Ischemia

About the Disease
Ischemia, also known as acute coronary syndrome, is related to limb ischemia and lipoprotein quantitative trait locus, and has symptoms including anoxemia, polydipsia and muscle weakness. An important gene associated with Ischemia is LINC01254 (Long Intergenic Non-Protein Coding RNA 1254), and among its related pathways/superpathways are Signal Transduction and Response to elevated platelet cytosolic Ca2+. The drugs Lovastatin and Nadroparin have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, heart and brain, and related phenotypes are homeostasis/metabolism and nervous system

Common Targets
G5743 | Integrin alphaMbeta2 (MAC-1) Receptor | Tubulin | GPR31 | MAS1L | G7852 | ACHE | m-Calpain | NOS1 | G4233 | Lipoxygenase (nonspecified subtype) | GABA(A) receptor | PIK3CB | ADORA1 | FKBP4 | G4318 | VDR | G23411 | SIGMAR1 | MAP3K5 | GRIN1 | Estrogen receptor (nonspecified subtype) | CHRM1 | GRIN2C | SPHK2 | BSG | T-Type Calcium Channel | G3569 | CCNH | MCU | APOA5 | CA1 | ADORA2B | Sodium channel (nonspecified subtype) | F2 | NOS3 | F11R | NPC1L1 | ADORA2A | IL1B | SLC22A12 | F10 | ARG1 | XDH | NTRK1 | CDK9 | G7124 | Neurotrophic Factor (nonspecified subtype) | Acetylcholine Receptors (Nicotinic) (nAChR) (nonspecified subtype) | AKR1B1 | G7422 | ABCG1 | PCSK9 | SERPINE1 | KCNK2 | NOX4 | FLT3 | MIR1-1 | GRIN2D | Guanylate cyclase (nonspecified subtype) | G836 | HPGD | RET | MMP2 | FPGT-TNNI3K | GRIA2 | CDO1 | DNM1L | APOC3 | ITGB2 | Alcohol Dehydrogenase (nonspecified subtype) | CES1 | SDC4 | PDE5A | MIR21 | TNNI3K | Death-associated protein kinase (nonspecified subtype) | ADORA3 | DAPK1 | TEK | PLG | GRIN2A | PTGER4 | Integrin alphaIIbbeta3 (fibrinogen gpIIb/IIIa) receptor | KCNK10 | GRIA3 | CHRM3 | AGTR1 | NF-kappaB (NFkB) | FKBP5 | PIKFYVE | NMDA receptor | P2RY12 | C3AR1 | NOS2 | CTSA | PRKCD | SMPD2 | KCNQ Channels (K(v) 7) (nonspecified subtype) | TIE1 | VHL | Amyloid beta A4 precursor protein-binding family (APP-BP) (nonspecified subtype) | G673 | CSNK2A2 | POSTN | ROCK2 | HRH1 | SCN9A | CAPN1 | NOX3 | Proteasome Complex | Complement Complex | L-Type calcium channel (nonspecified subtype) | CUL3 | ABHD6 | Pyruvate dehydrogenase kinase (nonspecified subtype) | SLC4A8 | Histone deacetylase (nonspecified subtype) | APAF1 | RXRA | SCN1A | GAA | TACR1 | CA2 | FPR2 | G3576 | Kallikrein (nonspecified subtype) | HTR6 | PPP5C | alpha1-Adrenoceptor (nonspecified subtype) | Muscarinic Acetylcholine Receptor (mAChR) (nonspecified subtype) | Poly [ADP-ribose] polymerase (nonspecified subtype) | CDK12/Cyclin K | Integrin alphavbeta6 receptor | MIF | PARP2 | CHI3L1 | Platelet-Derived Growth Factor (PDGF) (nonspecified subtype) | GJA1 | EPOR | C3 | Glycine receptor | AGER | F11 | NAMPT | CACNA1A | CD47 | NADPH Oxidase Complex | Glycylpeptide N-tetradecanoyltransferase (nonspecified subtype) | TMEM97 | APP | TRPM7 | Nitric oxide synthase (NOS) (nonspecified subtype) | SPHK1 | Potassium Channels (nonspecified subtype) | MC4R | KLKB1 | C5AR1 | P2RX7 | MLYCD | PIK3CG | NQO2 | GLP1R | Large Conductance BK(Ca) Potassium Channel (Maxi K+ Channel) (nonspecified subtype) | ASIC1 | FAF1 | Hypoxia-Inducible Factor Prolyl Hydroxylase (nonspecified subtype) | GPR55 | EGLN1 | KRR1 | SCN5A | MIR92A1 | Fibroblast Growth Factor Receptor (FGFR) (nonspecified subtype) | F2R | GLP2R | PLA2G7 | F2RL3 | FGFR2 | cGMP-inhibited 3',5'-cyclic phosphodiesterase 3 (PDE3) (nonspecified subtype) | RIPK1 | NADPH Oxidase (nonspecified subtype) | Soluble guanylyl cyclase | CTSB | MIR92A2 | Chemokine receptor (nonspecified subtype) | Fatty Acid Binding Protein (nonspecified subtype) | ACE | CACNA1E | RIPK3 | AMP-activated protein kinase (AMPK) | GRIN2B | HIF1A | SERPING1 | Dual Specificity Mitogen-Activated Protein Kinase Kinase (MEK) (nonspecified subtype) | CDK7/Cyclin H | EPAS1 | NMT1 | AURKA | MPO | RHOA | CDK7 | PTAFR | USP7 | AOC3 | G4780 | PTGER2 | RORC | ARG2 | CNR2 | EGLN2 | SLC1A2 | ADRA2C | MC1R | GPER1 | SLC8A1 | LDLR | TBXAS1 | HTR7 | Melanocortin receptor (nonspecified subtype) | GPR17 | SCN2A | GRK6 | mu-Calpain (calpain 1) | GPBAR1 | KCNN2 | MC5R | ITGAM | Calcium channel (nonspecified subtype) | CYP2C19 | PIK3CA | Interleukin 17 (nonspecified subtype) | CCNK | CETP | Integrin alphavbeta3 (vitronectin) receptor | CAPN2 | G1956 | MTHFR | PARP3 | HFE | Phosphatidylinositol 3-kinase (PI3K) (nonspecified subtype) | CFB | KAT2B | GJB2 | Protein Phosphatase 2A | EGLN3 | L-type voltage-dependent calcium channel complex | GSK3A | G142 | Protein kinase C (nonspecified subtype) | G5243 | NPR3 | CASP7 | CNR1 | ADRA1A | Tyrosine-Protein Kinases Src (nonspecified subtype) | TTR | G3309 | PIK3CD | SLC27A2 | gamma-Secretase

Note: If you'd like to get a target analysis report for Ischemia, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Ischemia at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Erdheim-Chester Disease | Progressive Familial Intrahepatic Cholestasis | Hypertensive Nephropathy | Necrobiosis Lipoidica | Vici Syndrome | Oguchi Disease-2 | Retinal Telangiectasia | Netherton Syndrome | 3-methylglutaconic Aciduria Type I | Arteriosclerosis | Histoplasmosis | Light Chain Amyloidosis | Asphyxia Neonatorum | Endometriosis | Fucosidosis | Chordoma | Amelanotic Melanoma | ACTH-independent Macronodular Adrenal Hyperplasia | Acanthosis Nigricans | Corneal Dystrophy And Perceptive Deafness | Parapsoriasis | Chromosome 8q21.11 Deletion Syndrome | Splenomegaly | Moyamoya Disease | Hydrolethalus Syndrome | Hypobetalipoproteinemias | Chronic Idiopathic Myelofibrosis | Antisynthetase Syndrome | Erythema Multiforme | High Molecular Weight Kininogen Deficiency | Pathological Gambling | Hoyeraal-Hreidarsson Syndrome | Creutzfeldt-Jakob Disease | Werner's Syndrome | Macular Degeneration | Duchenne Muscular Dystrophy | Diffuse Palmoplantar Keratoderma | Leukoplakia, Oral | Hyperprolactinemia | Fibrillation, Atrial | Genee-Wiedemann Syndrome | Frontotemporal Dementia | Neuronal Ceroid Lipofuscinosis | Sotos Syndrome | Hyperhomocysteinemia | Skin Carcinoma | Fibrodysplasia Ossificans Progressiva | Hyper IgE Syndrome | Aldosterone Deficiency | Diastrophic Dysplasia | Pneumonia, Mycoplasma | Melnick-Needles Syndrome | Spinal And Bulbar Muscular Atrophy | Diabetic Macular Edema | Hypolipoproteinemia | Knobloch Syndrome | Carcinoid Syndrome | T-cell Prolymphocytic Leukemia | Charcot-Marie-Tooth Disease, Type 2C | Trigonocephaly | Galactosemia | Hemorrhage | Encephalocele | Micro Syndrome | Hypomyelination With Atrophy Of Basal Ganglia And Cerebellum | Leiomyosarcoma | Acute Tubular Necrosis | Meconium Ileus | Ichthyosis Bullosa Of Siemens | Stomatitis | Hypokalemic Periodic Paralysis | Myhre Syndrome | Barrett Esophagus | Hereditary Sensory And Autonomic Neuropathy | Epithelioid Hemangioma | Citrullinemia | Peritonitis | Ameloblastoma | Astigmatism | Smoldering Myeloma | Glaucoma, Congenital | Arteriovenous Malformations | Large Granular Lymphocytic Leukemia | Periventricular Leukomalacia | Mitochondrial DNA Depletion Syndrome | Rhinitis | Retinoschisis | Hypoparathyroidism | Tenosynovial Giant Cell Tumor | Scapuloperoneal Myopathy, X-linked Dominant | Ileitis | Chondromyxoid Fibroma | Lassa Fever | Pain | Mood Disorder | Encephalitis, Tick-borne | Keratosis, Seborrheic | Charcot-Marie-Tooth Disease, Type 1A | Ganglioneuroma | Hydrocephalus | Congenital Primary Aphakia | Anorectal Fistula | Nijmegen Breakage Syndrome | Phosphoglycerate Dehydrogenase Deficiency | Glanzmann Thrombasthenia | Tendinopathy | Periodic Limb Movement Disorder | Uveitis | Takayasu's Arteritis | Bernard-Soulier Syndrome | Multiple System Atrophy | Chondroma | Thyrotoxic Periodic Paralysis | Malnutrition | Sarcoma | Retinitis Pigmentosa 3 | Osteoporosis, Postmenopausal | Atopic Dermatitis | Chronic Thromboembolic Pulmonary Hypertension | Double Outlet Right Ventricle | Congenital Hypofibrinogenemia | Chronic Neutrophilic Leukemia | Combined Deficiency Of Factor V And Factor VIII | Mucolipidosis Type II | Porphyria, Acute Intermittent | Dysplastic Nevus | Pheochromocytoma | Gastroschisis | Hemangioendothelioma | Greenberg Dysplasia | Nephritis, Interstitial | Presbyopia | Mastitis | Crimean-Congo Hemorrhagic Fever | Chronic Myelomonocytic Leukemia | Chondrosarcoma | Bruck Syndrome | Nanophthalmos | VACTERL Association | Cleidocranial Dysplasia | Dent Disease | Fukuyama Congenital Muscular Dystrophy | Porphyria | Metachromatic Leukodystrophy | Gardner Syndrome | Split Hand-foot Malformation | Torticollis | Dwarfism | Primary Sclerosing Cholangitis | Cartilage Disorders | Congenital Nephrotic Syndrome | Tangier Disease | Ganglioglioma | Acne Vulgaris | Phosphoenolpyruvate Carboxykinase Deficiency, Cytosolic | Blepharitis | Polycystic Kidney, Autosomal Recessive | Meesmann Corneal Dystrophy | Acrocallosal Syndrome | Williams Syndrome | Kallmann Syndrome | Heterotaxy | Pierson Syndrome | Lymphopenia | Spinocerebellar Ataxia Type 3 | Familial Pheochromocytoma-paraganglioma | Non-Langerhans Cell Histiocytosis | Gastritis, Atrophic | Ocular Surface Squamous Neoplasia | Reflex Epilepsy | Adenylosuccinate Lyase Deficiency | Tonsillitis | Lipoma | Spinocerebellar Ataxia | 3-methylglutaconic Aciduria Type IV | Addison Disease | 3-methylcrotonyl-CoA Carboxylase Deficiency | Peripheral Neuropathy | Multisystemic Smooth Muscle Dysfunction Syndrome | Pulmonary Stenosis | Waldenstrom Macroglobulinemia | Malignant Fibrous Histiocytoma | Ophthalmoplegia | Chromosome 17q21.31 Deletion Syndrome | Renal-hepatic-pancreatic Dysplasia | Syndactyly | Poirier-Bienvenu Neurodevelopmental Syndrome | Hyperandrogenemia | Maple Syrup Urine Disease | Spinocerebellar Ataxia Type 5 | Phenylketonuria | Pulmonary Veno-occlusive Disease | Acral Lentiginous Melanoma | Progressive Familial Intrahepatic Cholestasis Type 2 | Ependymoma | Pigment Dispersion Syndrome | Filariasis | Epithelial-myoepithelial Carcinoma | Short-chain Acyl-CoA Dehydrogenase Deficiency | Cri-du-chat Syndrome | Vertebrobasilar Insufficiency | Borjeson-Forssman-Lehmann Syndrome | Paracoccidioidomycosis | Diabetic Neuropathy | Infantile Spasm | Anti-NMDA Receptor Encephalitis | Loeys-Dietz Syndrome | Thanatophoric Dysplasia | Fuchs Heterochromic Iridocyclitis | Crigler-Najjar Syndrome | Angioedema | Precocious Puberty | Aspartylglycosaminuria | Nephrocalcinosis | Reticular Dysgenesis | Urea Cycle Disorder | Thyroid Dysgenesis | Galactosialidosis | 3C Syndrome | Hemochromatosis | Cryoglobulinemia | Achondrogenesis | Amelogenesis Imperfecta | Alpers Syndrome | Spinocerebellar Ataxia Type 2 | Heavy Chain Disease | Colitis | Restrictive Dermopathy | HANAC Syndrome | Olmsted Syndrome | Limb Girdle Muscular Dystrophy | Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive 2 | Cerebral Cavernous Malformations | Hyperglycemia | LMNA-related Congenital Muscular Dystrophy | Anosmia, Congenital | Gaucher Disease | Ghosal Syndrome | Kearns-Sayre Syndrome | Spinocerebellar Ataxia Type 6 | Epidermolytic Hyperkeratosis | Sarcoidosis | AIDS | Congenital Absence Of Vas Deferens | Disseminated Intravascular Coagulation | Congenital Nystagmus | Coronary Restenosis | Ureteropelvic Junction Obstruction | Chronic Periodontitis | Measles | Axenfeld-Rieger Syndrome | IMAGe Syndrome | Frank-ter Haar Syndrome | Hypertriglyceridemia | Leukodystrophies | Spermatocele | Speech Disorders | Anti-glomerular Basement Membrane Disease | Thromboembolism | Amblyopia | Pfeiffer Syndrome | Hidradenitis Suppurativa | Arthritis, Gouty | Autoimmune Interstitial Lung, Joint, And Kidney Disease | Chylothorax, Congenital | Paronychia | Usher Syndrome Type II | Blue Nevus | Tyrosinemia Type 1 | Infantile Neuroaxonal Dystrophy | Pulmonary Vein Stenosis | Intermittent Explosive Disorder | Congenital Bile Acid Synthesis Defect | Hypercholesterolemia | Carbamoyl Phosphate Synthetase I Deficiency | Actinomycetoma | Keratopathy | Waardenburg Syndrome Type 4 | Pyruvate Dehydrogenase Deficiency | Venous Insufficiency | Carpal Tunnel Syndrome | Hydronephrosis | Crohn's Disease | Cutaneous