Disease

Ischemia

About the Disease
Ischemia, also known as acute coronary syndrome, is related to limb ischemia and lipoprotein quantitative trait locus, and has symptoms including anoxemia, polydipsia and muscle weakness. An important gene associated with Ischemia is LINC01254 (Long Intergenic Non-Protein Coding RNA 1254), and among its related pathways/superpathways are Signal Transduction and Response to elevated platelet cytosolic Ca2+. The drugs Lovastatin and Nadroparin have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, heart and brain, and related phenotypes are homeostasis/metabolism and nervous system

Common Targets
G5743 | Integrin alphaMbeta2 (MAC-1) Receptor | Tubulin | GPR31 | MAS1L | G7852 | ACHE | m-Calpain | NOS1 | G4233 | Lipoxygenase (nonspecified subtype) | GABA(A) receptor | PIK3CB | ADORA1 | FKBP4 | G4318 | VDR | G23411 | SIGMAR1 | MAP3K5 | GRIN1 | Estrogen receptor (nonspecified subtype) | CHRM1 | GRIN2C | SPHK2 | BSG | T-Type Calcium Channel | G3569 | CCNH | MCU | APOA5 | CA1 | ADORA2B | Sodium channel (nonspecified subtype) | F2 | NOS3 | F11R | NPC1L1 | ADORA2A | IL1B | SLC22A12 | F10 | ARG1 | XDH | NTRK1 | CDK9 | G7124 | Neurotrophic Factor (nonspecified subtype) | Acetylcholine Receptors (Nicotinic) (nAChR) (nonspecified subtype) | AKR1B1 | G7422 | ABCG1 | PCSK9 | SERPINE1 | KCNK2 | NOX4 | FLT3 | MIR1-1 | GRIN2D | Guanylate cyclase (nonspecified subtype) | G836 | HPGD | RET | MMP2 | FPGT-TNNI3K | GRIA2 | CDO1 | DNM1L | APOC3 | ITGB2 | Alcohol Dehydrogenase (nonspecified subtype) | CES1 | SDC4 | PDE5A | MIR21 | TNNI3K | Death-associated protein kinase (nonspecified subtype) | ADORA3 | DAPK1 | TEK | PLG | GRIN2A | PTGER4 | Integrin alphaIIbbeta3 (fibrinogen gpIIb/IIIa) receptor | KCNK10 | GRIA3 | CHRM3 | AGTR1 | NF-kappaB (NFkB) | FKBP5 | PIKFYVE | NMDA receptor | P2RY12 | C3AR1 | NOS2 | CTSA | PRKCD | SMPD2 | KCNQ Channels (K(v) 7) (nonspecified subtype) | TIE1 | VHL | Amyloid beta A4 precursor protein-binding family (APP-BP) (nonspecified subtype) | G673 | CSNK2A2 | POSTN | ROCK2 | HRH1 | SCN9A | CAPN1 | NOX3 | Proteasome Complex | Complement Complex | L-Type calcium channel (nonspecified subtype) | CUL3 | ABHD6 | Pyruvate dehydrogenase kinase (nonspecified subtype) | SLC4A8 | Histone deacetylase (nonspecified subtype) | APAF1 | RXRA | SCN1A | GAA | TACR1 | CA2 | FPR2 | G3576 | Kallikrein (nonspecified subtype) | HTR6 | PPP5C | alpha1-Adrenoceptor (nonspecified subtype) | Muscarinic Acetylcholine Receptor (mAChR) (nonspecified subtype) | Poly [ADP-ribose] polymerase (nonspecified subtype) | CDK12/Cyclin K | Integrin alphavbeta6 receptor | MIF | PARP2 | CHI3L1 | Platelet-Derived Growth Factor (PDGF) (nonspecified subtype) | GJA1 | EPOR | C3 | Glycine receptor | AGER | F11 | NAMPT | CACNA1A | CD47 | NADPH Oxidase Complex | Glycylpeptide N-tetradecanoyltransferase (nonspecified subtype) | TMEM97 | APP | TRPM7 | Nitric oxide synthase (NOS) (nonspecified subtype) | SPHK1 | Potassium Channels (nonspecified subtype) | MC4R | KLKB1 | C5AR1 | P2RX7 | MLYCD | PIK3CG | NQO2 | GLP1R | Large Conductance BK(Ca) Potassium Channel (Maxi K+ Channel) (nonspecified subtype) | ASIC1 | FAF1 | Hypoxia-Inducible Factor Prolyl Hydroxylase (nonspecified subtype) | GPR55 | EGLN1 | KRR1 | SCN5A | MIR92A1 | Fibroblast Growth Factor Receptor (FGFR) (nonspecified subtype) | F2R | GLP2R | PLA2G7 | F2RL3 | FGFR2 | cGMP-inhibited 3',5'-cyclic phosphodiesterase 3 (PDE3) (nonspecified subtype) | RIPK1 | NADPH Oxidase (nonspecified subtype) | Soluble guanylyl cyclase | CTSB | MIR92A2 | Chemokine receptor (nonspecified subtype) | Fatty Acid Binding Protein (nonspecified subtype) | ACE | CACNA1E | RIPK3 | AMP-activated protein kinase (AMPK) | GRIN2B | HIF1A | SERPING1 | Dual Specificity Mitogen-Activated Protein Kinase Kinase (MEK) (nonspecified subtype) | CDK7/Cyclin H | EPAS1 | NMT1 | AURKA | MPO | RHOA | CDK7 | PTAFR | USP7 | AOC3 | G4780 | PTGER2 | RORC | ARG2 | CNR2 | EGLN2 | SLC1A2 | ADRA2C | MC1R | GPER1 | SLC8A1 | LDLR | TBXAS1 | HTR7 | Melanocortin receptor (nonspecified subtype) | GPR17 | SCN2A | GRK6 | mu-Calpain (calpain 1) | GPBAR1 | KCNN2 | MC5R | ITGAM | Calcium channel (nonspecified subtype) | CYP2C19 | PIK3CA | Interleukin 17 (nonspecified subtype) | CCNK | CETP | Integrin alphavbeta3 (vitronectin) receptor | CAPN2 | G1956 | MTHFR | PARP3 | HFE | Phosphatidylinositol 3-kinase (PI3K) (nonspecified subtype) | CFB | KAT2B | GJB2 | Protein Phosphatase 2A | EGLN3 | L-type voltage-dependent calcium channel complex | GSK3A | G142 | Protein kinase C (nonspecified subtype) | G5243 | NPR3 | CASP7 | CNR1 | ADRA1A | Tyrosine-Protein Kinases Src (nonspecified subtype) | TTR | G3309 | PIK3CD | SLC27A2 | gamma-Secretase

疾病靶点研报
Ischemia

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