Other Name(s): mTOR
Drug Target Analysis Report Drug Target Analysis Report Content

About the Target

Based on the given context information, here are some key viewpoints related to mTOR:

mTOR is a highly conserved pathway across eukaryotic life and plays a crucial role in cell fate decisions [1].
The activation of mTOR is influenced by various upstream inputs, including nutrients, insulin signaling, and TNF pathway [1].
The mTOR pathway can be activated by the exchange of RAGC-GTP to RAGC-GDP, which is facilitated by a deformed nuclear envelope [2].
Upregulation of miR-101, which targets mTOR, can inhibit IAV infection at a later stage [3].
Inhibition of mTOR signaling can enhance the DNA damage response [4].
Hyperactivation of mTOR, as seen in AD brain, can impair autophagy machinery and dysregulate insulin signaling [5].

These viewpoints provide a comprehensive summary of the different aspects and functions of mTOR as highlighted in the provided context information.
Based on the provided context information, here is a comprehensive summary of key viewpoints related to the mTOR pathway:

The mTOR pathway, also known as the PI3K/AKT/mTOR pathway, plays a critical role in multiple cellular functions and is tightly regulated under normal physiological conditions [7].
Dysregulation of the mTOR pathway occurs in various tumors through different mechanisms, leading to its hyperactivation [7].
Hyperactivated mTOR signaling is associated with resistance to anti-tumor treatment, such as rapamycin analogs, due to feedback activation of PI3K and AKT, loss of mTORC2 inhibition, and up-regulation of HIF-2 alpha [7].
The mTOR pathway consists of two main complexes: mTORC1 and mTORC2, each with distinct protein components and downstream effectors [8].
In Schizosaccharomyces pombe (S. pombe), a type of yeast, there are two mTOR homologues (Tor1 and Tor2) and two TORC complexes (TORC1 and TORC2), similar to mammalian cells [9].
The TORC complexes in S. pombe and mammalian cells have some structural differences [9].
The TORC complexes, including mTORC1 and mTORC2, have essential roles in metabolism, cell organization, growth, and survival [9].
The mTORC complexes are also involved in catabolic processes like autophagy and protein degradation to maintain the metabolic state of the cell [9].
In S. pombe, the TORC2 complex is connected to DNA damage response pathways, highlighting its role in maintaining the genome [9].
10. The mTOR kinase interacts with several proteins to form mTOR Complex 1 (mTORC1) and mTOR Complex 2 (mTORC2), which regulate different major cellular processes [10].
11. The differences between mTORC1 and mTORC2 are not solely based on their protein components but also on their distinct roles in cellular regulation [10].

[6] - Biorender.com (Figure designed by)
[7] - Provided source [7]
[8] - Provided source [8]
[9] - Provided source [9]
[10] - Provided source [10]

Figure [1]

Figure [2]

Figure [3]

Figure [4]

Figure [5]

Figure [6]

Figure [7]

Figure [8]

Figure [9]

Figure [10]

Note: If you are interested in the full version of this target analysis report, or if you'd like to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the MTOR target at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

More Common Targets

ABCB1 | ABCG2 | ACE2 | AHR | AKT1 | ALK | AR | ATM | BAX | BCL2 | BCL2L1 | BECN1 | BRAF | BRCA1 | CAMP | CASP3 | CASP9 | CCL5 | CCND1 | CD274 | CD4 | CD8A | CDH1 | CDKN1A | CDKN2A | CREB1 | CXCL8 | CXCR4 | DNMT1 | EGF | EGFR | EP300 | ERBB2 | EREG | ESR1 | EZH2 | FN1 | FOXO3 | HDAC9 | HGF | HMGB1 | HSP90AA1 | HSPA4 | HSPA5 | IDO1 | IFNA1 | IGF1 | IGF1R | IL17A | IL6 | INS | JUN | KRAS | MAPK1 | MAPK14 | MAPK3 | MAPK8 | MAPT | MCL1 | MDM2 | MET | MMP9 | MTOR | MYC | NFE2L2 | NLRP3 | NOTCH1 | PARP1 | PCNA | PDCD1 | PLK1 | PRKAA1 | PRKAA2 | PTEN | PTGS2 | PTK2 | RELA | SIRT1 | SLTM | SMAD4 | SOD1 | SQSTM1 | SRC | STAT1 | STAT3 | STAT5A | TAK1 | TERT | TLR4 | TNF | TP53 | TXN | VEGFA | YAP1