Hypoplastic Left Heart Syndrome

About the Disease
Hypoplastic Left Heart Syndrome, also known as hlhs, is related to aortic valve disease 2 and aortic valve disease 1. An important gene associated with Hypoplastic Left Heart Syndrome is TBX20 (T-Box Transcription Factor 20), and among its related pathways/superpathways are Embryonic and Induced Pluripotent Stem Cells and Lineage-specific Markers and Neural crest differentiation. The drugs Ambrisentan and Sildenafil have been mentioned in the context of this disorder. Affiliated tissues include heart, skin and brain, and related phenotypes are hypoplastic left heart and hypoplastic aortic arch

Common Targets
G4851 | ADRA2A | FOXP1 | NKX2-5 | RAF1 | ADRB1 | HMCN1 | TBX5 | PTPRB | NR2F2 | MYH6 | FOXL1 | FOXC2 | HEYL | HEY2 | MYH7 | MYRF

Note: If you'd like to get a target analysis report for Hypoplastic Left Heart Syndrome, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Hypoplastic Left Heart Syndrome at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Hemimegalencephaly | Cataract | Cerebellofaciodental Syndrome | Thalassemia, Beta | Acromegaly | Placenta Previa | Eosinophilia | Herpes Genitalis | Adenoma, Villous | Rhabdomyosarcoma | McCune-Albright Syndrome | Pigment Dispersion Syndrome | Specific Granule Deficiency | Fowler's Syndrome | Barrett Esophagus | Hepatitis D | Connective Tissue Disorders | Porphyria, Acute Intermittent | Hemophilia | Craniopharyngioma | Neuroleptic Malignant Syndrome | Facioscapulohumeral Muscular Dystrophy Type 2 | Cabezas Syndrome | Endocarditis | Nevus | Sarcoma, Alveolar Soft Part | Nijmegen Breakage Syndrome | Intermittent Claudication | Pulmonary Veno-occlusive Disease | Mucolipidosis Type IV | AIDS Dementia Complex | Myositis | Dentinogenesis Imperfecta | Congenital Aniridia | Mast Cell Leukemia | Syncope | Microphthalmia, Syndromic 7 | Mycosis Fungoides | Pseudohypoaldosteronism | Personality Disorders | Congenital Hereditary Endothelial Dystrophy Type II | Hypermetropia | Pernicious Anemia | Macrophage Activation Syndrome | Lipid Storage Myopathy | Juvenile Xanthogranuloma | Contact Dermatitis | Dyslipidemia | Neuroectodermal Tumors, Primitive | Congenital Stationary Night Blindness | Kabuki Syndrome | Cystitis | Cutaneous Angiosarcoma | Skin Carcinoma | Niemann-Pick Disease, Type A | Crouzon Syndrome With Acanthosis Nigricans | Schwannomatosis | Chronic Beryllium Disease | Nephropathy | Gardner Syndrome | Pseudohypoparathyroidism Type 1B | Blomstrand Osteochondrodysplasia | Niemann-Pick Disease, Type C | Heart Failure | Bietti Crystalline Dystrophy | Persistent Hyperplastic Primary Vitreous | Shwachman-Bodian-Diamond Syndrome | Congenital Bile Acid Synthesis Defect | Congenital Diaphragmatic Hernia | Speech Disorders | Dementia, Vascular | Early Infantile Epileptic Encephalopathy 28 | Molybdenum Cofactor Deficiency | Mitochondrial Disease | Neuroma | Primrose Syndrome | Reflex Epilepsy | Plasmacytoma | Impetigo | Cousin Syndrome | Fibrosarcoma | Dysgerminoma | Retinal Detachment | Herpes Simplex Dermatitis | Thyroiditis | Craniolenticulosutural Dysplasia | Long QT Syndrome Type 2 | Li-Fraumeni Syndrome | Corneal Dystrophy And Perceptive Deafness | Cervical Dystonia | Microphthalmia | Chromosome 8q21.11 Deletion Syndrome | Pelvic Inflammatory Disease | Lymphopenia | Meningococcal Meningitis | Chondrodysplasia Punctata | Primary Ovarian Insufficiency | Chronic Leukemia | Hereditary Elliptocytosis | Leiomyosarcoma | Crigler-Najjar Syndrome | Spinocerebellar Ataxia Type 1 | Fanconi Anemia | Desmosterolosis | Lysosomal Acid Lipase Deficiency | Angelman Syndrome | Mucolipidosis Type III | Congenital Myasthenic Syndrome | Coffin-Siris Syndrome | Alopecia Totalis | Polyneuropathy | Oculocutaneous Albinism | Antisocial Personality Disorder | Palmoplantar Keratoderma | Granular Corneal Dystrophy | Dystonia-parkinsonism, X-linked | Gestational Trophoblastic Disease | Tylosis With Esophageal Cancer | Crisponi Syndrome | Erdheim-Chester Disease | Geleophysic Dysplasia | Delirium | Angina Pectoris | Infertility | Low Phospholipid Associated Cholelithiasis | Hemangioendothelioma | Intestinal Obstruction | Desbuquois Syndrome | Spinocerebellar Ataxia Type 13 | Periodic Limb Movement Disorder | Phosphoglycerate Dehydrogenase Deficiency | Angiosarcoma Of The Breast | Pituitary Stalk Interruption Syndrome | Ectodermal Dysplasia | Lassa Fever | Autonomic Nervous System Disorders | Adenosine Deaminase 2 Deficiency | Heart Septal Defects | CREST Syndrome | Meningeal Melanocytoma | Neurodermatitis | Babesiosis | Spondylolisthesis | Dyskeratosis Congenita | Chordoid Glioma | Parapsoriasis | Tendinopathy | Idiopathic Multicentric Castleman Disease | Schnitzler Syndrome | Gastric Atrophy | Neurodegeneration Due To Cerebral Folate Transport Deficiency | Seizures | Borderline Personality Disorder | Gastrointestinal Disorders | Astrocytoma, Anaplastic | Schistosomiasis | Meningioma | CHOPS Syndrome | Androgen Insensitivity | Fetal Alcohol Syndrome | Venous Insufficiency | Familial Digital Arthropathy-brachydactyly | Asphyxia Neonatorum | Charcot-Marie-Tooth Disease, Type 2 | Seizures-scoliosis-macrocephaly Syndrome | Systemic Lupus Erythematosus | Seminoma | Sialidosis | Charcot-Marie-Tooth Disease, Type 1A | Anxiety Disorders | Scapuloperoneal Myopathy, X-linked Dominant | Hereditary Sensory And Autonomic Neuropathy | Hypobetalipoproteinemias | Congenital Bilateral Absence Of Vas Deferens | Pathological Gambling | Multiple Congenital Anomalies-hypotonia-seizures Syndrome 2 | Sertoli Cell-only Syndrome | Pearson Syndrome | Chudley-McCullough Syndrome | Pseudohypoparathyroidism Type 1C | Pulmonary Alveolar Proteinosis | Primary Hyperoxaluria | Osteochondroma | Cold Agglutinin Disease | Hairy Cell Leukemia | Monilethrix | Cat Eye Syndrome | Pneumonia, Mycoplasma | Lichen Sclerosus | Epilepsy | Adenomyosis | Retinal Dystrophy | Ichthyosis Bullosa Of Siemens | Hepatitis, Chronic | Multiple Myeloma | Endometrial Hyperplasia | Iron Deficiency Anemia | Depression | Klinefelter Syndrome | Arteriosclerosis | Tibial Muscular Dystrophy | C3 Glomerulopathy | Frank-ter Haar Syndrome | Pterygium | Lissencephaly 2 | Erythema Nodosum | Brachydactyly | Pierre Robin Syndrome | Bartsocas-Papas Syndrome | Intermittent Explosive Disorder | Autism Spectrum Disorders | Megaloblastic Anemia | Chronic Kidney Disease | Hypopigmentation | Potocki-Shaffer Syndrome | Pituitary Disorders | Ollier Disease | Apert Syndrome | Blepharospasm | Choreoathetosis, Hypothyroidism, And Neonatal Respiratory Distress | Crohn's Disease | Aphasia | Conn Syndrome | Alveolar Capillary Dysplasia | Localized Scleroderma | Focal Segmental Glomerulosclerosis | Hereditary Pyropoikilocytosis | Stroke | Stroke, Hemorrhagic | Robinow Syndrome | Progressive Familial Intrahepatic Cholestasis Type 2 | Tuberculosis | Cherubism | Aplastic Anemia | Protein S Deficiency | Maple Syrup Urine Disease | Keratitis | Arthritis, Psoriatic | Cellulitis | Hereditary Hemorrhagic Telangiectasia Type 2 | Duodenal Atresia | Pulmonary Capillary Hemangiomatosis | Tietze Syndrome | Sickle Cell Anemia | Influenza | Demyelinating Diseases | Precocious Puberty | Thrombotic Microangiopathy | Keloid | Neuromyotonia | Tinea | Galactosialidosis | Ileitis | Dysferlinopathy | Familial Hyperaldosteronism | Congenital Absence Of Vas Deferens | Urethritis | Anthrax | Avian Influenza | Juvenile Hyaline Fibromatosis | Proctitis | Gray Platelet Syndrome | Cholecystitis | Bernard-Soulier Syndrome | Pain | Multiple Sulfatase Deficiency | Supravalvular Aortic Stenosis | Lattice Corneal Dystrophy Type 1 | Hashimoto Thyroiditis | Prune Belly Syndrome | Wagner Disease | Osteoglophonic Dysplasia | Coronary Artery Disease | Congenital Disorders Of Glycosylation | Papillorenal Syndrome | Mixed Connective Tissue Disease | Giant Cell Glioblastoma | Chondrodysplasia Punctata 2, X-linked Dominant | Persistent Truncus Arteriosus | Cardiomyopathy, Peripartum | Intracranial Hypertension | Duane Retraction Syndrome | Fragile X Syndrome | Mitochondrial DNA Depletion Syndrome, Myopathic Form | Hyperlipidemia Type V | Choroideremia | Benign Familial Neonatal Convulsions | Prostatitis | Carney-Stratakis Syndrome | Myoclonus-dystonia Syndrome | Neuromuscular Disorders | Achromatopsia | Generalized Epilepsy And Paroxysmal Dyskinesia | Obesity, Morbid | Dysequilibrium Syndrome | Cryptosporidiosis | Ocular Hypertension | Bartter Syndrome | Graft-versus-host Disease | Thrombophlebitis | Antithrombin III Deficiency | Charcot-Marie-Tooth Disease, Type 2A | Silicosis | Facioscapulohumeral Muscular Dystrophy | Medium-chain Acyl-CoA Dehydrogenase Deficiency | Weill-Marchesani Syndrome | Arthropathy | Sensorineural Hearing Loss | Basal Cell Nevus Syndrome | Pycnodysostosis | Salla Disease | Cranial Nerve Disease | Bursitis | Hyperinsulinism-hyperammonemia Syndrome | N-acetylglutamate Synthase Deficiency | Schuurs-Hoeijmakers Syndrome | Familial Pheochromocytoma-paraganglioma | Osteonecrosis Of The Jaw | Sweet Syndrome | Osteoporosis | Pseudohypoparathyroidism Type 1A | Waldenstrom Macroglobulinemia | Heimler Syndrome | Trichomegaly | Saethre-Chotzen Syndrome | Schaaf-Yang Syndrome | Episodic Ataxia | Poirier-Bienvenu Neurodevelopmental Syndrome | Atrial Septal Defect | Alkaptonuria | Spinocerebellar Ataxia Type 8 | Acrodermatitis Enteropathica | Melanocytic Nevus | Hyperinsulinemic Hypoglycemia | Exotropia | Arterial Tortuosity Syndrome | Optic Nerve Hypoplasia, Bilateral | Muscle Wasting | Transcobalamin Deficiency | Conjunctivitis | Encephalopathy, Hepatic | Light Chain Amyloidosis | Leishmaniasis, Cutaneous | Proopiomelanocortin Deficiency | Hepatitis | Hyperparathyroidism, Primary | Primary Aldosteronism | Skin Fragility-woolly Hair Syndrome | Meckel-Gruber Syndrome | Uterine Leiomyoma | Chronic Inflammatory Demyelinating Polyneuropathy | Citrullinemia | Cavitary Optic Disc Anomalies | Rhabdoid Tumor | Psoriasis | Chromosome 16p11.2 Deletion Syndrome | Thymoma, Malignant | LRBA Deficiency | Cold-induced Sweating Syndrome | Adenosine Deaminase Deficiency | Pulmonary Tuberculosis | Insulinoma | Waardenburg Syndrome | Encephalopathy, Glycine | Pure Red Cell Aplasia | Long-chain 3-hydroxyacyl-coenzyme A Dehydrogenase Deficiency | Macrophagic Myofasciitis | Fahr Disease | Cardiomyopathy, Hypertrophic | Urea Cycle Disorder | Pheochromocytoma | Major Depression | Pseudo-pseudohypoparathyroidism | Neurofibromatosis-Noonan Syndrome | Glycogen Storage Disease Type 5 | Primary Torsion Dystonia | Hypertension, Renovascular | Dysplastic Nevus | Lymphangioma | Swine Influenza | Paracoccidioidomycosis | Pantothenate Kinase-associated Neurodegeneration | Acute Chest Syndrome | Dengue Hemorrhagic Fever | Myosin Storage Myopathy | Epidermolytic Ichthyosis, Annular | Meningitis | Hepatorenal Syndrome | Hypersensitivity Pneumonitis | Multicystic Renal Dysplasia | Epidermolysis Bullosa Simplex, Dowling-Meara Type | Bone Giant Cell Tumor | Gangliosidosis | Dyslexia | Nephrotic Syndrome Type 1 | Spinal Muscular Atrophy Type 3 | Cleidocranial Dysplasia | Spinocerebellar Ataxia | Pneumonia, Viral | Osteoporosis, Postmenopausal