Disease

Mood Disorder

About the Disease
Mood Disorder, also known as mood disorders, is related to major depressive disorder and schizoaffective disorder, and has symptoms including alexithymia and psychiatric symptom. An important gene associated with Mood Disorder is DISC2 (Disrupted In Schizophrenia 2), and among its related pathways/superpathways are Signal Transduction and GPCR downstream signalling. The drugs Lithium carbonate and Risperidone have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and pituitary, and related phenotypes are nervous system and homeostasis/metabolism

Common Targets
GPR139 | BDNF | PROKR2 | 5-Hydroxytryptamine Receptor 3 (5-HT3 receptor) (nonspecified subtype) | CACNA1B | AVPR1A | WDR5 | Corticotropin-Releasing Factor (CRF) Receptor (nonspecified subtype) | KCNC1 | Phosphodiesterase IV (PDE4) (nonspecified subtype) | KCNN3 | OPRK1 | GRM5 | SLC18A2 | FKBP4 | OPRM1 | ACE | Metabotropic glutamate (mGluR) receptor (nonspecified subtype) | NOS1 | CNR2 | GRIN2C | GRIN1 | Folate Receptor (nonspecified subtype) | DRD4 | ADRA2B | GPR52 | AANAT | G5594 | DRD2 | NPSR1 | ESR2 | SIGMAR1 | T-Type Calcium Channel | Neuropeptide Y receptor (NPY-R) (nonspecified subtype) | KCND3 | MAOA | AVPR1B | SLCO2B1 | COMT | Estrogen receptor (nonspecified subtype) | TRPC5 | GABRB2 | BRD4 | GABRG2 | CHRM1 | HTR1A | KCNC2 | PDE10A | HDAC1 | SLC6A2 | CNR1 | Small Conductance Calcium-Activated Potassium Channel (SK) (nonspecified subtype) | ADORA1 | HCRTR1 | GRIN2D | SCN8A | PDE9A | GRM2 | Glutamate Transporter (nonspecified subtype) | DYRK1A | NAPEPLD | HTR2B | Neurotrophic Factor (nonspecified subtype) | DRD5 | GABA(A) receptor | Opioid receptor (nonspecified subtype) | SLC6A9 | TRPV1 | CHRNA7 | DPP4 | G9429 | ADORA2A | Nicotinic alpha4beta2 receptor | ADRA2A | ADA | HTR5A | GSK3B | Voltage-Gated Sodium Channel Complex | OXT | NR3C1 | FKBP5 | KCNQ Channels (K(v) 7) (nonspecified subtype) | G4318 | Orexin receptor (nonspecified subtype) | OPRD1 | GABRB3 | GABRA1 | Glycogen synthase kinase 3 (GSK-3) (nonspecified subtype) | Sodium channel (nonspecified subtype) | HCRTR2 | DRD1 | G5243 | TPH2 | KCNK3 | FAAH | MTHFR | CHRNA3 | MMP2 | LINC02210-CRHR1 | SLC6A4 | EDN1 | PDE2A | Dopamine receptor (nonspecified subtype) | GRM3 | TRPM2 | Glycine receptor | CRHR1 | HTR6 | ADM | TDO2 | CLK1 | KCNK9 | PROKR1 | SCN9A | NMDA receptor | GABRA5 | HTR2A | 5-Hydroxytryptamine Receptor 2 (5-HT2) (nonspecified subtype) | HTR1B | VHL | Histone deacetylase (nonspecified subtype) | TACR1 | APP | SLCO1B1 | alpha1-Adrenoceptor (nonspecified subtype) | Large Conductance BK(Ca) Potassium Channel (Maxi K+ Channel) (nonspecified subtype) | GABRA2 | P2RX7 | Nitric oxide synthase (NOS) (nonspecified subtype) | FGF14 | HTR2C | DRD3 | GRM4 | ANK3 | CSNK1D | SLCO1A2 | MAOB | SLC6A3 | OXTR | CHRNB2 | GPR55 | MCHR1 | GRIN2B | SCN5A | HTR1D | ADRA2C | GABRA3 | GRIK4 | HTR7 | KCNIP4 | GSK3A | G3620 | Glutamate Receptor Ionotropic AMPA Receptor | HDAC2 | CSNK1E | HRH3

疾病靶点研报
Mood Disorder

