Rickets

About the Disease
Rickets, also known as vitamin d deficiency, is related to vitamin d-dependent rickets, type 3 and dent disease 1, and has symptoms including back pain, muscle cramp and sciatica. An important gene associated with Rickets is PHEX (Phosphate Regulating Endopeptidase X-Linked), and among its related pathways/superpathways are Metabolism of steroids and Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs). The drugs Clomifene and Dinoprostone have been mentioned in the context of this disorder. Affiliated tissues include bone, liver and kidney, and related phenotypes are no effect and no effect

Common Targets
VDR | ENPP3 | PHEX | CYP2R1 | SGK3 | NF-kappaB (NFkB) | PTH1R | CTSK | SLC34A3 | ALPI | SLC2A2 | ALPL

Note: If you'd like to get a target analysis report for Rickets, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Rickets at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Eclampsia | Amelogenesis Imperfecta | Sarcosinemia | Macular Corneal Dystrophy Type 1 | WAGR Syndrome | Phosphoenolpyruvate Carboxykinase Deficiency, Cytosolic | Myoclonic Epilepsy With Ragged Red Fibers | Enhanced S-cone Syndrome | VACTERL/VATER Association | Erdheim-Chester Disease | Waardenburg Syndrome | Budd-Chiari Syndrome | Prostatitis | Chloridorrhea, Congenital | Cat Eye Syndrome | Echinococcosis | Chronic Mucocutaneous Candidiasis | Constipation | Pyruvate Kinase Deficiency | Porphyria, Acute Intermittent | Neurofibrosarcoma | Charcot-Marie-Tooth Disease Type 3 | Rhizomelic Chondrodysplasia Punctata | Neurogenic Bladder | Nephropathy | Epidermolysis Bullosa Dystrophica | Moyamoya Disease | Spinocerebellar Ataxia Type 8 | Pseudohypoparathyroidism Type 1C | Ocular Hypertension | Iron Deficiency Anemia | Nephrotic Syndrome | Neuromyotonia | Woodhouse-Sakati Syndrome | Incontinentia Pigmenti | Tay-Sachs Disease | Porphyria Cutanea Tarda | Agoraphobia | Cerebral Amyloid Angiopathy | Creutzfeldt-Jakob Disease | Microcephalic Osteodysplastic Primordial Dwarfism, Type II | Kaposi Sarcoma | Chronic Kidney Disease | Basal Ganglia Disease | Craniometaphyseal Dysplasia | Aplasia Cutis Congenita | Blomstrand Osteochondrodysplasia | Cerebrovascular Disorders | Fanconi Anemia | Hyperparathyroidism, Secondary | Seminoma | Cancer, Colon | Pseudo-pseudohypoparathyroidism | Lymphangioleiomyomatosis | Sertoli Cell-only Syndrome | Hepatitis A | Blepharo-cheilo-odontic Syndrome | Menkes Disease | Adrenal Insufficiency | Richter's Syndrome | Osteosarcoma | Galactosialidosis | Temporal Lobe Epilepsy | Hypermethioninemia | Osteoporosis-pseudoglioma Syndrome | Usher Syndrome Type II | Osteogenesis Imperfecta Type IV | Cancer, Bladder | FG Syndrome | Loeys-Dietz Syndrome | Pontocerebellar Hypoplasia Type 7 | Congenital Central Hypoventilation Syndrome | 3-methylcrotonyl-CoA Carboxylase Deficiency | Neurodegeneration Due To Cerebral Folate Transport Deficiency | Van Der Knaap Disease | Anxiety Disorders | Ataxia-ocular Apraxia 2 | Renal Hypouricemia | Asperger Syndrome | Triple A Syndrome | Microphthalmia | Hypotrichosis, Congenital, With Juvenile Macular Dystrophy | Glycogen Storage Disease Type 4 | Spinocerebellar Ataxia Type 21 | Chromosome 16p11.2 Deletion Syndrome | Cholesteryl Ester Storage Disease | Optic Neuropathy | Goiter, Nodular | Alopecia Totalis | Epicondylitis | Clouston Hidrotic Ectodermal Dysplasia | Chondrosarcoma | Hidradenitis | Spondyloepimetaphyseal Dysplasia With Joint Laxity, Type 3 | Arthritis, Psoriatic | Bone Marrow Necrosis | Central Pain Syndrome | Hereditary Folate Malabsorption | Lymphangioma | Congenital Adrenal Hyperplasia | Astigmatism | Esotropia | Adenoma, Pituitary | Dentinogenesis Imperfecta | Cranial Nerve Disease | Nephrotic Syndrome