Disease

Rickets

About the Disease
Rickets, also known as vitamin d deficiency, is related to vitamin d-dependent rickets, type 3 and dent disease 1, and has symptoms including back pain, muscle cramp and sciatica. An important gene associated with Rickets is PHEX (Phosphate Regulating Endopeptidase X-Linked), and among its related pathways/superpathways are Metabolism of steroids and Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs). The drugs Clomifene and Dinoprostone have been mentioned in the context of this disorder. Affiliated tissues include bone, liver and kidney, and related phenotypes are no effect and no effect

Common Targets
VDR | ENPP3 | PHEX | CYP2R1 | SGK3 | NF-kappaB (NFkB) | PTH1R | CTSK | SLC34A3 | ALPI | SLC2A2 | ALPL

疾病靶点研报
Rickets

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