Note: If you'd like to get a target analysis report for Mood Disorder, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Mood Disorder at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Premature Ejaculation | Hypersensitivity | Limb Girdle Muscular Dystrophy | Polycythemia | Diabetes | Saethre-Chotzen Syndrome | Carcinoid Tumor | Vitamin B12 Deficiency | Tumoral Calcinosis | Usher Syndrome Type III | LEOPARD Syndrome | Porphyria | Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive 2 | Diabetic Nephropathy | Erythrokeratodermia Variabilis | Charcot-Marie-Tooth Disease, Type 2C | Glaucoma | Glycogen Storage Disease Type 1 | Cheilitis | Erythromelalgia | Acute Coronary Syndrome | Mevalonate Kinase Deficiency | Familial Advanced Sleep Phase Syndrome | Charcot-Marie-Tooth Disease Type 2T | Scabies | Ischemia | Alpha-mannosidosis | Cerebellar Ataxia, Cayman Type | Cold-induced Sweating Syndrome | Hemochromatosis Type 2 | Lymphoma, AIDS-related | Focal Cortical Dysplasia Type 2 | Lipid Storage Myopathy | Hypocalcemia | Keratocystic Odontogenic Tumor | Giant Cell Arteritis | Supravalvular Aortic Stenosis | Waardenburg Syndrome Type 2A | Schizencephaly | Lymphoma, Primary Cutaneous Anaplastic Large Cell | Kaposi Sarcoma | Communication Disorders | Pure Red Cell Aplasia | Metabolic Diseases | Cutaneous Angiosarcoma | Osteosarcoma | Parvovirus B19 Infection | Hypertensive Retinopathy | Hypermethioninemia | Localized Scleroderma | Spondylolisthesis | Jaundice, Obstructive | Coronary Heart Disease | Liver Diseases | Blepharophimosis Syndrome | Hepatic Veno-occlusive Disease | Duodenal Atresia | Tracheal Disorders | Spondyloperipheral Dysplasia | Rhizomelic Chondrodysplasia Punctata | Creatine Deficiency Syndrome Due To AGAT Deficiency | Veno-occlusive Disease | 3-hydroxy-3-methylglutaric Aciduria | Hyperinsulinemia | Pulmonary Capillary Hemangiomatosis | Avellino Corneal Dystrophy | Angina Pectoris | Guttate Psoriasis | Treacher Collins Syndrome | Osteoarthritis | Gaucher Disease | Toxoplasmosis | Potocki-Shaffer Syndrome | Ligneous Conjunctivitis | Diffuse Intrinsic Pontine Glioma | Chondrodysplasia Punctata | Thanatophoric Dysplasia | Polycythemia Vera | Vogt-Koyanagi-Harada Syndrome | Hepatitis C, Chronic | Leishmaniasis, Visceral | Anorectal Fistula | Stomatitis | Sialidosis Type I | 5-oxoprolinase Deficiency | Teratozoospermia | Chylomicron Retention Disease | Episodic Ataxia | Anthrax | Hereditary Coproporphyria | Myopathy | NDH Syndrome | Leiomyosarcoma | Ectrodactyly | Congenital Ichthyosiform Erythroderma | Beare-Stevenson Syndrome | Joubert Syndrome 2 | Autonomic Neuropathy | Osteogenesis Imperfecta Type II | Stuttering | Cerebrotendinous Xanthomatosis | HUPRA Syndrome | Cabezas Syndrome | Mitochondrial DNA Depletion Syndrome, Myopathic Form | Osteogenesis Imperfecta | Intracranial Hypertension | Beckwith-Wiedemann Syndrome | Huntington's Disease | Meningitis | 3-methylglutaconic Aciduria Type IV | Cardiomyopathy, Dilated, 1L | T-cell Prolymphocytic Leukemia | Persistent Fetal Circulation | Prediabetes | Myositis | Tyrosinemia Type 1 | Cellulitis | Charcot-Marie-Tooth Disease Type 2E | Dermatitis Herpetiformis | Hennekam Lymphangiectasia-lymphedema Syndrome | Aarskog-Scott Syndrome | ICF Syndrome | Gastroenteritis, Eosinophilic | Amebiasis | Gynecomastia | Cardiomyopathy, Hypertrophic | Inflammatory Bowel Disease | CHOPS Syndrome | Depression | Steel Syndrome | Hypolipoproteinemia | Mucormycosis | Alpers Syndrome | Chanarin-Dorfman Syndrome | Parapsoriasis | Traboulsi Syndrome | Melnick-Needles