Pre-eclampsia

About the Disease
Pre-Eclampsia, also known as preeclampsia, is related to severe pre-eclampsia and eclampsia, and has symptoms including edema, hyperemesis gravidarum and morning sickness. An important gene associated with Pre-Eclampsia is PEE1 (Preeclampsia/Eclampsia 1), and among its related pathways/superpathways are Angiogenesis (CST) and Angiogenesis (WikiPathways). The drugs Azithromycin and Levobupivacaine have been mentioned in the context of this disorder. Affiliated tissues include placenta, kidney and liver, and related phenotypes are hypertension and proteinuria

Common Targets
CENPQ | ICOS | CYBA | SOS1 | TBXAS1 | EDNRA | BAIAP3 | CYP3A4 | ZNF366 | FCGR2B | NPR3 | TRIM17 | RNLS | SLC43A3 | RPTOR | SH3RF3 | SLC39A8 | SLC5A12 | MGP | OAS1 | ZNRF3 | ARL5A | LAMA5 | ERVFRD-1 | CHST15 | RUNX2 | HEATR3 | CXCL9 | PNMT | NREP | ITPR2 | IL36B | PDIA5 | CHRNB3 | NPHS1 | KAZN | CDK2 | CLCNKA | PIK3R5 | C20orf203 | LOC107986598 | ZC3H12D | IL12B | TSPYL5 | INO80B | TRDN | MID2 | KLRC2 | LPL | MYO7A | PDHX | KLHL21 | SDC1 | OLFML2A | TPM3 | MTA1 | JAKMIP2 | MFGE8 | TRAF1 | PHACTR1 | TMX2 | ZBTB38 | GYPB | PTHLH | SLC1A3 | C1orf226 | FAM184A | CD247 | CSK | C17orf98 | MC1R | TSPAN16 | DNTTIP2 | KNL1 | LACTB | ERP27 | STEAP4 | ADAM28 | FNIP2 | PTGES | ABI3 | NECTIN4 | GSTM3 | TAS2R7 | AVPR1A | CACNA2D2 | CD27 | UPK3B | TACR3 | MYO7B | TCL6 | SH3BP5 | MRGPRD | ADRM1 | CTF1 | LORICRIN | MYH9 | CAMK4 | HFE | HLA-DMA | CLCNKB | INSIG1 | ZSWIM4 | TGFB1 | PKD1 | H1-1 | KCNN3 | C1S | MOGAT2 | CCND2 | ACVR1C | CSF1R | XIRP1 | CAMK1 | NCOR2 | AMP-activated protein kinase (AMPK) | SLC25A11 | HPS4 | ZBTB4 | NACC2 | MCC | DYNLRB1 | ARHGEF26 | LAX1 | PITPNM2 | ZNF554 | AGTRAP | EVA1A | LINC02860 | PBLD | TTTY15 | SLC12A3 | ARHGEF37 | DUSP4 | HAX1 | RNF25 | CANX | BANP | ETV5 | DIP2C | ITGB1BP2 | GJA4 | INHBA-AS1 | GPR176 | CTNNA1 | GATA3-AS1 | PRKCZ | MZT2B | SYDE1 | LOC105370834 | FILIP1L | SPRR1A | OPN5 | SERPINB9 | CIAO1 | LRBA | DIPK1B | ABCC12 | SPRR1B | NR3C2 | GPX8 | SLC43A2 | DUSP5 | C8B | ATP1A1 | HMGCLL1 | SPHK2 | LRMDA | MMP24 | DKC1 | CMIP | LRRC37A11P | SLC7A5 | CADM2 | LSM2 | ERAP2 | ADRA1A | MIR34A | MMRN2 | VILL | PRSS8 | ACSM3 | TSPAN8 | IQSEC3 | NCAM1 | SFT2D3 | GGT2P | ALDH3B1 | PAMR1 | ADARB2 | ADD2 | TEX29 | CSTL1 | CTPS1 | ADRA2B | GFRAL | GNB3 | EFEMP2 | PRRG2 | ZFP36L1 | TAFAZZIN | TGM1 | IL17RA | NDUFAF2 | MAN1C1 | SCN3A | SCNN1A | LTA | G1950 | MSH4 | KALRN | NOD1 | FAM221A | ACE | BRCA2 | VEGFC | AOC4P | EPHX2 | C5 | OBSCN | CYP8B1 | CAB39L | G1029 | ADIPOQ | RGL3 | IL24 | ATP2C2 | C4orf33 | TM4SF4 | ITGA8 | CDKN2B | ACADVL | TTC23L | MIR568 | SBNO1 | DNAJB7 | AGT | REEP3 | NEDD4L | MYOZ2 | Relaxin receptor (nonspecified subtype) | MITF | SHANK2 | IGFALS | CRH | MIR205 | ALDH2 | EIF4H | TIAM2 | TMEM129 | LGALS16 | SLC3A2 | CYP17A1 | MFSD2A | DROSHA | DYNC1I1 | AQP3 | ITIH4 | SGK1 | ELMO3 | AP3S1 | RRM2 | SCNN1B | FAM151B | SULT1C3 | YPEL4 | CHRM1 | ICAM4 | PAPPA2 | G3725 | APLNR | VWA3B | TNFRSF18 | LOC101929130 | SP140 | ERICH1 | LINC00518 | FGF5 | PIK3R1 | TEX15 | FES | SCARB1 | PIGU | PDLIM2 | MSH5 | MYF6 | TWF2 | TBCD | F3 | AMBP | ZNF300 | CEACAM7 | HLA-G | SLC22A12 | TRPM1 | EHD3 | ASTN2-AS1 | WWOX | IKBKG | GFPT1 | HTR4 | FAM186A | COMT | TNFSF13B | ENG | CACNB2 | OGG1 | CPSF3 | RAMP2 | OR8D4 | RPS6KB1 | MOG | SDHAP3 | PDGFD | KAZALD1 | ICAM1 | FOXJ3 | GNL1 | OR10AG1 | KIF15 | ATP10A | HMGCR | PTK6 | NEUROG1 | BACE2 | CLCA1 | ADORA2B | KIF21B | SNN | HSD17B8 | GALNT2 | ARG1 | FAM133CP | GTDC1 | PYM1 | ADIPOQ-AS1 | CDH15 | ODF3L2 | NAT1 | CFDP1 | CELF5 | GALM | SLC6A2 | BPIFA1 | POMP | WDR27 | PPP2R2B | NRM | MOV10 | ERRFI1 | KRT73 | SLC9A3 | CYP11A1 | LEP | LGALS8 | CDKN2B-AS1 | POU5F1 | SPTLC3 | MOB3A | WNK4 | STC1 | SYN3 | GNRH2 | ANK1 | TRANK1 | SLC2A6 | PARVG | CLN8 | DKK1 | BICC1 | PGR | LOC100287329 | DNM2 | PWWP2B | TNNT2 | NCF4 | VASH1 | ACTN4 | SLURP1 | ERCC8 | COL5A1 | FLT4 | PDE6C | TP63 | RDH13 | SERPINC1 | PCNX2 | RAMP1 | PTGIS | POLD4 | INHA | SLC16A14 | ADD1 | CRHBP | SOD2 | EYA4 | PRKAG2 | TANC2 | SYNJ2 | ARHGAP36 | GP9 | S100A4 | WSB1 | GPX1 | SCNN1G | CABCOCO1 | FCGR3A | PPARG | GRM7 | ULK4 | ZFAT | GADD45A | RXFP1 | PLEKHA7 | ZNF417 | ANGPTL1 | FCMR | AVPR2 | TGFBR1 | UROS | ANGPT4 | RAMP3 | EMILIN1 | TBC1D14 | SELP | TBP | MTNR1B | CCN3 | UTS2 | G999 | RIMS2 | IL12RB2 | G3605 | ADRA2A | ATP2B1 | FLT1 | SETBP1 | CBR1 | COL18A1-AS1 | SLC22A25 | FRMD6 | NPPA | IL4I1 | PZP | INSR | SPRR4 | TFAP2A | MKLN1 | SLC45A4 | MECOM | PRKAB1 | LDB3 | IFNA17 | POPDC3 | CTSZ | RNF133 | STOX1 | ST6GALNAC5 | GCLC | TMEM86A | PAX5 | SLC12A7 | PTPN1 | VIT | PPFIA4 | SLC4A5 | DIRC3 | PC | CMSS1 | DAW1 | AP1B1P1 | ANAPC11 | IFNA21 | ADGRV1 | YPEL1 | P2RX4 | GCKR | SERPINE1 | RAB34 | TMX2-CTNND1 | GPX2 | FBXO44 | ERVW-1 | CTXN3 | COL17A1 | SLC16A12 | LGALS14 | PLIN2 | CXCL12 | INHBA | F2 | OXT | TCIM | AATK | BACH2 | AGXT2 | WNK1 | CD55 | JAG1 | G2099 | ADARB1 | PTPN14 | CCDC33 | PTP4A3 | OSBPL5 | NPY5R | PRL | HIC1 | RBBP8NL | MX1 | NNAT | ANP32D | GRK4 | LCT | ZNF175 | H2AC14 | SIRPB1 | MEPCE | BCAR1 | TRPC6 | FYB1 | ACVR1 | EIF1B | OSBPL6 | AGAP1 | CALHM3 | CNBD2 | KLK1 | FHL2 | GATA5 | HIPK4 | SLC45A1 | RTEL1 | CUL3 | HAVCR1 | AFMID | MME | TBATA | LHFPL2 | CTNNBL1 | ELAVL3 | ITLN1 | G3630 | GDPD5 | RGS5 | RBP1 | KRT222 | ANOS1 | LTBP1 | G4318 | CPEB4 | PROZ | LGALS13 | ACVRL1 | ACKR3 | MBL2 | GPX3 | KRT39 | ZDHHC3 | CBS | HCRTR2 | IDH2 | MAST4 | BDNF-AS | KLF7 | SOD3 | CDH11 | CLIC3 | SRPRB | PLA2G4E | INHBB | TNS3 | CAPN8 | ARID3A | MARK3 | TIMP1 | CACNA1D | KLHL3 | GUCY1A1 | AJAP1 | MIEF2 | TEK | NDUFAF3 | AKR1C3 | GPD2 | CD200R1 | SLAMF1 | LIMCH1 | ADA2 | NPHP3 | SERINC5 | KCNJ5 | DGLUCY | KCNH4 | NR3C1 | IL17F | CPD | LRRC4 | CYP2J2 | FGF23 | FBXL19 | CCL27 | ZNF423 | ADAM12 | CNDP1 | TTC7A | MYG1 | G2064 | MBD3L1 | CALCRL | CEP41 | INHBC | TGFB2 | HIPK2 | ASPA | ODAD4 | PKM | BHLHE40 | PTPN3 | CTLA4 | SBSN | PSG8 | PEBP1 | DDO | LINC01317 | EDN1 | EPHA2 | G7124 | ATF3 | CCNB3 | HECTD2-AS1 | DLL1 | COL26A1 | LEPR | LTBP2 | MYO1B | CELA2B | ANTXR1 | ALPK3 | IGFBP5 | WBP1 | TMCO3 | TRAPPC1 | F5 | NFIX | ZBTB20 | GPLD1 | Serine protease (nonspecified subtype) | ELN | FASN | DYNC2H1 | IQCJ-SCHIP1 | LINC00310 | LAMA2 | ANKH | PLEKHH1 | PTPRN2 | NFKBIZ | MICOS10 | C6 | CRTC1 | LOC90246 | NDUFA4L2 | G5743 | ESRRB | MYLK | ACP6 | USHBP1 | CUL2 | TMEM41A | GGTLC2 | HSD11B2 | CBLC | ZMIZ1-AS1 | RUSC1-AS1 | HOOK2 | NRXN2 | S100A10 | DACT3 | DAPK3 | DLX5 | XRCC4 | OLR1 | INTS14 | SLC37A1 | IFT20 | BAIAP2L1 | CCSAP | SNAP25 | KRTCAP3 | NOS3 | FASLG | ST3GAL1 | SLC4A4 | RUSC2 | SLC35F4 | MMP2 | USP44 | ARPC1B | ENPEP | DENND2D | TMEM97 | CDHR1 | RPL36AL | MIR205HG | GZF1 | SLC34A1 | LMNA | G196 | WRAP73 | CRMA | ITGB1BP1 | WT1 | ERAP1 | GRK5 | GPX4 | IRF8 | MIR216A | UMOD | CA9 | ELOVL1 | CNTN4 | RSPO1 | KNSTRN | STRA8 | ERN1 | FCGR2A | RSPH9 | FAM110A | BMP10 | NAPRT | IRF6 | MIR29A | PDGFRA | PANK4 | NMUR1 | RAB4A | SLC2A1 | GCA | CDSN | DYRK1B | SCHIP1 | PDE5A | SLC39A5 | LCE4A | ZC3HC1 | WFIKKN1 | CCDC89 | TCAP | SCUBE2 | APOD | B3GNT6 | TH | GCAT | GK2 | KL | MGMT | GP6 | ZNF783 | SLC26A8 | FAS | MMP8 | INHBE | KRT24 | ATP6V0D2 | NATD1 | WFDC1 | CLNS1A | IL10 | MB21D2 | PGF | SCAI | CORIN | ZSWIM6 | CCDC81 | TIMP2 | CYP4F2 | APOL1 | MASP1 | NPAT | Complement