Disease

Colon Cancer

About the Disease
Colorectal Cancer, also known as colon cancer, is related to lynch syndrome and colonic benign neoplasm, and has symptoms including abdominal pain, constipation and diarrhea. An important gene associated with Colorectal Cancer is CTNNB1 (Catenin Beta 1), and among its related pathways/superpathways are Disease and ERK Signaling. The drugs Tramadol and Ferrous fumarate have been mentioned in the context of this disorder. Affiliated tissues include colon, rectum and liver, and related phenotypes are renal cell carcinoma and neoplasm of the stomach

Common Targets
CBLN1 | ZNF257 | DCAF4L2 | MDM4 | CEACAM5 | ICOS | CDK4/Cyclin D1 | CNTN5 | BCL2L12 | TNKS | KSR2 | LDLR | RPTOR | G6774 | RUNX2 | CD36 | FAP | IL6ST | EPCAM | CD24 | CDK2 | G5599 | PRPS2 | G3309 | Protein Phosphatase 2A | PRKAR1A | Tumor-Associated Glycoprotein 72 (TAG-72) | MUC17 | EN2 | NRSN1 | G4089 | ITGA1 | G3620 | CSK | HDAC6 | OXSR1 | FGFR2 | ZNF396 | PTGES | TNFRSF1B | GPR35 | HIF1A | G5133 | TNFSF14 | G1026 | G595 | TRAF2 | AVPR1A | SLIT2 | LRRK2 | ITGAV | EMBP1 | KIT | ANKRD13B | MIR106B | MAP3K9 | FSD1 | SFRP2 | CTAG1A | CDK6 | LATS1 | NF-kappaB (NFkB) | KISS1 | SMARCA2 | CCND2 | IL2RG | IL13RA2 | NRAS | AMP-activated protein kinase (AMPK) | BSG | TGFB1 | G29126 | OSR1 | LGALS3 | Protein Kinase B (PKB/Akt) (nonspecified subtype) | CSF1R | CD3 Complex (T Cell Receptor Complex) | TNFRSF10A | FAT4 | IKBKB | DCAF12L1 | TACC1 | FER1L4 | MAP3K10 | TRAF3 | FAT1 | ALOX5AP | POLM | HOXB13 | FSCN1 | SOX1 | DOK3 | YEATS4 | BMP4 | ABCC5 | PRDM16 | FLNC | G7099 | TOP1 | XRCC2 | ZFP82 | G5728 | RAD52 | IL2RA | MIR34A | VIM | ITGA2 | G5594 | STAT6 | SLC7A5 | AURKB | PTPRZ1 | CA1 | NAT2 | ITGB1 | MIR137 | CDK4 | LAG3 | G673 | MIR10B | G7295 | CCDC85B | DMRT1 | SCGB3A1 | Protein kinase C (nonspecified subtype) | POLE | LTA | G1950 | SLC7A11 | CD69 | JAG2 | HLTF | BRCA2 | ALOX12 | G842 | EPS8L1 | RUNX3 | LGMN | KLK6 | MMP3 | SOX17 | G7852 | ATP5MK | MITF | IL3 | SCD | BMP2 | PPARA | IRAK3 | IRF3 | TYK2 | DDR2 | DROSHA | G3479 | ERBB3 | MUTYH | IRS2 | IDH1 | TEX26 | MIR1-1 | MAP2K1 | MYH11 | VGF | FGFR3 | Lipoxygenase (nonspecified subtype) | SHOX | ACSL1 | TNIK | SPARCL1 | PMS2 | BVES | IL4R | FGF5 | PLS3 | EED | G1029 | SDC2 | DNA Topoisomerase II (nonspecified subtype) | TNFRSF18 | Integrin alpha4beta7 (LPAM-1) receptor | SLC22A3 | MAOA | CACNA1G | PDGFRB | HS3ST2 | ITGA3 | MIR34B | PIK3R1 | TRNP1 | F3 | CCKBR | ESR2 | ACTN2 | FBLIM1 | MAP3K11 | G142 | ENG | FCAMR | SPARC | BACE2 | DLC1 | CHFR | CEACAM1 | SHOX2 | FOXD3 | WWP2 | ADORA2B | NOD2 | C3orf36 | CD44 | HMGCR | ADAM17 | OGG1 | CDH17 | CD86 | GCOM1 | PDE9A | EIF4E | MIR143 | MYOD1 | G23411 | NAT1 | EFCAB13-DT | DRG1 | PCSK2 | BLOC1S5-TXNDC5 | CDO1 | IL-2 receptor | LEP | MICB | SPACA6 | Raf kinase (nonspecified subtype) | ANGPT2 | HDAC1 | DNM2 | CD40 | WIF1 | CDKL3 | SELENOS | SFRP4 | MIR25 | RPS6KB2 | DACT2 | ALCAM | EEF1E1-BLOC1S5 | EYA4 | IL-4 receptor | PRKAG2 | SYNJ2 | G6772 | MUC1 | G2475 | MIR605 | DYRK1A | TTK | VENTX | HPGD | VSIG4 | DCAF12L2 | SMAD7 | TPBG | CCR2 | IL15 | SEPTIN9 | SIRPA | C6orf118 | TBX3 | KLRK1 | PLEKHA7 | LCN2 | FLT4 | MIR34C | FCGR3A | PPARG | REG1A | MIR21 | CASP8 | B3GNT2 | IL11 | ZNF154 | CD22 | CD8 | G7157 | DLK1 | LAPTM4B | DPP4 | MUC15 | ITGA4 | CYP24A1 | MIR124-1 | TGFBR1 | GAS7 | HLA-A | ADORA2A | LCP1 | PTGS1 | EPO | TNKS2 | WNT5B | G3605 | CDH9 | AKR1B1 | LILRB2 | FLT1 | G9429 | MUC13 | SNTB2 | TNFRSF12A | KRT23 | SLC22A2 | PAX5 | CCAT1 | SEMA4C | PTPN1 | CCAT2 | IGFBP3 | MRE11 | C1orf167 | XDH | XRCC3 | G3480 | CCR8 | ACHE | SERPINE1 | LONRF2 | STIM1 | PCBP1 | DAPK1 | DICER1 | NRP1 | ERCC2 | MTHFD1 | CXCL12 | MIR210 | LGR5 | FGB | MERTK | DNA-Directed RNA Polymerase II | EEF1A1 | NCL | FOXF2 | WWTR1 | HIC1 | HOXA2 | CYP2R1 | SMAD2 | GALK1 | Tubulin | MAP3K7 | ATG4B | B4GALT2 | CCND3 | G836 | Platelet-Derived Growth Factor Receptor (nonspecified subtype) | MIR124-2 | BLOC1S5 | FERMT3 | sigma Receptor (nonspecified subtype) | Vascular endothelial growth factor receptor (VEGFR) (nonspecified subtype) | CDH18 | NADSYN1 | BCL9 | G3630 | LAD1 | ATP2A3 | PRNCR1 | GEN1 | NR1H4 | NTSR1 | XPO5 | RAN | Mitogen-Activated Protein Kinase (nonspecified subtype) | CXXC4 | ZIC5 | MIR3652 | RPL17 | STK3 | G4318 | NLRC5 | RAF1 | MIR9-1 | G2033 | ASTN1 | KDM1A | KIRREL3 | PPP5C | RAD51 | TEK | FGFR4 | CD3E | PDE6D | EMCN | KLRC4-KLRK1 | RB1 | BCL11B | Transforming growth factor beta (nonspecified subtype) | DDR1 | ZFP57 | RXRA | ADAMTS16 | CD80 | G4193 | PROM1 | APOBEC3A_B | EPHA2 | HNRNPM | MIR124-3 | G4233 | CCNA1 | SEMG1 | MYCL | TINCR | CYGB | CTLA4 | G2064 | AP-1 Transcription Factor Complex | MACC1 | FASN | PIK3CA | DCLK1 | TNFRSF17 | RYR3 | EDN2 | NLRP2 | SNORA86 | IL1A | NPSR1-AS1 | AXIN2 | G5743 | IL2 | STK4 | DOT1L | XRCC4 | NHEJ1 | SLC10A7 | MUC21 | G7124 | FLT3 | ADAM9 | CXCR2 | ARHGAP9 | AP4M1 | Glutaminase (nonspecified subtype) | CTAG1B | STMN1 | PDCD1LG2 | CNTN4 | G196 | SNORD58A | CCL20 | ITGB3 | EDN3 | MMP2 | ZIC2 | HAVCR2 | APOA1 | TNFRSF4 | GC | LINC02456 | TIGIT | EPHA5 | WT1 | DYRK1B | CYP2C9 | G1786 | AFF1 | VDR | CCKAR | G367 | G2069 | TYMS | G5243 | HSPA12A | CTCF | PAX8 | DCBLD1 | ROCK2 | TLR9 | RET | NLRP1 | CLDN4 | G672 | SLCO2A1 | DOCK8 | CD63 | Cyclooxygenase (COX) (nonspecified subtype) | METAP2 | MIR146A | PGF | HPSE | CDK6/Cyclin D3 | TXNDC5 | RUNX1 | SOCS2 | MIR93 | ANGPT1 | CD47 | CD164 | PRKCQ | NAMPT | GUCY2C | ULBP2 | LRRC32 | SMAD3 | IL22RA2 | G6776 | AGTR1 | MGMT | TOP2A | NOS2 | GDF10 | BIRC5 | IFNG | MTHFR | TNFRSF10C | SIGLEC15 | CD28 | IL10 | SFRP1 | MCM7 | ALB | CLDN3 | KDR | TACSTD2 | XRCC5 | TM4SF5 | ROBO1 | CREBBP | DEFB1 | GSTM1 | CRACD | STING1 | ZNF582 | CLDN18 | HCAR2 | Proteasome Complex | ITGB4 | RCAN1 | MIR9-3 | G1956 | PKP2 | TWIST1 | ULBP1 | BMPR1A | SLC5A8 | CLEC9A | G925 | PAK4 | FSTL1 | GRIP1 | DKK3 | Carcinoembryonic Antigen-Related Cell Adhesion Molecule (CEA) (nonspecified subtype) | Ras GTPase (nonspecified subtype) | BST2 | G7422 | MALL | TAF1C | GSTP1 | FRZB | GLS2 | COL6A3 | MIR196A2 | IL6R | ABCC4 | SIRT3 | CCND2-AS1 | DLL4 | KIF1A | Protein phosphatase-1 | CDK1 | ADCY9 | GRK2 | TFPI2 | APC | YBX3 | PRKCE | Fibroblast Growth Factor Receptor (FGFR) (nonspecified subtype) | G3845 | FGF2 | MICA | CHEK2 | MUC20 | HSPC324 | CD19 | EGFL7 | PLAUR | PRKG1 | ITGB5 | CUX2 | PELO | PPARGC1A | Ribosomal Protein S6 Kinase, 70kDa (p70S6K) (nonspecified subtype) | XRCC1 | Vascular endothelial growth factors (VEGF) (nonspecified subtype) | MSH2 | MUC6 | CRBN | POLR1C | CAMK1D | RASSF1 | STAT5B | IGF2-AS | MSH6 | BRINP3 | VCAN | SLC2A4 | ATF7IP | TNFRSF9 | GPR55 | REC8 | CHRM2 | CTNNB1 | BMPR1B | TGFBR2 | G472 | FUT3 | KCNB1 | MLH1 | MIR5196 | FBXW7 | IL23R | DCC | DUSP1 | GLI1 | RAB27A | IGF2 | SHMT1 | MUC7 | ODC1 | DKK2 | ST6GALNAC2 | IL2RB | MAP3K3 | TOGARAM1 | TNFRSF10B | G10413 | TCF7L2 | ULBP3 | PTPN6 | CA4 | AURKA | MED12 | CDK4/Cyclin D3 | VTCN1 | ADAMTS12 | RIGI | MIR1307 | Transforming growth factor (TGF)-beta receptor (nonspecified subtype) | JAK2 | LIG4 | DPYD | NFKB1 | LATS2 | G3576 | KLRC1 | G7015 | Mitogen-activated protein kinase p38 (MAPK p38) (nonspecified subtype) | NBN | IL1B | SCN5A | HSP90B1 | SELE | ITGA6 | ITGAM | DUSP2 | LOC101928760 | CCDC190 | SH3PXD2A | CGAS | G3569

疾病靶点研报
Colon Cancer

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