Syndrome | Retinal Degeneration | Coronary Artery Disease | Keratosis, Actinic | Hypertelorism | 3C Syndrome | Charcot-Marie-Tooth Disease, Type 6 | Pleomorphic Xanthoastrocytoma | Epidermolytic Ichthyosis, Annular | Waardenburg Syndrome Type 4A | Primary Sclerosing Cholangitis | Vascular Calcification | Colitis, Collagenous | Postaxial Polydactyly | Alstrom Syndrome | Papillon-Lefevre Syndrome | Tenosynovial Giant Cell Tumor | Primary Cutaneous Amyloidosis | Antiphospholipid Syndrome | Ophthalmia, Sympathetic | Fukuyama Congenital Muscular Dystrophy | Spinocerebellar Ataxia Type 6 | Gilbert Syndrome | Ulcerative Colitis | Myasthenia Gravis | Infertility | Feingold Syndrome | Craniometaphyseal Dysplasia | Lentigo | Congenital Nystagmus | Hereditary Multiple Exostoses | Lassa Fever | Overactive Bladder | Pyelonephritis | Sclerosteosis 2 | Renal Oncocytoma | Open-angle Glaucoma | Very Long-chain Acyl-CoA Dehydrogenase Deficiency | Methemoglobinemia | Hartnup Disease | Focal Dermal Hypoplasia | Renal Failure | Donnai-Barrow Syndrome | Inflammatory Myopathy | Early Infantile Epileptic Encephalopathy 28 | Cenani-Lenz Syndactyly Syndrome | Paraganglioma | Spinocerebellar Ataxia Type 8 | Tinea Versicolor | Nutrition Disorders | Pain | Huntington's Disease-like 2 | Nevus | Long QT Syndrome Type 2 | Hereditary Hemorrhagic Telangiectasia | Congenital Absence Of Vas Deferens | Cancer, Colon | Knobloch Syndrome | Speech Disorders | Dengue Hemorrhagic Fever | Precocious Puberty | Shprintzen-Goldberg Syndrome | Torticollis | Schnitzler Syndrome | Majeed Syndrome | Chondrodysplasia Punctata 1, X-linked Recessive | Pericarditis | Galactosemia | Corneal Ulcer | Proteus Syndrome | Spinocerebellar Ataxia Type 42 | GLUT1 Deficiency Syndrome | Bone Giant Cell Tumor | Retinal Dystrophy | Irritable Bowel Syndrome | IgA Deficiency | Congenital Heart Block | Osteopathia Striata With Cranial Sclerosis | Purpura | Aplasia Cutis Congenita | Actinomycetoma | Esophagitis, Eosinophilic | Hyperparathyroidism, Primary | Cervical Dystonia | Alazami Syndrome | Hereditary Sensory Neuropathy Type 1 | Acquired Partial Lipodystrophy | PHARC Syndrome | Chronic Periodontitis | Sandhoff Disease | Osteogenesis Imperfecta Type IV | Episodic Ataxia Type 1 | Rheumatoid Arthritis | Tonsillitis | Chronic Inflammatory Demyelinating Polyneuropathy | Lymphoma Lymphoblastic | Sarcoma, Ewing | Esophageal Motility Disorders | Axenfeld-Rieger Syndrome | Schwannomatosis | Christianson Syndrome | Lymphoma, B-cell | Pyoderma Gangrenosum | Glutaric Aciduria Type 1 | Nijmegen Breakage Syndrome | Polyomavirus Nephropathy | Porokeratosis | Retinal Coloboma | Left Ventricular Noncompaction | Keloid | Fibronectin Glomerulopathy | Meningococcal Meningitis | Protein C Deficiency | Autosomal Recessive Spastic Paraplegia Type 75 | DOCK8 Immunodeficiency Syndrome | Primrose Syndrome | Gray Platelet Syndrome | Pseudohypoaldosteronism | Arterial Tortuosity Syndrome | Peeling Skin Syndrome Type B | Takayasu's Arteritis | Uremia | Porphyria, Acute Intermittent | 17-beta-hydroxysteroid Dehydrogenase X Deficiency | Sponastrime Dysplasia | Papilloma | TARP Syndrome | Vascular Cognitive Impairment | Kabuki Syndrome 2 | Dyggve-Melchior-Clausen Disease | Pulmonary Tuberculosis | Chronic Granulomatous