MTOR Target Analysis Report Summary
About the Target
Based on the given context information, here are some key viewpoints related to mTOR:
mTOR is a highly conserved pathway across eukaryotic life and plays a crucial role in cell fate decisions [1].
The activation of mTOR is influenced by various upstream inputs, including nutrients, insulin signaling, and TNF pathway [1].
The mTOR pathway can be activated by the exchange of RAGC-GTP to RAGC-GDP, which is facilitated by a deformed nuclear envelope [2].
Upregulation of miR-101, which targets mTOR, can inhibit IAV infection at a later stage [3].
Inhibition of mTOR signaling can enhance the DNA damage response [4].
Hyperactivation of mTOR, as seen in AD brain, can impair autophagy machinery and dysregulate insulin signaling [5].
These viewpoints provide a comprehensive summary of the different aspects and functions of mTOR as highlighted in the provided context information.
Based on the provided context information, here is a comprehensive summary of key viewpoints related to the mTOR pathway:
The mTOR pathway, also known as the PI3K/AKT/mTOR pathway, plays a critical role in multiple cellular functions and is tightly regulated under normal physiological conditions [7].
Dysregulation of the mTOR pathway occurs in various tumors through different mechanisms, leading to its hyperactivation [7].
Hyperactivated mTOR signaling is associated with resistance to anti-tumor treatment, such as rapamycin analogs, due to feedback activation of PI3K and AKT, loss of mTORC2 inhibition, and up-regulation of HIF-2 alpha [7].
The mTOR pathway consists of two main complexes: mTORC1 and mTORC2, each with distinct protein components and downstream effectors [8].
In Schizosaccharomyces pombe (S. pombe), a type of yeast, there are two mTOR homologues (Tor1 and Tor2) and two TORC complexes (TORC1 and TORC2), similar to mammalian cells [9].
The TORC complexes in S. pombe and mammalian cells have some structural differences [9].
The TORC complexes, including mTORC1 and mTORC2, have essential roles in metabolism, cell organization, growth, and survival [9].
The mTORC complexes are also involved in catabolic processes like autophagy and protein degradation to maintain the metabolic state of the cell [9].
In S. pombe, the TORC2 complex is connected to DNA damage response pathways, highlighting its role in maintaining the genome [9].
10. The mTOR kinase interacts with several proteins to form mTOR Complex 1 (mTORC1) and mTOR Complex 2 (mTORC2), which regulate different major cellular processes [10].
11. The differences between mTORC1 and mTORC2 are not solely based on their protein components but also on their distinct roles in cellular regulation [10].
References:
[6] - Biorender.com (Figure designed by)
[7] - Provided source [7]
[8] - Provided source [8]
[9] - Provided source [9]
[10] - Provided source [10]
Figure [1]
Figure [2]
Figure [3]
Figure [4]
Figure [5]
Figure [6]
Figure [7]
Figure [8]
Figure [9]
Figure [10]
Note: If you are interested in the full version of this target analysis report, or if you'd like to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the MTOR target at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.
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