IMAGe Syndrome

About the Disease
Intrauterine Growth Retardation, Metaphyseal Dysplasia, Adrenal Hypoplasia Congenita, and Genital Anomalies, also known as image syndrome, is related to glycerol kinase deficiency and metaphyseal dysplasia. An important gene associated with Intrauterine Growth Retardation, Metaphyseal Dysplasia, Adrenal Hypoplasia Congenita, and Genital Anomalies is CDKN1C (Cyclin Dependent Kinase Inhibitor 1C), and among its related pathways/superpathways is Mitotic G1 phase and G1/S transition. The drugs Iron and Copper have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and kidney, and related phenotypes are frontal bossing and depressed nasal bridge

Common Targets
POLE | CHFR | CDKN1C

Note: If you'd like to get a target analysis report for IMAGe Syndrome, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of IMAGe Syndrome at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Chorea | Hyperlipidemia, Familial Combined | Beckwith-Wiedemann Syndrome | Congenital Dyserythropoietic Anemia Type 1 | Diffuse Mesangial Sclerosis | Vitamin B12 Deficiency | Encephalocele | Chronic Neutrophilic Leukemia | Panniculitis | Hepatoblastoma | Spondylocarpotarsal Synostosis Syndrome | Mandibuloacral Dysplasia With Type A Lipodystrophy | Oligoastrocytoma | Peeling Skin Syndrome Type B | Ebstein Anomaly | Opisthorchiasis | Myotonic Disorders | Exfoliative Dermatitis | Megaloblastic Anemia | Purpura, Thrombotic Thrombocytopenic | Meningococcal Meningitis | Richter's Syndrome | Uveitis, Anterior | Pleomorphic Xanthoastrocytoma | Heimler Syndrome | Aicardi-Goutieres Syndrome | Danon Disease | Hydrocephalus, Normal Pressure | Atrial Septal Defect | Neutropenia | Retinal Telangiectasia | Niemann-Pick Disease, Type C | Chordoma | Bursitis | Retinal Degeneration | Ehlers-Danlos Syndrome With Progressive Kyphoscoliosis, Myopathy, And Hearing Loss | Acrodermatitis | Early Infantile Epileptic Encephalopathy | Osteoglophonic Dysplasia | Sepiapterin Reductase Deficiency | Dysmorphophobia | Acromegaly | NDH Syndrome | Wolcott-Rallison Syndrome | Progressive Familial Intrahepatic Cholestasis | Hypertension, Essential | Tibial Muscular Dystrophy | Endophthalmitis | Neonatal Progeroid Syndrome | Keratopathy | Early Infantile Epileptic Encephalopathy 13 | Cervical Dystonia | Colitis, Lymphocytic | Endocarditis | Borjeson-Forssman-Lehmann Syndrome | Carcinoma, Merkel Cell | Retinopathy Of Prematurity | Paracoccidioidomycosis | Vaginitis | Peeling Skin Syndrome, Acral Type | Colorectal Adenoma | Hypogammaglobulinemia | Takenouchi-Kosaki Syndrome | Rosacea | Tyrosinemia Type 2 | Neurodevelopmental Disorder With Central Hypotonia And Dysmorphic Facies | Hypoalbuminemia | Rhabdomyosarcoma, Alveolar | Renal Tubular Dysgenesis | Porphyria Cutanea Tarda | Neutrophilia | Meconium Ileus | Frank-ter Haar Syndrome | Triple A Syndrome | Alopecia Areata | Juvenile Hyaline Fibromatosis | Salla Disease | Primary Biliary Cholangitis | Guttate Psoriasis | Platelet Disorders | Familial Hypobetalipoproteinemia | Paraplegia | Farber Disease | Coloboma | Charcot-Marie-Tooth Disease, Type 6 | Porphyria | Hepatitis E | Sarcomatoid Carcinoma Of The Lung | Cancer, Brain | Kleine-Levin Syndrome | Rett Syndrome | Epidermolysis Bullosa Simplex, Generalized | Lattice Corneal Dystrophy | Klippel-Feil Syndrome | Hyperlipidemia Type V | Restless Legs Syndrome | Yellow Fever | Spondylocostal Dysostosis | Hidradenitis | Chronic Enteropathy Associated With SLCO2A1 Gene | Delirium | Spinocerebellar Ataxia Type 17 | Diabetic Encephalopathy | Very Long-chain Acyl-CoA Dehydrogenase Deficiency | Neurofibroma, Plexiform | Meniere's Disease | Hennekam Lymphangiectasia-lymphedema Syndrome | Alkaptonuria | Acrocallosal Syndrome | Vascular Cognitive Impairment | Ureteropelvic Junction Obstruction | Stargardt Disease | Twin-to-twin Transfusion Syndrome | Acromesomelic Dysplasia | LMNA-related Congenital Muscular Dystrophy | Congenital Hereditary Endothelial Dystrophy Type II | Dyskeratosis Congenita | Congenital Dyserythropoietic Anemia | Extramammary Paget's Disease | Hyperinsulinism-hyperammonemia Syndrome | Schistosomiasis Mansoni | Endometriosis | CHOPS Syndrome | Alopecia Totalis | Hypodontia | Chronic Granulomatous Disease, X-linked | Ornithine Transcarbamylase Deficiency | Pleurisy | Potocki-Shaffer Syndrome | Galactosemia | Takayasu's Arteritis | Methemoglobinemia Type IV | Spinocerebellar Ataxia Type 40 | Early Infantile Epileptic Encephalopathy 28 | Hamartoma | Papulopustular Rosacea | Generalized Epilepsy And Paroxysmal Dyskinesia | Adenosine Deaminase Deficiency | Pigment Dispersion Syndrome | Von Hippel-Lindau Disease | 3-hydroxyacyl-CoA Dehydrogenase Deficiency | Multiple System Atrophy | Arteriovenous Malformations | Blomstrand Osteochondrodysplasia | Spinocerebellar Ataxia Type 1 | Enterocolitis, Necrotizing | Autoimmune Disease | Retinal Dystrophy | Dermatomyositis | 3-methylglutaconic Aciduria | Progressive Familial Intrahepatic Cholestasis Type 3 | Brachydactyly | Emery-Dreifuss Muscular Dystrophy | Feingold Syndrome | Constipation | Lysosomal Acid Lipase Deficiency | Hypothalamic Obesity | Gastritis, Atrophic | Amish Infantile Epilepsy Syndrome | Myocardial Infarction | Rickets | Congenital Ichthyosiform Erythroderma | Spondyloperipheral Dysplasia | Alpha-mannosidosis | Carbohydrate Metabolism Disorders | Glycogen Storage Disease Type 4 | Stroke, Hemorrhagic | Gout | CHARGE Syndrome | Bladder Exstrophy | Distal Myopathy | Osteopetrosis | Tetanus | Primary Lateral Sclerosis | Stomatitis | Gliosarcoma | Ovarian Hyperstimulation Syndrome | Cholesteryl Ester Storage Disease | Mast Cell Leukemia | Benign Familial Neonatal Convulsions | Tetraplegia | Hodgkin Lymphoma | Neurofibroma | Hereditary Multiple Exostoses | Angiodysplasia | Tonsillitis | Idiopathic Multicentric Castleman Disease | Charcot-Marie-Tooth Disease Type 2E | Sturge-Weber Syndrome | HIBCH Deficiency | Paroxysmal Nocturnal Hemoglobinuria | Congenital Disorders Of Glycosylation | Low Phospholipid Associated Cholelithiasis | Craniometaphyseal Dysplasia | Basan Syndrome | Adult Polyglucosan Body Disease | Anencephaly | Neuronal Ceroid Lipofuscinosis | Temporal Lobe Epilepsy | Paraganglioma | Familial Dysautonomia | Cryopyrin-associated Periodic Syndromes | Oguchi Disease-2 | VACTERL Association | Macrophage Activation Syndrome | Porphyria, Acute Intermittent | Congenital Central Hypoventilation Syndrome | Lesch-Nyhan Syndrome | Disseminated Intravascular Coagulation | Central Pain Syndrome | Hypoplastic Left Heart Syndrome | Lamellar Ichthyosis | Hyperostosis | Corneal Neovascularization | Autonomic Nervous System Disorders | Protein C Deficiency | Thyroid Dysgenesis | Infertility | Presbyopia | Contact Dermatitis | Chondroma | Fibrillation, Atrial | Seizures-scoliosis-macrocephaly Syndrome | Hypophosphatasia | Hyperuricemic Nephropathy, Familial Juvenile | Charcot-Marie-Tooth Disease Type 4E | Plasmacytoma | Sulfite Oxidase Deficiency | Exotropia | Gastroschisis | Chylomicron Retention Disease | Early Infantile Epileptic Encephalopathy 4 | Spitzoid Melanoma | Myofibromatosis | Glaucomatocyclitic Crisis | Malignant Fibrous Histiocytoma | Onchocerciasis | Enlarged Vestibular Aqueduct | Glycogen Storage Disease Type 1 | LEOPARD Syndrome | Auriculocondylar Syndrome | Amyloidosis | Amenorrhea | DRESS Syndrome | Malnutrition | Subacute Sclerosing Panencephalitis | Primrose Syndrome | Cardiospondylocarpofacial Syndrome | Schwannoma | Premenstrual Syndrome | Epicondylitis | DICER1 