Mood Disorder

About the Disease
Mood Disorder, also known as mood disorders, is related to major depressive disorder and schizoaffective disorder, and has symptoms including alexithymia and psychiatric symptom. An important gene associated with Mood Disorder is DISC2 (Disrupted In Schizophrenia 2), and among its related pathways/superpathways are Signal Transduction and GPCR downstream signalling. The drugs Lithium carbonate and Risperidone have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and pituitary, and related phenotypes are nervous system and homeostasis/metabolism

Common Targets
GPR139 | BDNF | PROKR2 | 5-Hydroxytryptamine Receptor 3 (5-HT3 receptor) (nonspecified subtype) | CACNA1B | AVPR1A | WDR5 | Corticotropin-Releasing Factor (CRF) Receptor (nonspecified subtype) | KCNC1 | Phosphodiesterase IV (PDE4) (nonspecified subtype) | KCNN3 | OPRK1 | GRM5 | SLC18A2 | FKBP4 | OPRM1 | ACE | Metabotropic glutamate (mGluR) receptor (nonspecified subtype) | NOS1 | CNR2 | GRIN2C | GRIN1 | Folate Receptor (nonspecified subtype) | DRD4 | ADRA2B | GPR52 | AANAT | G5594 | DRD2 | NPSR1 | ESR2 | SIGMAR1 | T-Type Calcium Channel | Neuropeptide Y receptor (NPY-R) (nonspecified subtype) | KCND3 | MAOA | AVPR1B | SLCO2B1 | COMT | Estrogen receptor (nonspecified subtype) | TRPC5 | GABRB2 | BRD4 | GABRG2 | CHRM1 | HTR1A | KCNC2 | PDE10A | HDAC1 | SLC6A2 | CNR1 | Small Conductance Calcium-Activated Potassium Channel (SK) (nonspecified subtype) | ADORA1 | HCRTR1 | GRIN2D | SCN8A | PDE9A | GRM2 | Glutamate Transporter (nonspecified subtype) | DYRK1A | NAPEPLD | HTR2B | Neurotrophic Factor (nonspecified subtype) | DRD5 | GABA(A) receptor | Opioid receptor (nonspecified subtype) | SLC6A9 | TRPV1 | CHRNA7 | DPP4 | G9429 | ADORA2A | Nicotinic alpha4beta2 receptor | ADRA2A | ADA | HTR5A | GSK3B | Voltage-Gated Sodium Channel Complex | OXT | NR3C1 | FKBP5 | KCNQ Channels (K(v) 7) (nonspecified subtype) | G4318 | Orexin receptor (nonspecified subtype) | OPRD1 | GABRB3 | GABRA1 | Glycogen synthase kinase 3 (GSK-3) (nonspecified subtype) | Sodium channel (nonspecified subtype) | HCRTR2 | DRD1 | G5243 | TPH2 | KCNK3 | FAAH | MTHFR | CHRNA3 | MMP2 | LINC02210-CRHR1 | SLC6A4 | EDN1 | PDE2A | Dopamine receptor (nonspecified subtype) | GRM3 | TRPM2 | Glycine receptor | CRHR1 | HTR6 | ADM | TDO2 | CLK1 | KCNK9 | PROKR1 | SCN9A | NMDA receptor | GABRA5 | HTR2A | 5-Hydroxytryptamine Receptor 2 (5-HT2) (nonspecified subtype) | HTR1B | VHL | Histone deacetylase (nonspecified subtype) | TACR1 | APP | SLCO1B1 | alpha1-Adrenoceptor (nonspecified subtype) | Large Conductance BK(Ca) Potassium Channel (Maxi K+ Channel) (nonspecified subtype) | GABRA2 | P2RX7 | Nitric oxide synthase (NOS) (nonspecified subtype) | FGF14 | HTR2C | DRD3 | GRM4 | ANK3 | CSNK1D | SLCO1A2 | MAOB | SLC6A3 | OXTR | CHRNB2 | GPR55 | MCHR1 | GRIN2B | SCN5A | HTR1D | ADRA2C | GABRA3 | GRIK4 | HTR7 | KCNIP4 | GSK3A | G3620 | Glutamate Receptor Ionotropic AMPA Receptor | HDAC2 | CSNK1E | HRH3

Note: If you'd like to get a target analysis report for Mood Disorder, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Mood Disorder at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

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