Other Name(s): Caspase 3, Caspase-3, Caspase-3
Assay:Amidolytic activity of THP.1 cell lysate against Caspase-3 using C3-Asp-AMC as a substrate
Type:IC50
SMILES:CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@H](C=O)CC(=O)O)C(C)C
Value:=190000nM
Source:
Assay:Amidolytic activity of THP.1 cell lysate against Caspase-3 using C3-Asp-AMC as a substrate
Type:IC50
SMILES:CC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)N[C@H](CC=O)CC(=O)O)C(C)C
Value:=438nM
Source:
Assay:Binding affinity towards human Caspase-3
Type:IC50
SMILES:CC(C)C[C@H](NC(=O)CNc1cccc2ccccc12)C(=O)N[C@H](C=O)CC(=O)O
Value:=13nM
Source:
Assay:Binding affinity towards human Caspase-3
Type:IC50
SMILES:CC(C)C[C@H](NC(=O)C(=O)Nc1cccc2ccccc12)C(=O)N[C@H](C=O)CC(=O)O
Value:=10nM
Source:
Assay:Binding affinity towards human Caspase-3
Type:IC50
SMILES:CC(C)C[C@H](NC(=O)COc1cccc2ccccc12)C(=O)N[C@H](C=O)CC(=O)O
Value:=135nM
Source:
Assay:Inhibitory activity against human Caspase-3 using Ac-AspGluValAsp as substrate
Type:IC50
SMILES:O=C1C[C@H](NC(=O)[C@@H]2CS[C@H]3CC[C@H](NC(=O)OCc4ccccc4)C(=O)N32)C(O)O1
Value:=86000nM
Source:
Assay:Inhibitory activity against human Caspase-3 using Ac-AspGluValAsp as substrate
Type:IC50
SMILES:CC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)N[C@H]1CC(=O)OC1O)C(C)C
Value:=1.2nM
Source:
Assay:Inhibitory activity against human Caspase-3 using Ac-AspGluValAsp as substrate
Type:IC50
SMILES:O=C(CN1CCC[C@H](NC(=O)OCc2ccccc2)C1=O)N[C@H]1CC(=O)OC1O
Value:>100000nM
Source:
Assay:Inhibitory activity against human Caspase-3 using Ac-AspGluValAsp as substrate
Type:IC50
SMILES:CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@H]1CC(=O)OC1O)C(C)C
Value:=15000nM
Source:
Assay:Inhibitory activity against human Caspase-3 using Ac-AspGluValAsp as substrate
Type:IC50
SMILES:CC(=O)N[C@@H](CC(=O)O)C(=O)N[C@H]1CCC[C@H]2SC[C@@H](C(=O)N[C@H]3CC(=O)OC3O)N2C1=O
Value:=18nM
Source:
Assay:Inhibitory activity against human Caspase-3 using Ac-AspGluValAsp as substrate
Type:IC50
SMILES:CC(C)[C@H](NC(=O)OCc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@H]1CC(=O)OC1O
Value:=14000nM
Source:
Assay:Inhibitory activity against human Caspase-3 using Ac-AspGluValAsp as substrate
Type:IC50
SMILES:O=C(CN1CCCC[C@H](NC(=O)OCc2ccccc2)C1=O)N[C@H]1CC(=O)OC1O
Value:=53000nM
Source:
Assay:Inhibitory activity against human Caspase-3 using Ac-AspGluValAsp as substrate
Type:IC50
SMILES:CC(C)[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@H]1CC(=O)OC1O
Value:=47000nM
Source:
Assay:Inhibitory activity against human Caspase-3 using Ac-AspGluValAsp as substrate
Type:IC50
SMILES:O=C1C[C@H](NC(=O)[C@@H]2CCC[C@@H]3CCC[C@H](NC(=O)OCc4ccccc4)C(=O)N32)C(O)O1
Value:>10000nM
Source:
Assay:Inhibitory activity against human Caspase-3 using Ac-AspGluValAsp as substrate
Type:IC50
SMILES:C[C@@H](C(=O)N[C@H]1CC(=O)OC1O)N1CCCC[C@H](NC(=O)OCc2ccccc2)C1=O
Value:>10000nM
Source:
Assay:Inhibitory activity against human Caspase-3 using Ac-AspGluValAsp as substrate
Type:IC50
SMILES:CC(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@H]1CC(=O)OC1O)C(C)C
Value:=74nM
Source:
Assay:Inhibitory activity against human Caspase-3 using Ac-AspGluValAsp as substrate
Type:IC50
SMILES:O=C1C[C@H](NC(=O)[C@@H]2CS[C@@H]3CCC[C@H](NC(=O)OCc4ccccc4)C(=O)N32)C(O)O1
Value:>10000nM
Source:
Assay:Inhibitory activity against human Caspase-3 using Ac-AspGluValAsp as substrate
Type:IC50
SMILES:O=C(CN1CC[C@H](NC(=O)OCc2ccccc2)C1=O)N[C@H]1CC(=O)OC1O
Value:>10000nM
Source:
Assay:Inhibitory activity against human Caspase-3 using Ac-AspGluValAsp as substrate
Type:IC50
SMILES:C[C@@H](C(=O)N[C@H]1CC(=O)OC1O)N1CC[C@H](NC(=O)OCc2ccccc2)C1=O
Value:>100000nM
Source:
Assay:Inhibitory activity against human Caspase-3 using Ac-AspGluValAsp as substrate
Type:IC50
SMILES:CC(C)[C@H](NC(=O)OCc1ccccc1)C(=O)N1CCCC[C@H]1C(=O)N[C@H]1CC(=O)OC1O
Value:=3490nM
Source:

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