Disease

Hairy Cell Leukemia

About the Disease
Classic Hairy Cell Leukemia, also known as leukemic reticuloendotheliosis, is related to intrapelvic lymph node leukemic reticuloendotheliosis and reticuloendotheliosis, x-linked. An important gene associated with Classic Hairy Cell Leukemia is BRAF (B-Raf Proto-Oncogene, Serine/Threonine Kinase). The drugs Cladribine and 2-chloro-3'-deoxyadenosine have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, spleen and bone.

Common Targets
DUSP2 | CHEK2 | ACTB | CXCR5 | MAP1A | Na+/H+ Exchanger (NHE) (nonspecified subtype) | C17orf80 | POLD2 | MAGEC3 | TOM1L1 | RASL12 | CDK2 | BTK | TNFRSF10A | TP53I3 | LMX1A | CDK6 | IL2RA | CHEK1 | NCKAP1 | Phosphatidylinositol 3-kinase (PI3K) (nonspecified subtype) | GMNC | BMX | RAPGEFL1 | Protein kinase C (nonspecified subtype) | LCA5 | CDK4 | CDKN2B | SLC22A24 | CLEC6A | FAT3 | MAP2K1 | IL-2 receptor | HLA-DRB1 | TPPP2 | TAF3 | Adenosine deaminase (nonspecified subtype) | G673 | ADA | CHD7 | PDPK1 | CNOT10 | CD22 | SLC22A8 | TMSB4X | FOXA1 | MUC5B | KLF2 | DDX56 | ZFP36 | SPATA5L1 | ISX | Interferon alpha/beta Receptor (nonspecified subtype) | STARD4 | MAPK15 | ZFYVE21 | ATP1A4 | BLK | RAF1 | ADIPOR2 | CRYBB1 | IFNAR1 | SCD5 | MCM5 | DMXL2 | CDKN1B | ABHD17B | PEX1 | OGFOD1 | NUDT6 | STYXL2 | PMAIP1 | RUNX1 | GRHL1 | LAPTM5 | KBTBD7 | ABCC1 | KMT2D | GNAS | CREBBP | SDHAF2 | MGMT | VHL | ARID1A | IFNAR2 | CDK1 | CNTNAP4 | CD19 | KIAA1755

疾病靶点研报
Hairy Cell Leukemia

Note: If you'd like to get a target analysis report for Hairy Cell Leukemia, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Hairy Cell Leukemia at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Chloridorrhea, Congenital | Antley-Bixler Syndrome | Conjunctivitis | Fibronectin Glomerulopathy | Hyper IgE Syndrome | MELAS Syndrome | Scoliosis | Hypersensitivity | Pseudohypoparathyroidism Type 1B | Retinitis Pigmentosa 3 | Spinocerebellar Ataxia Type 5 | Microcephalic Osteodysplastic Primordial Dwarfism, Type I | Dystrophy, Cone-rod | Aplastic Anemia | Retinal Dystrophy, Early-onset Severe | Infantile Neuroaxonal Dystrophy | Brugada Syndrome 1 | Erdheim-Chester Disease | Arthritis, Gouty | Neurodegeneration With Brain Iron Accumulation | HIBCH Deficiency | Alexander Disease | Pregnancy, Ectopic | Pilomatrix Carcinoma | Cervical Dystonia | Acrodermatitis | Congenital Poikiloderma | Pathological Gambling | Acne Vulgaris | Liver Failure | Congenital Hypofibrinogenemia | Growth Hormone Excess | Babesiosis | Hyperinsulinism-hyperammonemia Syndrome | Spermatocele | Carcinoma, Signet Ring Cell | Lewy Body Dementia | Stuve-Wiedemann Syndrome | Hepatitis E | MIRAGE Syndrome | Basal Ganglia Cerebrovascular Disease | Carcinoma In Situ | Neurofibromatosis-Noonan Syndrome | Sotos Syndrome | Urea Cycle Disorder | Polymyositis | Bernard-Soulier Syndrome | Supravalvular Aortic Stenosis | Hypervalinemia | Hyperuricemia | Myelomeningocele | Alcoholism | Polycystic Kidney, Autosomal Recessive | Pneumothorax | Takenouchi-Kosaki Syndrome | Carney-Stratakis Syndrome | Pseudoachondroplasia | Anosmia, Congenital | Polydactyly | Pneumonia, Mycoplasma | Epidermolytic Hyperkeratosis | Ependymoma | Schistosomiasis | Charcot-Marie-Tooth Disease | Focal Facial Dermal Dysplasia | Diabetic Macular Edema | Blomstrand Osteochondrodysplasia | Central Retinal Artery Occlusion | Hypotrichosis | Hypertriglyceridemia | Cardiac Sarcoidosis | Hereditary Hemorrhagic Telangiectasia | Spondylocarpotarsal Synostosis Syndrome | Sclerosteosis 2 | Amebiasis | Pyruvate Dehydrogenase Deficiency | Congenital Ichthyosiform Erythroderma | Melnick-Needles Syndrome | Osteomalacia | Vitamin D Deficiency | Hypoproteinemia, Hypercatabolic | Kaposiform Hemangioendothelioma | Hepatic Steatosis | Enlarged Vestibular Aqueduct | Prune Belly Syndrome | Cardiac Arrest | Usher Syndrome Type II | Congenital Torticollis | Atrioventricular Septal Defect | Desbuquois Syndrome | Papilloma | Intestinal Hypomagnesemia 1 | Nasodigitoacoustic Syndrome | Myelitis, Transverse | Peripheral Neuropathy | Hemimegalencephaly | Nicolaides-Baraitser Syndrome | Scleritis | Familial Pheochromocytoma-paraganglioma | Rickets | Lipoma | Monilethrix | Glycogen Storage Disease Type 1 | Mesial Temporal Lobe Epilepsy With Hippocampal Sclerosis | Limb Girdle Muscular Dystrophy | Hashimoto Thyroiditis | Neutrophilia | Chondrosarcoma | C3 Glomerulopathy | Neurocutaneous Syndromes | Stevens-Johnson Syndrome | Xeroderma Pigmentosum | Leber Congenital Amaurosis | Spinocerebellar Ataxia Type 38 | Familial Advanced Sleep Phase Syndrome | Glucagonoma | Micro Syndrome | Thyroid Dysgenesis | 3-methylglutaconic Aciduria Type IV | Malonyl-CoA Decarboxylase Deficiency | Endocarditis | Heart Failure | Osteochondrosis | Congenital Hereditary Endothelial Dystrophy Type II | Robinow Syndrome | Progressive External Ophthalmoplegia | Juvenile Myelomonocytic Leukemia | Chronic Thromboembolic Pulmonary Hypertension | Cystinuria | Arthritis, Reactive | Whipple's Disease | Sensory Neuropathy | Azoospermia | Macular Corneal Dystrophy Type 1 | Autosomal Recessive Spastic Paraplegia Type 54 | Cirrhosis | Presbyopia | Congenital Dyserythropoietic Anemia | Inflammatory Linear Verrucous Epidermal Nevus | Esophagitis, Eosinophilic | Contact Dermatitis | Congenital Stationary Night Blindness | Hypercalciuria | Anti-glomerular Basement Membrane Disease | Charcot-Marie-Tooth Disease Axonal Type 2N | Okihiro Syndrome | Hernia, Inguinal | Diabetes Mellitus, Transient Neonatal | Carey-Fineman-Ziter Syndrome | Encephalopathy, Ethylmalonic | Rett Syndrome | Vitamin K Deficiency | Congenital Lipoid Adrenal Hyperplasia | Ectodermal Dysplasia | Orotic Aciduria | Osteogenesis Imperfecta Type VI | Hypercalcemia | Schwartz-Jampel-Aberfeld Syndrome | Traboulsi Syndrome | Snyder-Robinson Syndrome | Renal Hypomagnesemia 3 | Takayasu's Arteritis | Netherton Syndrome | Huntington's Disease-like 2 | Aneurysm, Abdominal Aortic | Tyrosinemia | Speech Disorders | Hyperglycemia | Saul-Wilson Syndrome | Autoimmune Disease | Norrie Disease | Retinal Dystrophy | Lymphedema-distichiasis Syndrome | Aspartylglycosaminuria | Diastrophic Dysplasia | Nutrition Disorders | Iron Overload | Leukemia-lymphoma, Adult T-cell | Vasculitis | Niemann-Pick Disease, Type A | Miyoshi Myopathy | Progressive Familial Intrahepatic Cholestasis | Platyspondylic Lethal Skeletal Dysplasia, Torrance Type | McCune-Albright Syndrome | Waardenburg Syndrome Type 1 | Methylmalonic Acidemia | Epithelial-myoepithelial Carcinoma | Holt-Oram Syndrome | Major Depression | Autoimmune Hemolytic Anemia | X-linked Sideroblastic Anemia | KBG Syndrome | Sarcoma, Endometrial Stromal | Glycogen Storage Disease Type 4 | Oligoastrocytoma | Pseudo-pseudohypoparathyroidism | Dowling-Degos Disease | Juvenile Myoclonic Epilepsy | Parapsoriasis | Birk-Barel Syndrome | Imerslund-Grasbeck Syndrome | Mesothelioma, Malignant | Palmoplantar Keratoderma | Chitayat Syndrome | Xeroderma Pigmentosum Variant Type | Primary Aldosteronism | Priapism | Glutathione Synthetase Deficiency | Synpolydactyly | Idiopathic Multicentric Castleman Disease | Dent Disease | Tibial Muscular Dystrophy | Chondrodysplasia Punctata 2, X-linked Dominant | Endometritis | Hemochromatosis Type 2 | Juvenile Xanthogranuloma | Seasonal Mood Disorder | Creatine Deficiency Syndrome | Amish Infantile Epilepsy Syndrome | Familial Episodic Pain Syndrome | Meningioma, Benign | Focal Segmental Glomerulosclerosis | Skin Carcinoma | Kallmann Syndrome | Lymphoma | Colorectal Adenoma | Pyoderma Gangrenosum | Spinocerebellar Ataxia Type 6 | Congenital Afibrinogenemia | Fibrodysplasia Ossificans Progressiva | Glycogen Storage Disease Type 3 | Wolfram Syndrome | Hypertension, Essential | Malaria, Cerebral | Hepatic Veno-occlusive Disease | Coronary Heart Disease | Hennekam Lymphangiectasia-lymphedema Syndrome | Trichomegaly | Fetal Akinesia Deformation Sequence | Basan Syndrome | Hyperhomocysteinemia | Cartilage Disorders | Bacterial Meningitis | Menetrier Disease | Necrotizing Autoimmune Myopathy | Sarcomatoid Carcinoma Of The Lung | Granular Corneal Dystrophy Type 1 | Joubert Syndrome | Swine Influenza | Fascioliasis | Motor Neuron Diseases | Takotsubo Cardiomyopathy | Autoimmune Autonomic Ganglionopathy | Autosomal Recessive Congenital Ichthyosis | Familial Glucocorticoid Deficiency | Gastric Atrophy | Systemic Mastocytosis | Crigler-Najjar Syndrome | Autoimmune Polyendocrine Syndrome | Distal Myopathy | Cystinosis | Astrocytoma, Anaplastic | Hepatitis C, Chronic | Long QT Syndrome Type 1 | Bethlem Myopathy | Smith-Magenis Syndrome | Prolactinoma | Hypothalamic Obesity | Retinal Detachment | Polyneuropathy | Paronychia | Twin-to-twin Transfusion Syndrome | Antisynthetase Syndrome | Shock, Cardiogenic | X-linked Acrogigantism | Ichthyosis Hystrix, Curth-Macklin Type | Sweet Syndrome | Bardet-Biedl Syndrome | Waardenburg Syndrome Type 4A | Dystonia