avian Influenza | Pulmonary Alveolar Microlithiasis | Coloboma | Rhinitis | Cardiospondylocarpofacial Syndrome | Cyclic Vomiting Syndrome | Frontotemporal Dementia With Amyotrophic Lateral Sclerosis | D-2-Hydroxyglutaric Aciduria | Osteomyelitis | Aplastic Anemia | Rubeosis Iridis | Preaxial Polydactyly | Aarskog-Scott Syndrome | Johanson-Blizzard Syndrome | Acromesomelic Dysplasia | Toxic Epidermal Necrolysis | Chromosome 17q21.31 Deletion Syndrome | Leprosy | Chondrodysplasia Punctata | Autism Spectrum Disorders | Hydrocephalus | Familial Partial Lipodystrophy | Tracheal Disorders | Kabuki Syndrome | Primary Progressive Nonfluent Aphasia | Holt-Oram Syndrome | Central Retinal Artery Occlusion | Neuromyelitis Optica | Dysequilibrium Syndrome | Superficial Spreading Melanoma | Cluster Headache | Malaria, Cerebral | VEXAS Syndrome | Cystitis | Eiken Syndrome | Corneal Ulcer | Familial Advanced Sleep Phase Syndrome | Neurofibromatosis Type 2 | Anal Fissure | Spinocerebellar Ataxia Type 1 | Rhabdomyosarcoma, Alveolar | Malnutrition | Parapsoriasis | Pseudohermaphroditism | Reticular Dysgenesis | Glioblastoma Multiforme | Plasma Cell Dyscrasia | Asphyxia Neonatorum | Peutz-Jeghers Syndrome | Split Hand-foot Malformation | Bare Lymphocyte Syndrome | Osteoporosis | Thromboembolism | IgA Nephropathy | Dowling-Degos Disease | Enlarged Vestibular Aqueduct | Sandhoff Disease | Fetal And Neonatal Alloimmune Thrombocytopenia | Congenital Myasthenic Syndrome | 5-oxoprolinase Deficiency | Adenoma, Villous | Neuromuscular Disorders | CHOPS Syndrome | Hermansky-Pudlak Syndrome | Pulmonary Alveolar Proteinosis | Purpura | Leishmaniasis, Visceral | Congestive Heart Failure | Oculopharyngeal Muscular Dystrophy | Benign Familial Pemphigus | Birt-Hogg-Dube Syndrome | Atrial Septal Defect | Cervical Dystonia | Chondromyxoid Fibroma | Macrodactyly | Dominant Optic Atrophy | Smoldering Myeloma | Spinocerebellar Ataxia Type 2 | Osteoglophonic Dysplasia | Trigonocephaly | Epidermodysplasia Verruciformis | Blepharo-cheilo-odontic Syndrome | Pulverulent Zonular Cataract | Hyperbilirubinemia, Neonatal | Microcephaly, Seizures, And Developmental Delay | Silver-Russell Syndrome | Guanidinoacetate Methyltransferase Deficiency | Familial Hyperaldosteronism | Infantile Liver Failure Syndrome 1 | Stroke, Ischemic | Idiopathic Pulmonary Fibrosis | Norrie Disease | Lymphoproliferative Disorders | Molybdenum Cofactor Deficiency | Spondylosis | Castleman Disease | Vitreoretinal Degeneration, Snowflake Type | Bursitis | Pearson Syndrome | Hypodontia | Carcinoma, Transitional Cell | Limb Girdle Muscular Dystrophy | Ocular Surface Squamous Neoplasia | Niemann-Pick Disease | Nanophthalmos | Kleine-Levin Syndrome | Iron Metabolism Disorders | Glycogen Storage Disease Type 0 | Long QT Syndrome Type 2 | Biotinidase Deficiency | Gingivitis | Spinocerebellar Ataxia Type 21 | Parkinson's Disease | Gynecomastia | Retinal Degeneration | Patent Ductus Arteriosus | Cardiofaciocutaneous Syndrome | Vascular Cognitive Impairment | Hypotrichosis Simplex | Patent Foramen Ovale | Spinocerebellar Ataxia Type 17 | Congenital Ichthyosiform Erythroderma | Von Hippel-Lindau Disease | Osteoarthritis | Double Outlet Right Ventricle | Autoimmune Polyendocrinopathy Syndrome Type I | Diabetic Neuropathy | Myositis, Focal | Interstitial Lung Diseases | Cole-Carpenter Syndrome | Congenital Dyserythropoietic Anemia Type 1 | Polycystic Kidney, Autosomal Dominant | Paroxysmal Nocturnal Hemoglobinuria | Spinocerebellar Ataxia Type 3 | Encephalitis, Tick-borne | Optic Nerve Hypoplasia, Bilateral | Familial Glucocorticoid Deficiency | Hypopigmentation | Nephritis, Interstitial | Argininosuccinic Aciduria | Chitayat Syndrome | Microphthalmia, Syndromic 7 | Pancreatitis, Chronic | Mucolipidosis Type II | Hypertension, Portal | Heimler Syndrome | Phenylketonuria II | Trichuriasis | Hypoproteinemia, Hypercatabolic | Beta-Propeller Protein-associated Neurodegeneration | Melnick-Needles Syndrome | Tricho-hepato-enteric Syndrome | Pneumothorax | Acute Generalized Exanthematous Pustulosis | Mitochondrial DNA Depletion Syndrome 13 | Congenital Myopathy | Basal Ganglia Disease | Duchenne Muscular Dystrophy | Sarcoidosis, Pulmonary | Spondylo-megaepiphyseal-metaphyseal Dysplasia | HUPRA Syndrome | Fundus Albipunctatus | Viral Meningitis | Diabetes Insipidus, Neurogenic | Fascioliasis | Bronchiolitis | Hypermetropia | Ocular Albinism Type 1 | Diverticulitis | Mabry Syndrome | DICER1 Syndrome | Corneal Dystrophies, Hereditary | Protein S Deficiency | Orotic Aciduria | Netherton Syndrome | Roberts Syndrome | Hemangioendothelioma | Diffuse Palmoplantar Keratoderma | Adrenal Insufficiency | Sporadic Hemiplegic Migraine | GAPO Syndrome | Gray Platelet Syndrome | Ehlers-Danlos Syndrome With Progressive Kyphoscoliosis, Myopathy, And Hearing Loss | Achondrogenesis | Bardet-Biedl Syndrome | Atopic Dermatitis | Ehlers-Danlos Syndrome