Disease

Optic Neuropathy

About the Disease
Optic Nerve Disease, also known as optic neuropathy, is related to leber optic atrophy and dystonia and toxic optic neuropathy, and has symptoms including eye manifestations and sciatica. An important gene associated with Optic Nerve Disease is TYR (Tyrosinase), and among its related pathways/superpathways are Metabolism and "Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.". The drugs Dalfampridine and Prednisone have been mentioned in the context of this disorder. Affiliated tissues include optic nerve, eye and retina, and related phenotype is vision/eye.

Common Targets
MAP3K12 | RTN4IP1 | ROCK1 | ND1 | cAMP-Dependent protein kinase (PKA) | MAP3K13 | AARS2 | TULP1 | ACO2 | CASP2 | MFN2 | SPG7 | ROCK2 | KARS1 | ATP6 | OPA1 | Rho kinase (ROCK) (nonspecified subtype) | Soluble guanylyl cyclase | MCAT | GPR17 | G5728 | ND6

疾病靶点研报
Optic Neuropathy

Note: If you'd like to get a target analysis report for Optic Neuropathy, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Optic Neuropathy at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Amelogenesis Imperfecta | Chondrodysplasia Punctata 1, X-linked Recessive | Leishmaniasis, Visceral | Neuromuscular Disorders | Epidermolysis Bullosa Simplex, Dowling-Meara Type | Hemophagocytic Lymphohistiocytosis | Open-angle Glaucoma | Congenital Nephrotic Syndrome | Heroin Dependence | Premature Ejaculation | Medium-chain Acyl-CoA Dehydrogenase Deficiency | Myelitis, Transverse | Spinocerebellar Ataxia Type 7 | Onchocerciasis | Craniosynostosis | Autoimmune Disease | Pancreatitis | Common Cold | Hypotension, Orthostatic | Precocious Puberty | Maple Syrup Urine Disease | Congenital Afibrinogenemia | Muscular Dystrophy | Spinocerebellar Ataxia Type 17 | Episodic Ataxia Type 1 | Encephalopathy | Dysplastic Nevus | Ameloblastic Carcinoma | Pouchitis | Alkaptonuria | Combined Pituitary Hormone Deficiency | Giant Axonal Neuropathy | Cheilitis | Growth Hormone Excess | Seizures | Hernia, Inguinal | Meconium Ileus | Renal-hepatic-pancreatic Dysplasia | Keratoconjunctivitis | Hyperlipidemia, Familial Combined | Bethlem Myopathy | Epidermodysplasia Verruciformis | Norrie Disease | Creatine Deficiency Syndrome Due To AGAT Deficiency | Urofacial Syndrome | Charcot-Marie-Tooth Disease | Pierson Syndrome | Postpartum Depression | Corticobasal Syndrome | Neurodevelopmental Disorder With Central Hypotonia And Dysmorphic Facies | Tyrosinemia Type 2 | Benign Hereditary Chorea | Congenital Tufting Enteropathy | Hepatorenal Syndrome | Meningococcal Infections | Synpolydactyly | Thanatophoric Dysplasia | Carcinoid Tumor | Presbycusis | Alzheimer Disease, Late Onset | Nance-Horan Syndrome | Neovascular Glaucoma | Nijmegen Breakage Syndrome | Headache | Leukocyte Adhesion Deficiency | 17-beta-hydroxysteroid Dehydrogenase X Deficiency | Gallstones | Occipital Neuralgia | Pulmonary Alveolar Microlithiasis | 3-hydroxy-3-methylglutaric Aciduria | Goiter | Ligneous Conjunctivitis | Ebstein Anomaly | Thyroiditis, Autoimmune | Colorectal Adenoma | Varicocele | Leber Hereditary Optic Neuropathy | Wieacker-Wolff Syndrome | Aspergillosis | Microvillus Inclusion Disease | Diffuse Intrinsic Pontine Glioma | GNE Myopathy | Birt-Hogg-Dube Syndrome | Stargardt Disease | Malignant Fibrous Histiocytoma | Hereditary Multiple Exostoses | Guillain-Barre Syndrome | Hyperuricemic Nephropathy, Familial Juvenile | Mandibuloacral Dysplasia With Type A Lipodystrophy | Paroxysmal Kinesigenic Dyskinesia | Arthritis, Psoriatic | Hemolytic Uremic Syndrome | Carey-Fineman-Ziter Syndrome | Charcot-Marie-Tooth Disease Type 4B1 | Epilepsy | Tracheal Disorders | Carpal Tunnel Syndrome | Trichomegaly | Papillorenal Syndrome | Atherosclerosis | Focal Dermal Hypoplasia | Camurati-Engelmann Disease | T-cell Leukemia | Fetal Alcohol Syndrome | Familial Thoracic Aortic Aneurysm | Cramp Fasciculation Syndrome | Glioma | Aldosterone Synthase Deficiency | Peters-plus Syndrome | Fascioliasis | Meningioma | Multiple Myeloma | Persistent Fetal Circulation | Micro Syndrome | Keratosis | Sickle Cell Disease | Chondrodysplasia Punctata | Chromosome 5q Deletion Syndrome | Thyroiditis | Glioblastoma Multiforme | Acute Anterior Uveitis | REM Sleep Behavior Disorder | Primary Erythromelalgia | Hypercalcemia | Blastomycosis | Angiosarcoma Of The Breast | Dysgerminoma | Ophthalmoplegia | Nephronophthisis | Sporadic Hemiplegic Migraine | Liver Failure | Psoriasis | Gynecomastia | Cerebellar Ataxia, Cayman Type | Schindler Disease | Mitochondrial DNA Depletion Syndrome, Hepatocerebral Form | Vulvovaginitis | Gastric Atrophy | Benign Familial Neonatal Convulsions | Retinal Dystrophy, Early-onset Severe | Hydrops Fetalis | Spinocerebellar Ataxia Type 16 | Huntington's Disease-like 2 | Adenosine Deaminase 2 Deficiency | Multiple System Atrophy | Mesial Temporal Lobe Epilepsy With Hippocampal Sclerosis | Alopecia | Retinal Coloboma | Juvenile Myoclonic Epilepsy | Hereditary Mixed Polyposis Syndrome | Osteogenesis Imperfecta Type I | Cellulitis | Goiter, Nodular | Interstitial Lung Diseases | Choroiditis | Congenital Adrenal Hyperplasia | Costello Syndrome | Pseudohypoparathyroidism Type 1C | Bone Marrow Necrosis | Teratozoospermia | Obsessive-compulsive Disorder | Prostatitis | Kawasaki Disease | Avian Influenza | Brooke-Spiegler Syndrome | Acne Vulgaris | Brenner Tumor | Migraine | Familial Isolated Hyperparathyroidism | Keratoconus | Carney Triad | Oculocutaneous Albinism Type 2 | Ghosal Syndrome | Stevens-Johnson Syndrome | Epilepsy, Generalized | Rubinstein-Taybi Syndrome | Hereditary Sensory Neuropathy Type 1 | Eclampsia | Alpha-thalassemia Myelodysplasia Syndrome | Goldenhar Syndrome | Roberts Syndrome | Hypohidrotic Ectodermal Dysplasia | Antley-Bixler Syndrome | Episodic Ataxia | Riboflavin Transporter Deficiency Neuronopathy | Choriocarcinoma | Muir-Torre Syndrome | Brachial Plexus Neuropathy | Adenoma, Villous | Warsaw Breakage Syndrome | Non-bullous Congenital Ichthyosiform Erythroderma | ADNP Syndrome | Inflammatory Myofibroblastic Tumor | Blue Rubber Bleb Nevus Syndrome | Trichuriasis | Pantothenate Kinase-associated Neurodegeneration | Optic Nerve Hypoplasia, Bilateral | Tyrosinemia | Hyperthyroidism | Prader-Willi Syndrome | Frontotemporal Dementia With Amyotrophic Lateral Sclerosis | Tangier Disease | Hypothyroidism | Rhizomelic Chondrodysplasia Punctata | Schnitzler Syndrome | Viral Meningitis | Gastroenteritis | Carcinoma, Signet Ring Cell | Hereditary Folate Malabsorption | Renal Failure | Progressive Myoclonic Epilepsy | HUPRA Syndrome | Atrioventricular Septal Defect | Craniofacial Dysostosis | Arterial Tortuosity Syndrome | Infertility | Spinocerebellar Ataxia Type 27 | Ventricular Septal Defect | Hemorrhagic Disorders | Agranulocytosis | SAPHO Syndrome | Sleep Disorder | Peroxisomal Disorder | Stuve-Wiedemann Syndrome | Maternally Inherited Diabetes And Deafness | Hypertension, Essential | Lipoma | Walker-Warburg Syndrome | Renal Hypomagnesemia 3 | Narcolepsy | Melanoma | Sweet Syndrome | Bronchiolitis | Spinocerebellar Ataxia Type 15 | Hydrocephalus | Myasthenia Gravis | Cardiospondylocarpofacial Syndrome | Dent Disease | Fibronectin Glomerulopathy | Sjogren Syndrome | Autosomal Recessive Bestrophinopathy | Schizophrenia, Paranoid | Canavan Disease | Thrombophilia | Ganglioglioma | Hemochromatosis | Osteoporosis-pseudoglioma