Mastocytosis | Hyperinsulinism-hyperammonemia Syndrome | Alstrom Syndrome | Cyst | Familial Hyperaldosteronism | Constipation | Tetanus | Pilomatrix Carcinoma | Dermatofibrosarcoma | Cerebrovascular Disorders | Hypophosphatemic Rickets With Hypercalciuria, Hereditary | Spinal Muscular Atrophy With Progressive Myoclonic Epilepsy | Succinic Semialdehyde Dehydrogenase Deficiency | Hypertensive Retinopathy | Prostatitis | Von Willebrand Disease | Best Macular Dystrophy | Bartsocas-Papas Syndrome | Microcephalic Osteodysplastic Primordial Dwarfism, Type II | Cardiospondylocarpofacial Syndrome | Tetraplegia | Diabetes Insipidus, Nephrogenic | Juvenile Hyaline Fibromatosis | Stromal Corneal Dystrophy | Viral Meningitis | Cholestasis | Costello Syndrome | Lennox-Gastaut Syndrome | Hemophagocytic Lymphohistiocytosis | Hereditary Spastic Paraplegia | Keratitis | Diverticulitis | Megaloblastic Anemia | Hepatic Steatosis | Paroxysmal Kinesigenic Dyskinesia | Larsen Syndrome | Heterotopic Ossification | Spinocerebellar Ataxia Type 20 | Bronchitis, Chronic | Transcobalamin Deficiency | Chediak-Higashi Syndrome | Leishmaniasis, Visceral | Cryopyrin-associated Periodic Syndromes | Yellow Fever | Oculodentodigital Dysplasia | Hypocalcemia | Osteogenesis Imperfecta Type III | Nail-Patella Syndrome | Basal Cell Nevus Syndrome | Facioscapulohumeral Muscular Dystrophy Type 2 | Maternally Inherited Diabetes And Deafness | Hereditary Inclusion Body Myopathy | Greig Cephalopolysyndactyly Syndrome | Choroiditis | Nephroblastoma | Angioimmunoblastic T-cell Lymphoma | Urethritis | Thrombocythemia, Essential | Spondylosis | Wieacker-Wolff Syndrome | Sturge-Weber Syndrome | Zellweger Syndrome | Melanoma | Teratozoospermia | Esotropia | Adrenal Insufficiency | PASLI Disease | Lymphoma, Follicular | C3 Glomerulonephritis | Lesch-Nyhan Syndrome | Spitz Nevus | Persistent Mullerian Duct Syndrome | Branchiootorenal Syndrome | Multiple Sclerosis, Relapsing-remitting | Dysequilibrium Syndrome | Acromesomelic Dysplasia | Pulmonary Capillary Hemangiomatosis | Acrodermatitis Enteropathica | Infantile Nephropathic Cystinosis | Charcot-Marie-Tooth Disease, Type 2A | Hypopigmentation | Hypertelorism | Renal Dysplasia | Silver-Russell Syndrome | Neuropathy | Chorioretinitis | Usher Syndrome Type I | Lung Diseases | Creatine Deficiency Syndrome | Macrophagic Myofasciitis | Retinal Degeneration | Keratoconjunctivitis | Myelitis, Transverse | Retinal Dystrophy, Early-onset Severe | Diarrhea | Eclampsia | Ligneous Conjunctivitis | Adenoid Cystic Carcinoma | Anorchia | Auriculocondylar Syndrome | Histiocytic Sarcoma | Anemia | Postpoliomyelitis Syndrome | Burn-McKeown Syndrome | Spinocerebellar Ataxia Type 13 | Chronic Inflammatory Demyelinating Polyneuropathy | Pupil Disorders | Fascioliasis | Pycnodysostosis | Cancer, Breast | Metabolic Syndrome | Microcephaly, Seizures, And Developmental Delay | Nevus | Pontocerebellar Hypoplasia Type 7 | Hemangioblastoma | Preaxial Polydactyly | Rothmund-Thomson Syndrome