Bicuspid Aortic Valve

About the Disease
Aortic Valve Disease 2, also known as aortic valve stenosis, is related to holt-oram syndrome and aortic aneurysm. An important gene associated with Aortic Valve Disease 2 is SMAD6 (SMAD Family Member 6), and among its related pathways/superpathways are Human Embryonic Stem Cell Pluripotency and Mesenchymal Stem Cells and Lineage-specific Markers. The drugs Desflurane and Captopril have been mentioned in the context of this disorder. Affiliated tissues include heart, endothelial and kidney, and related phenotypes are bicuspid aortic valve and coarctation of aorta

Common Targets
EGFR-AS1 | FBN1 | GATA4 | BMP4 | G4851 | PDIA2 | BMP2 | G1956 | ENG | GATA6 | TEX26 | HMCN2 | NKX2-5 | MIB1 | AXIN1 | GATA5 | ZFPM2 | CH25H | ROBO1 | TGFBR2 | GTPBP10 | ISL1

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