Disease

Primary Aldosteronism

About the Disease
Conn's Syndrome, also known as cushing syndrome, is related to ectopic cushing syndrome and acth-secreting pituitary adenoma, and has symptoms including cushingoid facies An important gene associated with Conn's Syndrome is USP8 (Ubiquitin Specific Peptidase 8), and among its related pathways/superpathways are Metabolism and Disease. The drugs Bromocriptine and Metformin have been mentioned in the context of this disorder. Affiliated tissues include pituitary, adrenal gland and adrenal cortex, and related phenotypes are increased circulating cortisol level and paradoxical increased cortisol secretion on dexamethasone suppression test

Common Targets
Kir 3.1/3.4 | CYP17A1 | STAR | G protein-Coupled Inwardly-Rectifying Potassium Channel (GIRK) (nonspecified subtype) | CYP11A1 | NR5A1 | LINGO1 | KCNJ3 | CYP11B1 | TSPO | DHCR24 | CACNA1D | KCNJ5 | PDE3B | CLCN2 | PDE2A | GNAS | HSD3B1 | CYP11B2 | HSD3B2 | CASZ1

疾病靶点研报
Primary Aldosteronism

Note: If you'd like to get a target analysis report for Primary Aldosteronism, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Primary Aldosteronism at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Pemphigus Vulgaris | Periodontitis | Paget's Disease Of The Breast | Facioscapulohumeral Muscular Dystrophy Type 1 | Diffuse Palmoplantar Keratoderma | Colitis | Chorioretinitis | Epithelial-myoepithelial Carcinoma | Non-proliferative Diabetic Retinopathy | Asplenia | Succinic Semialdehyde Dehydrogenase Deficiency | Stroke, Ischemic | Chitayat Syndrome | Methylmalonic Acidemia | Pycnodysostosis | Mycosis Fungoides | Gigantism | Posterior Polar Cataract | Heart Failure | Patent Foramen Ovale | Diabetes Type 1 | Congenital Nephrotic Syndrome | Cutaneous Mastocytosis | Glutaric Aciduria Type 1 | Usher Syndrome | Nail-Patella Syndrome | Disseminated Superficial Actinic Porokeratosis | Diamond-Blackfan Anemia | Encephalocele | Sarcosinemia | Cholangitis | Hypoglycemia | Nevus | Autoimmune Hemolytic Anemia | Niemann-Pick Disease, Type B | Birt-Hogg-Dube Syndrome | Schwannoma | Coloboma | Evans Syndrome | Leiomyoma | Benign Familial Neonatal Convulsions | Parkinsonism | Patent Ductus Arteriosus | Pulmonary Tuberculosis | Glycogen Storage Disease | Norrie Disease | Renal Oncocytoma | Congenital Muscular Dystrophy | Adrenomyeloneuropathy | Ulcerative Colitis | Spinocerebellar Ataxia Type 13 | AIDS Dementia Complex | Rickets | Gynecomastia | Hereditary Coproporphyria | Congenital Stationary Night Blindness | Brachial Plexus Neuropathy | Panic Disorder | Cholesteryl Ester Storage Disease | MIRAGE Syndrome | Choriocarcinoma | Borderline Personality Disorder | Carcinoid Tumor | Ectrodactyly | Autism Spectrum Disorders | Primary Hyperoxaluria Type 1 | Hypertensive Nephropathy | Inflammatory Linear Verrucous Epidermal Nevus | Vitreoretinal Degeneration, Snowflake Type | Multiple Sclerosis, Primary Progressive | B-cell Prolymphocytic Leukemia | Vitamin K Deficiency | Acute Motor Axonal Neuropathy | Hyperuricemia | Atrioventricular Septal Defect | Hypophosphatemic Rickets, Autosomal Recessive, 1 | Hereditary Xerocytosis | Citrullinemia | Multiple Epiphyseal Dysplasia | Asphyxia Neonatorum | Omenn Syndrome | Absence Epilepsy | Narcolepsy | Subcortical Band Heterotopia | Cervical Dystonia | Birk-Barel Syndrome | Juvenile Myelomonocytic Leukemia | Glycogen Storage Disease Type 9 | Leukoplakia, Oral | Iron Overload | Amyotrophic Lateral Sclerosis-parkinsonism-dementia Complex | Autism | Takenouchi-Kosaki Syndrome | Leri Pleonosteosis | Schizotypal Personality Disorder | Sturge-Weber Syndrome | Nance-Horan Syndrome | GM2-gangliosidosis AB Variant | Agnathia-Otocephaly Complex | Nanophthalmos | Infantile Spasm | Wolfram Syndrome | Pulmonary Stenosis | Myoclonus-dystonia Syndrome | Esophagitis, Eosinophilic | Primary Carnitine Deficiency | Long-chain 3-hydroxyacyl-coenzyme A Dehydrogenase Deficiency | Cat Eye Syndrome | Autosomal Recessive Congenital Ichthyosis | Hemangioblastoma | Dysferlinopathy | Epidermolysis Bullosa Simplex, Localized | Riboflavin Transporter Deficiency Neuronopathy | Cryopyrin-associated Periodic Syndromes | 3-hydroxy-3-methylglutaryl-CoA Synthase Deficiency | Trismus-pseudocamptodactyly Syndrome | Primary Hyperoxaluria Type 3 | Creatine Deficiency Syndrome Due To AGAT Deficiency | Cluster Headache | Phenylketonuria II | Poirier-Bienvenu Neurodevelopmental Syndrome | Vestibular Disease | Aplastic Anemia | Loeys-Dietz Syndrome Type 4 | Alpha-mannosidosis | Hartnup Disease | Neural Tube Defect | Campomelic Dysplasia | Aceruloplasminemia | Glycogen Storage Disease Type 6 | Choreoathetosis, Hypothyroidism, And Neonatal Respiratory Distress | Paraganglioma | Chronic Neutrophilic Leukemia | Sialidosis Type I | Pleural Tuberculosis | Ornithine Transcarbamylase Deficiency | Polydactyly | Ellis-Van Creveld Syndrome | Ligneous Conjunctivitis | Miyoshi Myopathy | Gray Platelet Syndrome | Charcot-Marie-Tooth Disease Axonal Type 2N | Genitopatellar Syndrome | Histiocytosis | Intestinal Obstruction | PHARC Syndrome | Liver Failure, Acute Infantile | Osteopathia Striata With Cranial Sclerosis | Non-small Cell Lung Cancer | Pancreatitis | Enlarged Vestibular Aqueduct | Arteriosclerosis | Xeroderma Pigmentosum | Impetigo | Lymphangioma | Iron Metabolism Disorders | Hemosiderosis | Membranous Nephropathy | Peripheral Neuropathy | Chiari Malformation Type I | Seborrheic Dermatitis | Dubin-Johnson Syndrome | Holoprosencephaly | Cervicitis | Splenomegaly | Agammaglobulinemia | Osteochondrosis | Thrombotic Microangiopathy | Pleurisy | Peutz-Jeghers Syndrome | Progressive Myoclonic Epilepsy | Leukemia-lymphoma, Adult T-cell | IgA Deficiency | X-linked Charcot-Marie-Tooth Disease | Endometritis | Seizures | Retinitis Pigmentosa 3 | Osteonecrosis Of The Jaw | Ataxia-ocular Apraxia 2 | DOCK8 Immunodeficiency Syndrome | Kohlschutter-Tonz Syndrome | Gaze Palsy, Familial Horizontal, With Progressive Scoliosis, 2 | Antley-Bixler Syndrome | Neonatal Progeroid Syndrome | Cyst | Pilomatrix Carcinoma | Spermatocele | Bone Marrow Necrosis | Glycogen Storage Disease Type 5 | Ovarian Hyperstimulation Syndrome | Chronic Myelomonocytic Leukemia | Antisocial Personality Disorder | Osteochondroma | Metatropic Dysplasia | Erythema Nodosum | Focal Segmental Glomerulosclerosis | Charcot-Marie-Tooth Disease, Type 2C | Graft-versus-host Disease | Arteriovenous Malformations | Polycythemia | Barrett Esophagus | Fowler's Syndrome | Hyperthyroidism | Cholestasis, Intrahepatic | Sponastrime Dysplasia | Polyradiculopathy | Malaria, Cerebral | Smith-Lemli-Opitz Syndrome | Dermatitis | Ichthyosis Hystrix, Curth-Macklin Type | Hepatitis, Chronic | Blomstrand Osteochondrodysplasia | Medium-chain Acyl-CoA Dehydrogenase Deficiency | Combined Malonic And Methylmalonic Acidemia | Fragile X Syndrome | Diabetic Nephropathy | Meningeal Melanocytoma | Sorsby Fundus Dystrophy | Postpoliomyelitis Syndrome | Keratoconjunctivitis | Alpha-1 Antitrypsin Deficiency | Potocki-Shaffer Syndrome | Vitreoretinopathy, Proliferative | Japanese Encephalitis | Glucagonoma | Sepiapterin Reductase Deficiency | Anthrax | Infertility, Male | Porokeratosis | Tatton-Brown-Rahman Syndrome | Erythema Multiforme | Malignant Fibrous Histiocytoma | Rhabdoid Tumor | Hemochromatosis Type 2 | Amyotrophic Lateral Sclerosis, Juvenile | Pierson Syndrome | Kabuki Syndrome | Hyperbilirubinemia, Neonatal | Cholangiocarcinoma | Usher Syndrome Type IIC | Fibromuscular Dysplasia | Primary Pigmented Nodular Adrenocortical Disease | Hypermetropia | Leukocyte Adhesion Deficiency | Chudley-McCullough Syndrome | Craniometaphyseal Dysplasia | Cancer, Bladder | Cancer, Colon | Oligospermia | Keloid | Malonyl-CoA Decarboxylase Deficiency | Encephalopathy | Thromboembolism | Protein C Deficiency | Compartment Syndrome | Growth Hormone Excess | 3-methylglutaconic Aciduria Type IV | Thyroid Hormone Resistance | Atrial Septal Defect | Hypohidrotic Ectodermal Dysplasia, X-linked | Dyskeratosis Congenita | Spondylosis | Pneumonia, Viral | Weill-Marchesani Syndrome | Scleroderma | Renal Tubular Dysgenesis | Hepatitis | Erythrokeratodermia Variabilis | Oligoasthenoteratozoospermia | Huntington's Disease | Anorchia | Branchiootorenal Syndrome | Arthritis | Congenital Primary Aphakia | Disseminated Intravascular Coagulation | Erysipelas | Joubert Syndrome | Lyme Disease | Stroke, Hemorrhagic | Carbohydrate Metabolism Disorders | Hemochromatosis Type 1 | Spinocerebellar Ataxia Type 10 | Premenstrual Syndrome | Adenoma, Pleomorphic | Carcinoma, Transitional Cell | Congenital Ichthyosiform Erythroderma | Nemaline Myopathy 10 | Lymphedema | Acquired Partial Lipodystrophy | Dental Caries | Thyroiditis | Acute Coronary Syndrome | Isovaleric Acidemia | Bloom Syndrome | Vasculitis | Parapsoriasis | Macrophage Activation Syndrome | Dystrophy, Cone-rod | Waardenburg Syndrome Type 4A | Osteogenesis Imperfecta Type VI | Hereditary Hemorrhagic Telangiectasia Type 2 | Nicotine Addiction | Chylomicron Retention Disease | Congenital Adrenal Hyperplasia 1 | Congenital Bilateral Absence Of Vas Deferens | Learning Disability | Platelet Disorders | Aspartylglycosaminuria | Wagner Disease | Hyperparathyroidism | Oculodentodigital Dysplasia | Chromosome 9q34.3 Deletion Syndrome | Cavitary Optic Disc Anomalies | DNA Ligase IV Deficiency | Aromatic L-amino Acid Decarboxylase Deficiency | Cryoglobulinemia | Leishmaniasis, Visceral | Spinocerebellar Ataxia Type 40 | Chordoma | Angiomyolipoma | Apraxia | Myositis, Focal | Retinitis Pigmentosa | Acne Vulgaris | Muscle Wasting | KBG Syndrome | Microphthalmia | Cranial Nerve Disease | Myoclonic Atonic Epilepsy | Liebenberg Syndrome | Pneumothorax | Thalassemia, Beta | Exostoses | Nutrition Disorders | Tularemia | Lymphomatoid Granulomatosis | Metabolic Syndrome | Meningioma, Benign | Psoriasis | Hereditary Multiple Exostoses | Multiple Sclerosis | Adenosine Deaminase 2 Deficiency | 3-methylcrotonyl-CoA Carboxylase Deficiency | Hypersomnia | Triphalangeal Thumb-polysyndactyly Syndrome | Trachoma | Prurigo Nodularis | Infantile Refsum Disease | Hypothyroidism | Pompe Disease | Hyperparathyroidism, Secondary | Congenital Dyserythropoietic Anemia | Hydrolethalus Syndrome | Hypercholesterolemia | Pneumococcal Meningitis | Antenatal Bartter Syndrome Type 1 | Conn Syndrome | Pyloric Stenosis, Infantile Hypertrophic | Saul-Wilson Syndrome | Multiple Sclerosis, Chronic Progressive | Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia | Optic Atrophy 2 | Carcinoma, Small Cell | Arthritis, Reactive | Transcobalamin Deficiency | Hyperammonemia | Gilbert Syndrome | Leiomyosarcoma | Melanoma | Lipoma | 17-beta-hydroxysteroid Dehydrogenase X Deficiency | HIBCH Deficiency | Sitosterolemia | Demyelinating Diseases | Amish Infantile Epilepsy Syndrome | Spinocerebellar Ataxia Type 6 | Glioblastoma | Mesothelioma, Malignant | 3-methylglutaconic Aciduria Type I | Fanconi Anemia | Lateral Meningocele Syndrome | Intermittent Claudication | Hepatic Adenomatosis | Subacute Sclerosing Panencephalitis | Transthyretin-related Amyloidosis | Neuroectodermal Tumors, Primitive | Raynaud Phenomenon | Autosomal Recessive Bestrophinopathy | Charcot-Marie-Tooth Disease, Type 6 | Kleine-Levin Syndrome | Carpenter Syndrome | Rubinstein-Taybi Syndrome | Restless Legs Syndrome | Mitochondrial Disease | Kearns-Sayre Syndrome | Zygomycosis | Granular Corneal Dystrophy Type 1 | Neovascular Glaucoma | Vitiligo | Epicondylitis