Type 1 | Parkinson Disease 6, Autosomal Recessive Early-onset | Netherton Syndrome | Atrioventricular Septal Defect | Myofibromatosis | Epilepsy Of Infancy With Migrating Focal Seizures | Omenn Syndrome | Duodenal Atresia | Tendinopathy | Retinal Diseases | Central Retinal Artery Occlusion | Pfeiffer Syndrome | Joubert Syndrome 2 | Atelosteogenesis Type 2 | Cutaneous T-cell Lymphoma | 3-hydroxy-3-methylglutaric Aciduria | Salla Disease | LEOPARD Syndrome | Fibromyalgia | Meesmann Corneal Dystrophy | Light Chain Amyloidosis | X-linked Acrogigantism | Chronic Myeloid Leukemia | Fahr Disease | Osteitis | Giant Cell Glioblastoma | Angina Pectoris | Macular Degeneration | Cerebrotendinous Xanthomatosis | Myelitis | Binge Eating Disorder | Blau Syndrome | Acquired Partial Lipodystrophy | Congenital Dysfibrinogenemia | Hepatic Veno-occlusive Disease | Goldenhar Syndrome | Prune Belly Syndrome | Cholangiocarcinoma | Chanarin-Dorfman Syndrome | Cryptosporidiosis | Toxoplasmosis | Fetal And Neonatal Alloimmune Thrombocytopenia | Infantile Liver Failure Syndrome 1 | Smoldering Myeloma | Myelodysplasia | Cholestasis | Enterocolitis, Necrotizing | Hypertrophy | Erythromelalgia | Heterotopic Ossification | Coma | Hereditary Hemorrhagic Telangiectasia Type 2 | Acanthosis Nigricans | Osmotic Demyelination Syndrome | Retinitis Pigmentosa 3 | Membranous Nephropathy | Botulism | Carney Triad | Trichomegaly | Congenital Myasthenic Syndrome | X-linked Myotubular Myopathy | Pure Red Cell Aplasia | Hamartoma | Medium-chain Acyl-CoA Dehydrogenase Deficiency | Inflammatory Bowel Disease | Non-Langerhans Cell Histiocytosis | Congenital Dyserythropoietic Anemia | Epidermolysis Bullosa Simplex, Dowling-Meara Type | Gastritis, Atrophic | Encephalopathy | Otitis Media | Crisponi Syndrome | Hereditary Sensory And Autonomic Neuropathy | Hepatitis | Cystitis | Uterine Leiomyoma | Otosclerosis | Myelitis, Transverse | Leukocyte Adhesion Deficiency Type 1 | Dental Caries | Sialidosis Type I | Familial Male-limited Precocious Puberty | Blood Protein Disorders | 17-beta-hydroxysteroid Dehydrogenase X Deficiency | Charcot-Marie-Tooth Disease Type 4 | Sotos Syndrome | Aldosterone Synthase Deficiency | Lactose Intolerance | Cysticercosis | Hepatitis, Autoimmune | Angiosarcoma | Carbohydrate Metabolism Disorders | Plasma Cell Dyscrasia | Lewy Body Dementia | Cutaneous Mastocytosis | Metachondromatosis | Eosinophilic Asthma | Epidermolysis Bullosa Simplex, Generalized | Panniculitis | Nijmegen Breakage Syndrome | Acute Lung Injury | Warsaw Breakage Syndrome | Spinocerebellar Ataxia Type 13 | Conjunctivitis | Centronuclear Myopathy | Microcephalic Primordial Dwarfism | Myotonic Disorders | Tenosynovial Giant Cell Tumor | Meningeal Melanocytoma | Diffuse Palmoplantar Keratoderma | Tuberculosis | Primary Progressive Nonfluent Aphasia | Rash | Epidermolysis Bullosa Simplex With Mottled Pigmentation | Neuroendocrine Cancer | Bulimia Nervosa | Fibronectin Glomerulopathy | Sarcomatoid Carcinoma Of The Lung | Migraine | Glaucoma | Multifocal Motor Neuropathy | Juvenile Xanthogranuloma | Vascular Cognitive Impairment | Polymyalgia Rheumatica | Best Macular Dystrophy | Bietti Crystalline Dystrophy | Hypercholesterolemia | Veno-occlusive Disease | B-cell Prolymphocytic Leukemia | Agammaglobulinemia | Atrial Septal Defect | Sclerocornea | Strabismus | Campomelic Dysplasia | Recurrent Respiratory Papillomatosis | Persistent Hyperplastic Primary Vitreous | Spinocerebellar Ataxia Type 20 | Rotor Syndrome | Hereditary Spherocytosis | Hairy Cell Leukemia | Sick Sinus Syndrome | Meniere's Disease | Periventricular Nodular Heterotopia | Inflammatory Joint Disease | Thrombosis | Influenza | Spinal Cord Diseases | Myasthenia | Bruck Syndrome | Splenomegaly | Hepatitis, Chronic | Iron Overload | Nager Acrofacial Dysostosis | Ichthyosis | Ameloblastoma | Gastroschisis | Metachromatic Leukodystrophy | Hypokalemic Periodic Paralysis | Tuberculous Meningitis | Gastritis | Pleurisy | Aneurysm, Thoracic Aortic | LRBA Deficiency | Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive 1 | Epidermolysis Bullosa | Familial Hypertrophic Cardiomyopathy | Lissencephaly 2 | Mucolipidosis | Tendinitis | Transient Bullous Dermolysis Of The Newborn | Spinocerebellar Ataxia Type 38 | Intermittent Explosive Disorder | Kawasaki Disease | Hepatitis C, Chronic | Metaphyseal Chondrodysplasia, Schmid Type | Mitochondrial DNA Depletion Syndrome, Encephalomyopathic Form | Fuchs Dystrophy | Smith-Kingsmore Syndrome | Acute Anterior Uveitis | Corneal Neovascularization | Cholera | Tetanus | Noonan Syndrome-like Disorder With Loose Anagen Hair | Schizencephaly | Autoimmune Disease | Inflammatory Linear Verrucous Epidermal Nevus | Oligoasthenoteratozoospermia | Leukoplakia, Oral | Autosomal Recessive Spastic Paraplegia Type 35 | Krabbe Disease | Niemann-Pick Disease, Type C | Keratosis | Varices | Blastomycosis | Antithrombin III Deficiency | Spondylolisthesis | Gilbert Syndrome | Proctitis | Cryoglobulinemia | Myopathy | Rosacea | Oculocutaneous Albinism Type 4 | Walker-Warburg Syndrome | CHOPS Syndrome | Hyperprolactinemia | Cutaneous Lupus Erythematosus | Cervical Dystonia | Split Hand-foot Malformation | Jalili Syndrome | Stroke, Ischemic | Malaria, Cerebral | Neurofibromatosis-Noonan Syndrome | Headache | Intracranial Hypertension | Esophageal Carcinoma | Facioscapulohumeral Muscular Dystrophy Type 2 | Chronic Granulomatous Disease, X-linked | Pemphigus | Transcobalamin Deficiency | Stroke | Myasthenia Gravis | Hemolytic Uremic Syndrome, Atypical | Usher Syndrome Type III | Lupus Erythematosus | Globozoospermia | Pathological Gambling | Lymphangiomatosis | Japanese Encephalitis | Dowling-Degos Disease | Pycnodysostosis | Gingivitis | Small Lymphocytic Lymphoma | Diarrhea | Scapuloperoneal Spinal Muscular Atrophy | Eczema | Nevus | Nutrition Disorders | Personality Disorders | Dementia | Iron Metabolism Disorders | Prolymphocytic Leukemia | Congenital Hereditary Endothelial Dystrophy Type II | Waardenburg Syndrome Type 4A | Stargardt Disease | PHARC Syndrome | Chorea-acanthocytosis | Chorioretinitis | Thyroid Dyshormonogenesis | Osteochondrosis | Waardenburg Syndrome Type 1 | LMNA-related Congenital Muscular Dystrophy | Pendred Syndrome | Aarskog-Scott Syndrome | Pleural Tuberculosis | L-2-Hydroxyglutaric Aciduria | Spinal Muscular Atrophy | Rubeosis Iridis | Adrenomyeloneuropathy | Tangier Disease | Amyotrophic Lateral Sclerosis, Juvenile | Charcot-Marie-Tooth Disease, Type 2 | Cardiomyopathy, Peripartum | Osteopathia Striata With Cranial Sclerosis | Papilloma | Congenital Bilateral Absence Of Vas Deferens | Donnai-Barrow Syndrome | Von Hippel-Lindau Disease | Leishmaniasis, Cutaneous | Central Core Disease | Dominant Optic Atrophy | Unverricht-Lundborg Syndrome | Hydrocephalus | Spitz Nevus | Benign Hereditary Chorea | Acute Generalized Exanthematous Pustulosis | Ataxia-hypogonadism-choroidal Dystrophy Syndrome | Meningitis | Optic Nerve Hypoplasia, Bilateral | Renal Oncocytoma | Pseudohypoparathyroidism Type 1B | Retinal Vasculitis | Lassa Fever | Oculopharyngeal Muscular Dystrophy | Papulopustular Rosacea | Connective Tissue Disorders | Chylomicron Retention Disease | X-linked Sideroblastic Anemia | Fundus Albipunctatus | Cherubism | Osteoglophonic Dysplasia | Retinoschisis | Progressive Familial Intrahepatic Cholestasis | Peripheral T-cell Lymphoma | Kaposiform Hemangioendothelioma | Absence Epilepsy