Musculorum Deformans | Cystitis | Pericarditis | Hypopigmentation | Behcet's Disease | 6-pyruvoyl-tetrahydropterin Synthase Deficiency | Ventricular Septal Defect | Myoclonus-dystonia Syndrome | AIDS | Lupus Erythematosus | Glycogen Storage Disease Type 0, Muscle | Analgesia | Cyst | Distal Myopathy 2 | DICER1 Syndrome | Histoplasmosis | Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia | Neurofibroma, Plexiform | Anuria | COACH Syndrome | Cataplexy | Carbohydrate Metabolism Disorders | Myhre Syndrome | Carbamoyl Phosphate Synthetase I Deficiency | Neurocysticercosis | Gangliosidosis, GM1 | Lymphoma, Mantle Cell | Myofibromatosis | Dystonia-parkinsonism, X-linked | Sjogren Syndrome | Craniopharyngioma | Aplasia Cutis Congenita | Hypoplastic Left Heart Syndrome | Gyrate Atrophy Of The Choroid And Retina | Myopia | Heart Septal Defects | Leiomyoma | Trichothiodystrophy | Hypotrichosis Simplex | Demyelinating Diseases | Tremor | Viral Meningitis | Hypertensive Nephropathy | Pseudomyxoma Peritonei | Osteochondroma | Charcot-Marie-Tooth Disease Type 4 | Methemoglobinemia Type IV | Acute Motor Axonal Neuropathy | Fibrosarcoma | Apert Syndrome | Diabetic Neuropathy | Cat Eye Syndrome | Chromosome 8q21.11 Deletion Syndrome | Retinal Diseases | Psoriasis | Perivascular Epithelioid Cell Tumor | Cleidocranial Dysplasia | Intracerebral Hemorrhage | Progressive Familial Intrahepatic Cholestasis Type 3 | Hyperoxaluria | Alpha-1 Antitrypsin Deficiency | High Molecular Weight Kininogen Deficiency | Periodic Limb Movement Disorder | Lymphoproliferative Disease, X-linked | Fibrillation, Atrial | Lymphoma, Follicular | Glutaric Aciduria Type 1 | Carbonic Anhydrase VA Deficiency | Hyperkalemic Periodic Paralysis | Adult Polyglucosan Body Disease | Gastritis | Adenosine Deaminase 2 Deficiency | Globozoospermia | Gangliosidosis | Headache | Mitochondrial DNA Depletion Syndrome, Hepatocerebral Form | Pineoblastoma | Chondroma | Amenorrhea | Charcot-Marie-Tooth Disease Type 4B1 | Thrombasthenia | Acute Anterior Uveitis | Meconium Ileus | Goldenhar Syndrome | Keratosis, Actinic | Arteriovenous Malformations | Anovulation | Acute Chest Syndrome | Osteopetrosis | Congenital Heart Block | Periventricular Leukomalacia | Keratitis-ichthyosis-deafness Syndrome | Spondylo-ocular Syndrome | Cerebrovascular Disorders | Erythrokeratodermia Variabilis | Angiodysplasia | Schistosomiasis Mansoni | Chronic Lymphocytic Leukemia | Hemolytic Anemia | Uveitis | Autosomal Recessive Spastic Paraplegia Type 75 | Pemphigus Vulgaris | Tularemia | Influenza | Charcot-Marie-Tooth Disease Type 2E | Scleroderma, Diffuse | Otitis Externa | Megalencephaly | Chondrodysplasia Punctata 1, X-linked Recessive | Pituitary Dwarfism | Fragile X Syndrome | Duane Retraction Syndrome | Renal Hypouricemia | Danon Disease | Polymicrogyria | Sickle Cell Disease | Retinal Coloboma | Exotropia | Hepatorenal Syndrome | Orthostatic Intolerance | Epidermolysis Bullosa Simplex, Dowling-Meara Type