Molecules to IL17A (Q16552) Target Generated and Optimized

Molecules against Target IL17A

Uniprot ID: Q16552

Other Name(s): IL-17, IL-17A

Assay:	Inhibitory concentration of compound (dissolved in DMSO) against binding of human INTERLEUKIN-17A (expressed in CHO cells) to soluble IL-17RA (33-317) expressed in Expi HEK 293 cells upon incubation for 1 hr by FLUORESCENCE RESONANCE ENERGY TRANSFER (FRET) ASSAY
Type:	IC50
SMILES:	O=C(NC1=CC2=C(C=C1)C1(CCOCC1)C(=O)N2)[C@@H](NC1=CC2=C(C=CC=C2)N=N1)C1CCCCC1
Value:	<=C10uM
Source:	Human

Assay:	Inhibitory concentration of compound (dissolved in DMSO) against binding of human INTERLEUKIN-17A (expressed in CHO cells) to soluble IL-17RA (33-317) expressed in Expi HEK 293 cells upon incubation for 1 hr by FLUORESCENCE RESONANCE ENERGY TRANSFER (FRET) ASSAY
Type:	IC50
SMILES:	CC(C)C1=NN=C(N[C@@H](C2CCCCC2)C(=O)NC2=CC3=C(C=C2)C2(CCOCC2)C(=O)N3)C=C1
Value:	<=C10uM
Source:	Human

Assay:	Inhibitory concentration of compound (dissolved in DMSO) against binding of human INTERLEUKIN-17A (expressed in CHO cells) to soluble IL-17RA (33-317) expressed in Expi HEK 293 cells upon incubation for 1 hr by FLUORESCENCE RESONANCE ENERGY TRANSFER (FRET) ASSAY
Type:	IC50
SMILES:	CCC1=NN=C(N[C@@H](C2CCCCC2)C(=O)NC2=CC3=C(C=C2)C2(CCOCC2)C(=O)N3)C=C1
Value:	<=C10uM
Source:	Human

Assay:	Inhibitory concentration of compound (dissolved in DMSO) against binding of human INTERLEUKIN-17A (expressed in CHO cells) to soluble IL-17RA (33-317) expressed in Expi HEK 293 cells upon incubation for 1 hr by FLUORESCENCE RESONANCE ENERGY TRANSFER (FRET) ASSAY
Type:	IC50
SMILES:	O=C(NC1=CC2=C(C=C1)C1(CCOCC1)C(=O)N2)C(NC1=NN=CC=C1)C1CCCCCCC1
Value:	<=C10uM
Source:	Human

Assay:	Inhibitory concentration of compound (dissolved in DMSO) against binding of human INTERLEUKIN-17A (expressed in CHO cells) to soluble IL-17RA (33-317) expressed in Expi HEK 293 cells upon incubation for 1 hr by FLUORESCENCE RESONANCE ENERGY TRANSFER (FRET) ASSAY
Type:	IC50
SMILES:	CC(C)(C)OC(=O)N[C@@H](C1CCCCCCC1)C(=O)NC1=CC2=C(C=C1)C1(CCOCC1)C(=O)N2
Value:	<=C10uM
Source:	Human

Assay:	Inhibitory concentration of compound (dissolved in DMSO) against binding of human INTERLEUKIN-17A (expressed in CHO cells) to soluble IL-17RA (33-317) expressed in Expi HEK 293 cells upon incubation for 1 hr by FLUORESCENCE RESONANCE ENERGY TRANSFER (FRET) ASSAY
Type:	IC50
SMILES:	CCC1=NOC=C1C(=O)NC(C1CCCCCCC1)C(=O)NC1=CC2=C(C=C1)C1(CCOCC1)C(=O)N2C
Value:	<=C10uM
Source:	Human

Assay:	Inhibitory concentration of compound (dissolved in DMSO) against binding of human INTERLEUKIN-17A (expressed in CHO cells) to soluble IL-17RA (33-317) expressed in Expi HEK 293 cells upon incubation for 1 hr by FLUORESCENCE RESONANCE ENERGY TRANSFER (FRET) ASSAY
Type:	IC50
SMILES:	CC1CC\C(CC1)=C(/NC(=O)C1=CC=NN1C)C(=O)NC1=CC2=C(C=C1)C1(CCOCC1)C(=O)N2
Value:	<=C10uM
Source:	Human

