Chronic Myelomonocytic Leukemia

About the Disease
Chronic Myelomonocytic Leukemia, also known as leukemia, myelomonocytic, chronic, is related to juvenile myelomonocytic leukemia and myelodysplastic syndrome, and has symptoms including fatigue, fever and night sweats. An important gene associated with Chronic Myelomonocytic Leukemia is ETV6 (ETS Variant Transcription Factor 6), and among its related pathways/superpathways are Disease and Akt Signaling. The drugs homoharringtonine and Daunorubicin have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, myeloid and monocytes, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Common Targets
PCDHA10 | SHTN1 | G596 | ACTB | GNB1 | KDM6A | PCDHA8 | RUNX1T1 | FBXW11 | DNA Methyltransferase (DNMT) (nonspecified subtype) | ITPR2 | PCDHA7 | TM9SF4 | AURKA | AP2M1 | DNA-Directed DNA Polymerase Complex | ABL1 | Protein farnesyltransferase | FADD | PCDHA6 | JAK2 | G3845 | MIR150 | PCDHGA12 | TIPRL | CDH13 | PCDHA5 | ASXL2 | PCDHA4 | OPHN1 | G7015 | ASXL1 | EPN2 | DAPP1 | PCDHA3 | PRKCZ | NFATC1 | ETNK1 | LILRB4 | CTAG1A | GATAD2B | PCDHA9 | PHF6 | PRMT5 | PCDHA2 | ARRB2 | PRKCG | NAE1 | GNB3 | DNMT3A | PCDHGB7 | FAT1 | PCDHA1 | PRKCA | CDA | NRAS | AURKB | RIPOR3 | Ribonucleoside-diphosphate reductase | GNG7 | EED | CSF1R | PCDH12 | TET3 | SMC1A | DHODH | G29126 | KIT | AIM2 | ATP10A | IL3RA | SF3B1 | IDH1 | CSF3R | PCDHGB4 | PCDHGB3 | EPHB4 | PCDHGB1 | TBC1D14 | RIT1 | SMARCC2 | TMEM120A | SRCAP | TBL1XR1 | WNT5B | SYK | SETBP1 | ARVCF | TET2 | PCDHGA6 | AATK | STAT5 (nonspecified subtype) | ABCC9 | CCDC141 | NEDD8-activating enzyme E1 | VAPA | PCDHGA5 | CUL3 | G999 | CSNK1A1 | SMARCA4 | MYOM1 | MAP3K7 | CDH18 | PCDHGA3 | G3480 | HUWE1 | AURKC | DOCK2 | CBL | PCDHGA2 | BCOR | IDH2 | CUX1 | KDM1A | CSF2 | MPL | EP400 | DOK1 | PCDHGA1 | ACTG1 | PCDHB15 | G7157 | IDH3A | ZRSR2 | CDHR2 | ICE1 | PCDHB14 | PCDHB13 | KIF21A | PCDHB12 | HPS3 | SIN3A | PCDHB11 | PTH1R | LGR4 | CTAG1B | PCDHB9 | SRSF2 | HAVCR2 | NOX3 | DOK2 | PCDHGA8 | TTN | PCDHB7 | PPP3R1 | Histamine Receptor (HR) (nonspecified subtype) | G1786 | SDK1 | PLK4 | C3 | RUNX1 | NF1 | PRPF40A | MEST | PCDHB6 | PCDHB3 | CSNK1D | BMPR1A | APOC2 | G7124 | PSAPL1 | NADPH Oxidase Complex | PHIP | TRAPPC12 | CREBBP | FLT3 | PTPN11 | BAP1 | ACTR10 | PCDHAC1 | PTPRC | DAXX | ATR | CDH23 | PCDHA13 | G2146 | ITPR1 | U2AF1 | PCDHA12 | PLCB3 | NADPH Oxidase (nonspecified subtype) | TP53BP2 | ETS1 | PCDHA11 | JAK3

Note: If you'd like to get a target analysis report for Chronic Myelomonocytic Leukemia, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Chronic Myelomonocytic Leukemia at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

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