Syndrome | Ganglioglioma | 3-methylglutaconic Aciduria Type I | Hemorrhage | Spondylo-ocular Syndrome | Vitamin D Deficiency | Myopathy | Epidermolysis Bullosa | Spinocerebellar Ataxia Type 27 | Diverticulitis | Eczema | Wiskott-Aldrich Syndrome | Pantothenate Kinase-associated Neurodegeneration | Blue Nevus | Intestinal Obstruction | Spinocerebellar Ataxia Type 10 | Neuropathy | Cold-induced Sweating Syndrome | Donnai-Barrow Syndrome | Oligodendroglioma | Craniosynostosis | Pterygium | Multiple Sclerosis | Neuromyotonia | Sarcoma | Ectopia Lentis, Isolated, Autosomal Recessive | Osteogenesis Imperfecta Type V | Proteus Syndrome | Choriocarcinoma | Blastomycosis | Hydrolethalus Syndrome | Riboflavin Transporter Deficiency Neuronopathy | Craniofacial Dysostosis | Cholangiocarcinoma | Spondylometaphyseal Dysplasia | Renal Dysplasia | Familial Digital Arthropathy-brachydactyly | Hypertension, Pulmonary | Schaaf-Yang Syndrome | Galloway-Mowat Syndrome | Renal-hepatic-pancreatic Dysplasia | Crimean-Congo Hemorrhagic Fever | Rhinitis | Cranioectodermal Dysplasia | Barrett Esophagus | Prolactinoma | Pemphigus Foliaceus | Alstrom Syndrome | Persistent Truncus Arteriosus | Familial Glucocorticoid Deficiency | Nicotine Dependence | Marfan Syndrome | Diabetic Nephropathy | Nemaline Myopathy | Sponastrime Dysplasia | Ocular Albinism Type 1 | Schwannomatosis | Dystonia-parkinsonism, X-linked | GATA2 Deficiency | Atrioventricular Septal Defect | Pyruvate Decarboxylase Deficiency | Tenosynovial Giant Cell Tumor | Charcot-Marie-Tooth Disease, Type 2C | Scoliosis | Splenomegaly | Peters-plus Syndrome | Neurodegeneration Due To Cerebral Folate Transport Deficiency | Chorioretinitis | Chromosome 17q21.31 Deletion Syndrome | Osteosclerosis | Vertigo | Hypotrichosis, Congenital, With Juvenile Macular Dystrophy | Epithelioid Hemangioma | Lipoma | Myasthenia Gravis | Atherosclerosis | Hypertelorism | Anorectal Malformations | Senior-Loken Syndrome | Hereditary Sensory Neuropathy Type 1 | Primary Progressive Aphasia | Steel Syndrome | Spinocerebellar Ataxia Type 2 | H Syndrome | Carcinoid Syndrome | Choroideremia | NGLY1 Deficiency | Speech Disorders | Hairy Cell Leukemia | Viral Meningitis | Discoid Lupus Erythematosus | Cholestasis | Spinocerebellar Ataxia Type 38 | Mosaic Variegated Aneuploidy Syndrome 2 | Arthropathy | Episodic Ataxia Type 1 | Malaria | Intestinal Tuberculosis | Charcot-Marie-Tooth Disease Type 2T | Interstitial Lung Diseases | Fontaine Progeroid Syndrome | Hyperprolactinemia | Dermatofibrosarcoma | Microcephaly, Seizures, And Developmental Delay | Prolymphocytic Leukemia | Perry Syndrome | Proteasome-associated Autoinflammatory Syndrome 2 | Toxoplasmosis | Dowling-Degos Disease | Majeed Syndrome | Lymphopenia | Rhizomelic Chondrodysplasia Punctata | Medulloblastoma | Optic Atrophy 2 | Glycogen Storage Disease Type 3 | Chudley-McCullough Syndrome | Kohlschutter-Tonz Syndrome | Myosin Storage Myopathy | Oculopharyngeal Muscular Dystrophy | Stiff-man Syndrome | Perivascular Epithelioid Cell Tumor | Dental Caries | Dubin-Johnson Syndrome | Charcot-Marie-Tooth Disease Axonal Type 2N | Giant Axonal Neuropathy | Coronary Artery Disease | GNE Myopathy | Kawasaki Disease | Cutaneous T-cell Lymphoma | Impetigo | Congenital Adrenal Hyperplasia 1 | Sensory Ataxic Neuropathy, Dysarthria, And Ophthalmoparesis | Lattice Corneal Dystrophy Type 1 | Cerebrovascular Disorders | Graft-versus-host Disease | Jawad Syndrome | Leber Hereditary Optic Neuropathy | Lewy Body Dementia | Major Depression | Stickler Syndrome | Wolfram Syndrome | Acral Lentiginous Melanoma | Hepatopulmonary Syndrome | Orotic Aciduria | Kearns-Sayre Syndrome | Tardive Dyskinesia | Vitreoretinal Degeneration, Snowflake Type | CREST Syndrome | Retinal Diseases