Hereditary Sensory And Autonomic Neuropathy

About the Disease
Hereditary Sensory Neuropathy, also known as hereditary sensory and autonomic neuropathy, is related to insensitivity to pain, congenital, with anhidrosis and neuropathy, hereditary sensory and autonomic, type i, with cough and gastroesophageal reflux. An important gene associated with Hereditary Sensory Neuropathy is SPTLC1 (Serine Palmitoyltransferase Long Chain Base Subunit 1), and among its related pathways/superpathways are Neuroscience and Signaling by NTRKs. The drugs Folic acid and Lipoic acid have been mentioned in the context of this disorder. Affiliated tissues include tongue, spinal cord and tonsil, and related phenotypes are growth/size/body region and nervous system

Common Targets
DST | RETREG1 | SPTLC2 | MPZ | IQGAP3 | SCN11A | SPTLC1 | WNK1 | CLCN5 | ATL3 | KIF1A

Note: If you'd like to get a target analysis report for Hereditary Sensory And Autonomic Neuropathy, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Hereditary Sensory And Autonomic Neuropathy at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Spinal Muscular Atrophy Type 2 | Combined Malonic And Methylmalonic Acidemia | Neuroectodermal Tumors, Primitive | Cholestasis, Intrahepatic | Neuromyotonia | Multiple Sulfatase Deficiency | Non-small Cell Lung Cancer | Liddle Syndrome | 3-hydroxy-3-methylglutaryl-CoA Synthase Deficiency | Pompe Disease | Gangliosidosis, GM1 | Familial Retinal Arterial Macroaneurysm | Neurocysticercosis | Carbamoyl Phosphate Synthetase I Deficiency | Mitochondrial DNA Depletion Syndrome | Sertoli Cell-only Syndrome | Macrophage Activation Syndrome | Albinism | Menetrier Disease | Mitochondrial DNA Depletion Syndrome 13 | Blepharospasm | Charcot-Marie-Tooth Disease Type 4 | Klippel-Feil Syndrome | HELLP Syndrome | L-2-Hydroxyglutaric Aciduria | Hypertension, Pulmonary | Wolfram Syndrome | Parvovirus B19 Infection | Cardiomyopathy, Dilated, 1L | Werner's Syndrome | Familial Digital Arthropathy-brachydactyly | Cataplexy | Nijmegen Breakage Syndrome | Anovulation | Localized Scleroderma | Stroke, Ischemic | Intestinal Pseudo-obstruction | Osteonecrosis Of The Jaw | Benign Familial Infantile Seizures | Creutzfeldt-Jakob Disease | Pneumococcal Meningitis | T-cell Lymphoma, Subcutaneous Panniculitis-like | Essential Fructosuria | Juvenile Hyaline Fibromatosis | Hypospadias | Contact Dermatitis | Acute Tubular Necrosis | Uterine Leiomyoma | Pseudoachondroplasia | Intellectual Disability, Autosomal Dominant 5 | Schwannomatosis | Spinal Muscular Atrophy With Progressive Myoclonic Epilepsy | Inflammatory Joint Disease | Keratosis | Myotonia | Persistent Truncus Arteriosus | Neovascular Glaucoma | Genitopatellar Syndrome | Membranous Nephropathy | Glioma | Bipolar Disorder | Cardiospondylocarpofacial Syndrome | Cutaneous Angiosarcoma | Craniofrontonasal Syndrome | Cryptorchidism | Histiocytic Sarcoma | Cri-du-chat Syndrome | Blue Rubber Bleb Nevus Syndrome | Demyelinating Diseases | Tylosis With Esophageal Cancer | Dengue Shock Syndrome | Thalassemia, Beta | Blood Protein Disorders | Ollier Disease | Subcortical Band Heterotopia | Bietti Crystalline Dystrophy | Polycystic Kidney, Autosomal Dominant | Multiple Sclerosis, Primary Progressive | Restless Legs Syndrome | Gaze Palsy, Familial Horizontal, With Progressive Scoliosis, 2 | Chordoma | Acne | Oculodentodigital Dysplasia | Irritable Bowel Syndrome | Congenital Stationary Night Blindness | TARP Syndrome | Leukocyte Adhesion Deficiency Type 1 | Primary Cutaneous Amyloidosis | Primary Lateral Sclerosis | Bronchitis, Chronic | Dermatofibrosarcoma | Phosphoglycerate Dehydrogenase Deficiency | Progressive External Ophthalmoplegia | Ganglioneuroma | Cardiac Arrest | Meningioma, Benign | Kleine-Levin Syndrome | Cerebral