Spondyloarthritis

About the Disease
Spondyloarthropathy 1, also known as ankylosing spondylitis, is related to ankylosing spondylitis 1 and spondylitis, and has symptoms including pain, stiffness in the spine and stiffness in the neck. An important gene associated with Spondyloarthropathy 1 is HLA-B (Major Histocompatibility Complex, Class I, B), and among its related pathways/superpathways are Innate Immune System and MIF Mediated Glucocorticoid Regulation. The drugs Tofacitinib and Etoricoxib have been mentioned in the context of this disorder. Affiliated tissues include Placenta and Umbilical Cord, and related phenotypes are kyphosis and inflammation of the large intestine

Common Targets
IL23R | CTNNB1 | TNFSF8 | RORC | Protein Phosphatase 2A | Metabotropic glutamate (mGluR) receptor (nonspecified subtype) | IL12B | TNFRSF1B | CCR6 | G6774 | ERAP2 | G3569 | G1432 | TGFB1 | CDKAL1 | ANXA5 | DIAPH3 | NAT1 | HLA-B | Interleukin-12 (IL-12) | KLRK1 | LOC105369735 | G3605 | FCGR3A | ACVR1 | PTGS1 | STAT4 | MEFV | ERAP1 | IL12A | PTH1R | FCGR2A | KRR1 | G5743 | RIPK1 | MICA | Interleukin 23 complex (IL-23) | IL6R | G7124

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