Assay: Inhibition of BCRP expressed in human HEK293 cells assessed as maximal mitoxantrone accumulation Type: IC50 SMILES: COc1cc(O)c2c(=O)c3c(oc2c1)C(OC)Oc1c(O)cccc1-3 Value: =700nM Source: Homo sapiens
	Assay: Inhibition of BCRP expressed in human HEK293 cells assessed as maximal mitoxantrone accumulation Type: IC50 SMILES: COc1cc2oc3c(c(=O)c2c(O)c1C)-c1cccc(O)c1OC3OC Value: =2500nM Source: Homo sapiens
	Assay: Inhibition of ABCG2 expressed in HEK293 cells assessed as mitoxantrone-mediated efflux by flow cytometry Type: IC50 SMILES: COc1cccc2[nH]c3ccccc3c(=O)c12 Value: =6300nM Source: Homo sapiens
	Assay: Inhibition of ABCG2 expressed in HEK293 cells assessed as mitoxantrone-mediated efflux by flow cytometry Type: IC50 SMILES: COc1ccc2c(=O)c3cccc(C(=O)NCCc4ccc(OC)c(OC)c4)c3[nH]c2c1 Value: =1380nM Source: Homo sapiens
	Assay: Inhibition of ABCG2 expressed in HEK293 cells assessed as mitoxantrone-mediated efflux by flow cytometry Type: IC50 SMILES: COc1ccc(CCNC(=O)c2cccc3c(=O)c4ccc(OC)cc4[nH]c23)cc1 Value: =560nM Source: Homo sapiens
	Assay: Inhibition of ABCG2 expressed in HEK293 cells assessed as mitoxantrone-mediated efflux by flow cytometry Type: IC50 SMILES: COc1ccc(CCNC(=O)c2cccc3c(=O)c4ccccc4[nH]c23)cc1OC Value: =450nM Source: Homo sapiens
	Assay: Inhibition of ABCG2 expressed in HEK293 cells assessed as mitoxantrone-mediated efflux by flow cytometry Type: IC50 SMILES: COc1ccc(CCNC(=O)c2cccc3c(=O)c4ccccc4[nH]c23)cc1 Value: =350nM Source: Homo sapiens
	Assay: Inhibition of ABCG2 expressed in HEK293 cells assessed as mitoxantrone-mediated efflux by flow cytometry Type: IC50 SMILES: COc1cc(C(F)(F)F)cc2[nH]c3ccccc3c(=O)c12 Value: =770nM Source: Homo sapiens
	Assay: Inhibition of ABCG2 expressed in HEK293 cells assessed as mitoxantrone-mediated efflux by flow cytometry Type: IC50 SMILES: COc1cc(OC)c2c(=O)c3ccccc3[nH]c2c1 Value: =7900nM Source: Homo sapiens
	Assay: Inhibition of ABCG2 expressed in HEK293 cells assessed as mitoxantrone-mediated efflux by flow cytometry Type: IC50 SMILES: COc1ccc2[nH]c3ccccc3c(=O)c2c1 Value: =4800nM Source: Homo sapiens
	Assay: Inhibition of ABCG2 expressed in HEK293 cells assessed as mitoxantrone-mediated efflux by flow cytometry Type: IC50 SMILES: COc1ccc2[nH]c3ccccc3c(=O)c2c1OC Value: >20000nM Source: Homo sapiens
	Assay: Inhibition of ABCG2 expressed in HEK293 cells assessed as mitoxantrone-mediated efflux by flow cytometry Type: IC50 SMILES: O=c1c2ccccc2[nH]c2cc(C(F)(F)F)cc(O)c12 Value: >20000nM Source: Homo sapiens
	Assay: Inhibition of ABCG2 expressed in HEK293 cells assessed as mitoxantrone-mediated efflux by flow cytometry Type: IC50 SMILES: COc1cc(O)c2c(=O)c3ccccc3[nH]c2c1 Value: >20000nM Source: Homo sapiens
	Assay: Inhibition of ABCG2 expressed in HEK293 cells assessed as mitoxantrone-mediated efflux by flow cytometry Type: IC50 SMILES: O=c1c2ccccc2[nH]c2ccc(O)cc12 Value: >20000nM Source: Homo sapiens
	Assay: Inhibition of ABCG2 expressed in HEK293 cells assessed as mitoxantrone-mediated efflux by flow cytometry Type: IC50 SMILES: O=c1c2ccccc2[nH]c2cccc(O)c12 Value: >20000nM Source: Homo sapiens
	Assay: Inhibition of ABCG2 expressed in HEK293 cells assessed as mitoxantrone-mediated efflux by flow cytometry Type: IC50 SMILES: COc1cc2c(cc1OC)CN(CCc1ccc(NC(=O)c3cccc4c(=O)c5cccc(OC)c5[nH]c34)cc1)CC2 Value: =410nM Source: Homo sapiens
	Assay: Inhibition of human BCRP pump mediated [3H]mitoxantrone transport in human Caco-2 cells Type: EC50 SMILES: COc1cccc(COc2ccccc2CCc2ccccc2)c1OC Value: =75000nM Source: Homo sapiens
	Assay: Inhibition of human BCRP pump mediated [3H]mitoxantrone transport in human Caco-2 cells Type: EC50 SMILES: COc1cccc(CCc2ccccc2NCc2ccc(OC)c(OC)c2)c1 Value: =500nM Source: Homo sapiens
	Assay: Inhibition of human BCRP pump mediated [3H]mitoxantrone transport in human Caco-2 cells Type: EC50 SMILES: COc1cccc(CCc2ccccc2NCc2cccc(OC)c2OC)c1 Value: =1500nM Source: Homo sapiens
	Assay: Inhibition of human BCRP pump mediated [3H]mitoxantrone transport in human Caco-2 cells Type: EC50 SMILES: COc1cccc(CCc2ccccc2NCc2cccc(OC)c2)c1 Value: =7000nM Source: Homo sapiens

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