Amyloid Angiopathy | Spastic Paraplegia Type 7 | Hypopituitarism | Focal Cortical Dysplasia Type 2 | Macrodactyly | Spinocerebellar Ataxia Type 16 | Blepharitis | Orthostatic Intolerance | Congenital Nystagmus | Congenital Generalized Lipodystrophy | Multiple Sclerosis, Secondary Progressive | Common Cold | Progressive Familial Intrahepatic Cholestasis Type 3 | Medulloblastoma | Chorea | Porphyria, Variegate | Erythema Nodosum | Vestibular Disease | Pleural Tuberculosis | Myhre Syndrome | Micro Syndrome | Hodgkin Lymphoma | Glutaric Aciduria Type 3 | Neuroleptic Malignant Syndrome | Achondrogenesis | Ophthalmoplegia | Aspartylglycosaminuria | Trimethylaminuria | Cervicitis | Nephrocalcinosis | Heavy Chain Disease | Charcot-Marie-Tooth Disease Type 4B1 | Insulin Resistance | Pseudohypoaldosteronism | Leukemia | Congenital Lipoid Adrenal Hyperplasia | Cystitis, Interstitial | Early Infantile Epileptic Encephalopathy 13 | Cold Agglutinin Disease | Hemochromatosis Type 1 | Niemann-Pick Disease, Type B | Methylmalonic Acidemia | Rhabdoid Tumor | Tyrosinemia | Hoyeraal-Hreidarsson Syndrome | Asplenia | Polymyalgia Rheumatica | Cheilitis | Mastitis | Chronic Myeloid Leukemia | Retinal Coloboma | Spinocerebellar Ataxia Type 12 | Spinocerebellar Ataxia Type 21 | Otitis Externa | Neurogenic Bladder | Progressive Myoclonic Epilepsy | Erdheim-Chester Disease | Cavitary Optic Disc Anomalies | Galactosemia | Alpers Syndrome | Von Willebrand Disease | Early Infantile Epileptic Encephalopathy 28 | Iron Overload | Polycystic Kidney, Autosomal Recessive | Hyperparathyroidism, Secondary | Lissencephaly 2 | Rett Syndrome | Lactose Intolerance | Succinic Semialdehyde Dehydrogenase Deficiency | Williams Syndrome | Alstrom Syndrome | Cone Dystrophy | Epilepsy, Generalized | Inflammatory Myofibroblastic Tumor | Pityriasis Rubra Pilaris | Autosomal Recessive Spastic Paraplegia Type 35 | Dementia, Vascular | Adenoma, Villous | Charcot-Marie-Tooth Disease Type 4E | Autosomal Recessive Bestrophinopathy | Carcinoma In Situ | Colitis, Microscopic | Metabolic Syndrome | Mandibuloacral Dysplasia With Type A Lipodystrophy | Ataxia-ocular Apraxia 2 | Osteogenesis Imperfecta Type IV | Metachondromatosis | NGLY1 Deficiency | Prune Belly Syndrome | Trachoma | Schaaf-Yang Syndrome | Corticobasal Syndrome | Malignant Peripheral Nerve Sheath Tumor | Juvenile Myelomonocytic Leukemia | Gastrointestinal Disorders | Congenital Fiber-type Disproportion Myopathy | Proctitis | Myelitis, Transverse | Mabry Syndrome | Synpolydactyly | Lymphedema | Stuttering | Aplasia Cutis Congenita | Ellis-Van Creveld Syndrome | Rhabdomyosarcoma, Alveolar | Fontaine Progeroid Syndrome | Blau Syndrome | Hereditary Sensory Neuropathy Type 1 | Diffuse Mesangial Sclerosis | Majeed Syndrome | Spitzoid Melanoma | Neuropathy | Osteosclerosis | Neurocutaneous Syndromes | Homocystinuria | GLUT1 Deficiency Syndrome | Ischemia | Neurofibromatosis | Brachial Plexus Neuropathy | Swine Influenza | Mevalonate Kinase Deficiency | Atelosteogenesis Type 2 | Acquired Partial Lipodystrophy | T-cell Chronic Lymphocytic Leukemia | Myasthenia | Schizophrenia | Osteogenesis Imperfecta Type V | Neutropenia | Intestinal Hypomagnesemia 1 | Agnathia-Otocephaly Complex | Alexander Disease | Lipodystrophy | Hyperphosphatasia With Intellectual Disability Syndrome 4 | Peripheral Neuropathy | Cannabis Abuse | Usher Syndrome Type I | Polycystic Ovary Syndrome | Pernicious Anemia | Tumoral Calcinosis | Scoliosis | Glycogen Storage Disease Type 3 | Jawad Syndrome | Hemolytic Anemia | Benign Familial Pemphigus | Pendred Syndrome | Congenital Hereditary Endothelial Dystrophy Type II | Amish Infantile Epilepsy Syndrome | Gerodermia Osteodysplastica | Arteriovenous Malformations | Mitochondrial Myopathy | Vitelliform