Assay:	Inhibitory concentration of compound (dissolved in DMSO) against binding of human INTERLEUKIN-17A (expressed in CHO cells) to soluble IL-17RA (33-317) expressed in Expi HEK 293 cells upon incubation for 1 hr by FLUORESCENCE RESONANCE ENERGY TRANSFER (FRET) ASSAY
Type:	IC50
SMILES:	CC1=NOC=C1C(=O)N[C@@H](C1CCCCC1)C(=O)NC1=CC2=C(C=C1)C1(CCOCC1)C(=O)N2
Value:	<=C10uM
Source:	Human

Assay:	Inhibitory concentration of compound (dissolved in DMSO) against binding of human INTERLEUKIN-17A (expressed in CHO cells) to soluble IL-17RA (33-317) expressed in Expi HEK 293 cells upon incubation for 1 hr by FLUORESCENCE RESONANCE ENERGY TRANSFER (FRET) ASSAY
Type:	IC50
SMILES:	CC1=NOC=C1C(=O)N[C@@H](C1CCCCCCC1)C(=O)NC1=CC2=C(C=C1)C1(CCOCC1)C(=O)N2
Value:	<=C10uM
Source:	Human

Assay:	Inhibitory concentration of compound (dissolved in DMSO) against binding of human INTERLEUKIN-17A (expressed in CHO cells) to soluble IL-17RA (33-317) expressed in Expi HEK 293 cells upon incubation for 1 hr by FLUORESCENCE RESONANCE ENERGY TRANSFER (FRET) ASSAY
Type:	IC50
SMILES:	CC1=NOC=C1C(=O)NC(C1CCCCCCC1)C(=O)NC1=CC2=C(C=C1)C1(CCOCC1)C(=O)N2
Value:	<=C10uM
Source:	Human

Assay:	Inhibitory concentration of compound (dissolved in DMSO) against binding of human INTERLEUKIN-17A (expressed in CHO cells) to soluble IL-17RA (33-317) expressed in Expi HEK 293 cells upon incubation for 1 hr by FLUORESCENCE RESONANCE ENERGY TRANSFER (FRET) ASSAY
Type:	IC50
SMILES:	CN1N=CC=C1C(=O)NC(C1CCCCCCC1)C(=O)NC1=NC2=C(C=N1)C1(CCOCC1)C(=O)N2
Value:	<=C10uM
Source:	Human

Assay:	Inhibitory concentration of compound (dissolved in DMSO) against binding of human INTERLEUKIN-17A (expressed in CHO cells) to soluble IL-17RA (33-317) expressed in Expi HEK 293 cells upon incubation for 1 hr by FLUORESCENCE RESONANCE ENERGY TRANSFER (FRET) ASSAY
Type:	IC50
SMILES:	CN1N=CC=C1C(=O)NC(C1CCCCCCC1)C(=O)NC1=CC2=C(N=C1)C1(CCOCC1)C(=O)N2
Value:	<=C10uM
Source:	Human

Assay:	Inhibitory concentration of compound (dissolved in DMSO) against binding of human INTERLEUKIN-17A (expressed in CHO cells) to soluble IL-17RA (33-317) expressed in Expi HEK 293 cells upon incubation for 1 hr by FLUORESCENCE RESONANCE ENERGY TRANSFER (FRET) ASSAY
Type:	IC50
SMILES:	CN1N=CC=C1C(=O)NC(C1CCCCCCC1)C(=O)NC1=CC2=C(C=N1)C1(CCOCC1)C(=O)N2
Value:	<=C10uM
Source:	Human

