IL17A Target Analysis Report Summary
About the Target
IL-17A, also known as IL-17, plays critical roles in various immune responses and diseases. In the context of SARS-CoV-2 infection, IL-17A is found to be enriched, leading to a disproportionate immune response and recruitment of innate immune cells, which can result in complications such as ARDS, sepsis, and fibrosis . Furthermore, deficiencies in the IL-17 response pathway can impair cellular responses to IL-17A/F and IL-17A/F production, leading to certain genetic disorders . In psoriasis, IL-17 production by gammadelta T cells contributes to the development of the disease . Additionally, IL-17A is implicated in bone erosion and bone formation in spondyloarthritis . The role of IL-17A in signaling pathways and its interaction with other components, such as NEMO and TBK1/IKKepsilon, is also being studied .
Based on the given context information, here is a summary of key viewpoints related to IL-17A:
IL-17A plays a role in regulating inflammation induced by rhinovirus infections in the upper airways .
IL-17A can inhibit the expression of low-density lipoprotein receptor (LDL-R) and restrict the entry of rhinovirus into airway epithelial cells .
Rhinovirus has the ability to suppress the release of IL-17A, enabling it to evade the immune system .
IL-17A has both tumor-promoting and tumor-protective effects in cancer, with its effects attributed to various molecular signaling pathways and immune cell recruitment .
IL-17A is produced by different immune cell subsets, such as MAIT cells, gammadelta T cells, NKT cells, and ILC3s, and contributes to the pathogenesis of immune-mediated inflammatory diseases like psoriatic arthritis and psoriasis .
IL-17A induces the production of pro-inflammatory cytokines and drives disease progression in psoriatic skin lesions .
IL-17A is involved in the immune response to H. pylori infection, with Th1 and Th17 cells producing proinflammatory cytokines that recruit immune cells to the gastric mucosa .
Overall, IL-17A has diverse roles in regulating inflammation, immune responses, and disease progression in various contexts. Further research is needed to fully understand its mechanisms and potential therapeutic interventions.
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