Syndrome | Bardet-Biedl Syndrome | Hartnup Disease | Thalassemia | Cryptosporidiosis | Hennekam Lymphangiectasia-lymphedema Syndrome | Fibromyalgia | Diastrophic Dysplasia | Lipid Metabolism Disorders | Amyloidosis | Familial Hypobetalipoproteinemia | Beta-Propeller Protein-associated Neurodegeneration | Thromboembolism | Peyronie's Disease | Cryptococcal Meningitis | Coronary Restenosis | Malnutrition | Spinocerebellar Ataxia Type 8 | Encephalopathy, Glycine | Azoospermia | Splenomegaly | Glycogen Storage Disease Type 1b | Schaaf-Yang Syndrome | Hypoproteinemia, Hypercatabolic | Asplenia | Sialidosis Type I | Scabies | Lymphoma, Primary Cutaneous Anaplastic Large Cell | Thin Basement Membrane Disease | Congenital Fiber-type Disproportion Myopathy | Phosphoglycerate Dehydrogenase Deficiency | Inflammatory Bowel Disease | Mucolipidosis | Myosin Storage Myopathy | Eczema | Danon Disease | Familial Hemiplegic Migraine | Barrett Esophagus | Leigh Syndrome | Sleep Apnea, Obstructive | Gerstmann-Straussler-Scheinker Syndrome | Knobloch Syndrome | Blomstrand Osteochondrodysplasia | Hyperammonemia | Trigonocephaly | Bleeding Disorder Due To CalDAG-GEFI Deficiency | Arthritis, Gouty | Trimethylaminuria | Glycogen Storage Disease Type 4 | Pyruvate Kinase Deficiency | Albinism | Van Der Knaap Disease | Cri-du-chat Syndrome | 3-hydroxy-3-methylglutaryl-CoA Synthase Deficiency | Usher Syndrome Type II | Eating Disorder | Desbuquois Syndrome | Hartsfield Syndrome | Jawad Syndrome | Tay-Sachs Disease | Primary Cutaneous Amyloidosis | Major Depression | Encephalitis, Tick-borne | Pre-eclampsia | Skin Papilloma | Hypobetalipoproteinemias | Gray Platelet Syndrome | Colitis | Vertebrobasilar Insufficiency | Alopecia Totalis | Torticollis | Pulmonary Sclerosing Hemangioma | Spondyloarthritis | Congenital Poikiloderma | Diffuse Palmoplantar Keratoderma | Keratocystic Odontogenic Tumor | Leukocyte Adhesion Deficiency Type 1 | Epilepsy Of Infancy With Migrating Focal Seizures | Pyruvate Carboxylase Deficiency Disease | Lipodystrophy | Prolidase Deficiency | Peripheral Neuropathy | Cancer, Brain | Oguchi Disease-2 | Amenorrhea | Adams-Oliver Syndrome | Neurotoxicity | Central Core Disease | Congestive Heart Failure | Stromal Corneal Dystrophy | Waardenburg Syndrome | Hypotonia-cystinuria Syndrome | Thrombophlebitis | Schizencephaly | Combined Malonic And Methylmalonic Acidemia | Bicuspid Aortic Valve | Castleman Disease | Dysthymia | Bloom Syndrome | Skin Fragility-woolly Hair Syndrome | Fibrosis | Creutzfeldt-Jakob Disease | Juvenile Myelomonocytic Leukemia | Osteogenesis Imperfecta Type II | Sarcoma, Endometrial Stromal | Cutaneous T-cell Lymphoma | Familial Dysautonomia | Leukodystrophies | Meningioma, Benign | Constipation | Sorsby Fundus Dystrophy | Niemann-Pick Disease, Type A | Hemangioblastoma | Sengers Syndrome | Erythema Multiforme | Tendinopathy | Hypertension, Pulmonary | Dermatofibrosarcoma | Osteogenesis Imperfecta | Wolfram Syndrome | Desmosterolosis | Pneumothorax | Varices | Pulmonary Veno-occlusive Disease | Sarcoidosis | Lymphoma, Follicular | Methylmalonic Acidemia | Spondylocarpotarsal Synostosis Syndrome | Atelosteogenesis Type 2 | Kernicterus | Angioedema | Thyroid Dysgenesis | Dyskeratosis Congenita | Johanson-Blizzard Syndrome | Stroke | Beckwith-Wiedemann Syndrome | Localized Scleroderma | Farber Disease | Silver-Russell Syndrome | Spondylosis | Nephropathy | Tardive Dyskinesia | Parkinsonism | Obesity | Muckle-Wells Syndrome | Chronic Enteropathy Associated With SLCO2A1 Gene | Wagner Disease | Insulin Resistance | Brugada Syndrome 1 | Primary Carnitine Deficiency | Cranioectodermal Dysplasia | Cherubism | Moyamoya Disease | Hemophilia