Assay:	Inhibitory concentration of compound (dissolved in DMSO) against binding of human INTERLEUKIN-17A (expressed in CHO cells) to soluble IL-17RA (33-317) expressed in Expi HEK 293 cells upon incubation for 1 hr by FLUORESCENCE RESONANCE ENERGY TRANSFER (FRET) ASSAY
Type:	IC50
SMILES:	[H][C@@]1(CC[C@H](C)CC1)[C@H](NC1=NN=C(C=C1)C(F)F)C(=O)NC1=CC2=C(C=N1)C1(CCOCC1)C(=O)N2
Value:	<=C10uM
Source:	Human

Assay:	Inhibitory concentration of compound (dissolved in DMSO) against binding of human INTERLEUKIN-17A (expressed in CHO cells) to soluble IL-17RA (33-317) expressed in Expi HEK 293 cells upon incubation for 1 hr by FLUORESCENCE RESONANCE ENERGY TRANSFER (FRET) ASSAY
Type:	IC50
SMILES:	[H][C@@]1(CC[C@H](C)CC1)[C@H](NC(=O)C1=CC=NN1C(C)C)C(=O)NC1=CC2=C(C=N1)C1(CCOCC1)C(=O)N2
Value:	<=C10uM
Source:	Human

Assay:	Inhibitory concentration of compound (dissolved in DMSO) against binding of human INTERLEUKIN-17A (expressed in CHO cells) to soluble IL-17RA (33-317) expressed in Expi HEK 293 cells upon incubation for 1 hr by FLUORESCENCE RESONANCE ENERGY TRANSFER (FRET) ASSAY
Type:	IC50
SMILES:	CC(C)N1N=CC=C1C(=O)N[C@@H](C1CCCCC1)C(=O)NC1=CC2=C(C=C1)C1(CCOCC1)C(=O)N2
Value:	<=C10uM
Source:	Human

Assay:	Inhibitory concentration of compound (dissolved in DMSO) against binding of human INTERLEUKIN-17A (expressed in CHO cells) to soluble IL-17RA (33-317) expressed in Expi HEK 293 cells upon incubation for 1 hr by FLUORESCENCE RESONANCE ENERGY TRANSFER (FRET) ASSAY
Type:	IC50
SMILES:	CCCN1N=CC=C1C(=O)N[C@@H](C1CCCCC1)C(=O)NC1=CC2=C(C=C1)C1(CCOCC1)C(=O)N2
Value:	<=C10uM
Source:	Human

Assay:	Inhibitory concentration of compound (dissolved in DMSO) against binding of human INTERLEUKIN-17A (expressed in CHO cells) to soluble IL-17RA (33-317) expressed in Expi HEK 293 cells upon incubation for 1 hr by FLUORESCENCE RESONANCE ENERGY TRANSFER (FRET) ASSAY
Type:	IC50
SMILES:	CC1CCC(CC1)C(NC(=O)C1=CC=NN1C)C(=O)NC1=CC2=C(C(F)=C1)C1(CCOCC1)C(=O)N2
Value:	<=C10uM
Source:	Human

Assay:	Inhibitory concentration of compound (dissolved in DMSO) against binding of human INTERLEUKIN-17A (expressed in CHO cells) to soluble IL-17RA (33-317) expressed in Expi HEK 293 cells upon incubation for 1 hr by FLUORESCENCE RESONANCE ENERGY TRANSFER (FRET) ASSAY
Type:	IC50
SMILES:	CCC1=NOC=C1C(=O)NC(C1CCCCCCC1)C(=O)NC1=CC2=C(C=C1)C1(CCOCC1)C(=O)N2
Value:	<=C10uM
Source:	Human

Assay:	Inhibitory concentration of compound (dissolved in DMSO) against binding of human INTERLEUKIN-17A (expressed in CHO cells) to soluble IL-17RA (33-317) expressed in Expi HEK 293 cells upon incubation for 1 hr by FLUORESCENCE RESONANCE ENERGY TRANSFER (FRET) ASSAY
Type:	IC50
SMILES:	FC(F)CN1N=CC=C1C(=O)NC(C1CCCCCCC1)C(=O)NC1=CC2=C(C=C1)C1(CCOCC1)C(=O)N2
Value:	<=C10uM
Source:	Human

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