Primary Aldosteronism

About the Disease
Conn's Syndrome, also known as cushing syndrome, is related to ectopic cushing syndrome and acth-secreting pituitary adenoma, and has symptoms including cushingoid facies An important gene associated with Conn's Syndrome is USP8 (Ubiquitin Specific Peptidase 8), and among its related pathways/superpathways are Metabolism and Disease. The drugs Bromocriptine and Metformin have been mentioned in the context of this disorder. Affiliated tissues include pituitary, adrenal gland and adrenal cortex, and related phenotypes are increased circulating cortisol level and paradoxical increased cortisol secretion on dexamethasone suppression test

Common Targets
Kir 3.1/3.4 | CYP17A1 | STAR | G protein-Coupled Inwardly-Rectifying Potassium Channel (GIRK) (nonspecified subtype) | CYP11A1 | NR5A1 | LINGO1 | KCNJ3 | CYP11B1 | TSPO | DHCR24 | CACNA1D | KCNJ5 | PDE3B | CLCN2 | PDE2A | GNAS | HSD3B1 | CYP11B2 | HSD3B2 | CASZ1

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