Hairy Cell Leukemia

About the Disease
Classic Hairy Cell Leukemia, also known as leukemic reticuloendotheliosis, is related to intrapelvic lymph node leukemic reticuloendotheliosis and reticuloendotheliosis, x-linked. An important gene associated with Classic Hairy Cell Leukemia is BRAF (B-Raf Proto-Oncogene, Serine/Threonine Kinase). The drugs Cladribine and 2-chloro-3'-deoxyadenosine have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, spleen and bone.

Common Targets
DUSP2 | CHEK2 | ACTB | CXCR5 | MAP1A | Na+/H+ Exchanger (NHE) (nonspecified subtype) | C17orf80 | POLD2 | MAGEC3 | TOM1L1 | RASL12 | CDK2 | BTK | TNFRSF10A | TP53I3 | LMX1A | CDK6 | IL2RA | CHEK1 | NCKAP1 | Phosphatidylinositol 3-kinase (PI3K) (nonspecified subtype) | GMNC | BMX | RAPGEFL1 | Protein kinase C (nonspecified subtype) | LCA5 | CDK4 | CDKN2B | SLC22A24 | CLEC6A | FAT3 | MAP2K1 | IL-2 receptor | HLA-DRB1 | TPPP2 | TAF3 | Adenosine deaminase (nonspecified subtype) | G673 | ADA | CHD7 | PDPK1 | CNOT10 | CD22 | SLC22A8 | TMSB4X | FOXA1 | MUC5B | KLF2 | DDX56 | ZFP36 | SPATA5L1 | ISX | Interferon alpha/beta Receptor (nonspecified subtype) | STARD4 | MAPK15 | ZFYVE21 | ATP1A4 | BLK | RAF1 | ADIPOR2 | CRYBB1 | IFNAR1 | SCD5 | MCM5 | DMXL2 | CDKN1B | ABHD17B | PEX1 | OGFOD1 | NUDT6 | STYXL2 | PMAIP1 | RUNX1 | GRHL1 | LAPTM5 | KBTBD7 | ABCC1 | KMT2D | GNAS | CREBBP | SDHAF2 | MGMT | VHL | ARID1A | IFNAR2 | CDK1 | CNTNAP4 | CD19 | KIAA1755

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