Macular Dystrophy | Bethlem Myopathy | KBG Syndrome | MELAS Syndrome | Pearson Syndrome | Pierson Syndrome | Zygomycosis | Paracoccidioidomycosis | Epithelial-myoepithelial Carcinoma | Epilepsy | Hyperlipidemia, Familial Combined | Ganglioglioma | Mood Disorder | Hereditary Pyropoikilocytosis | Arteriosclerosis | Neurofibromatosis-Noonan Syndrome | Sick Sinus Syndrome | Polyneuropathy | Headache | Cranial Nerve Disease | Marfan Syndrome | Sclerosteosis | 3C Syndrome | Blue Nevus | Lipid Storage Myopathy | Spinocerebellar Ataxia Type 15 | Chediak-Higashi Syndrome | Babesiosis | Thrombophilia | Skin Papilloma | Epidermolysis Bullosa | Basal Ganglia Disease, Biotin-responsive | Optic Nerve Hypoplasia, Bilateral | Placenta Previa | Epidermolytic Palmoplantar Keratoderma | Spina Bifida | Olmsted Syndrome | Glycogen Storage Disease Type 9 | Retinal Vasculitis | Glycogen Storage Disease Type 0, Muscle | Pancreatitis | Myopathy | Pituitary Dwarfism | Sarcoma, Ewing | Muckle-Wells Syndrome | Dyggve-Melchior-Clausen Disease | Multisystemic Smooth Muscle Dysfunction Syndrome | Lymphangiomatosis | Autosomal Recessive Spastic Paraplegia Type 54 | Hypoplastic Left Heart Syndrome | Motor Neuron Diseases | Adams-Oliver Syndrome | Syncope | Globozoospermia | Cancer, Lung | Osteosarcoma | Ameloblastoma | Thrombosis | Neuromyelitis Optica | Scabies | Spondylocarpotarsal Synostosis Syndrome | Pleomorphic Xanthoastrocytoma | Scleroderma, Diffuse | Intracerebral Hemorrhage | Blastomycosis | Hypersensitivity Pneumonitis | Neurodevelopmental Disorder With Central Hypotonia And Dysmorphic Facies | Zollinger-Ellison Syndrome | Familial Exudative Vitreoretinopathy | Hyperphenylalaninemia | Adrenomyeloneuropathy | Incontinentia Pigmenti | Juvenile Polyposis | Coronary Artery Disease | Tracheal Disorders | Spinocerebellar Ataxia Type 1 | Hypoglycemia | Epidermolysis Bullosa Simplex | Polyomavirus Nephropathy | Conduct Disorder | Crigler-Najjar Syndrome | Choroiditis | Optic Nerve Diseases | Disseminated Intravascular Coagulation | Encephalopathy, Ethylmalonic | Frontotemporal Dementia With Amyotrophic Lateral Sclerosis | Focal Segmental Glomerulosclerosis | GM2-gangliosidosis AB Variant | Osteoporosis | Erythematotelangiectatic Rosacea | Hypertension, Renal | Rhabdomyosarcoma, Embryonal | Hypersomnia | Marshall-Smith Syndrome | Megaloblastic Anemia | Bronchitis | Occipital Neuralgia | T-cell Prolymphocytic Leukemia | Sialoadenitis | Esophagitis, Eosinophilic | Lattice Corneal Dystrophy Type 1 | Stickler Syndrome | Chromosome 16p11.2 Deletion Syndrome | Congenital Dyserythropoietic Anemia Type 1 | Early Infantile Epileptic Encephalopathy 1 | DOCK8 Immunodeficiency Syndrome | Schizophrenia, Paranoid | Cutaneous Mastocytosis | Eiken Syndrome | Leukemia-lymphoma, Adult T-cell | Hypotrichosis | Leigh Syndrome | Cyclic Vomiting Syndrome | Hypobetalipoproteinemias | Thyrotoxic Periodic Paralysis | Osteochondroma | Hyperandrogenemia | Pheochromocytoma | Enlarged Vestibular Aqueduct | Gigantism | Gnathodiaphyseal Dysplasia | Rheumatic Heart Disease | Hartnup Disease | Epidermodysplasia Verruciformis | Tularemia | Hyper IgE Syndrome | Chordoid Glioma | Heart Septal Defects | Adrenal Insufficiency | Autoimmune Disease | Fibromuscular Dysplasia | Prurigo Nodularis | Tricho-hepato-enteric Syndrome | Veno-occlusive Disease | Nephrotic Syndrome | N-acetylglutamate Synthase Deficiency | X-linked Sideroblastic Anemia | Thrombocythemia, Essential | Nail Disorder, Nonsyndromic Congenital | Cancer, Colon | Eating Disorder | Impulse Control Disorder | Uveitis | Benign Recurrent Intrahepatic Cholestasis 1 | Gastritis | Stuve-Wiedemann Syndrome | Congenital Myopathy | Impetigo | Dysthymia | CHOPS Syndrome | Heimler Syndrome | Lafora Disease | Pigment Dispersion Syndrome