Disease, X-linked | Angioimmunoblastic T-cell Lymphoma | Pemphigoid | Crohn's Disease | Pseudohypoparathyroidism Type 1B | Hepatopulmonary Syndrome | Marshall-Smith Syndrome | Keratosis | Otitis Media | Duchenne Muscular Dystrophy | Pierson Syndrome | Schnyder Crystalline Corneal Dystrophy | Renal Medullary Carcinoma | Myeloid Leukemia | Hairy Cell Leukemia | Lymphoproliferative Disorders | Combined Pituitary Hormone Deficiency | Muckle-Wells Syndrome | Glaucomatocyclitic Crisis | Methylmalonic Aciduria And Homocystinuria, CblC Type | Ocular Surface Squamous Neoplasia | Tendinopathy | Pseudohypoparathyroidism Type 1A | Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia | Varices | Pituitary Dwarfism | Atopy | Ataxia-hypogonadism-choroidal Dystrophy Syndrome | Cri-du-chat Syndrome | Hyperostosis | Carcinoma, Signet Ring Cell | Necrotizing Autoimmune Myopathy | Lymphedema | Trichuriasis | Leigh Syndrome | Filariasis | Alzheimer Disease, Late Onset | Familial Glucocorticoid Deficiency | Odonto-onycho-dermal Dysplasia | Macular Corneal Dystrophy | Cancer, Brain | Vitreoretinopathy, Proliferative | Enlarged Vestibular Aqueduct | Primary Erythromelalgia | C3 Glomerulopathy | Peripheral T-cell Lymphoma | Angiosarcoma Of The Breast | Pure Autonomic Failure | Prune Belly Syndrome | Spondyloarthritis | Adenosine Deaminase 2 Deficiency | Bruck Syndrome | Diabetes Type 2 | Zygomycosis | Peritonitis | Infectious Diarrhea | Pigment Dispersion Syndrome | Fanconi Anemia | Diarrhea | Aceruloplasminemia | Dystonia-parkinsonism, X-linked | Malnutrition | Corneal Neovascularization | Headache | Neuroblastoma | Alexander Disease | Agranulocytosis | Heart Septal Defects | Sclerosing Cholangitis | Tetraplegia | Insulinoma | Spinocerebellar Ataxia Type 2 | Myopia | Macular Degeneration | Angiosarcoma | Spinal Muscular Atrophy | Paternal Uniparental Disomy Of Chromosome 14 | Neurocutaneous Melanocytosis | Cardiac Arrest | Loeys-Dietz Syndrome | Larsen Syndrome | Sporadic Hemiplegic Migraine | Cranioectodermal Dysplasia | Exotropia | Wolff-Parkinson-White Syndrome | Delayed Sleep Phase Syndrome | ADNP Syndrome | Hidradenitis Suppurativa | Contact Dermatitis | Fascioliasis | Conn Syndrome | Liddle Syndrome | Pulverulent Zonular Cataract | Mucolipidosis Type IV | Brenner Tumor | Okihiro Syndrome | Hyperprolactinemia | Nestor-Guillermo Progeria Syndrome | Poretti-Boltshauser Syndrome | Cerebrovascular Disorders | DEND Syndrome | Parkinson's Disease | Leukocyte Adhesion Deficiency | Familial Exudative Vitreoretinopathy | Epicondylitis | Long QT Syndrome Type 3 | Aldosterone Synthase Deficiency | Weill-Marchesani Syndrome | Constipation | Oligoasthenoteratozoospermia | Gastroschisis | Adult Polyglucosan Body Disease | Myotonia | Maternally Inherited Diabetes And Deafness | Hyperlipidemia, Familial Combined | Peeling Skin Syndrome, Acral Type | X-linked Myotubular Myopathy | Primary Hyperoxaluria | Progressive Encephalopathy-optic Atrophy Syndrome | Mitochondrial DNA Depletion Syndrome | Kernicterus | Sertoli Cell-only Syndrome | Sick Sinus Syndrome 1 | Major Depression | Martsolf Syndrome | Amyloidosis | Polymyositis | Pseudohypoparathyroidism Type 1C | Hydronephrosis | Lissencephaly 2 | Uremic Pruritus | Pineoblastoma | Glycogen Storage Disease Type 5