Complex | KDR | FLNB | NAMPT | CTRC | IFNG | ECE1 | MTHFR | CRB1 | PIN4 | SLC43A1 | ANGPT1 | TRIB3 | COL4A3 | TMEM161B | STX1A | SMAD3 | C3 | GNAS | LY86-AS1 | SLC2A9 | KCNMB1 | SYNE1 | PANK2 | SCARF1 | AGTR1 | SDK1 | MAS1 | G1956 | NPR1 | CPED1 | ZNF385A | CCR5 | ALB | FGD2 | NOTCH2 | GABRA2 | CD28 | ORMDL3 | IL22RA2 | RPS2 | CCL23 | DSCAM | GAD1 | SCAMP5 | STX17 | ZNF83 | AGER | CSGALNACT1 | EML1 | BCL6 | LIPJ | SLC35F1 | GATA3 | STK39 | TPM1 | DNM3 | MYOF | PRSS16 | APOBEC2 | TREX1 | IL1R2 | GHRHR | CRACD | APOB | G7422 | SLC38A5 | H1-6 | LOC107985434 | HIVEP3 | PARP4 | MFRP | PPP2CA | HCAR2 | VDAC2 | KCNMB2 | GSTP1 | SCRN1 | ZNF618 | ASTN2 | COPE | AGXT | DDAH2 | GRHL1 | SLC11A1 | LNPEP | ASAP1 | ANK2 | RXFP4 | RRBP1 | INPP5A | AHSG | TRPC1 | CNKSR2 | PRCP | CADPS2 | GPD1L | APC | HSD3B1 | MYO5A | CLDN7 | ZFP90 | HOXA3 | ANKRD45 | TYRP1 | WNT2 | ATP5PB | MSH5-SAPCD1 | GPR39 | PRR5 | FRS2 | TPM2 | MYBPC2 | FCGR3B | INO80B-WBP1 | RGS2 | IL4 | CRP | FAM135B | ITCH | CD19 | GPR68 | PDE1A | CTTNBP2 | KCNIP1 | CYP19A1 | TVP23A | AUTS2 | HS6ST3 | GPX5 | SPOCD1 | PLAUR | PRKCE | GTF2A1L | G596 | CX3CR1 | LHX8 | ZBTB12 | L3MBTL1 | STON1 | VTI1A | RAB4B | Long intergenic non-protein coding RNA 205 | PRKG1 | REN | COL4A4 | ABCD1 | H2AC1 | GPX7 | Voltage-Gated Calcium Channel alpha-2/delta (nonspecified subtype) | APOE | CYP11B2 | LOC105370135 | ZPBP2 | FAM163A | EPAS1 | FKBP1B | NAA11 | PER3 | PRELP | NOTO | INF2 | CD46 | TGFBR2 | ZCCHC14 | SMC6 | MARVELD1 | MT4 | LINC01415 | CELA3A | ZSCAN1 | IGBP1 | TRIM40 | SLC1A2 | LOC400622 | MIR548N | LOC102723576 | IRAG1 | PDP2 | SARDH | SLC5A9 | PPEF2 | CHRM2 | ARG2 | BTBD6 | ZNF831 | SLC47A1 | CHGA | SVIL | OTX1 | GAS6 | G3308 | HTR1D | SMCP | TSPAN18 | CTIF | COL11A2 | CCDC9B | DUSP1 | FOXP3 | CPZ | BIVM | ACTMAP | CCRL2 | SLC7A14 | IGFBP7 | LTF | HMOX1 | TCF7L2 | KDM7A | TAF1B | G114548 | Vasopressin V1 Receptor (nonspecified subtype) | DELE1 | CHI3L2 | TREML2 | UTP11 | STC2 | APELA | LGALS17A | DPYD | TEAD3 | TLR1 | L1TD1 | MIR4761 | NPHP1 | IQCK | IL1B | DMRTB1 | SLC12A1 | CBLL2 | CER1 | PIGS | MPO | C2 | MYO6 | G3569 | DNAH10 | GNA12 | TNFAIP8L2 | STOX2 | C10orf90 | LHPP | ADRA2C | G6647 | TIMP3 | RAD51AP2 | ATXN10 | NEB | SLC22A11 | NKAIN2 | DYNLT5 | H3-4 | GPX6 | GAS8 | GNAI1 | GRAMD2B | DUSP2 | AMN1 | CASZ1 | PCSK1 | PDE4D | SOX6 | SH3PXD2A | BTG3 | RASA3 | SHTN1 | ENPP2

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