About the Target

Based on the given context information, the proposed model suggests that LL-37, also known as hCAP18, is an antimicrobial peptide (AMP) that plays a crucial role in protecting the skin against S. aureus infection. LL-37 works in various ways to defend against S. aureus:

Direct inhibition and killing of S. aureus: LL-37 can directly inhibit and kill S. aureus bacteria [1].

Cooperation with other AMPs: LL-37 can cooperate with host-derived AMPs like hCAP18/LL-37 and dermcidin-derived peptides DCD-1(L) to effectively kill S. aureus [1].

Induction of innate immune response: LL-37 prompts an innate immune response in the skin, leading to the recruitment of phagocytic immune cells that help eliminate potential invading pathogens [1].

Amplification of innate immune response: The innate immune response triggered by LL-37 can be greatly enhanced by factors derived from the skin commensal S. epidermidis [1].

Furthermore, the study reveals that lugdunin, a compound with both immunomodulatory and bactericidal activities, offers multi-level protection against S. aureus [1]. Additionally, it is noteworthy that Bacillus subtilis, along with S. aureus, is susceptible to lugdunin and lugdunin/DCD-1(L) combinations [1]. The presence of other microbiota- or host-derived factors can amplify the protective effects of lugdunin [1].

In summary, LL-37 (or hCAP18) plays a critical role in safeguarding the skin against S. aureus infection through multiple mechanisms. Lugdunin, in combination with LL-37 and other factors, provides robust protection against S. aureus and potentially other bacteria [1].

Note: If you are interested in the full version of this target analysis report, or if you'd like to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the CAMP target at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

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